Strain Name:
C57BL/6J-MtgxR5926Btlr
Stock Number:
044121-MU
Citation ID:
RRID:MMRRC_044121-MU
Other Names:
R5926 (G1)
Major Collection:

Gene Information

Hfe
Name: homeostatic iron regulator
Synonyms: MR2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 15216
HGNC: HGNC:4886
Homologene: 88330
Ptch1
Name: patched 1
Synonyms: Ptc, Patched 1, Ptc1, A230106A15Rik, wig
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Mark3
Name: MAP/microtubule affinity regulating kinase 3
Synonyms: ETK-1, 1600015G02Rik, A430080F22Rik, C-TAK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 17169
VEGA: 12
HGNC: HGNC:6897
Homologene: 55653
Cyb5r4
Name: cytochrome b5 reductase 4
Synonyms: B5+B5R, b5/b5r, 2810034J18Rik, Ncb5or
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 266690
Homologene: 69207
Kcnn2
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Synonyms: small conductance calcium-activated potassium channel 2, SK2, fri, bc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 140492
HGNC: HGNC:6291
Homologene: 135651
Doc2a
Name: double C2, alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13446
HGNC: HGNC:2985
Homologene: 2657
Notch1
Name: notch 1
Synonyms: lin-12, Tan1, Mis6, 9930111A19Rik, Motch A, N1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18128
HGNC: HGNC:7881
Homologene: 32049
Raf1
Name: v-raf-leukemia viral oncogene 1
Synonyms: Raf-1, v-Raf, sarcoma 3611 oncogene, 6430402F14Rik, c-Raf, Craf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 110157
HGNC: HGNC:9829
Homologene: 48145
Brca2
Name: breast cancer 2, early onset
Synonyms: RAB163, Fancd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12190
HGNC: HGNC:1101
Homologene: 41
Pi4kb
Name: phosphatidylinositol 4-kinase beta
Synonyms: ESTM41, Pik4cb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 107650
HGNC: HGNC:8984
Homologene: 6741
Ddx41
Name: DEAD box helicase 41
Synonyms: 2900024F02Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 72935
VEGA: 13
Homologene: 9431
Cyp20a1
Name: cytochrome P450, family 20, subfamily a, polypeptide 1
Synonyms: A930011N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 77951
Homologene: 18584
Spaca4
Name: sperm acrosome associated 4
Synonyms: 1700008E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69363
Homologene: 41708
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: calcium release channel isoform 1, Ryr, skrr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20190
Homologene: 68069
Kcnd2
Name: potassium voltage-gated channel, Shal-related family, member 2
Synonyms: Kv4.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16508
HGNC: HGNC:6238
Homologene: 40828
Spata31
Name: spermatogenesis associated 31
Synonyms: 4930458L03Rik, Spata31a, Fam75a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 78124
Homologene: 84621
Arnt2
Name: aryl hydrocarbon receptor nuclear translocator 2
Synonyms: bHLHe1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11864
Homologene: 7230
Vwf
Name: Von Willebrand factor
Synonyms: B130011O06Rik, 6820430P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22371
Homologene: 466
Jakmip1
Name: janus kinase and microtubule interacting protein 1
Synonyms: Marlin-1, 5830437M04Rik, C330021K24Rik, Gababrbp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 76071
Homologene: 90789
Arhgef15
Name: Rho guanine nucleotide exchange factor (GEF) 15
Synonyms: D530030K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 442801
Homologene: 18345
Ptprn
Name: protein tyrosine phosphatase, receptor type, N
Synonyms: IA-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19275
HGNC: HGNC:9676
Homologene: 48142
A2ml1
Name: alpha-2-macroglobulin like 1
Synonyms: Ovos2, BC048546
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232400
Homologene: 45969
Myt1l
Name: myelin transcription factor 1-like
Synonyms: Png-1, Nztf1, Pmng1, C630034G21Rik, 2900093J19Rik, 2900046C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 17933
VEGA: 12
HGNC: HGNC:7623
Homologene: 7435
Ptprt
Name: protein tyrosine phosphatase, receptor type, T
Synonyms: RPTPrho
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19281
HGNC: HGNC:9682
Homologene: 56924
Trpm8
Name: transient receptor potential cation channel, subfamily M, member 8
Synonyms: CMR1, TRPP8, Trp-p8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 171382
Homologene: 23433
Olfr512
Name: olfactory receptor 512
Synonyms: GA_x6K02T2PBJ9-11043421-11044365, MOR268-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258719
Homologene: 138316
Atp9a
Name: ATPase, class II, type 9A
Synonyms: Class II, IIa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11981
Homologene: 69194
L3hypdh
Name: L-3-hydroxyproline dehydratase (trans-)
Synonyms: 2810055F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 67217
Homologene: 12100
Med16
Name: mediator complex subunit 16
Synonyms: 95kDa, Trap95, Thrap5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216154
Homologene: 64602
Mup5
Name: major urinary protein 5
Synonyms: Mup V
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17844
Homologene: 74304
Lrit1
Name: leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
Synonyms: Lrrc21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239037
Homologene: 9215
Kcnh1
Name: potassium voltage-gated channel, subfamily H (eag-related), member 1
Synonyms: ether a go-go, Eag1, Kv10.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16510
HGNC: HGNC:6250
Homologene: 68242
Cdk5r1
Name: cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Synonyms: p35, D11Bwg0379e, p25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12569
HGNC: HGNC:1775
Homologene: 31200
Dnm1
Name: dynamin 1
Synonyms: dynamin 1, Ftfl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13429
HGNC: HGNC:2972
Homologene: 123905
Olfr473
Name: olfactory receptor 473
Synonyms: GA_x6K02T2PBJ9-10262759-10263691, MOR204-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258771
Homologene: 74116
Kcnb2
Name: potassium voltage gated channel, Shab-related subfamily, member 2
Synonyms: Kv2.2, 9630047L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98741
HGNC: HGNC:6232
Homologene: 31263
Vps16
Name: VSP16 CORVET/HOPS core subunit
Synonyms: 1810074M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 80743
Homologene: 7116
Haus6
Name: HAUS augmin-like complex, subunit 6
Synonyms: D4Ertd27e, 6230416J20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230376
Homologene: 9760
Olfr1415
Name: olfactory receptor 1415
Synonyms: GA_x6K02T2R7CC-81266841-81267776, MOR103-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 258228
Homologene: 79367
Acer2
Name: alkaline ceramidase 2
Synonyms: 2410116I05Rik, Asah3l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230379
Homologene: 14986
Tbx6
Name: T-box 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 21389
Homologene: 3389
Ghdc
Name: GH3 domain containing
Synonyms: D11Lgp1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 80860
Homologene: 32760
Abra
Name: actin-binding Rho activating protein
Synonyms: C130068O12Rik, STARS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223513
VEGA: 15
Homologene: 34713
Gldn
Name: gliomedin
Synonyms: Crlg2, CRG-L2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235379
Homologene: 14529
Fam188a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Vprbp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 15,313,011 bp
  • T to A, chromosome 1 at 60,363,242 bp
  • G to A, chromosome 1 at 75,254,598 bp
  • T to A, chromosome 1 at 88,330,747 bp
  • A to T, chromosome 1 at 92,491,566 bp
  • A to G, chromosome 1 at 192,413,077 bp
  • T to C, chromosome 2 at 12,348,100 bp
  • A to G, chromosome 2 at 26,476,104 bp
  • C to T, chromosome 2 at 32,315,804 bp
  • T to A, chromosome 2 at 130,443,556 bp
  • T to C, chromosome 2 at 161,564,686 bp
  • T to A, chromosome 2 at 168,706,271 bp
  • A to G, chromosome 3 at 94,998,996 bp
  • A to T, chromosome 4 at 61,833,049 bp
  • A to T, chromosome 4 at 86,599,316 bp
  • T to C, chromosome 4 at 86,874,568 bp
  • C to T, chromosome 5 at 37,085,280 bp
  • A to G, chromosome 5 at 150,534,622 bp
  • A to G, chromosome 6 at 21,217,085 bp
  • T to C, chromosome 6 at 115,619,898 bp
  • T to C, chromosome 6 at 125,604,174 bp
  • T to A, chromosome 6 at 128,560,645 bp
  • A to G, chromosome 7 at 29,104,360 bp
  • G to T, chromosome 7 at 45,725,295 bp
  • G to T, chromosome 7 at 84,343,946 bp
  • T to C, chromosome 7 at 107,933,903 bp
  • T to C, chromosome 7 at 108,713,587 bp
  • G to A, chromosome 7 at 126,784,853 bp
  • T to C, chromosome 7 at 126,849,525 bp
  • A to G, chromosome 9 at 54,338,438 bp
  • C to T, chromosome 9 at 87,057,261 bp
  • T to C, chromosome 9 at 106,838,362 bp
  • C to T, chromosome 10 at 79,902,528 bp
  • A to G, chromosome 11 at 68,951,955 bp
  • T to C, chromosome 11 at 80,478,302 bp
  • C to T, chromosome 11 at 100,768,237 bp
  • G to A, chromosome 12 at 29,832,332 bp
  • T to A, chromosome 12 at 72,077,185 bp
  • T to A, chromosome 12 at 111,592,734 bp
  • A to T, chromosome 13 at 23,708,264 bp
  • A to T, chromosome 13 at 55,534,299 bp
  • A to G, chromosome 13 at 63,545,055 bp
  • A to G, chromosome 13 at 64,920,725 bp
  • T to A, chromosome 14 at 37,055,009 bp
  • T to A, chromosome 15 at 41,866,254 bp
  • A to G, chromosome 18 at 45,685,284 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5926 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044121-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.