Strain Name:
C57BL/6J-MtgxR5991Btlr
Stock Number:
044171-MU
Citation ID:
RRID:MMRRC_044171-MU
Other Names:
R5991 (G1)
Major Collection:

Gene Information

Col1a1
Name: collagen, type I, alpha 1
Synonyms: Col1a-1, Mov-13, Cola-1, Cola1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12842
HGNC: HGNC:2197
Homologene: 73874
Plin3
Name: perilipin 3
Synonyms: M6prbp1, Tip47, 1300012C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66905
VEGA: 17
Homologene: 4247
Zmym6
Name: zinc finger, MYM-type 6
Synonyms: 9330177P20Rik, D4Wsu24e, Zfp258
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100177
Homologene: 5186
Tead3
Name: TEA domain family member 3
Synonyms: DTEF-1, Tcf13r2, ETFR-1, TEAD-3, TEF-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21678
Homologene: 81821
Cnot7
Name: CCR4-NOT transcription complex, subunit 7
Synonyms: Caf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18983
Homologene: 49011
Ltbp4
Name: latent transforming growth factor beta binding protein 4
Synonyms: 2310046A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 108075
HGNC: HGNC:6717
Homologene: 2645
Dnttip1
Name: deoxynucleotidyltransferase, terminal, interacting protein 1
Synonyms: 6430706C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76233
Homologene: 14189
Focad
Name: focadhesin
Synonyms: BC057079
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230393
Homologene: 9842
Ep300
Name: E1A binding protein p300
Synonyms: KAT3B, p300
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 328572
HGNC: HGNC:3373
Homologene: 1094
Tmem245
Name: transmembrane protein 245
Synonyms: D730040F13Rik, A630051L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242474
HGNC: HGNC:1363
Homologene: 41841
Adam8
Name: a disintegrin and metallopeptidase domain 8
Synonyms: CD156, CD156a, MS2, E430039A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11501
HGNC: HGNC:215
Homologene: 74384
Rnd2
Name: Rho family GTPase 2
Synonyms: Rohn, Arhn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11858
Homologene: 21123
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 665775
Homologene: 45109
Aars
Name: alanyl-tRNA synthetase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234734
HGNC: HGNC:20
Homologene: 1213
Shoc2
Name: Shoc2, leucine rich repeat scaffold protein
Synonyms: Sur-8, soc-2 (suppressor of clear) homolog (C. elegans)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56392
VEGA: 19
Homologene: 7219
Cep120
Name: centrosomal protein 120
Synonyms: Ccdc100
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225523
VEGA: 18
Homologene: 27415
Jup
Name: junction plakoglobin
Synonyms: PG, plakoglobin, Ctnng, gamma-catenin, D930025P04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16480
HGNC: HGNC:6207
Homologene: 1680
Pdcd1lg2
Name: programmed cell death 1 ligand 2
Synonyms: PD-L2, Btdc, F730015O22Rik, B7-DC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 58205
Homologene: 10973
Lyar
Name: Ly1 antibody reactive clone
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17089
Homologene: 41200
Scmh1
Name: sex comb on midleg homolog 1
Synonyms: Scml3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 29871
Homologene: 32146
Nol11
Name: nucleolar protein 11
Synonyms: 1500002M01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68979
Homologene: 32264
Rfx7
Name: regulatory factor X, 7
Synonyms: D130086K05Rik, 2510005N23Rik, 9930116O05Rik, Rfxdc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319758
Homologene: 11275
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: skrr, calcium release channel isoform 1, Ryr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20190
Homologene: 68069
Capn11
Name: calpain 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268958
HGNC: HGNC:1478
Homologene: 21392
Ercc5
Name: excision repair cross-complementing rodent repair deficiency, complementation group 5
Synonyms: Xpg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22592
HGNC: HGNC:3437
Homologene: 133551
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 5330435L01Rik, 4632412F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237979
Homologene: 10406
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241516
Homologene: 110349
Hc
Name: hemolytic complement
Synonyms: C5, C5a, Hfib2, He
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15139
HGNC: HGNC:1331
Homologene: 20412
Gpr158
Name: G protein-coupled receptor 158
Synonyms: 5330427M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241263
Homologene: 19381
Hipk3
Name: homeodomain interacting protein kinase 3
Synonyms: DYRK6, FIST3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15259
HGNC: HGNC:4915
Homologene: 55923
Gm9733
Name: predicted gene 9733
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 751864
Homologene: 135594
Fap
Name: fibroblast activation protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14089
HGNC: HGNC:3590
Homologene: 48282
Serpinb9e
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9e
Synonyms: NK26, Spi14, ovalbumin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20710
HGNC: HGNC:8955
Homologene: 69093
Vps33b
Name: vacuolar protein sorting 33B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233405
Homologene: 10261
Parp14
Name: poly (ADP-ribose) polymerase family, member 14
Synonyms: collaborator of Stat6, 1600029O10Rik, CoaSt6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 547253
Homologene: 19697
Vmn1r80
Name: vomeronasal 1 receptor 80
Synonyms: V1rg3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 171238
Ssrp1
Name: structure specific recognition protein 1
Synonyms: Hmg1-rs1, T160, Hmgox, Hmgi-rs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20833
Homologene: 110735
Timd4
Name: T cell immunoglobulin and mucin domain containing 4
Synonyms: B430010N18Rik, TIM-4, Tim4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 276891
Homologene: 51381
Olfr1218
Name: olfactory receptor 1218
Synonyms: GA_x6K02T2Q125-50536041-50535106, MOR233-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258815
Homologene: 73986
Olfr167
Name: olfactory receptor 167
Synonyms: MOR272-1, GA_x54KRFPKG5P-15963726-15962788
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258937
Homologene: 78689
Pcdhb3
Name: protocadherin beta 3
Synonyms: PcdhbC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93874
HGNC: HGNC:8688
Homologene: 115665
Olfr1034
Name: olfactory receptor 1034
Synonyms: Olfr1533-ps1, MOR227-8P, MOR245-14P, MOR227-8P, GA_x6K02T2Q125-47521463-47522395
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258216
Homologene: 51741
Olfr1314
Name: olfactory receptor 1314
Synonyms: MOR245-2, GA_x6K02T2Q125-73139026-73138088
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258442
Homologene: 121538
Spink10
Name: serine peptidase inhibitor, Kazal type 10
Synonyms: A230091H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 328971
Homologene: 131225
Lyg2
Name: lysozyme G-like 2
Synonyms: LOC332427
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 332427
Homologene: 18483
Carmil2
Name: capping protein regulator and myosin 1 linker 2
Synonyms: Rltpr, D130029J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234695
Homologene: 128439
Dyrk4
Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
Synonyms: Dyrk4b, Dyrk4a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101320
HGNC: HGNC:3095
Homologene: 37858
Myct1
Name: myc target 1
Synonyms: 1110020B04Rik, MT-MC1, Mtmc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 68632
VEGA: 10
Homologene: 11833
Bbs2
Name: Bardet-Biedl syndrome 2 (human)
Synonyms: 2410125H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67378
HGNC: HGNC:967
Homologene: 12122
Mtmr11
Name: myotubularin related protein 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 194126
Homologene: 82382
Olfr32
Name: olfactory receptor 32
Synonyms: GA_x6K02T2Q125-51573576-51572650, MOR227-7P, MOR227-9_p, MTPCR05
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18331
HGNC: HGNC:8290
Homologene: 110550
Slc25a4
Name: solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
Synonyms: adenine nucleotide translocase-1, Ant1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11739
Homologene: 36058
Tbc1d24
Name: TBC1 domain family, member 24
Synonyms: C530046L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224617
Homologene: 27469
Tmem181a
Name: transmembrane protein 181A
Synonyms: C76977, Tmem181, 5930418K15Rik, Gpr178
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 77106
Homologene: 44787
Slc4a1ap
Name: solute carrier family 4 (anion exchanger), member 1, adaptor protein
Synonyms: kanadaptin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20534
Homologene: 7543
Vmn1r12
Name: vomeronasal 1 receptor 12
Synonyms: Gm6674
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 626397
Homologene: 74373
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 37,915,719 bp
  • T to A, chromosome 1 at 44,180,830 bp
  • T to C, chromosome 2 at 21,368,508 bp
  • A to G, chromosome 2 at 35,006,105 bp
  • A to T, chromosome 2 at 62,518,521 bp
  • C to T, chromosome 2 at 82,990,468 bp
  • A to G, chromosome 2 at 85,042,296 bp
  • A to G, chromosome 2 at 86,046,910 bp
  • C to T, chromosome 2 at 89,054,782 bp
  • T to A, chromosome 2 at 90,138,234 bp
  • C to T, chromosome 2 at 104,437,983 bp
  • C to T, chromosome 2 at 112,092,615 bp
  • A to T, chromosome 2 at 164,754,180 bp
  • G to T, chromosome 3 at 15,320,758 bp
  • T to A, chromosome 3 at 96,168,589 bp
  • G to A, chromosome 4 at 56,916,733 bp
  • C to A, chromosome 4 at 88,401,019 bp
  • T to C, chromosome 4 at 120,522,620 bp
  • T to A, chromosome 4 at 127,108,473 bp
  • A to G, chromosome 5 at 31,534,069 bp
  • A to G, chromosome 5 at 38,227,865 bp
  • A to T, chromosome 5 at 41,816,863 bp
  • G to C, chromosome 6 at 57,159,655 bp
  • A to G, chromosome 6 at 126,880,225 bp
  • A to G, chromosome 7 at 12,193,496 bp
  • A to G, chromosome 7 at 27,309,316 bp
  • G to T, chromosome 7 at 29,104,610 bp
  • T to A, chromosome 7 at 80,283,414 bp
  • T to A, chromosome 7 at 139,990,287 bp
  • A to C, chromosome 8 at 40,495,655 bp
  • T to C, chromosome 8 at 46,209,336 bp
  • G to T, chromosome 8 at 94,098,286 bp
  • A to G, chromosome 8 at 105,691,391 bp
  • G to A, chromosome 8 at 111,050,400 bp
  • G to A, chromosome 9 at 72,619,538 bp
  • A to T, chromosome 10 at 5,604,426 bp
  • A to G, chromosome 11 at 46,843,203 bp
  • T to C, chromosome 11 at 94,937,919 bp
  • T to C, chromosome 11 at 100,379,569 bp
  • C to T, chromosome 11 at 101,468,999 bp
  • T to C, chromosome 11 at 107,171,145 bp
  • G to A, chromosome 11 at 113,943,254 bp
  • T to A, chromosome 13 at 33,259,807 bp
  • A to G, chromosome 15 at 81,648,466 bp
  • T to C, chromosome 16 at 19,514,757 bp
  • G to A, chromosome 16 at 35,841,457 bp
  • T to A, chromosome 17 at 6,289,037 bp
  • G to A, chromosome 17 at 24,209,069 bp
  • A to T, chromosome 17 at 28,334,378 bp
  • G to T, chromosome 17 at 45,659,352 bp
  • T to C, chromosome 17 at 56,286,576 bp
  • T to C, chromosome 18 at 37,301,508 bp
  • T to C, chromosome 18 at 53,721,798 bp
  • T to A, chromosome 18 at 62,657,885 bp
  • C to T, chromosome 19 at 29,454,467 bp
  • T to A, chromosome 19 at 54,003,049 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5991 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044171-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.