Strain Name:
C57BL/6J-MtgxR6021Btlr
Stock Number:
044194-MU
Citation ID:
RRID:MMRRC_044194-MU
Other Names:
R6021 (G1)
Major Collection:

Gene Information

Pak1
Name: p21 (RAC1) activated kinase 1
Synonyms: PAK-1, Paka
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18479
HGNC: HGNC:8590
Homologene: 1936
Notch2
Name: notch 2
Synonyms: Motch B, N2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18129
HGNC: HGNC:7882
Homologene: 7865
D630045J12Rik
Name: RIKEN cDNA D630045J12 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330286
Homologene: 19782
Ltbp3
Name: latent transforming growth factor beta binding protein 3
Synonyms: Ltbp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16998
VEGA: 19
HGNC: HGNC:6716
Homologene: 7405
Aopep
Name: aminopeptidase O
Synonyms: 2010111I01Rik, ApO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 72061
HGNC: HGNC:1361
Homologene: 66273
Paip1
Name: polyadenylate binding protein-interacting protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218693
Homologene: 4709
Brix1
Name: BRX1, biogenesis of ribosomes
Synonyms: 1110064N10Rik, Bxdc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67832
Homologene: 10133
Myh10
Name: myosin, heavy polypeptide 10, non-muscle
Synonyms: Fltn, nonmuscle myosin heavy chain IIB, 5730504C04Rik, nonmuscle myosin heavy chain II-B, Myosin IIB, 9330167F11Rik, NMHC II-B, NMHC-B, Myhn2, SMemb, myosin IIB, Myhn-2, Fltn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77579
HGNC: HGNC:7568
Homologene: 55941
Mtf2
Name: metal response element binding transcription factor 2
Synonyms: C76717, M96, 9230112N11Rik, Pcl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17765
Homologene: 7207
Rsf1
Name: remodeling and spacing factor 1
Synonyms: C030033M12Rik, XAP8, p325, 4832420A03Rik, Hbxap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233532
Homologene: 41142
Tlr4
Name: toll-like receptor 4
Synonyms: Rasl2-8, Lps, lipopolysaccharide response
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21898
Homologene: 41317
Slc6a11
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 11
Synonyms: E130202I16Rik, D930045G19Rik, GAT4, Gat3, Gabt4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243616
Homologene: 129935
Robo3
Name: roundabout guidance receptor 3
Synonyms: Rig1, Rbig1, Rig-1, Robo3a, Robo3b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19649
Homologene: 32119
Igfbp5
Name: insulin-like growth factor binding protein 5
Synonyms: IGFBP-5P, IGFBP-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16011
HGNC: HGNC:5474
Homologene: 56489
Raver1
Name: ribonucleoprotein, PTB-binding 1
Synonyms: 1300006N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71766
VEGA: 9
Homologene: 12410
Crebbp
Name: CREB binding protein
Synonyms: KAT3A, CBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12914
HGNC: HGNC:2348
Homologene: 68393
Atf7
Name: activating transcription factor 7
Synonyms: 9430065F09Rik, C130020M04Rik, 1110012F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223922
HGNC: HGNC:792
Homologene: 4994
Boc
Name: biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 117606
Homologene: 32819
Crtam
Name: cytotoxic and regulatory T cell molecule
Synonyms: class I-restricted T cell-associated molecule
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 54698
Homologene: 10454
Enpp5
Name: ectonucleotide pyrophosphatase/phosphodiesterase 5
Synonyms: D17Abb1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 83965
Homologene: 23313
Azi2
Name: 5-azacytidine induced gene 2
Synonyms: AZ2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 27215
Homologene: 8443
AW209491
Name: expressed sequence AW209491
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105351
VEGA: 13
Homologene: 11439
Trmt61a
Name: tRNA methyltransferase 61A
Synonyms: 6720458F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 328162
VEGA: 12
Homologene: 6229
Slc4a4
Name: solute carrier family 4 (anion exchanger), member 4
Synonyms: NBC, NBC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 54403
Homologene: 55776
Grm2
Name: glutamate receptor, metabotropic 2
Synonyms: mGluR2, Gprc1b, 4930441L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 108068
HGNC: HGNC:4594
Homologene: 20229
Pfdn2
Name: prefoldin 2
Synonyms: ESTM27, W48336
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18637
HGNC: HGNC:8867
Homologene: 7887
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, A2mr, b2b1554Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Gabra5
Name: gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5
Synonyms: A230018I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 110886
HGNC: HGNC:4079
Homologene: 20219
Loxhd1
Name: lipoxygenase homology domains 1
Synonyms: sba, 1700096C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240411
Mylk3
Name: myosin light chain kinase 3
Synonyms: D830007F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 213435
Homologene: 35278
A1bg
Name: alpha-1-B glycoprotein
Synonyms: C44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 117586
VEGA: 15
HGNC: HGNC:5
Homologene: 11167
Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
Synonyms: flamingo, mfmi1, EGFL2, Adgrc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 53883
HGNC: HGNC:3231
Homologene: 1078
Olfr1253
Name: olfactory receptor 1253
Synonyms: GA_x6K02T2Q125-51193814-51192857, Olfr1253-ps1, Olfr1559-ps1, MOR231-19P, MOR231-18, MOR231-19P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258370
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: Cchl1a3, sj, Cav1.1, muscle dysgenesis, fmd, DHPR alpha1s, mdg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Vmn2r75
Name: vomeronasal 2, receptor 75
Synonyms: EG546981
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 546981
Homologene: 115466
Tas2r135
Name: taste receptor, type 2, member 135
Synonyms: mt2r38, Tas2r35
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387512
Homologene: 52230
Crybg1
Name: crystallin beta-gamma domain containing 1
Synonyms: Aim1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11630
HGNC: HGNC:356
Homologene: 18168
Ildr2
Name: immunoglobulin-like domain containing receptor 2
Synonyms: ENSMUSG00000040612, OTTMUSG00000021748, 3110063L10Rik, D1Ertd471e, 2810478N18Rik, Dbsm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100039795
Homologene: 52388
Tmem145
Name: transmembrane protein 145
Synonyms: B930076A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330485
Homologene: 18333
4933427I04Rik
Name: Riken cDNA 4933427I04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
VEGA: 4
Rxfp2
Name: relaxin/insulin-like family peptide receptor 2
Synonyms: Great, Gpr106, LGR8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 140498
Homologene: 15402
Lrrc9
Name: leucine rich repeat containing 9
Synonyms: 4921529O18Rik, 4930432K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 78257
Homologene: 12692
Vmn2r99
Name: vomeronasal 2, receptor 99
Synonyms: EG665376
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665376
Homologene: 115024
Gm13101
Name: predicted gene 13101
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 626922
Sardh
Name: sarcosine dehydrogenase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 192166
Homologene: 5149
Ggps1
Name: geranylgeranyl diphosphate synthase 1
Synonyms: 9530089B04Rik, GGPP synthase, 1810026C22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 14593
VEGA: 13
HGNC: HGNC:4249
Homologene: 31267
Pde8b
Name: phosphodiesterase 8B
Synonyms: B230331L10Rik, C030047E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218461
HGNC: HGNC:8794
Homologene: 2758
Olfr1197
Name: olfactory receptor 1197
Synonyms: MOR225-10P, MOR225-14, GA_x6K02T2Q125-50202854-50201910
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 433449
Homologene: 123770
Samhd1
Name: SAM domain and HD domain, 1
Synonyms: E330031J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56045
Homologene: 9160
Vmn1r85
Name: vomeronasal 1 receptor 85
Synonyms: V1rj3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 252909
Homologene: 74338
H2-Bl
Name: histocompatibility 2, blastocyst
Synonyms: blastocyst MHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14963
HGNC: HGNC:4931
Homologene: 128352
Get1
Name: guided entry of tail-anchored proteins factor 1
Synonyms: 5530402J05Rik, Wrb, Chd5, C030018G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 71446
Homologene: 37945
Msantd4
Name: Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
Synonyms: 8430410K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78100
Homologene: 34935
Zfp964
Name: zinc finger protein 964
Synonyms: Gm7187
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 636741
Homologene: 130114
Trp53tg5
Name: transformation related protein 53 target 5
Synonyms: 1700126L10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 73603
Homologene: 49386
Akr1b10
Name: aldo-keto reductase family 1, member B10 (aldose reductase)
Synonyms: 2310005E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67861
Homologene: 128412
P2ry2
Name: purinergic receptor P2Y, G-protein coupled 2
Synonyms: P2Y2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18442
HGNC: HGNC:8541
Homologene: 1927
Ndufaf4
Name: NADH:ubiquinone oxidoreductase complex assembly factor 4
Synonyms: 1110007M04Rik, 3000003G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68493
Homologene: 40928
Fzd4
Name: frizzled class receptor 4
Synonyms: Fz4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14366
HGNC: HGNC:4042
Homologene: 7325
Gm13762
Name: predicted gene 13762
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Gm3173
Name: predicted gene 3173
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 100169868
Homologene: 115686
Gm4869
Name: predicted gene 4869
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 101055939
Homologene: 82478
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 72,863,204 bp
  • T to C, chromosome 1 at 136,106,487 bp
  • T to A, chromosome 1 at 166,303,604 bp
  • C to A, chromosome 1 at 171,345,770 bp
  • A to G, chromosome 2 at 27,189,643 bp
  • C to A, chromosome 2 at 41,344,427 bp
  • G to T, chromosome 2 at 88,728,950 bp
  • G to T, chromosome 2 at 88,973,032 bp
  • A to C, chromosome 2 at 89,752,121 bp
  • T to C, chromosome 2 at 157,120,554 bp
  • T to A, chromosome 2 at 164,471,471 bp
  • T to C, chromosome 3 at 98,121,972 bp
  • G to T, chromosome 3 at 108,401,245 bp
  • A to G, chromosome 4 at 24,901,760 bp
  • T to A, chromosome 4 at 66,840,866 bp
  • A to G, chromosome 4 at 123,860,716 bp
  • A to T, chromosome 4 at 143,965,766 bp
  • A to T, chromosome 5 at 89,040,402 bp
  • A to G, chromosome 5 at 108,081,137 bp
  • A to G, chromosome 5 at 124,736,984 bp
  • A to T, chromosome 5 at 140,469,679 bp
  • A to G, chromosome 5 at 150,063,737 bp
  • T to A, chromosome 6 at 34,392,374 bp
  • T to C, chromosome 6 at 38,190,617 bp
  • T to C, chromosome 6 at 42,406,387 bp
  • T to C, chromosome 6 at 114,230,051 bp
  • T to C, chromosome 7 at 13,084,689 bp
  • C to T, chromosome 7 at 25,308,845 bp
  • A to G, chromosome 7 at 57,507,992 bp
  • T to C, chromosome 7 at 86,171,612 bp
  • G to A, chromosome 7 at 89,407,734 bp
  • G to GACGGCGGCT, chromosome 7 at 97,579,909 bp
  • T to C, chromosome 7 at 97,854,463 bp
  • T to C, chromosome 7 at 100,998,400 bp
  • G to T, chromosome 8 at 69,663,092 bp
  • A to G, chromosome 8 at 85,364,813 bp
  • T to A, chromosome 9 at 4,384,063 bp
  • A to G, chromosome 9 at 21,076,622 bp
  • C to T, chromosome 9 at 37,422,533 bp
  • T to A, chromosome 9 at 40,990,181 bp
  • T to C, chromosome 9 at 106,650,800 bp
  • T to A, chromosome 9 at 118,047,419 bp
  • G to T, chromosome 10 at 43,997,538 bp
  • T to C, chromosome 10 at 127,578,014 bp
  • G to A, chromosome 11 at 9,290,465 bp
  • T to A, chromosome 11 at 68,808,862 bp
  • A to T, chromosome 12 at 72,469,231 bp
  • C to A, chromosome 12 at 111,680,977 bp
  • T to C, chromosome 13 at 14,054,004 bp
  • C to T, chromosome 13 at 14,637,780 bp
  • A to G, chromosome 13 at 63,061,082 bp
  • A to T, chromosome 13 at 95,026,162 bp
  • T to "TTA,TT", chromosome 13 at 119,457,135 bp
  • A to C, chromosome 14 at 4,514,873 bp
  • C to T, chromosome 15 at 10,476,589 bp
  • T to C, chromosome 15 at 60,919,864 bp
  • T to C, chromosome 15 at 102,557,473 bp
  • G to A, chromosome 16 at 4,085,418 bp
  • T to A, chromosome 16 at 44,488,654 bp
  • T to C, chromosome 16 at 96,145,678 bp
  • A to G, chromosome 17 at 19,377,948 bp
  • T to G, chromosome 17 at 36,081,274 bp
  • A to T, chromosome 17 at 44,085,319 bp
  • A to T, chromosome 18 at 77,412,250 bp
  • A to T, chromosome 19 at 5,753,680 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6021 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044194-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.