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Strain Name:
C57BL/6J-MtgxR5929Btlr/Mmmh
Stock Number:
044124-MU
Citation ID:
RRID:MMRRC_044124-MU
Other Names:
R5929 (G1)
Major Collection:

Strain Information

Gabra6
Name: gamma-aminobutyric acid type A receptor subunit alpha 6
Synonyms: Gabra-6, alpha6, GABA-ARalpha6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14399
HGNC: HGNC:4080
Homologene: 20220
Mtmr7
Name: myotubularin related protein 7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54384
HGNC: HGNC:7454
Homologene: 99732
Xpnpep1
Name: X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
Synonyms: D230045I08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 170750
Homologene: 6424
Sema3f
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
Synonyms: Sema IV, Semak
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20350
Homologene: 20885
Paip1
Name: polyadenylate binding protein-interacting protein 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218693
Homologene: 4709
Psmd3
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
Synonyms: AntP91a, Psd3, Tstap91a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22123
HGNC: HGNC:9560
Homologene: 2102
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 22,468,241 bp
  • A to T, chromosome 1 at 78,523,733 bp
  • A to G, chromosome 1 at 136,151,207 bp
  • A to G, chromosome 1 at 150,454,129 bp
  • C to A, chromosome 1 at 150,577,296 bp
  • A to T, chromosome 1 at 171,559,367 bp
  • A to G, chromosome 1 at 195,171,111 bp
  • G to A, chromosome 2 at 73,373,667 bp
  • T to A, chromosome 2 at 111,844,286 bp
  • T to C, chromosome 2 at 152,397,388 bp
  • T to A, chromosome 2 at 160,753,602 bp
  • T to C, chromosome 3 at 19,546,855 bp
  • T to G, chromosome 3 at 115,101,880 bp
  • T to C, chromosome 4 at 11,051,150 bp
  • G to T, chromosome 4 at 59,092,497 bp
  • T to C, chromosome 4 at 63,168,517 bp
  • T to C, chromosome 4 at 124,682,243 bp
  • T to G, chromosome 4 at 140,944,537 bp
  • C to T, chromosome 4 at 148,938,696 bp
  • T to A, chromosome 4 at 148,938,969 bp
  • T to C, chromosome 4 at 150,196,135 bp
  • T to C, chromosome 5 at 3,769,633 bp
  • G to T, chromosome 5 at 32,975,506 bp
  • A to T, chromosome 5 at 105,812,606 bp
  • T to A, chromosome 6 at 4,629,993 bp
  • A to G, chromosome 6 at 21,772,747 bp
  • T to C, chromosome 6 at 41,376,804 bp
  • T to A, chromosome 6 at 81,946,599 bp
  • A to T, chromosome 6 at 108,423,336 bp
  • G to A, chromosome 6 at 124,326,609 bp
  • A to G, chromosome 7 at 19,857,822 bp
  • A to G, chromosome 7 at 90,236,316 bp
  • A to C, chromosome 7 at 126,759,858 bp
  • T to A, chromosome 8 at 11,216,788 bp
  • T to C, chromosome 8 at 40,558,358 bp
  • A to G, chromosome 8 at 85,970,914 bp
  • A to G, chromosome 8 at 105,093,165 bp
  • T to C, chromosome 9 at 18,304,362 bp
  • T to C, chromosome 9 at 22,002,422 bp
  • T to C, chromosome 9 at 106,063,044 bp
  • T to C, chromosome 9 at 107,692,193 bp
  • G to T, chromosome 10 at 7,774,050 bp
  • A to T, chromosome 10 at 33,949,047 bp
  • T to A, chromosome 10 at 39,551,461 bp
  • A to T, chromosome 10 at 62,559,402 bp
  • T to A, chromosome 11 at 42,317,562 bp
  • A to T, chromosome 11 at 50,922,455 bp
  • G to T, chromosome 11 at 96,827,359 bp
  • C to T, chromosome 11 at 98,695,596 bp
  • G to C, chromosome 13 at 32,806,966 bp
  • A to T, chromosome 13 at 38,195,434 bp
  • T to C, chromosome 13 at 41,004,800 bp
  • C to T, chromosome 13 at 58,343,970 bp
  • C to T, chromosome 13 at 119,445,790 bp
  • T to A, chromosome 14 at 31,616,388 bp
  • C to T, chromosome 14 at 51,764,251 bp
  • T to C, chromosome 14 at 55,631,189 bp
  • G to A, chromosome 15 at 28,311,207 bp
  • G to T, chromosome 15 at 28,311,208 bp
  • T to A, chromosome 15 at 39,143,653 bp
  • G to T, chromosome 17 at 45,566,661 bp
  • A to T, chromosome 17 at 56,652,493 bp
  • A to T, chromosome 17 at 88,743,008 bp
  • G to A, chromosome 18 at 37,490,484 bp
  • C to T, chromosome 18 at 37,941,341 bp
  • G to A, chromosome 19 at 7,199,985 bp
  • T to G, chromosome 19 at 8,742,311 bp
  • T to C, chromosome 19 at 36,117,877 bp
  • T to C, chromosome 19 at 53,013,489 bp
  • C to A, chromosome X at 167,306,882 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5929 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044124-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.