Strain Name:
C57BL/6J-MtgxR6075Btlr
Stock Number:
044236-MU
Citation ID:
RRID:MMRRC_044236-MU
Other Names:
R6075 (G1)
Major Collection:

Gene Information

Ncor1
Name: nuclear receptor co-repressor 1
Synonyms: A230020K14Rik, N-CoR, 5730405M06Rik, Rxrip13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20185
HGNC: HGNC:7672
Homologene: 38166
Nae1
Name: NEDD8 activating enzyme E1 subunit 1
Synonyms: Appbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234664
HGNC: HGNC:621
Homologene: 68370
Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: Cav3.1d, a1G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Areg
Name: amphiregulin
Synonyms: Sdgf, AR, Mcub
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11839
HGNC: HGNC:651
Homologene: 1252
Kl
Name: klotho
Synonyms: alpha-kl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16591
HGNC: HGNC:6344
Homologene: 68415
Barhl1
Name: BarH like homeobox 1
Synonyms: MBH2, Dres115
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 54422
HGNC: HGNC:953
Homologene: 81871
Dock9
Name: dedicator of cytokinesis 9
Synonyms: Zizimin1, B230309H04Rik, D14Wsu89e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105445
Homologene: 41026
Mcm5
Name: minichromosome maintenance complex component 5
Synonyms: Cdc46, Mcmd5, mCD46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17218
HGNC: HGNC:6948
Homologene: 4904
Atxn2l
Name: ataxin 2-like
Synonyms: A2lp, A2RP, A2LG, A2D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233871
Homologene: 16513
Hat1
Name: histone aminotransferase 1
Synonyms: 2410071B14Rik, KAT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 107435
HGNC: HGNC:4821
Homologene: 2701
Tet2
Name: tet methylcytosine dioxygenase 2
Synonyms: E130014J05Rik, Ayu17-449
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 214133
Homologene: 49498
Fbxo21
Name: F-box protein 21
Synonyms: 2810425J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231670
Homologene: 14145
Mdn1
Name: midasin AAA ATPase 1
Synonyms: LOC213784, D4Abb1e, 4833432B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100019
Homologene: 39689
Ank3
Name: ankyrin 3, epithelial
Synonyms: 2900054D09Rik, AnkG, Ank-3, Ankyrin-G, Ankyrin-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Nop14
Name: NOP14 nucleolar protein
Synonyms: Nol14, 2610033H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75416
Homologene: 41773
Afg3l2
Name: AFG3-like AAA ATPase 2
Synonyms: 2310036I02Rik, Emv66, par
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 69597
VEGA: 18
HGNC: HGNC:315
Homologene: 4947
Ccdc34
Name: coiled-coil domain containing 34
Synonyms: 2810027O19Rik, 4930522P10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68201
Homologene: 12245
Pxk
Name: PX domain containing serine/threonine kinase
Synonyms: C230080L11Rik, D14Ertd813e, MONaKA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218699
VEGA: 14
Homologene: 9828
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72205
Homologene: 8125
Zfyve26
Name: zinc finger, FYVE domain containing 26
Synonyms: A630028O16Rik, LOC380767, 9330197E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 211978
VEGA: 12
Homologene: 9102
Gpr107
Name: G protein-coupled receptor 107
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 277463
Homologene: 81077
BC055324
Name: cDNA sequence BC055324
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381306
Homologene: 10058
Trpm2
Name: transient receptor potential cation channel, subfamily M, member 2
Synonyms: LTRPC2, Trrp7, TRPC7, 9830168K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 28240
Homologene: 20709
Ptpn4
Name: protein tyrosine phosphatase, non-receptor type 4
Synonyms: testis-enriched phosphatase, TEP/mPTPMEG, TEP, protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte), hPTP-MEG, PTPMEG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19258
HGNC: HGNC:9656
Homologene: 2120
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: Ryr, skrr, calcium release channel isoform 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20190
Homologene: 68069
Ptprq
Name: protein tyrosine phosphatase, receptor type, Q
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: lrd, avc4, b2b1279Clo, b2b1727Clo, b2b1203Clo, Dnahc11, b2b1289Clo, b2b598Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Sntg1
Name: syntrophin, gamma 1
Synonyms: G1SYN, SYN4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71096
Homologene: 56834
Cyp2j11
Name: cytochrome P450, family 2, subfamily j, polypeptide 11
Synonyms: Cyp2j11-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100066
Homologene: 133819
Col5a2
Name: collagen, type V, alpha 2
Synonyms: 1110014L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12832
HGNC: HGNC:2210
Homologene: 20119
Cma1
Name: chymase 1, mast cell
Synonyms: Mcpt5, Mcp5, Mcp-5, MMCP-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 17228
VEGA: 14
HGNC: HGNC:2097
Homologene: 55606
Scap
Name: SREBF chaperone
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235623
Homologene: 8160
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329942
Homologene: 89034
Megf6
Name: multiple EGF-like-domains 6
Synonyms: Egfl3, 2600001P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230971
HGNC: HGNC:3232
Homologene: 45412
Kctd21
Name: potassium channel tetramerisation domain containing 21
Synonyms: EG622320
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 622320
Homologene: 54754
Speer4f1
Name: spermatogenesis associated glutamate (E)-rich protein 4F1
Synonyms: SPEER-4F, 4922502J04Rik, Speer4f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70935
Homologene: 69402
Parp14
Name: poly (ADP-ribose) polymerase family, member 14
Synonyms: collaborator of Stat6, 1600029O10Rik, CoaSt6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 547253
Homologene: 19697
Ptpn9
Name: protein tyrosine phosphatase, non-receptor type 9
Synonyms: Meg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56294
VEGA: 9
HGNC: HGNC:9661
Homologene: 2121
Slc5a12
Name: solute carrier family 5 (sodium/glucose cotransporter), member 12
Synonyms: SMCT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241612
Homologene: 15107
Lsamp
Name: limbic system-associated membrane protein
Synonyms: Lamp, Lam, B130007O04Rik, D930023J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 268890
HGNC: HGNC:6705
Homologene: 20533
Gm6526
Name: predicted gene 6526
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Taar7d
Name: trace amine-associated receptor 7D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 435206
Homologene: 115653
Nova2
Name: NOVA alternative splicing regulator 2
Synonyms: LOC384569
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384569
HGNC: HGNC:7887
Homologene: 134398
BC048507
Name: cDNA sequence BC048507
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 408058
VEGA: 13
Homologene: 133712
Dchs2
Name: dachsous cadherin related 2
Synonyms: LOC229459
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 100534287
Fam21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Hdhd1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 8,679,114 bp
  • A to G, chromosome 1 at 45,502,848 bp
  • T to C, chromosome 1 at 119,765,136 bp
  • T to C, chromosome 1 at 163,978,087 bp
  • T to C, chromosome 2 at 28,915,219 bp
  • T to A, chromosome 2 at 31,152,372 bp
  • A to T, chromosome 2 at 71,410,241 bp
  • T to C, chromosome 2 at 110,044,235 bp
  • T to C, chromosome 2 at 110,616,747 bp
  • A to G, chromosome 3 at 83,355,061 bp
  • T to C, chromosome 3 at 133,471,435 bp
  • T to C, chromosome 4 at 32,689,581 bp
  • T to G, chromosome 4 at 96,345,085 bp
  • C to A, chromosome 4 at 128,486,865 bp
  • T to A, chromosome 4 at 154,262,599 bp
  • A to C, chromosome 5 at 17,479,484 bp
  • A to T, chromosome 5 at 34,659,891 bp
  • A to T, chromosome 5 at 91,143,597 bp
  • G to A, chromosome 5 at 117,988,883 bp
  • C to G, chromosome 5 at 150,953,001 bp
  • T to A, chromosome 6 at 116,227,366 bp
  • G to A, chromosome 7 at 18,957,869 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • A to G, chromosome 7 at 29,087,438 bp
  • T to A, chromosome 7 at 97,347,407 bp
  • A to T, chromosome 7 at 126,492,517 bp
  • A to G, chromosome 8 at 75,114,197 bp
  • A to T, chromosome 8 at 104,524,369 bp
  • T to A, chromosome 9 at 57,061,146 bp
  • G to A, chromosome 9 at 110,378,777 bp
  • A to C, chromosome 10 at 24,027,660 bp
  • G to A, chromosome 10 at 70,002,565 bp
  • A to C, chromosome 10 at 77,935,043 bp
  • A to G, chromosome 10 at 107,525,760 bp
  • G to T, chromosome 11 at 62,317,849 bp
  • T to A, chromosome 11 at 94,416,665 bp
  • A to G, chromosome 12 at 79,293,854 bp
  • A to T, chromosome 12 at 118,104,851 bp
  • A to G, chromosome 13 at 67,863,704 bp
  • A to G, chromosome 14 at 8,150,964 bp
  • A to G, chromosome 14 at 43,748,874 bp
  • T to A, chromosome 14 at 55,942,314 bp
  • C to T, chromosome 14 at 121,545,973 bp
  • A to T, chromosome 16 at 35,857,019 bp
  • A to G, chromosome 16 at 42,134,425 bp
  • C to A, chromosome 18 at 50,568,228 bp
  • G to T, chromosome 18 at 67,421,259 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6075 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044236-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.