Strain Name:
C57BL/6J-MtgxR6047Btlr
Stock Number:
044215-MU
Citation ID:
RRID:MMRRC_044215-MU
Other Names:
R6047 (G1)
Major Collection:

Gene Information

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: polycystin-1, PC1, PC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Slc17a7
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
Synonyms: Vglut1, 2900052E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72961
Homologene: 113454
Nfyc
Name: nuclear transcription factor-Y gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18046
HGNC: HGNC:7806
Homologene: 7440
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 195018
Homologene: 9027
Nt5c3
Name: 5'-nucleotidase, cytosolic III
Synonyms: p36, lupin, Umph-1, PN-1, cN-III, PSN1, PN-I, Umph1, 1600024P05Rik, 2610206B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 107569
Homologene: 9534
Adgrb2
Name: adhesion G protein-coupled receptor B2
Synonyms: Bai2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230775
HGNC: HGNC:944
Homologene: 1288
Ptprc
Name: protein tyrosine phosphatase, receptor type, C
Synonyms: T200, B220, CD45, Lyt-4, Ly-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19264
HGNC: HGNC:9666
Homologene: 2126
Scn10a
Name: sodium channel, voltage-gated, type X, alpha
Synonyms: Nav1.8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20264
VEGA: 9
Homologene: 21300
Uty
Name: ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Synonyms: Hydb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 22290
Pak4
Name: p21 (RAC1) activated kinase 4
Synonyms: 5730488L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70584
Homologene: 4300
Pdia5
Name: protein disulfide isomerase associated 5
Synonyms: 2700053F16Rik, Pdir
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 72599
VEGA: 16
Homologene: 4957
Cblb
Name: Casitas B-lineage lymphoma b
Synonyms: Cbl-b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 208650
VEGA: 16
HGNC: HGNC:1542
Homologene: 15856
Msantd2
Name: Myb/SANT-like DNA-binding domain containing 2
Synonyms: 2810450G17Rik, 9530092B10Rik, BC024479
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235184
Homologene: 36421
Ftsj3
Name: FtsJ RNA methyltransferase homolog 3 (E. coli)
Synonyms: D11Ertd400e, C79843, Epcs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56095
Homologene: 5451
Dok7
Name: docking protein 7
Synonyms: EF-12, A930013K19Rik, Dok-7, Oit5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231134
Homologene: 18210
Lrp12
Name: low density lipoprotein-related protein 12
Synonyms: C820005L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239393
Homologene: 8385
Insrr
Name: insulin receptor-related receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 23920
HGNC: HGNC:6093
Homologene: 56539
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Ifngr1
Name: interferon gamma receptor 1
Synonyms: CD119, Nktar, Ifgr, Ifngr, IFN-gamma R, IFN-gammaR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15979
HGNC: HGNC:5439
Homologene: 359
Gpr179
Name: G protein-coupled receptor 179
Synonyms: 5330439C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217143
Homologene: 34917
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217843
Homologene: 41397
Abcb1b
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1B
Synonyms: Mdr1, Mdr1b, mdr, Pgy1, Pgy-1, Abcb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18669
Homologene: 69084
Hic1
Name: hypermethylated in cancer 1
Synonyms: HIC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15248
HGNC: HGNC:4909
Homologene: 4740
Nrg3
Name: neuregulin 3
Synonyms: ska
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18183
HGNC: HGNC:7999
Homologene: 32051
Slc34a1
Name: solute carrier family 34 (sodium phosphate), member 1
Synonyms: renal Na+/Pi transporter, Na/Pi cotransporter, Slc17a2, Npt2, NaPi-IIa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20505
VEGA: 13
Homologene: 20663
Pfpl
Name: pore forming protein-like
Synonyms: Epcs5, Epcs50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56093
VEGA: 19
Homologene: 130704
Cdk9
Name: cyclin-dependent kinase 9 (CDC2-related kinase)
Synonyms: PITALRE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 107951
HGNC: HGNC:1780
Homologene: 55566
Tldc2
Name: TBC/LysM associated domain containing 2
Synonyms: LOC383766, Gm1332
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 383766
Homologene: 31961
Lce1j
Name: late cornified envelope 1J
Synonyms: Sprrl8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 545547
Mical1
Name: microtubule associated monooxygenase, calponin and LIM domain containing 1
Synonyms: Nical
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 171580
Homologene: 11246
Bloc1s2
Name: biogenesis of lysosomal organelles complex-1, subunit 2
Synonyms: 2410089B13Rik, BLOS2, Bloc1s2, Bloc1s2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 73689
VEGA: 19
Homologene: 45479
Appl2
Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
Synonyms: Dip3b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216190
Homologene: 10046
Antxrl
Name: anthrax toxin receptor-like
Synonyms: 1700112N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239029
VEGA: 14
Homologene: 52111
Med24
Name: mediator complex subunit 24
Synonyms: Trap100, D11Ertd307e, R75526, 100kDa, DRIP100, Gse2, Pparb2, Thrap4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 23989
Homologene: 40795
Pick1
Name: protein interacting with C kinase 1
Synonyms: Prkcabp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18693
HGNC: HGNC:9394
Homologene: 7470
Mbd3l2
Name: methyl-CpG binding domain protein 3-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 234988
VEGA: 9
Homologene: 44896
Stmn3
Name: stathmin-like 3
Synonyms: Sclip, 9330161A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20262
Homologene: 7528
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 138,101,041 bp
  • T to C, chromosome 2 at 32,708,273 bp
  • A to G, chromosome 2 at 40,637,775 bp
  • A to G, chromosome 2 at 157,096,462 bp
  • A to T, chromosome 2 at 181,309,159 bp
  • A to G, chromosome 3 at 87,804,176 bp
  • G to C, chromosome 3 at 92,789,196 bp
  • T to A, chromosome 4 at 120,779,117 bp
  • G to T, chromosome 4 at 130,018,705 bp
  • T to C, chromosome 5 at 8,806,066 bp
  • G to A, chromosome 5 at 35,079,307 bp
  • G to A, chromosome 6 at 56,882,979 bp
  • A to G, chromosome 7 at 28,563,036 bp
  • A to T, chromosome 7 at 45,173,406 bp
  • A to T, chromosome 9 at 18,444,916 bp
  • A to T, chromosome 9 at 37,523,442 bp
  • A to G, chromosome 9 at 119,622,831 bp
  • T to C, chromosome 10 at 19,606,313 bp
  • T to C, chromosome 10 at 41,481,707 bp
  • C to T, chromosome 10 at 83,612,901 bp
  • A to G, chromosome 11 at 72,866,095 bp
  • A to T, chromosome 11 at 75,166,849 bp
  • G to T, chromosome 11 at 97,338,416 bp
  • A to T, chromosome 11 at 98,707,765 bp
  • C to T, chromosome 11 at 106,252,318 bp
  • A to G, chromosome 12 at 103,061,458 bp
  • G to T, chromosome 13 at 55,412,071 bp
  • T to C, chromosome 14 at 34,053,476 bp
  • T to A, chromosome 14 at 38,397,352 bp
  • T to C, chromosome 15 at 39,872,067 bp
  • A to G, chromosome 15 at 79,255,695 bp
  • T to C, chromosome 16 at 35,397,478 bp
  • G to T, chromosome 16 at 52,112,248 bp
  • T to C, chromosome 17 at 24,595,085 bp
  • T to C, chromosome 19 at 12,429,233 bp
  • T to C, chromosome 19 at 44,142,190 bp
  • G to T, chromosome Y at 1,158,288 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
(Deceased) Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6047 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044215-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.