Strain Name:
C57BL/6J-MtgxR5949Btlr
Stock Number:
044139-MU
Citation ID:
RRID:MMRRC_044139-MU
Other Names:
R5949 (G1)
Major Collection:

Gene Information

Cdon
Name: cell adhesion molecule-related/down-regulated by oncogenes
Synonyms: CAM-related/down-regulated by oncogenes, CDO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 57810
Homologene: 22996
Ifng
Name: interferon gamma
Synonyms: IFN-gamma, Ifg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15978
VEGA: 10
HGNC: HGNC:5438
Homologene: 55526
Lrrn1
Name: leucine rich repeat protein 1, neuronal
Synonyms: 2810047E21Rik, NLRR-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16979
Homologene: 32036
Adcy10
Name: adenylate cyclase 10
Synonyms: sAC, soluble adenylyl cyclase, 4930431D04Rik, Sacy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 271639
Homologene: 10188
Tfpi
Name: tissue factor pathway inhibitor
Synonyms: A630013F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21788
Homologene: 4579
Emb
Name: embigin
Synonyms: Gp70
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13723
Homologene: 7743
Kif20a
Name: kinesin family member 20A
Synonyms: Rab6kifl, Rabkinesin-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 19348
VEGA: 18
HGNC: HGNC:9787
Homologene: 38093
Arhgap21
Name: Rho GTPase activating protein 21
Synonyms: ARHGAP10, 5530401C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71435
Homologene: 10822
Atad5
Name: ATPase family, AAA domain containing 5
Synonyms: LOC237877, C130052G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237877
Homologene: 32611
Ralgapb
Name: Ral GTPase activating protein, beta subunit (non-catalytic)
Synonyms: B230339M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228850
Homologene: 10666
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: 9430093H17Rik, Falz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 207165
HGNC: HGNC:3581
Homologene: 114397
Tshr
Name: thyroid stimulating hormone receptor
Synonyms: pet, hyt, hypothroid
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 22095
Homologene: 315
Vps39
Name: VPS39 HOPS complex subunit
Synonyms: A230065P22Rik, Vam6P, mVam6, Vam6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269338
Homologene: 41025
Zfp719
Name: zinc finger protein 719
Synonyms: C630016O21Rik, 9430094P17Rik, mszf6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210105
Cic
Name: capicua transcriptional repressor
Synonyms: 1200010B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71722
Homologene: 87637
Dcps
Name: decapping enzyme, scavenger
Synonyms: 1700001E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 69305
Homologene: 32202
Fam193a
Name: family with sequence homology 193, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231128
Homologene: 2746
Fchsd1
Name: FCH and double SH3 domains 1
Synonyms: A030002D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 319262
Homologene: 14127
Slc3a2
Name: solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
Synonyms: 4F2HC, Cd98, Ly-10, Ly-m10, Mdu1, Mgp-2hc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 17254
Homologene: 1795
Ddx41
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
Synonyms: 2900024F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 72935
VEGA: 13
Homologene: 9431
Cd209d
Name: CD209d antigen
Synonyms: SIGN-R3, SIGNR3, mSIGNR3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 170779
HGNC: HGNC:1641
Homologene: 8603
Pcdh17
Name: protocadherin 17
Synonyms: C030033F14Rik, LOC219228
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219228
VEGA: 14
Homologene: 8700
Ttn
Name: titin
Synonyms: L56, 2310074I15Rik, 2310036G12Rik, 1100001C23Rik, connectin, shru, D830007G01Rik, mdm, D330041I19Rik, 2310057K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Sec14l2
Name: SEC14-like lipid binding 2
Synonyms: 1300013M05Rik, tap, Spf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67815
Homologene: 8245
Xylt2
Name: xylosyltransferase II
Synonyms: E030002B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217119
Homologene: 23349
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 672511
Homologene: 45439
Mapkapk2
Name: MAP kinase-activated protein kinase 2
Synonyms: MK2, Rps6kc1, MAPKAP kinase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17164
HGNC: HGNC:6887
Homologene: 56412
Stab2
Name: stabilin 2
Synonyms: FEEL-2, STAB-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 192188
Homologene: 23022
Nlrp1a
Name: NLR family, pyrin domain containing 1A
Synonyms: Nalp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 195046
Homologene: 133820
A2m
Name: alpha-2-macroglobulin
Synonyms: A2mp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232345
HGNC: HGNC:7
Homologene: 37248
Sorbs2
Name: sorbin and SH3 domain containing 2
Synonyms: 2010203O03Rik, 9430041O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234214
Homologene: 83295
Rfx6
Name: regulatory factor X, 6
Synonyms: Rfxdc1, 4930572O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320995
Homologene: 18318
Tbc1d9b
Name: TBC1 domain family, member 9B
Synonyms: 2700008N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76795
Homologene: 28106
Cdh2
Name: cadherin 2
Synonyms: N-cadherin, N-CAD, Ncad
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12558
HGNC: HGNC:1759
Homologene: 20424
Tsfm
Name: Ts translation elongation factor, mitochondrial
Synonyms: 9430024O13Rik, EF-TS, 2310050B20Rik, EF-Tsmt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 66399
Homologene: 4184
Gm4788
Name: predicted gene 4788
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 214403
Krt87
Name: keratin 87
Synonyms: Krt83, Krt2-25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 406219
VEGA: 15
Homologene: 133804
Grip1
Name: glutamate receptor interacting protein 1
Synonyms: eb, 4931400F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 74053
Homologene: 12938
Atp8b4
Name: ATPase, class I, type 8B, member 4
Synonyms: Im
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241633
Homologene: 133162
Galnt6
Name: polypeptide N-acetylgalactosaminyltransferase 6
Synonyms: GalNAc-T6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 207839
HGNC: HGNC:4128
Homologene: 5218
Carf
Name: calcium response factor
Synonyms: Als2cr8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241066
Homologene: 11689
Pih1d2
Name: PIH1 domain containing 2
Synonyms: 2700059L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72614
Homologene: 12474
Olfr1233
Name: olfactory receptor 1233
Synonyms: GA_x6K02T2Q125-50784973-50784056, MOR238-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258974
Homologene: 74243
Ifih1
Name: interferon induced with helicase C domain 1
Synonyms: 9130009C22Rik, Helicard, MDA-5, MDA5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71586
Homologene: 32535
Olfr483
Name: olfactory receptor 483
Synonyms: GA_x6K02T2PBJ9-10432095-10433042, MOR204-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258730
Homologene: 133602
Alms1-ps1
Name: ALMS1, centrosome and basal body associated, pseudogene 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100043493
Tmem106b
Name: transmembrane protein 106B
Synonyms: 6430519M21Rik, 5830455K21Rik, 2310036D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 71900
Homologene: 56806
Mrap2
Name: melanocortin 2 receptor accessory protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244958
Homologene: 16307
Diras2
Name: DIRAS family, GTP-binding RAS-like 2
Synonyms: 2900052J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68203
VEGA: 13
Homologene: 56777
Ighv1-43
Name: immunoglobulin heavy variable V1-43
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 629908
Rdh5
Name: retinol dehydrogenase 5
Synonyms: cRDH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19682
HGNC: HGNC:9940
Homologene: 2179
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 60,139,313 bp
  • A to G, chromosome 1 at 131,058,005 bp
  • A to T, chromosome 1 at 139,733,149 bp
  • A to T, chromosome 1 at 165,539,817 bp
  • A to G, chromosome 2 at 20,849,041 bp
  • T to C, chromosome 2 at 62,610,560 bp
  • G to A, chromosome 2 at 76,777,900 bp
  • T to C, chromosome 2 at 84,444,748 bp
  • A to G, chromosome 2 at 89,339,885 bp
  • A to G, chromosome 2 at 120,328,668 bp
  • T to A, chromosome 2 at 126,405,322 bp
  • T to C, chromosome 2 at 158,454,259 bp
  • T to A, chromosome 5 at 34,440,472 bp
  • T to A, chromosome 6 at 13,083,419 bp
  • A to T, chromosome 6 at 85,721,961 bp
  • G to T, chromosome 6 at 107,567,504 bp
  • A to G, chromosome 6 at 121,678,073 bp
  • C to T, chromosome 7 at 25,272,305 bp
  • C to T, chromosome 7 at 43,584,117 bp
  • T to C, chromosome 7 at 108,104,197 bp
  • T to A, chromosome 8 at 3,877,949 bp
  • T to C, chromosome 8 at 45,769,897 bp
  • A to G, chromosome 9 at 35,125,261 bp
  • G to A, chromosome 9 at 35,486,951 bp
  • C to T, chromosome 9 at 50,624,984 bp
  • T to G, chromosome 9 at 87,182,605 bp
  • A to G, chromosome 10 at 51,678,333 bp
  • A to G, chromosome 10 at 86,969,849 bp
  • G to C, chromosome 10 at 118,442,624 bp
  • A to G, chromosome 10 at 120,050,242 bp
  • G to A, chromosome 10 at 127,028,375 bp
  • C to A, chromosome 10 at 128,918,267 bp
  • A to T, chromosome 11 at 4,108,972 bp
  • T to C, chromosome 11 at 50,148,049 bp
  • T to A, chromosome 11 at 71,098,989 bp
  • G to T, chromosome 11 at 80,096,009 bp
  • G to A, chromosome 11 at 94,668,483 bp
  • A to G, chromosome 11 at 107,111,089 bp
  • A to G, chromosome 11 at 119,443,079 bp
  • G to A, chromosome 12 at 91,537,218 bp
  • A to G, chromosome 12 at 114,946,382 bp
  • T to C, chromosome 13 at 52,507,711 bp
  • A to G, chromosome 13 at 55,532,061 bp
  • A to G, chromosome 13 at 117,267,392 bp
  • T to C, chromosome 14 at 84,447,556 bp
  • A to T, chromosome 15 at 100,696,550 bp
  • A to T, chromosome 15 at 101,487,595 bp
  • T to A, chromosome 18 at 16,601,630 bp
  • G to A, chromosome 18 at 34,632,415 bp
  • C to T, chromosome 18 at 37,959,873 bp
  • T to C, chromosome 19 at 8,713,395 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5949 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044139-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.