Strain Name:
C57BL/6J-MtgxR6111Btlr/Mmmh
Stock Number:
044260-MU
Citation ID:
RRID:MMRRC_044260-MU
Other Names:
R6111 (G1)
Major Collection:

Strain Information

Notch2
Name: notch 2
Synonyms: Motch B, N2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18129
HGNC: HGNC:7882
Homologene: 7865
Espl1
Name: extra spindle pole bodies 1, separase
Synonyms: PRCE, separase, SSE, ESP1, PRCE, Cerp
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105988
VEGA: 15
Homologene: 32151
Zfp423
Name: zinc finger protein 423
Synonyms: Roaz, ataxia1, Zfp104, Ebfaz
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94187
Homologene: 9010
Gria4
Name: glutamate receptor, ionotropic, AMPA4 (alpha 4)
Synonyms: Glur-4, Glur4, spkw1, Gluralpha4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14802
HGNC: HGNC:4574
Homologene: 20227
Usp38
Name: ubiquitin specific peptidase 38
Synonyms: 4631402N15Rik, 4833420O05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74841
Homologene: 12367
Map4k4
Name: mitogen-activated protein kinase kinase kinase kinase 4
Synonyms: Nik, 9430080K19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26921
HGNC: HGNC:6866
Homologene: 7442
Ddx4
Name: DEAD box helicase 4
Synonyms: mvh / m'vasa, VASA, Mvh, DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13206
VEGA: 13
Homologene: 49227
Daam1
Name: dishevelled associated activator of morphogenesis 1
Synonyms: 1700066F09Rik, 2310028E21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 208846
VEGA: 12
Homologene: 36635
Camsap2
Name: calmodulin regulated spectrin-associated protein family, member 2
Synonyms: 1600013L13Rik, 4930541M15Rik, Camsap1l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67886
Homologene: 18927
Rsf1
Name: remodeling and spacing factor 1
Synonyms: p325, XAP8, Hbxap, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Dclk2
Name: doublecortin-like kinase 2
Synonyms: 6330415M09Rik, Click-II, Dcamkl2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70762
Homologene: 69431
Ttll4
Name: tubulin tyrosine ligase-like family, member 4
Synonyms: 4632407P03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67534
Homologene: 8764
Osbpl2
Name: oxysterol binding protein-like 2
Synonyms: ORP-2, C130070J12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228983
Homologene: 77324
Ift122
Name: intraflagellar transport 122
Synonyms: C86139, Wdr10, sopb
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 81896
Homologene: 12819
Tnfrsf10b
Name: tumor necrosis factor receptor superfamily, member 10b
Synonyms: Trail Receptor, Ly98, Killer/Dr5, DR5, TRICK2B, TRAILR2, TRICKB, TRAIL-R2, TRICK2A, KILLER
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21933
VEGA: 14
Homologene: 129806
Spg11
Name: SPG11, spatacsin vesicle trafficking associated
Synonyms: C530005A01Rik, 6030465E24Rik, spastic paraplegia 11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214585
Homologene: 41614
Plpp1
Name: phospholipid phosphatase 1
Synonyms: mPAP, Lipid phosphate phosphatase 1, LPP1, LPP-1, Hpic53, Ppap2a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19012
VEGA: 13
HGNC: HGNC:9228
Homologene: 134049
Cpne6
Name: copine VI
Synonyms: neuronal copine
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12891
HGNC: HGNC:2319
Homologene: 81815
P3h1
Name: prolyl 3-hydroxylase 1
Synonyms: 2410024C15Rik, Gros1, Lepre1, Leprecan
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56401
Homologene: 10509
Atad2
Name: ATPase family, AAA domain containing 2
Synonyms: 2610509G12Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70472
VEGA: 15
Homologene: 6044
Zfp933
Name: zinc finger protein 933
Synonyms: 2810408P10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242747
Homologene: 138474
Sdc3
Name: syndecan 3
Synonyms: Synd3, syn-3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20970
Homologene: 7965
Rai1
Name: retinoic acid induced 1
Synonyms: Gt1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19377
HGNC: HGNC:9834
Homologene: 7508
Dock2
Name: dedicator of cyto-kinesis 2
Synonyms: MBC, CED-5, Hch
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94176
HGNC: HGNC:2988
Homologene: 37984
Wdr72
Name: WD repeat domain 72
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 546144
Homologene: 52326
Rexo2
Name: RNA exonuclease 2
Synonyms: 1810038D15Rik, Sfn, Smfn, Rex2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 104444
VEGA: 9
Homologene: 6447
Col24a1
Name: collagen, type XXIV, alpha 1
Synonyms: 5430404K19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71355
Homologene: 65061
Pigo
Name: phosphatidylinositol glycan anchor biosynthesis, class O
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56703
Homologene: 31761
Kcnq1
Name: potassium voltage-gated channel, subfamily Q, member 1
Synonyms: KVLQT1, Kcna9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16535
HGNC: HGNC:6294
Homologene: 85014
Tubgcp6
Name: tubulin, gamma complex component 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328580
Homologene: 32477
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: A530024P18Rik, 2310008C07Rik, 2310003D02Rik, mXin beta, myomaxin, Cmya3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241431
Homologene: 19388
Or8b12b
Name: olfactory receptor family 8 subfamily B member 12B
Synonyms: GA_x6K02T2PVTD-31458511-31459443, MOR161-4, Olfr875
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258744
Homologene: 121527
Nfatc1
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
Synonyms: NFAT2, NFATc, NF-ATc, 2210017P03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 18018
VEGA: 18
HGNC: HGNC:7775
Homologene: 32336
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242627
Homologene: 135888
Adcy2
Name: adenylate cyclase 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210044
VEGA: 13
HGNC: HGNC:233
Homologene: 75133
Bmal2
Name: basic helix-loop-helix ARNT like 2
Synonyms: 4632430A05Rik, MOP9, bHLHe6, Arntl2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 272322
Homologene: 10609
Tmem273
Name: transmembrane protein 273
Synonyms: 1810011H11Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 69069
VEGA: 14
Homologene: 78635
Zdhhc8
Name: zinc finger, DHHC domain containing 8
Synonyms: D16H22S1738E, E330009O14Rik, Op53c05
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 27801
VEGA: 16
Homologene: 8363
Vmn2r73
Name: vomeronasal 2, receptor 73
Synonyms: EG620928
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 620928
Homologene: 115466
Gfra3
Name: glial cell line derived neurotrophic factor family receptor alpha 3
Synonyms: GFR alpha-3, GFRalpha3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14587
VEGA: 18
HGNC: HGNC:4245
Homologene: 1146
Dlec1
Name: deleted in lung and esophageal cancer 1
Synonyms: D630005C06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320256
HGNC: HGNC:2899
Homologene: 84733
Abcd4
Name: ATP-binding cassette, sub-family D member 4
Synonyms: P69r, Pxmp1l
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19300
VEGA: 12
HGNC: HGNC:68
Homologene: 3703
Tsen54
Name: tRNA splicing endonuclease subunit 54
Synonyms: 0610034P02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76265
Homologene: 35476
Ttpa
Name: tocopherol (alpha) transfer protein
Synonyms: alpha TTP, alpha-TTP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50500
Homologene: 37295
Nudt19
Name: nudix hydrolase 19
Synonyms: androgen regulated gene RP2, D7Rp2-s, D7Rp2-r, D7Rp2, RP2-s, RP2-r, D7RP2e, nudix (nucleoside diphosphate linked moiety X)-type motif 19
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 110959
Homologene: 13211
Ino80b
Name: INO80 complex subunit B
Synonyms: Papa1, HMG1YL4, 2510009I23Rik, Hmga1l4, Znhit4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70020
Homologene: 32566
Pcdhb3
Name: protocadherin beta 3
Synonyms: PcdhbC
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93874
HGNC: HGNC:8688
Homologene: 115665
Eya4
Name: EYA transcriptional coactivator and phosphatase 4
Synonyms: B130023L16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14051
VEGA: 10
HGNC: HGNC:3522
Homologene: 3025
Mios
Name: meiosis regulator for oocyte development
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 252875
Homologene: 10371
Hace1
Name: HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
Synonyms: A730034A22Rik, 1700042J16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 209462
Homologene: 10807
Acd
Name: adrenocortical dysplasia
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 497652
Homologene: 23391
Zfp72
Name: zinc finger protein 72
Synonyms: Zfp74
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238722
VEGA: 13
Homologene: 108290
Fcmr
Name: Fc fragment of IgM receptor
Synonyms: 1810037B05Rik, FcmuR, Faim3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69169
Homologene: 48347
Smok3c
Name: sperm motility kinase 3C
Synonyms: EG622486
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 622486
Homologene: 128738
H2-Q5
Name: histocompatibility 2, Q region locus 5
Synonyms: Qa-5, Qat-5, H-2Q5, Qa5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15016
Gm25747
Name: predicted gene, 25747
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 40,011,662 bp
  • A to T, chromosome 1 at 74,697,539 bp
  • A to G, chromosome 1 at 130,877,829 bp
  • A to G, chromosome 1 at 136,281,298 bp
  • T to A, chromosome 2 at 67,511,817 bp
  • A to G, chromosome 2 at 122,093,482 bp
  • A to G, chromosome 2 at 158,213,448 bp
  • A to G, chromosome 2 at 180,150,201 bp
  • A to G, chromosome 3 at 86,805,661 bp
  • T to C, chromosome 3 at 98,146,293 bp
  • C to A, chromosome 3 at 145,314,054 bp
  • A to T, chromosome 4 at 20,014,772 bp
  • T to C, chromosome 4 at 43,019,724 bp
  • T to C, chromosome 4 at 113,705,648 bp
  • C to T, chromosome 4 at 119,241,132 bp
  • A to G, chromosome 4 at 130,818,842 bp
  • T to C, chromosome 4 at 147,828,760 bp
  • C to A, chromosome 5 at 138,065,103 bp
  • G to A, chromosome 6 at 8,214,836 bp
  • A to G, chromosome 6 at 83,124,366 bp
  • T to A, chromosome 6 at 115,875,286 bp
  • T to C, chromosome 6 at 146,820,599 bp
  • T to A, chromosome 7 at 35,555,527 bp
  • A to G, chromosome 7 at 85,871,789 bp
  • GCG to GCGACGGCGACG, chromosome 7 at 97,579,907 bp
  • A to G, chromosome 7 at 143,107,737 bp
  • A to G, chromosome 8 at 81,013,922 bp
  • A to G, chromosome 8 at 87,782,687 bp
  • A to G, chromosome 8 at 105,698,287 bp
  • G to A, chromosome 9 at 4,502,430 bp
  • T to C, chromosome 9 at 37,772,932 bp
  • A to T, chromosome 9 at 48,473,112 bp
  • T to C, chromosome 9 at 74,210,325 bp
  • T to C, chromosome 9 at 119,102,624 bp
  • T to A, chromosome 10 at 23,140,055 bp
  • A to T, chromosome 10 at 45,589,510 bp
  • G to A, chromosome 11 at 34,708,787 bp
  • T to A, chromosome 11 at 60,187,906 bp
  • T to C, chromosome 11 at 115,820,130 bp
  • T to A, chromosome 12 at 71,942,264 bp
  • G to A, chromosome 12 at 84,615,114 bp
  • A to G, chromosome 12 at 113,429,083 bp
  • T to A, chromosome 13 at 68,729,241 bp
  • T to G, chromosome 13 at 74,372,385 bp
  • A to G, chromosome 13 at 77,327,902 bp
  • A to T, chromosome 13 at 112,621,232 bp
  • A to G, chromosome 13 at 112,866,917 bp
  • T to C, chromosome 14 at 32,806,798 bp
  • G to A, chromosome 14 at 55,514,634 bp
  • T to A, chromosome 14 at 69,782,558 bp
  • G to A, chromosome 15 at 58,108,091 bp
  • T to C, chromosome 15 at 89,100,920 bp
  • A to G, chromosome 15 at 102,299,888 bp
  • G to T, chromosome 16 at 18,224,898 bp
  • A to T, chromosome 17 at 35,394,909 bp
  • T to A, chromosome 18 at 34,690,874 bp
  • A to T, chromosome 18 at 37,302,189 bp
  • A to G, chromosome 18 at 80,697,910 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6111 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044260-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.