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Strain Name:
C57BL/6J-MtgxR6073Btlr/Mmmh
Stock Number:
044234-MU
Citation ID:
RRID:MMRRC_044234-MU
Other Names:
R6073 (G1)
Major Collection:

Strain Information

Myo10
Name: myosin X
Synonyms: myosin-X, D15Ertd600e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17909
HGNC: HGNC:7593
Homologene: 36328
Cd74
Name: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
Synonyms: CLIP, Ii
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16149
VEGA: 18
HGNC: HGNC:1697
Homologene: 3209
Ntrk1
Name: neurotrophic tyrosine kinase, receptor, type 1
Synonyms: TrkA, Tkr
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18211
HGNC: HGNC:8031
Homologene: 1898
Kcnj5
Name: potassium inwardly-rectifying channel, subfamily J, member 5
Synonyms: Kir3.4, GIRK4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16521
VEGA: 9
HGNC: HGNC:6266
Homologene: 20248
Epb41l2
Name: erythrocyte membrane protein band 4.1 like 2
Synonyms: NBL2, 4.1G, D10Ertd398e, Epb4.1l2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13822
VEGA: 10
HGNC: HGNC:3379
Homologene: 37478
Ucp2
Name: uncoupling protein 2 (mitochondrial, proton carrier)
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22228
Homologene: 2516
Dscaml1
Name: DS cell adhesion molecule like 1
Synonyms: 4930435C18Rik, 4921507G06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 114873
VEGA: 9
Homologene: 79549
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 46,832,612 bp
  • T to C, chromosome 1 at 58,104,509 bp
  • T to C, chromosome 1 at 74,951,279 bp
  • T to C, chromosome 3 at 54,807,287 bp
  • T to C, chromosome 3 at 87,791,370 bp
  • T to A, chromosome 3 at 135,260,073 bp
  • T to C, chromosome 4 at 43,727,543 bp
  • A to G, chromosome 4 at 53,679,994 bp
  • T to A, chromosome 4 at 107,193,401 bp
  • A to G, chromosome 4 at 118,482,390 bp
  • T to C, chromosome 4 at 143,698,268 bp
  • G to A, chromosome 5 at 20,569,288 bp
  • A to G, chromosome 5 at 31,062,562 bp
  • C to T, chromosome 5 at 43,729,975 bp
  • A to G, chromosome 5 at 86,058,153 bp
  • A to G, chromosome 5 at 105,290,959 bp
  • A to G, chromosome 5 at 124,819,210 bp
  • A to G, chromosome 6 at 18,434,233 bp
  • T to C, chromosome 6 at 18,448,369 bp
  • T to C, chromosome 7 at 8,255,185 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • A to G, chromosome 7 at 42,580,741 bp
  • GGCGGCGGC to GGCGGCGGCCGCGGCGGC, chromosome 7 at 97,579,906 bp
  • G to A, chromosome 7 at 100,498,131 bp
  • G to A, chromosome 7 at 105,617,539 bp
  • G to A, chromosome 7 at 141,849,060 bp
  • A to C, chromosome 7 at 141,858,288 bp
  • T to A, chromosome 8 at 13,456,958 bp
  • A to T, chromosome 8 at 69,743,203 bp
  • G to T, chromosome 8 at 88,138,140 bp
  • A to T, chromosome 8 at 121,753,552 bp
  • T to C, chromosome 9 at 32,317,800 bp
  • G to A, chromosome 9 at 45,450,583 bp
  • T to G, chromosome 10 at 25,501,832 bp
  • A to G, chromosome 10 at 127,689,243 bp
  • T to C, chromosome 11 at 4,888,895 bp
  • T to C, chromosome 11 at 75,494,022 bp
  • T to A, chromosome 11 at 101,367,976 bp
  • G to T, chromosome 11 at 120,361,787 bp
  • T to A, chromosome 13 at 59,702,994 bp
  • G to A, chromosome 13 at 103,844,921 bp
  • A to T, chromosome 14 at 28,011,636 bp
  • C to T, chromosome 14 at 60,750,021 bp
  • G to A, chromosome 15 at 25,736,642 bp
  • A to G, chromosome 15 at 36,600,651 bp
  • T to C, chromosome 15 at 59,335,170 bp
  • G to A, chromosome 15 at 76,912,085 bp
  • T to C, chromosome 17 at 12,890,363 bp
  • A to G, chromosome 17 at 24,730,887 bp
  • A to T, chromosome 17 at 28,904,623 bp
  • A to G, chromosome 17 at 35,001,529 bp
  • C to T, chromosome 17 at 57,206,223 bp
  • G to A, chromosome 17 at 74,373,305 bp
  • G to A, chromosome 18 at 60,811,486 bp
  • A to T, chromosome 18 at 62,179,466 bp
  • A to G, chromosome 18 at 63,012,645 bp
  • A to T, chromosome 19 at 8,797,309 bp
  • T to C, chromosome 19 at 40,314,657 bp
  • G to T, chromosome 19 at 56,843,223 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6073 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044234-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.