Strain Name:
C57BL/6J-MtgxR5954Btlr
Stock Number:
044143-MU
Citation ID:
RRID:MMRRC_044143-MU
Other Names:
R5954 (G1)
Major Collection:

Gene Information

Cds2
Name: CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
Synonyms: 5730460C18Rik, D2Wsu127e, 5730450N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 110911
HGNC: HGNC:1801
Homologene: 37854
Itga8
Name: integrin alpha 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Ank2
Name: ankyrin 2, brain
Synonyms: Ankyrin-2, Gm4392, Ank-2, ankyrin B, Ankyrin-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 109676
HGNC: HGNC:493
Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: alpha13.2, Cav3.2, T-type Cav3.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Sept3
Name: septin 3
Synonyms: Gm46500, B530002E20Rik, Sep3, 3110018K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 108168219
VEGA: 15
Homologene: 99740
Ulk2
Name: unc-51 like kinase 2
Synonyms: Unc51.2, A830085I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 29869
Homologene: 5891
Rprd2
Name: regulation of nuclear pre-mRNA domain containing 2
Synonyms: 6720469I21Rik, 4930535B03Rik, 2810036A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 75137
Homologene: 19997
Prepl
Name: prolyl endopeptidase-like
Synonyms: 9530014L06Rik, D030028O16Rik, 2810457N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 213760
VEGA: 17
Homologene: 15481
Gatad2b
Name: GATA zinc finger domain containing 2B
Synonyms: C430014D17Rik, p66beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229542
Homologene: 32484
Senp7
Name: SUMO1/sentrin specific peptidase 7
Synonyms: 2900036C23Rik, 6030449K19Rik, 2410152H17Rik, 2810413I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 66315
Homologene: 10778
Ipo5
Name: importin 5
Synonyms: 1110011C18Rik, RanBP5, 5730478E03Rik, Kpnb3, IMB3, importin beta 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 70572
VEGA: 14
HGNC: HGNC:6402
Homologene: 1710
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, 2810449H11Rik, tbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Vps39
Name: VPS39 HOPS complex subunit
Synonyms: Vam6, Vam6P, A230065P22Rik, mVam6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 269338
Homologene: 41025
Ucn3
Name: urocortin 3
Synonyms: Urocortin III
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 83428
VEGA: 13
Homologene: 49959
Knstrn
Name: kinetochore-localized astrin/SPAG5 binding
Synonyms: D2Ertd750e, 1700025D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 51944
Homologene: 12198
Med23
Name: mediator complex subunit 23
Synonyms: ESTM7, X83317, 3000002A17Rik, Sur2, Crsp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 70208
HGNC: HGNC:2372
Homologene: 3552
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 5430439G14Rik, 6330406J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 71389
Homologene: 32772
Armc5
Name: armadillo repeat containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233912
Homologene: 32601
Uncx
Name: UNC homeobox
Synonyms: Uncx4.1, Chx4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 22255
Homologene: 56598
Gpatch8
Name: G patch domain containing 8
Synonyms: 5430405G24Rik, Gpatc8, ENSMUSG00000075516, Fbm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237943
Homologene: 46117
Dock8
Name: dedicator of cytokinesis 8
Synonyms: A130095G14Rik, 1200017A24Rik, 5830472H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 76088
VEGA: 19
Homologene: 52414
Kat2a
Name: K(lysine) acetyltransferase 2A
Synonyms: Gcn5, Gcn5l2, PCAF-B/GCN5, 1110051E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14534
HGNC: HGNC:4201
Homologene: 41343
Abca3
Name: ATP-binding cassette, sub-family A (ABC1), member 3
Synonyms: ABC-C, Abc3, 1810036E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 27410
HGNC: HGNC:33
Homologene: 37437
Fmnl3
Name: formin-like 3
Synonyms: Wbp3, 2700073B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 22379
Homologene: 69101
Fbxo24
Name: F-box protein 24
Synonyms: 4933422D21Rik, Fbx24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 71176
Homologene: 14131
Ptchd3
Name: patched domain containing 3
Synonyms: 4933440L20Rik, 4930451E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 74675
Homologene: 111041
Zfp790
Name: zinc finger protein 790
Synonyms: 6330581L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233056
Homologene: 51695
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Chdh
Name: choline dehydrogenase
Synonyms: D630034H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 218865
Homologene: 41261
Pak7
Name: p21 (RAC1) activated kinase 7
Synonyms: 2900083L08Rik, Pak5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241656
Homologene: 22211
Sarm1
Name: sterile alpha and HEAT/Armadillo motif containing 1
Synonyms: A830091I15Rik, MyD88-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237868
Homologene: 9015
Farp1
Name: FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)
Synonyms: Cdep
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 223254
HGNC: HGNC:3591
Homologene: 38098
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: A230061D21Rik, C030048J01Rik, Lba1, LOC235639
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 320429
Homologene: 45845
B4galnt3
Name: beta-1,4-N-acetyl-galactosaminyl transferase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 330406
Homologene: 18328
Olfr494
Name: olfactory receptor 494
Synonyms: GA_x6K02T2PBJ9-10697517-10698461, MOR204-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258732
Homologene: 133602
Ankrd42
Name: ankyrin repeat domain 42
Synonyms: 4933417L02Rik, Ikbn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 73845
Homologene: 23652
Olfr935
Name: olfactory receptor 935
Synonyms: GA_x6K02T2PVTD-32691280-32690354, MOR171-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258741
VEGA: 9
Homologene: 133683
Mefv
Name: Mediterranean fever
Synonyms: FMF, marenostrin, pyrin, TRIM20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 54483
VEGA: 16
HGNC: HGNC:6998
Homologene: 32441
Cnga1
Name: cyclic nucleotide gated channel alpha 1
Synonyms: Cncg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 12788
HGNC: HGNC:2148
Homologene: 55432
Bbs12
Name: Bardet-Biedl syndrome 12 (human)
Synonyms: LOC386537, LOC241950, LOC241950
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 241950
Homologene: 17634
Anks4b
Name: ankyrin repeat and sterile alpha motif domain containing 4B
Synonyms: 2010013E14Rik, Harp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 72074
Homologene: 49898
Sccpdh
Name: saccharopine dehydrogenase (putative)
Synonyms: C330023F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 109232
Homologene: 9334
Olfr1507
Name: olfactory receptor 1507
Synonyms: GA_x6K02T2RJGY-491851-492792, MOR28, MOR244-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 57269
Homologene: 10736
Zfp697
Name: zinc finger protein 697
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 242109
Homologene: 18241
Plppr3
Name: phospholipid phosphatase related 3
Synonyms: Lppr3, BC005764
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216152
Homologene: 11769
Olfr1425
Name: olfactory receptor 1425
Synonyms: GA_x6K02T2RE5P-2433425-2432490, MOR239-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258155
Homologene: 17398
Tnni3
Name: troponin I, cardiac 3
Synonyms: cardiac troponin I, cTnI, Tn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 21954
Homologene: 309
Hsd3b2
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 15493
Homologene: 133013
Gm7932
Name: predicted gene 7932
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 666105
Spag6
Name: sperm associated antigen 6
Synonyms: BC061194, Spag6l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 381350
Homologene: 133723
Gm20402
Name: predicted gene 20402
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
Apitd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 179,680,588 bp
  • C to A, chromosome 2 at 12,132,486 bp
  • G to T, chromosome 2 at 18,710,606 bp
  • A to G, chromosome 2 at 118,830,955 bp
  • A to G, chromosome 2 at 120,324,662 bp
  • A to G, chromosome 2 at 132,297,271 bp
  • G to T, chromosome 2 at 136,116,463 bp
  • A to C, chromosome 2 at 160,965,827 bp
  • C to T, chromosome 3 at 37,320,002 bp
  • C to T, chromosome 3 at 52,268,890 bp
  • T to C, chromosome 3 at 90,351,441 bp
  • T to C, chromosome 3 at 95,764,863 bp
  • C to A, chromosome 3 at 98,428,593 bp
  • T to A, chromosome 3 at 98,711,559 bp
  • T to C, chromosome 3 at 126,997,861 bp
  • C to A, chromosome 4 at 149,130,201 bp
  • T to C, chromosome 5 at 72,604,878 bp
  • T to A, chromosome 5 at 137,619,681 bp
  • C to T, chromosome 5 at 139,547,629 bp
  • C to T, chromosome 6 at 48,862,859 bp
  • A to G, chromosome 6 at 120,225,188 bp
  • C to T, chromosome 7 at 4,519,540 bp
  • G to T, chromosome 7 at 29,829,504 bp
  • C to G, chromosome 7 at 92,623,967 bp
  • T to A, chromosome 7 at 108,367,601 bp
  • T to A, chromosome 7 at 120,182,173 bp
  • A to G, chromosome 7 at 128,242,272 bp
  • A to G, chromosome 9 at 38,995,415 bp
  • T to G, chromosome 9 at 66,451,492 bp
  • A to G, chromosome 9 at 111,365,133 bp
  • A to G, chromosome 10 at 24,870,483 bp
  • G to T, chromosome 10 at 79,866,126 bp
  • A to T, chromosome 11 at 61,803,796 bp
  • C to A, chromosome 11 at 78,490,602 bp
  • A to G, chromosome 11 at 100,708,898 bp
  • A to T, chromosome 11 at 102,480,941 bp
  • C to T, chromosome 11 at 115,984,157 bp
  • A to T, chromosome 11 at 121,836,587 bp
  • T to C, chromosome 13 at 3,941,413 bp
  • C to T, chromosome 14 at 30,031,181 bp
  • T to A, chromosome 14 at 52,490,167 bp
  • A to G, chromosome 14 at 120,919,984 bp
  • T to A, chromosome 14 at 121,222,667 bp
  • T to C, chromosome 15 at 82,290,427 bp
  • G to A, chromosome 15 at 99,325,910 bp
  • A to G, chromosome 16 at 3,715,715 bp
  • A to G, chromosome 16 at 56,169,871 bp
  • T to C, chromosome 17 at 24,397,416 bp
  • A to G, chromosome 17 at 25,383,201 bp
  • A to G, chromosome 17 at 85,064,649 bp
  • A to T, chromosome 19 at 12,074,083 bp
  • G to A, chromosome 19 at 25,171,619 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5954 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044143-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.