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Strain Name:
C57BL/6J-MtgxR6023Btlr/Mmmh
Stock Number:
044195-MU
Citation ID:
RRID:MMRRC_044195-MU
Other Names:
R6023 (G1)
Major Collection:

Strain Information

Atrn
Name: attractin
Synonyms: Mgca
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11990
HGNC: HGNC:885
Homologene: 22542
Ap2b1
Name: adaptor-related protein complex 2, beta 1 subunit
Synonyms: 1300012O03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71770
HGNC: HGNC:563
Homologene: 137384
Abcc8
Name: ATP-binding cassette, sub-family C member 8
Synonyms: SUR1, Sur, D930031B21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20927
HGNC: HGNC:59
Homologene: 68048
Kif11
Name: kinesin family member 11
Synonyms: Eg5, Knsl1, Kifl1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16551
VEGA: 19
HGNC: HGNC:6388
Homologene: 3322
Ctc1
Name: CTS telomere maintenance complex component 1
Synonyms: 1500010J02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68964
Homologene: 11830
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: apollon, Bruce, A430032G04Rik, D630005A10Rik, A430040A19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: nesprin-1, SYNE-1, enaptin165, A330049M09Rik, C130039F11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 38,218,370 bp
  • T to C, chromosome 1 at 171,356,751 bp
  • A to G, chromosome 2 at 36,421,511 bp
  • G to T, chromosome 2 at 76,735,400 bp
  • A to G, chromosome 2 at 88,958,715 bp
  • T to G, chromosome 2 at 122,337,684 bp
  • T to C, chromosome 2 at 131,020,980 bp
  • A to G, chromosome 4 at 59,013,752 bp
  • T to A, chromosome 4 at 118,690,074 bp
  • T to C, chromosome 5 at 27,723,547 bp
  • T to A, chromosome 5 at 35,512,578 bp
  • T to A, chromosome 5 at 35,706,951 bp
  • T to A, chromosome 5 at 37,348,616 bp
  • G to A, chromosome 6 at 29,176,453 bp
  • T to C, chromosome 6 at 41,303,421 bp
  • C to A, chromosome 6 at 41,697,475 bp
  • A to G, chromosome 6 at 57,071,254 bp
  • G to T, chromosome 7 at 17,210,512 bp
  • T to G, chromosome 7 at 43,884,058 bp
  • T to C, chromosome 7 at 46,108,419 bp
  • T to C, chromosome 7 at 55,058,067 bp
  • T to C, chromosome 7 at 102,856,962 bp
  • T to C, chromosome 7 at 104,189,673 bp
  • A to T, chromosome 8 at 27,199,904 bp
  • A to G, chromosome 8 at 114,418,143 bp
  • A to T, chromosome 8 at 124,815,104 bp
  • A to C, chromosome 9 at 19,137,725 bp
  • T to A, chromosome 9 at 76,230,604 bp
  • T to C, chromosome 10 at 5,443,223 bp
  • A to T, chromosome 10 at 60,465,542 bp
  • T to C, chromosome 10 at 83,648,529 bp
  • T to C, chromosome 10 at 109,823,515 bp
  • A to T, chromosome 11 at 55,533,853 bp
  • T to A, chromosome 11 at 61,449,729 bp
  • A to G, chromosome 11 at 69,022,607 bp
  • C to T, chromosome 11 at 83,335,398 bp
  • A to G, chromosome 12 at 86,758,606 bp
  • T to A, chromosome 12 at 115,757,912 bp
  • T to C, chromosome 13 at 100,426,186 bp
  • A to G, chromosome 13 at 108,178,577 bp
  • C to T, chromosome 14 at 18,011,209 bp
  • A to T, chromosome 14 at 55,743,670 bp
  • T to C, chromosome 15 at 101,412,397 bp
  • T to C, chromosome 16 at 20,719,026 bp
  • C to A, chromosome 16 at 21,461,238 bp
  • C to T, chromosome 17 at 35,001,609 bp
  • A to T, chromosome 17 at 74,654,377 bp
  • T to C, chromosome 18 at 37,422,925 bp
  • A to G, chromosome 19 at 13,502,703 bp
  • T to C, chromosome 19 at 32,124,373 bp
  • A to G, chromosome 19 at 37,390,710 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6023 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044195-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.