Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR6113Btlr/Mmmh
Stock Number:
044262-MU
Citation ID:
RRID:MMRRC_044262-MU
Other Names:
R6113 (G1)
Major Collection:

Strain Information

Tle4
Name: transducin-like enhancer of split 4
Synonyms: Grg4, ESTM13, ESTM14, Bce1, 5730411M05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21888
VEGA: 19
Homologene: 38259
Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, Cspg2, DPEAAE
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Pcdh9
Name: protocadherin 9
Synonyms: C630029H24Rik, 1500001L12Rik, LOC382930, A730003J17Rik, C530050I23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211712
HGNC: HGNC:8661
Homologene: 10698
Slc17a7
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
Synonyms: Vglut1, 2900052E22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72961
Homologene: 113454
Cr1l
Name: complement C3b/C4b receptor 1 like
Synonyms: mCRY, Crry
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12946
Homologene: 128275
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Dclre1c
Name: DNA cross-link repair 1C
Synonyms: 9930121L06Rik, Artemis, Art
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227525
Homologene: 32547
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 60,222,263 bp
  • A to T, chromosome 1 at 131,355,505 bp
  • T to C, chromosome 1 at 193,129,502 bp
  • T to C, chromosome 1 at 195,131,411 bp
  • T to C, chromosome 2 at 3,452,863 bp
  • T to G, chromosome 2 at 60,368,873 bp
  • G to C, chromosome 2 at 69,483,557 bp
  • A to C, chromosome 2 at 151,657,478 bp
  • G to A, chromosome 2 at 153,910,731 bp
  • T to C, chromosome 3 at 55,489,819 bp
  • T to C, chromosome 3 at 64,491,399 bp
  • T to C, chromosome 3 at 89,367,885 bp
  • C to A, chromosome 3 at 90,224,866 bp
  • T to C, chromosome 4 at 14,708,673 bp
  • G to A, chromosome 4 at 62,340,647 bp
  • T to C, chromosome 4 at 154,924,492 bp
  • C to A, chromosome 5 at 35,020,323 bp
  • A to G, chromosome 5 at 72,329,800 bp
  • C to G, chromosome 5 at 112,866,385 bp
  • C to T, chromosome 6 at 41,116,379 bp
  • T to C, chromosome 6 at 57,978,572 bp
  • T to C, chromosome 6 at 127,015,937 bp
  • A to G, chromosome 6 at 127,078,154 bp
  • C to A, chromosome 7 at 44,537,700 bp
  • A to G, chromosome 7 at 45,174,751 bp
  • A to G, chromosome 7 at 97,324,326 bp
  • C to A, chromosome 7 at 127,560,281 bp
  • T to A, chromosome 7 at 141,082,656 bp
  • T to C, chromosome 8 at 69,882,359 bp
  • T to A, chromosome 8 at 108,947,421 bp
  • A to T, chromosome 9 at 21,107,922 bp
  • T to A, chromosome 9 at 57,602,440 bp
  • T to A, chromosome 9 at 57,701,891 bp
  • T to A, chromosome 9 at 74,152,641 bp
  • G to T, chromosome 10 at 83,508,134 bp
  • A to T, chromosome 11 at 48,915,340 bp
  • G to A, chromosome 11 at 73,286,018 bp
  • A to G, chromosome 11 at 118,126,275 bp
  • T to A, chromosome 12 at 98,824,674 bp
  • T to C, chromosome 12 at 110,620,414 bp
  • T to A, chromosome 13 at 38,192,047 bp
  • T to A, chromosome 13 at 89,657,536 bp
  • T to C, chromosome 13 at 100,299,286 bp
  • A to G, chromosome 14 at 30,815,184 bp
  • T to G, chromosome 14 at 53,649,725 bp
  • G to A, chromosome 14 at 55,622,478 bp
  • A to G, chromosome 14 at 93,887,108 bp
  • T to C, chromosome 15 at 31,608,162 bp
  • C to T, chromosome 15 at 59,651,638 bp
  • C to A, chromosome 16 at 8,572,900 bp
  • T to C, chromosome 16 at 16,341,003 bp
  • C to A, chromosome 16 at 20,728,847 bp
  • A to T, chromosome 16 at 25,981,153 bp
  • G to A, chromosome 17 at 25,722,867 bp
  • G to T, chromosome 17 at 33,138,068 bp
  • T to A, chromosome 17 at 57,301,884 bp
  • T to A, chromosome 18 at 36,765,395 bp
  • T to A, chromosome 18 at 53,473,601 bp
  • A to T, chromosome 19 at 14,595,588 bp
  • C to T, chromosome X at 42,827,195 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6113 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044262-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.