Strain Name:
C57BL/6J-MtgxR6109Btlr/Mmmh
Stock Number:
044259-MU
Citation ID:
RRID:MMRRC_044259-MU
Other Names:
R6109 (G1)
Major Collection:

Gene Information

Mitf
Name: melanogenesis associated transcription factor
Synonyms: mi, wh, BCC2, bHLHe32, Gsfbcc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17342
HGNC: HGNC:7105
Homologene: 4892
Acadm
Name: acyl-Coenzyme A dehydrogenase, medium chain
Synonyms: MCAD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11364
HGNC: HGNC:89
Homologene: 3
Camk2a
Name: calcium/calmodulin-dependent protein kinase II alpha
Synonyms: alpha-CaMKII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12322
HGNC: HGNC:1460
Homologene: 56577
H2-D1
Name: histocompatibility 2, D region locus 1
Synonyms: H-2D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14964
HGNC: HGNC:4931
Homologene: 128352
Pdk1
Name: pyruvate dehydrogenase kinase, isoenzyme 1
Synonyms: D530020C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228026
HGNC: HGNC:8809
Homologene: 134437
Gk5
Name: glycerol kinase 5 (putative)
Synonyms: G630067D24Rik, C330018K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235533
Homologene: 15141
Wdr70
Name: WD repeat domain 70
Synonyms: 4833422F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 545085
VEGA: 15
Homologene: 9972
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: ASC1p200, B630009I04Rik, Helic1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Arhgap32
Name: Rho GTPase activating protein 32
Synonyms: p200RhoGAP, GC-GAP, PX-RICS, 3426406O18Rik, Grit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330914
Homologene: 8812
Ncor2
Name: nuclear receptor co-repressor 2
Synonyms: SMRTe, SMRT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20602
HGNC: HGNC:7673
Homologene: 31370
Hdac2
Name: histone deacetylase 2
Synonyms: Yy1bp, D10Wsu179e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15182
HGNC: HGNC:4853
Homologene: 68187
Slf1
Name: SMC5-SMC6 complex localization factor 1
Synonyms: C730024G01Rik, 2700017A04Rik, Brctx, Brctd1, Ankrd32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105377
Homologene: 13000
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: A930005E13Rik, LOC381562, D930005K06Rik, 1810009A16Rik, Zubr1, p600
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69116
Homologene: 10804
Ebf3
Name: early B cell factor 3
Synonyms: O/E-2, Olf-1/EBF-like 2, 3110018A08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13593
Homologene: 56472
Muc16
Name: mucin 16
Synonyms: LOC385009, 1110008I14Rik, Gm21044
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 73732
Homologene: 141193
Farsb
Name: phenylalanyl-tRNA synthetase, beta subunit
Synonyms: PheRS alpha, Frsb, Farsl, Farslb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 23874
Homologene: 4160
Cd2bp2
Name: CD2 cytoplasmic tail binding protein 2
Synonyms: 2410024K20Rik, 1500011B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70233
HGNC: HGNC:1656
Homologene: 4455
Peak1
Name: pseudopodium-enriched atypical kinase 1
Synonyms: 1110049L02Rik, NKF3 kinase family member, C230081A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244895
Homologene: 18259
Kel
Name: Kell blood group
Synonyms: CD238
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 23925
HGNC: HGNC:6308
Homologene: 362
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94109
Homologene: 69536
Agtpbp1
Name: ATP/GTP binding protein 1
Synonyms: Nna1, 2900054O13Rik, 4930445M19Rik, 1700020N17Rik, 5730402G09Rik, 2310001G17Rik, Ccp1, atms
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67269
Homologene: 9067
Ngfr
Name: nerve growth factor receptor (TNFR superfamily, member 16)
Synonyms: p75, p75NGFR, p75NTR, p75 neurotrophin receptor, LNGFR, Tnfrsf16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18053
HGNC: HGNC:7809
Homologene: 1877
Nobox
Name: NOBOX oogenesis homeobox
Synonyms: Og2x
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18291
Homologene: 51066
Zscan10
Name: zinc finger and SCAN domain containing 10
Synonyms: Zscan10, Zfp206
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 332221
Homologene: 13122
Kdm5d
Name: lysine (K)-specific demethylase 5D
Synonyms: Smcy, Jarid1d, HY
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 20592
Homologene: 55838
Rad9b
Name: RAD9 checkpoint clamp component B
Synonyms: A630082N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231724
Homologene: 17006
S100a16
Name: S100 calcium binding protein A16
Synonyms: 2300002L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67860
Homologene: 12201
Ap3b2
Name: adaptor-related protein complex 3, beta 2 subunit
Synonyms: Naptb, beta3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11775
HGNC: HGNC:567
Homologene: 55837
Naip1
Name: NLR family, apoptosis inhibitory protein 1
Synonyms: D13Lsd1, Naip, Birc1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17940
VEGA: 13
HGNC: HGNC:7634
Homologene: 113589
Ankrd36
Name: ankyrin repeat domain 36
Synonyms: 1700012M14Rik, GC3, 1700008J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76389
Homologene: 137366
Olfr616
Name: olfactory receptor 616
Synonyms: GA_x6K02T2PBJ9-6289676-6288723, MOR19-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259103
Homologene: 64957
Zfp811
Name: zinc finger protein 811
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240063
Olfr937
Name: olfactory receptor 937
Synonyms: GA_x6K02T2PVTD-32756567-32755632, MOR171-24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258431
VEGA: 9
Homologene: 27167
Dlk2
Name: delta like non-canonical Notch ligand 2
Synonyms: Egfl9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106565
Homologene: 11397
Ccdc40
Name: coiled-coil domain containing 40
Synonyms: B930008I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 207607
Homologene: 27890
Meiob
Name: meiosis specific with OB domains
Synonyms: 4930528F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75178
VEGA: 17
Homologene: 102013
Clpx
Name: caseinolytic mitochondrial matrix peptidase chaperone subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270166
HGNC: HGNC:2088
Homologene: 4851
Cdh20
Name: cadherin 20
Synonyms: Cdh7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 23836
HGNC: HGNC:1760
Homologene: 8015
Agxt2
Name: alanine-glyoxylate aminotransferase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 268782
Homologene: 12887
Ms4a20
Name: membrane-spanning 4-domains, subfamily A, member 20
Synonyms: 1700017D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 69369
Apcdd1
Name: adenomatosis polyposis coli down-regulated 1
Synonyms: EIG180, Drapc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 494504
VEGA: 18
Homologene: 77420
Lcn11
Name: lipocalin 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227630
Homologene: 129702
Lmln
Name: leishmanolysin-like (metallopeptidase M8 family)
Synonyms: 5330415H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239833
Homologene: 13198
Pcdhb1
Name: protocadherin beta 1
Synonyms: PcdhbA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93872
HGNC: HGNC:8680
Homologene: 8348
Fkbpl
Name: FK506 binding protein-like
Synonyms: Ppiase-X, NG7, DIR1, WISp39, WAF-1/CIP1 stabilizing protein 39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56299
Homologene: 10529
Gnat2
Name: guanine nucleotide binding protein, alpha transducing 2
Synonyms: Gnat-2, Tcalpha, Gt-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14686
HGNC: HGNC:4394
Homologene: 21092
Abcc10
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 10
Synonyms: Mrp7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224814
HGNC: HGNC:52
Homologene: 58616
Cnnm4
Name: cyclin M4
Synonyms: Acdp4, 5430430O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 94220
HGNC: HGNC:105
Homologene: 75662
Serpine2
Name: serine (or cysteine) peptidase inhibitor, clade E, member 2
Synonyms: nexin, PN-1, PI7, protease nexin 1, Spi4, B230326M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20720
HGNC: HGNC:8951
Homologene: 21247
Btnl10
Name: butyrophilin-like 10
Synonyms: BUTR-1, Butr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192194
Homologene: 138184
Vav3
Name: vav 3 oncogene
Synonyms: A530094I06Rik, Idd18.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 57257
Homologene: 38143
Fastkd3
Name: FAST kinase domains 3
Synonyms: 2310010B21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69577
VEGA: 13
Homologene: 11457
Kmo
Name: kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98256
HGNC: HGNC:6381
Homologene: 2729
Cd200r3
Name: CD200 receptor 3
Synonyms: 4733401I18Rik, mCD200RLb, 4833409J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74603
Olfr811
Name: olfactory receptor 811
Synonyms: GA_x6K02T2PULF-11481207-11480248, MOR110-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258545
Homologene: 133725
Krt32
Name: keratin 32
Synonyms: mHa2, Krt1-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16670
HGNC: HGNC:6449
Homologene: 68246
Ctsw
Name: cathepsin W
Synonyms: lymphopain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 13041
VEGA: 19
HGNC: HGNC:2546
Homologene: 37471
Tssk5
Name: testis-specific serine kinase 5
Synonyms: 1700091F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 73542
VEGA: 15
Homologene: 18832
Tex101
Name: testis expressed gene 101
Synonyms: TES101RP, 1700008H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56746
Homologene: 10555
Foxl3
Name: forkhead box L3
Synonyms: Gm5294
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 384244
Homologene: 79931
Lce3b
Name: late cornified envelope 3B
Synonyms: 2310007F04Rik, Sprrl6A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66344
Aym1
Name: activator of yeast meiotic promoters 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 503692
Gm11271
Name: predicted gene 11271
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 36,498,479 bp
  • A to G, chromosome 1 at 78,463,270 bp
  • T to C, chromosome 1 at 79,810,671 bp
  • G to A, chromosome 1 at 104,994,014 bp
  • C to A, chromosome 1 at 175,637,908 bp
  • A to G, chromosome 2 at 25,779,296 bp
  • A to G, chromosome 2 at 71,883,506 bp
  • T to C, chromosome 3 at 90,542,074 bp
  • A to G, chromosome 3 at 92,933,687 bp
  • T to A, chromosome 3 at 108,100,135 bp
  • C to T, chromosome 3 at 109,664,365 bp
  • A to G, chromosome 3 at 153,941,943 bp
  • A to G, chromosome 4 at 139,417,364 bp
  • C to T, chromosome 5 at 113,357,541 bp
  • C to T, chromosome 5 at 122,344,297 bp
  • C to T, chromosome 5 at 125,055,846 bp
  • C to A, chromosome 5 at 138,820,095 bp
  • A to T, chromosome 6 at 41,688,862 bp
  • A to T, chromosome 6 at 43,305,169 bp
  • C to T, chromosome 6 at 97,996,468 bp
  • T to C, chromosome 7 at 24,668,313 bp
  • T to A, chromosome 7 at 81,493,592 bp
  • T to C, chromosome 7 at 103,565,139 bp
  • C to T, chromosome 7 at 127,194,815 bp
  • C to T, chromosome 7 at 137,206,226 bp
  • T to C, chromosome 8 at 16,199,860 bp
  • T to C, chromosome 9 at 18,655,359 bp
  • T to A, chromosome 9 at 32,260,111 bp
  • A to G, chromosome 9 at 39,060,196 bp
  • C to T, chromosome 9 at 56,259,283 bp
  • C to T, chromosome 9 at 65,299,952 bp
  • C to A, chromosome 9 at 96,140,610 bp
  • A to G, chromosome 10 at 36,986,389 bp
  • A to G, chromosome 10 at 50,649,247 bp
  • G to A, chromosome 10 at 129,801,820 bp
  • C to A, chromosome 10 at 129,801,821 bp
  • C to A, chromosome 11 at 5,628,941 bp
  • C to A, chromosome 11 at 58,920,304 bp
  • T to G, chromosome 11 at 95,578,057 bp
  • T to C, chromosome 11 at 100,087,965 bp
  • T to C, chromosome 11 at 119,231,978 bp
  • G to T, chromosome 13 at 21,381,139 bp
  • G to T, chromosome 13 at 59,473,746 bp
  • C to T, chromosome 13 at 68,590,218 bp
  • A to T, chromosome 13 at 77,126,680 bp
  • A to G, chromosome 13 at 100,427,182 bp
  • A to T, chromosome 15 at 8,079,154 bp
  • C to T, chromosome 15 at 10,377,422 bp
  • T to C, chromosome 15 at 76,373,716 bp
  • T to A, chromosome 16 at 33,069,111 bp
  • T to A, chromosome 16 at 44,953,682 bp
  • T to A, chromosome 17 at 23,607,129 bp
  • A to G, chromosome 17 at 24,813,019 bp
  • T to A, chromosome 17 at 32,797,374 bp
  • G to A, chromosome 17 at 34,645,329 bp
  • A to T, chromosome 17 at 35,263,937 bp
  • T to A, chromosome 17 at 46,301,697 bp
  • T to C, chromosome 17 at 46,310,377 bp
  • G to T, chromosome 18 at 37,265,253 bp
  • A to T, chromosome 18 at 60,943,234 bp
  • A to T, chromosome 18 at 62,937,366 bp
  • T to C, chromosome 19 at 5,467,119 bp
  • T to C, chromosome 19 at 11,101,912 bp
  • T to C, chromosome Y at 921,501 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6109 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044259-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.