Strain Name:
C57BL/6J-MtgxR6051Btlr
Stock Number:
044219-MU
Citation ID:
RRID:MMRRC_044219-MU
Other Names:
R6051 (G1)
Major Collection:

Gene Information

Trp53
Name: transformation related protein 53
Synonyms: p44, p53
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22059
Homologene: 460
Ncoa3
Name: nuclear receptor coactivator 3
Synonyms: 2010305B15Rik, AIB1, KAT13B, Src3, TRAM1, RAC3, bHLHe42, pCIP, TRAM-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17979
HGNC: HGNC:7670
Homologene: 4764
Cd2ap
Name: CD2-associated protein
Synonyms: Mets1, METS-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12488
VEGA: 17
Homologene: 7663
Abl2
Name: v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)
Synonyms: Abll, Arg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11352
HGNC: HGNC:77
Homologene: 5278
Ndc80
Name: NDC80 kinetochore complex component
Synonyms: Kntc2, HEC1, 2610020P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 67052
VEGA: 17
Homologene: 38141
Mllt6
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6
Synonyms: Af17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 246198
HGNC: HGNC:7138
Homologene: 31347
Rap1a
Name: RAS-related protein 1a
Synonyms: Krev-1, Rap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 109905
HGNC: HGNC:9855
Homologene: 2162
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Relch
Name: RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
Synonyms: 2310035C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227446
Homologene: 10834
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: b2b327Clo, opm, A630086P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Nufip2
Name: nuclear fragile X mental retardation protein interacting protein 2
Synonyms: 9530056D24Rik, 1110001M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68564
Homologene: 10808
Brca1
Name: breast cancer 1, early onset
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12189
HGNC: HGNC:1100
Homologene: 5276
Fgd6
Name: FYVE, RhoGEF and PH domain containing 6
Synonyms: ZFYVE24, Etohd4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13998
Homologene: 14209
Cit
Name: citron
Synonyms: CRIK-SK, Cit-k, citron kinase, C030025P15Rik, citron-N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12704
HGNC: HGNC:1985
Homologene: 21404
Wdr62
Name: WD repeat domain 62
Synonyms: 2310038K02Rik, b2b1508Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233064
Homologene: 15927
Chd2
Name: chromodomain helicase DNA binding protein 2
Synonyms: 2810040A01Rik, 2810013C04Rik, 5630401D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244059
HGNC: HGNC:1917
Homologene: 37462
Egfr
Name: epidermal growth factor receptor
Synonyms: Wa5, Erbb, Errb1, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, 9030024J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13649
HGNC: HGNC:3236
Homologene: 74545
Ppp3ca
Name: protein phosphatase 3, catalytic subunit, alpha isoform
Synonyms: 2900074D19Rik, Caln, Calna, CN, PP2BA alpha, PP2B alpha 1, CnA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19055
HGNC: HGNC:9314
Homologene: 55497
Hp1bp3
Name: heterochromatin protein 1, binding protein 3
Synonyms: Hp1bp74
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15441
Homologene: 7774
2700049A03Rik
Name: RIKEN cDNA 2700049A03 gene
Synonyms: talpid3, Ta3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76967
Homologene: 8839
Zmiz1
Name: zinc finger, MIZ-type containing 1
Synonyms: Rai17, Zimp10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 328365
Homologene: 10667
Mns1
Name: meiosis-specific nuclear structural protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17427
Homologene: 40628
Myof
Name: myoferlin
Synonyms: 2310051D19Rik, E030042N20Rik, Fer1l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226101
VEGA: 19
HGNC: HGNC:3656
Homologene: 40882
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Ttn
Name: titin
Synonyms: D830007G01Rik, L56, 1100001C23Rik, mdm, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, shru, connectin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Fat3
Name: FAT atypical cadherin 3
Synonyms: 9430076A06Rik, D430038H04Rik, LOC382129, LOC234973
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Lama4
Name: laminin, alpha 4
Synonyms: laminin [a]4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16775
HGNC: HGNC:6484
Homologene: 37604
Vmn2r57
Name: vomeronasal 2, receptor 57
Synonyms: EG269902
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269902
Homologene: 104832
Cracdl
Name: capping protein inhibiting regulator of actin like
Synonyms: 2010300C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 72097
Homologene: 19208
Olfr631
Name: olfactory receptor 631
Synonyms: MOR3-1, GA_x6K02T2PBJ9-6662699-6663658
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258961
Homologene: 64935
Adamts9
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9
Synonyms: UND3, 8430403M15Rik, E030027K14Rik, Mhdaund3, 1810011L16Rik, Gsfund3, Mhdaund4, UND4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101401
Homologene: 18821
Xcr1
Name: chemokine (C motif) receptor 1
Synonyms: GPR5, XCR1, Ccxcr1, C motif-1/lymphotactin receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 23832
HGNC: HGNC:1625
Homologene: 21095
Rbbp8
Name: retinoblastoma binding protein 8, endonuclease
Synonyms: 9930104E21Rik, CtIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225182
VEGA: 18
HGNC: HGNC:9891
Homologene: 28546
Kansl1l
Name: KAT8 regulatory NSL complex subunit 1-like
Synonyms: C430010P07Rik, 1110028C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68691
Homologene: 27376
Rtl1
Name: retrotransposon Gaglike 1
Synonyms: Mart1, Mar, Mor1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 353326
VEGA: 12
Homologene: 120261
Ntn4
Name: netrin 4
Synonyms: beta-netrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 57764
Homologene: 10934
Tkt
Name: transketolase
Synonyms: p68
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21881
Homologene: 68154
Cyp2c65
Name: cytochrome P450, family 2, subfamily c, polypeptide 65
Synonyms: 2210009K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72303
HGNC: HGNC:2623
Homologene: 133566
Ttc14
Name: tetratricopeptide repeat domain 14
Synonyms: 4930434D01Rik, cI-44, 4931403I22Rik, 2700016E08Rik, 4933402I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67120
Homologene: 12085
Ptprb
Name: protein tyrosine phosphatase, receptor type, B
Synonyms: 3230402H02Rik, VE-PTP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19263
VEGA: 10
HGNC: HGNC:9665
Homologene: 2125
Galnt6
Name: polypeptide N-acetylgalactosaminyltransferase 6
Synonyms: GalNAc-T6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 207839
HGNC: HGNC:4128
Homologene: 5218
Rbks
Name: ribokinase
Synonyms: 5230400M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71336
Homologene: 5482
Kbtbd12
Name: kelch repeat and BTB (POZ) domain containing 12
Synonyms: Klhdc6, 4933428M03Rik, 4833415F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74589
Homologene: 52613
BB014433
Name: expressed sequence BB014433
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 434285
Il10rb
Name: interleukin 10 receptor, beta
Synonyms: Crfb4, 6620401D04Rik, D21S58h, D16H21S58, CRF2-4, Il10r2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16155
HGNC: HGNC:5965
Homologene: 523
Phactr2
Name: phosphatase and actin regulator 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215789
Homologene: 8816
Pbxip1
Name: pre B cell leukemia transcription factor interacting protein 1
Synonyms: 4732463H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229534
Homologene: 10740
Vmn1r75
Name: vomeronasal 1 receptor 75
Synonyms: V1rg6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 171241
Homologene: 44234
Crisp1
Name: cysteine-rich secretory protein 1
Synonyms: CRISP-1, Aeg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 11571
Homologene: 135665
Cyp2d34
Name: cytochrome P450, family 2, subfamily d, polypeptide 34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223706
VEGA: 15
Homologene: 86099
Arhgef37
Name: Rho guanine nucleotide exchange factor (GEF) 37
Synonyms: 4933429F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 328967
VEGA: 18
Homologene: 28467
E130311K13Rik
Name: RIKEN cDNA E130311K13 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329659
Homologene: 35262
Tbc1d30
Name: TBC1 domain family, member 30
Synonyms: 4930505D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 74694
VEGA: 10
Homologene: 18930
Rnf186
Name: ring finger protein 186
Synonyms: 9130020G10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66825
Homologene: 10404
Bcas2
Name: breast carcinoma amplified sequence 2
Synonyms: 6430539P16Rik, C76366
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68183
HGNC: HGNC:975
Homologene: 4291
Gm5617
Name: predicted gene 5617
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 434402
VEGA: 9
Homologene: 49583
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 37,624,225 bp
  • A to T, chromosome 1 at 66,726,726 bp
  • G to T, chromosome 1 at 105,721,272 bp
  • A to G, chromosome 1 at 156,642,085 bp
  • A to G, chromosome 2 at 76,907,461 bp
  • T to C, chromosome 2 at 166,058,765 bp
  • T to C, chromosome 3 at 33,808,924 bp
  • T to C, chromosome 3 at 63,915,641 bp
  • T to C, chromosome 3 at 89,443,170 bp
  • T to C, chromosome 3 at 103,174,341 bp
  • C to T, chromosome 3 at 105,750,297 bp
  • T to A, chromosome 3 at 136,876,122 bp
  • A to G, chromosome 4 at 138,234,304 bp
  • G to T, chromosome 4 at 138,967,966 bp
  • T to C, chromosome 5 at 31,651,819 bp
  • C to T, chromosome 5 at 115,846,405 bp
  • T to C, chromosome 6 at 88,617,948 bp
  • G to A, chromosome 6 at 92,859,926 bp
  • A to G, chromosome 6 at 92,890,118 bp
  • A to T, chromosome 7 at 11,881,051 bp
  • T to C, chromosome 7 at 30,261,384 bp
  • T to A, chromosome 7 at 41,448,472 bp
  • A to T, chromosome 7 at 73,435,842 bp
  • T to C, chromosome 7 at 103,928,877 bp
  • T to A, chromosome 7 at 141,811,857 bp
  • T to C, chromosome 8 at 15,042,179 bp
  • A to G, chromosome 9 at 16,375,455 bp
  • T to C, chromosome 9 at 48,495,887 bp
  • T to C, chromosome 9 at 72,449,453 bp
  • T to A, chromosome 9 at 95,908,369 bp
  • A to T, chromosome 9 at 123,856,116 bp
  • A to T, chromosome 10 at 13,261,811 bp
  • G to A, chromosome 10 at 39,067,902 bp
  • A to G, chromosome 10 at 93,745,795 bp
  • T to C, chromosome 10 at 94,137,565 bp
  • C to A, chromosome 10 at 116,341,090 bp
  • T to A, chromosome 10 at 121,296,845 bp
  • C to A, chromosome 11 at 16,883,607 bp
  • G to A, chromosome 11 at 69,589,608 bp
  • T to A, chromosome 11 at 77,691,916 bp
  • G to T, chromosome 11 at 97,680,743 bp
  • C to T, chromosome 11 at 101,524,246 bp
  • G to T, chromosome 12 at 51,754,104 bp
  • G to T, chromosome 12 at 71,184,530 bp
  • G to A, chromosome 12 at 109,593,024 bp
  • T to A, chromosome 14 at 25,572,070 bp
  • C to T, chromosome 14 at 30,568,196 bp
  • A to T, chromosome 15 at 82,616,770 bp
  • A to T, chromosome 15 at 100,694,668 bp
  • A to G, chromosome 16 at 91,421,864 bp
  • T to C, chromosome 17 at 40,305,126 bp
  • T to C, chromosome 17 at 42,796,328 bp
  • C to T, chromosome 17 at 71,517,578 bp
  • G to A, chromosome 18 at 11,738,607 bp
  • A to G, chromosome 18 at 61,507,274 bp
  • A to G, chromosome 19 at 38,024,361 bp
  • A to G, chromosome 19 at 39,061,166 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6051 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044219-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.