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Strain Name:
C57BL/6J-MtgxR5943Btlr/Mmmh
Stock Number:
044135-MU
Citation ID:
RRID:MMRRC_044135-MU
Other Names:
R5943 (G1)
Major Collection:

Strain Information

Dhrs3
Name: dehydrogenase/reductase 3
Synonyms: retSDR1, Rsdr1, dehydrogenase/reductase (SDR family) member 3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20148
Homologene: 20994
Strn
Name: striatin, calmodulin binding protein
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268980
Homologene: 2380
Tsnax
Name: translin-associated factor X
Synonyms: Trax
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 53424
Homologene: 4374
Cdc6
Name: cell division cycle 6
Synonyms: cell division cycle 18 homolog (S.pombe)-like, CDC18L, CDC18(S.pombe)
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23834
HGNC: HGNC:1744
Homologene: 68172
Dido1
Name: death inducer-obliterator 1
Synonyms: DIO-1, 6720461J16Rik, D130048F08Rik, Datf1, dido, C130092D22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 23856
HGNC: HGNC:2680
Homologene: 34139
Mdn1
Name: midasin AAA ATPase 1
Synonyms: LOC213784, 4833432B22Rik, D4Abb1e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100019
Homologene: 39689
Cenpf
Name: centromere protein F
Synonyms: 6530404A22Rik, Lek1, mitosin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108000
HGNC: HGNC:1857
Homologene: 22969
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 54,300,367 bp
  • A to G, chromosome 1 at 82,525,016 bp
  • A to T, chromosome 1 at 189,659,969 bp
  • G to T, chromosome 2 at 23,168,330 bp
  • G to A, chromosome 2 at 70,286,941 bp
  • A to T, chromosome 2 at 70,475,315 bp
  • A to G, chromosome 2 at 74,746,829 bp
  • A to G, chromosome 2 at 76,968,436 bp
  • G to A, chromosome 2 at 122,333,435 bp
  • A to G, chromosome 2 at 165,724,689 bp
  • A to T, chromosome 2 at 180,661,882 bp
  • A to T, chromosome 3 at 19,964,306 bp
  • A to T, chromosome 3 at 89,356,411 bp
  • A to G, chromosome 3 at 155,163,950 bp
  • T to C, chromosome 4 at 32,678,330 bp
  • T to C, chromosome 4 at 46,522,136 bp
  • A to T, chromosome 4 at 144,919,976 bp
  • T to C, chromosome 4 at 155,899,422 bp
  • A to T, chromosome 5 at 45,463,719 bp
  • A to T, chromosome 5 at 121,322,294 bp
  • A to G, chromosome 5 at 123,286,357 bp
  • A to G, chromosome 5 at 142,485,458 bp
  • T to A, chromosome 6 at 23,246,949 bp
  • T to A, chromosome 6 at 29,471,909 bp
  • T to A, chromosome 6 at 42,292,966 bp
  • T to C, chromosome 6 at 92,903,786 bp
  • A to T, chromosome 6 at 118,505,746 bp
  • T to C, chromosome 6 at 124,329,602 bp
  • T to C, chromosome 7 at 16,946,437 bp
  • T to A, chromosome 7 at 27,212,979 bp
  • T to A, chromosome 7 at 27,234,003 bp
  • T to C, chromosome 7 at 85,565,991 bp
  • T to A, chromosome 7 at 104,938,643 bp
  • A to G, chromosome 7 at 142,297,051 bp
  • T to C, chromosome 8 at 41,084,265 bp
  • T to C, chromosome 8 at 47,990,102 bp
  • A to T, chromosome 8 at 84,254,319 bp
  • C to A, chromosome 8 at 125,024,539 bp
  • A to G, chromosome 9 at 26,999,444 bp
  • T to G, chromosome 9 at 54,338,437 bp
  • A to G, chromosome 9 at 96,839,150 bp
  • C to T, chromosome 9 at 108,812,236 bp
  • A to G, chromosome 10 at 33,866,641 bp
  • T to C, chromosome 10 at 88,433,514 bp
  • C to A, chromosome 10 at 128,545,527 bp
  • T to C, chromosome 11 at 7,161,337 bp
  • G to A, chromosome 11 at 87,731,735 bp
  • A to T, chromosome 11 at 98,673,026 bp
  • T to C, chromosome 11 at 98,920,763 bp
  • A to G, chromosome 12 at 72,579,458 bp
  • C to A, chromosome 12 at 85,289,709 bp
  • T to A, chromosome 13 at 22,355,197 bp
  • T to C, chromosome 13 at 74,480,888 bp
  • T to C, chromosome 13 at 81,386,866 bp
  • T to A, chromosome 14 at 122,658,776 bp
  • C to T, chromosome 17 at 24,442,747 bp
  • T to C, chromosome 17 at 27,706,071 bp
  • G to T, chromosome 17 at 33,818,401 bp
  • T to C, chromosome 17 at 34,184,291 bp
  • C to A, chromosome 17 at 45,517,711 bp
  • A to G, chromosome 17 at 64,625,380 bp
  • C to A, chromosome 17 at 78,669,847 bp
  • A to G, chromosome 18 at 37,816,512 bp
  • A to G, chromosome 18 at 74,792,382 bp
  • C to T, chromosome 19 at 13,887,752 bp
  • T to G, chromosome 19 at 34,320,587 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5943 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044135-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.