Strain Name:
C57BL/6J-MtgxR5983Btlr
Stock Number:
044164-MU
Citation ID:
RRID:MMRRC_044164-MU
Other Names:
R5983 (G1)
Major Collection:

Gene Information

Ide
Name: insulin degrading enzyme
Synonyms: 4833415K22Rik, 1300012G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 15925
HGNC: HGNC:5381
Homologene: 3645
Rbm5
Name: RNA binding motif protein 5
Synonyms: D030069N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 83486
HGNC: HGNC:9902
Homologene: 21177
Nvl
Name: nuclear VCP-like
Synonyms: 1200009I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67459
HGNC: HGNC:8070
Homologene: 1902
Nkapd1
Name: NKAP domain containing 1
Synonyms: AU019823, LOC270156
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270156
Homologene: 41233
Bach2
Name: BTB and CNC homology, basic leucine zipper transcription factor 2
Synonyms: E030004N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12014
Homologene: 7240
Aire
Name: autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11634
HGNC: HGNC:360
Homologene: 327
D430042O09Rik
Name: RIKEN cDNA D430042O09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233865
Homologene: 45841
Zfp940
Name: zinc finger protein 940
Synonyms: BC027344
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233057
Homologene: 138421
Tmc2
Name: transmembrane channel-like gene family 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 192140
Homologene: 25877
Ttn
Name: titin
Synonyms: L56, 2310036G12Rik, D330041I19Rik, shru, connectin, D830007G01Rik, 1100001C23Rik, mdm, 2310074I15Rik, 2310057K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Fbxw26
Name: F-box and WD-40 domain protein 26
Synonyms: Gm5163
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382109
Homologene: 110776
Dppa2
Name: developmental pluripotency associated 2
Synonyms: ECAT15-2, 2410088E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 73703
VEGA: 16
Homologene: 79572
Ecsit
Name: ECSIT signalling integrator
Synonyms: Sitpec
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 26940
Homologene: 8080
Morn3
Name: MORN repeat containing 3
Synonyms: 4930438O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74890
Homologene: 42069
Abhd18
Name: abhydrolase domain containing 18
Synonyms: 3110057O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 269423
Homologene: 105457
Tmem147
Name: transmembrane protein 147
Synonyms: 5033425B17Rik, 2010004E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69804
Homologene: 12330
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50720
Vmn2r104
Name: vomeronasal 2, receptor 104
Synonyms: V2r7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22313
Homologene: 129751
Serpina3n
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3N
Synonyms: antitrypsin, Spi2.2, Spi2/eb.4, Spi2-2, alpha-1 antiproteinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20716
HGNC: HGNC:16
Homologene: 111129
Grm8
Name: glutamate receptor, metabotropic 8
Synonyms: mGluR8, Gprc1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14823
HGNC: HGNC:4600
Homologene: 654
Ccdc170
Name: coiled-coil domain containing 170
Synonyms: Gm221, LOC237250
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 100504234
Homologene: 69393
Adam26b
Name: a disintegrin and metallopeptidase domain 26B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382007
Homologene: 128363
Abcc2
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Synonyms: multidrug resistance protein 2, Mrp2, Cmoat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 12780
HGNC: HGNC:53
Homologene: 68052
Cfap100
Name: cilia and flagella associated protein 100
Synonyms: Ccdc37, C030041G11Rik, C230069K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243538
Homologene: 18456
Zw10
Name: zw10 kinetochore protein
Synonyms: 6330566F14Rik, MmZw10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 26951
VEGA: 9
Homologene: 37959
Rsph9
Name: radial spoke head 9 homolog (Chlamydomonas)
Synonyms: 1700027N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75564
Homologene: 12606
Spsb2
Name: splA/ryanodine receptor domain and SOCS box containing 2
Synonyms: SSB2, Grcc9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14794
Homologene: 8404
Abraxas1
Name: BRCA1 A complex subunit
Synonyms: Fam175a, Ccdc98, 5630400M01Rik, 3830405G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70681
Homologene: 16376
Olfr1436
Name: olfactory receptor 1436
Synonyms: GA_x6K02T2RE5P-2634596-2633658, MOR214-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258682
Homologene: 83129
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 181,136,906 bp
  • A to G, chromosome 2 at 76,742,381 bp
  • T to A, chromosome 2 at 130,247,976 bp
  • T to A, chromosome 3 at 40,910,544 bp
  • A to T, chromosome 4 at 32,563,324 bp
  • A to G, chromosome 5 at 100,807,911 bp
  • T to C, chromosome 5 at 123,037,788 bp
  • T to C, chromosome 6 at 27,760,221 bp
  • A to C, chromosome 6 at 90,419,391 bp
  • A to C, chromosome 6 at 124,809,748 bp
  • C to T, chromosome 7 at 29,845,052 bp
  • T to C, chromosome 7 at 30,728,059 bp
  • T to A, chromosome 7 at 125,850,373 bp
  • T to C, chromosome 8 at 43,521,341 bp
  • C to T, chromosome 9 at 22,078,147 bp
  • A to G, chromosome 9 at 49,077,445 bp
  • A to G, chromosome 9 at 50,607,842 bp
  • G to A, chromosome 9 at 107,744,942 bp
  • A to G, chromosome 9 at 109,717,965 bp
  • A to T, chromosome 10 at 4,520,851 bp
  • A to G, chromosome 10 at 78,043,069 bp
  • T to C, chromosome 12 at 104,409,029 bp
  • G to A, chromosome 14 at 61,205,199 bp
  • G to A, chromosome 16 at 48,315,841 bp
  • G to A, chromosome 17 at 20,041,708 bp
  • A to G, chromosome 17 at 46,129,480 bp
  • T to A, chromosome 19 at 12,299,103 bp
  • C to T, chromosome 19 at 37,272,150 bp
  • T to A, chromosome 19 at 43,819,503 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5983 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044164-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.