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Strain Name:
C57BL/6J-MtgxR6051Btlr/Mmmh
Stock Number:
044219-MU
Citation ID:
RRID:MMRRC_044219-MU
Other Names:
R6051 (G1)
Major Collection:

Strain Information

Trp53
Name: transformation related protein 53
Synonyms: p53, p44
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22059
Homologene: 460
Ncoa3
Name: nuclear receptor coactivator 3
Synonyms: pCIP, TRAM-1, AIB1, RAC3, TRAM1, Src3, 2010305B15Rik, KAT13B, bHLHe42
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17979
HGNC: HGNC:7670
Homologene: 4764
Cd2ap
Name: CD2-associated protein
Synonyms: METS-1, Mets1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12488
VEGA: 17
Homologene: 7663
Abl2
Name: ABL proto-oncogene 2, non-receptor tyrosine kinase
Synonyms: Arg, Abll
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11352
HGNC: HGNC:77
Homologene: 5278
Ndc80
Name: NDC80 kinetochore complex component
Synonyms: HEC1, 2610020P18Rik, Kntc2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67052
VEGA: 17
Homologene: 38141
Mllt6
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6
Synonyms: Af17
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 246198
HGNC: HGNC:7138
Homologene: 31347
Rap1a
Name: RAS-related protein 1a
Synonyms: Krev-1, Rap1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109905
HGNC: HGNC:9855
Homologene: 2162
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 37,624,225 bp
  • A to T, chromosome 1 at 66,726,726 bp
  • G to T, chromosome 1 at 105,721,272 bp
  • A to G, chromosome 1 at 156,642,085 bp
  • A to G, chromosome 2 at 76,907,461 bp
  • T to C, chromosome 2 at 166,058,765 bp
  • T to C, chromosome 3 at 33,808,924 bp
  • T to C, chromosome 3 at 63,915,641 bp
  • T to C, chromosome 3 at 89,443,170 bp
  • T to C, chromosome 3 at 103,174,341 bp
  • C to T, chromosome 3 at 105,750,297 bp
  • T to A, chromosome 3 at 136,876,122 bp
  • A to G, chromosome 4 at 138,234,304 bp
  • G to T, chromosome 4 at 138,967,966 bp
  • T to C, chromosome 5 at 31,651,819 bp
  • C to T, chromosome 5 at 115,846,405 bp
  • T to C, chromosome 6 at 88,617,948 bp
  • G to A, chromosome 6 at 92,859,926 bp
  • A to G, chromosome 6 at 92,890,118 bp
  • A to T, chromosome 7 at 11,881,051 bp
  • T to C, chromosome 7 at 30,261,384 bp
  • T to A, chromosome 7 at 41,448,472 bp
  • A to T, chromosome 7 at 73,435,842 bp
  • T to C, chromosome 7 at 103,928,877 bp
  • T to A, chromosome 7 at 141,811,857 bp
  • T to C, chromosome 8 at 15,042,179 bp
  • A to G, chromosome 9 at 16,375,455 bp
  • T to C, chromosome 9 at 48,495,887 bp
  • T to C, chromosome 9 at 72,449,453 bp
  • T to A, chromosome 9 at 95,908,369 bp
  • A to T, chromosome 9 at 123,856,116 bp
  • A to T, chromosome 10 at 13,261,811 bp
  • G to A, chromosome 10 at 39,067,902 bp
  • A to G, chromosome 10 at 93,745,795 bp
  • T to C, chromosome 10 at 94,137,565 bp
  • C to A, chromosome 10 at 116,341,090 bp
  • T to A, chromosome 10 at 121,296,845 bp
  • C to A, chromosome 11 at 16,883,607 bp
  • G to A, chromosome 11 at 69,589,608 bp
  • T to A, chromosome 11 at 77,691,916 bp
  • G to T, chromosome 11 at 97,680,743 bp
  • C to T, chromosome 11 at 101,524,246 bp
  • G to T, chromosome 12 at 51,754,104 bp
  • G to T, chromosome 12 at 71,184,530 bp
  • G to A, chromosome 12 at 109,593,024 bp
  • T to A, chromosome 14 at 25,572,070 bp
  • C to T, chromosome 14 at 30,568,196 bp
  • A to T, chromosome 15 at 82,616,770 bp
  • A to T, chromosome 15 at 100,694,668 bp
  • A to G, chromosome 16 at 91,421,864 bp
  • T to C, chromosome 17 at 40,305,126 bp
  • T to C, chromosome 17 at 42,796,328 bp
  • C to T, chromosome 17 at 71,517,578 bp
  • G to A, chromosome 18 at 11,738,607 bp
  • A to G, chromosome 18 at 61,507,274 bp
  • A to G, chromosome 19 at 38,024,361 bp
  • A to G, chromosome 19 at 39,061,166 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6051 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044219-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.