Strain Name:
C57BL/6J-MtgxR6124Btlr
Stock Number:
044271-MU
Citation ID:
RRID:MMRRC_044271-MU
Other Names:
R6124 (G1)
Major Collection:

Strain Information

Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Cxcr4
Name: chemokine (C-X-C motif) receptor 4
Synonyms: PB-CKR, fusin, CD184, Cmkar4, Sdf1r, b2b220Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12767
HGNC: HGNC:2561
Homologene: 20739
Cyfip1
Name: cytoplasmic FMR1 interacting protein 1
Synonyms: P140SRA-1, Shyc, pl-1, l(7)1Rl, Sra-1, E030028J09Rik, l7Rl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20430
Homologene: 22628
Epg5
Name: ectopic P-granules autophagy protein 5 homolog (C. elegans)
Synonyms: 5430411K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 100502841
VEGA: 18
Homologene: 14575
Ptgfrn
Name: prostaglandin F2 receptor negative regulator
Synonyms: CD9P-1, 4833445A08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19221
HGNC: HGNC:9601
Homologene: 7908
Hgfac
Name: hepatocyte growth factor activator
Synonyms: HGFA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 54426
HGNC: HGNC:4894
Homologene: 1170
Snrnp48
Name: small nuclear ribonucleoprotein 48 (U11/U12)
Synonyms: 1110050F08Rik, 6530403A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67797
VEGA: 13
Homologene: 12191
2900026A02Rik
Name: RIKEN cDNA 2900026A02 gene
Synonyms: LOC231620, Gm449
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243219
Homologene: 129566
Lonrf1
Name: LON peptidase N-terminal domain and ring finger 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244421
Homologene: 34980
Hormad1
Name: HORMA domain containing 1
Synonyms: 4921522K05Rik, Nohma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67981
Homologene: 69415
Gm5422
Name: predicted pseudogene 5422
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432448
VEGA: 10
Sis
Name: sucrase isomaltase (alpha-glucosidase)
Synonyms: Si-s, sucrase-isomaltase, 2010204N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69983
Homologene: 37424
Tppp2
Name: tubulin polymerization-promoting protein family member 2
Synonyms: LOC219038, LOC386487
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219038
VEGA: 14
Homologene: 25079
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Mfsd6
Name: major facilitator superfamily domain containing 6
Synonyms: 9630025I22Rik, MMR2, 2210010L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98682
Homologene: 9784
Slco3a1
Name: solute carrier organic anion transporter family, member 3a1
Synonyms: MJAM, OATP-D, 5830414C08Rik, Anr1, Slc21a11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 108116
Homologene: 40862
Or13a20
Name: olfactory receptor family 13 subfamily A member 20
Synonyms: IE12, MOR253-5, GA_x6K02T2PBJ9-42798103-42799038, Olfr53
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258962
Homologene: 133678
Or6d15
Name: olfactory receptor family 6 subfamily D member 15
Synonyms: GA_x54KRFPKN04-58217732-58216800, MOR119-2, Olfr215
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258438
Homologene: 133693
Serpinb1b
Name: serine (or cysteine) peptidase inhibitor, clade B, member 1b
Synonyms: 6330533H24Rik, ovalbumin, EIB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 282663
HGNC: HGNC:3311
Homologene: 138408
Papss2
Name: 3'-phosphoadenosine 5'-phosphosulfate synthase 2
Synonyms: Sk2, Atpsk2, 1810018P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 23972
VEGA: 19
HGNC: HGNC:8604
Homologene: 55840
Vmn2r94
Name: vomeronasal 2, receptor 94
Synonyms: EG665227
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665227
Homologene: 129751
Nrap
Name: nebulin-related anchoring protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18175
HGNC: HGNC:7988
Homologene: 4499
Plekhn1
Name: pleckstrin homology domain containing, family N member 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 231002
VEGA: 4
Homologene: 12949
Mast1
Name: microtubule associated serine/threonine kinase 1
Synonyms: 9430008B02Rik, SAST170, SAST
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56527
Homologene: 10543
Atp8b3
Name: ATPase, class I, type 8B, member 3
Synonyms: SAPLT, 1700042F02Rik, 1700056N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67331
VEGA: 10
Homologene: 19034
Apc2
Name: APC regulator of WNT signaling pathway 2
Synonyms: APCL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 23805
Homologene: 4299
Fkbpl
Name: FK506 binding protein-like
Synonyms: Ppiase-X, NG7, DIR1, WISp39, WAF-1/CIP1 stabilizing protein 39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56299
Homologene: 10529
Vmn1r19
Name: vomeronasal 1 receptor 19
Synonyms: V1rc27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171200
Homologene: 134034
Slc41a2
Name: solute carrier family 41, member 2
Synonyms: A230035L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 338365
Homologene: 9870
Hook3
Name: hook microtubule tethering protein 3
Synonyms: E330005F07Rik, 5830454D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 320191
Homologene: 13022
2310050C09Rik
Name: RIKEN cDNA 2310050C09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66533
Homologene: 104374
Vav3
Name: vav 3 oncogene
Synonyms: A530094I06Rik, Idd18.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 57257
Homologene: 38143
Or10j2
Name: olfactory receptor family 10 subfamily J member 2
Synonyms: GA_x6K02T2P20D-20826777-20827719, GA_x6K02T2R7CC-581296-580364, MOR267-12P, MOR267-8, Olfr1403, Olfr418-ps1, Olfr418
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 258645
HGNC: HGNC:8175
Homologene: 8218
Fastkd3
Name: FAST kinase domains 3
Synonyms: 2310010B21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69577
VEGA: 13
Homologene: 11457
Nlrp6
Name: NLR family, pyrin domain containing 6
Synonyms: Nalp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101613
Homologene: 15881
Or6c215
Name: olfactory receptor family 6 subfamily C member 215
Synonyms: GA_x6K02T2PULF-11481207-11480248, MOR110-6, Olfr811
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258545
Homologene: 133725
Or5p72
Name: olfactory receptor family 5 subfamily P member 72
Synonyms: GA_x6K02T2PBJ9-10752603-10753547, MOR204-9, Olfr497
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258733
Homologene: 133602
Klrh1
Name: killer cell lectin-like receptor subfamily H, member 1
Synonyms: LOC232415, Gm156
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232415
Homologene: 16395
Mptx2
Name: mucosal pentraxin 2
Synonyms: Gm11062
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100504232
Homologene: 134535
Or10ak13
Name: olfactory receptor family 10 subfamily AK member 13
Synonyms: GA_x6K02SYWGW3-414-3, GA_x6K02T2QD9B-18767132-18768073, MOR259-10, Olfr219-ps1, Olfr1337
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 258306
Homologene: 121524
Mcee
Name: methylmalonyl CoA epimerase
Synonyms: 1110007A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 73724
Homologene: 13078
Gm9913
Name: predicted gene 9913
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Whsc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 52,708,252 bp
  • A to G, chromosome 1 at 128,589,660 bp
  • T to A, chromosome 1 at 173,270,279 bp
  • G to A, chromosome 1 at 173,274,847 bp
  • T to A, chromosome 2 at 125,506,473 bp
  • T to C, chromosome 3 at 72,953,211 bp
  • G to T, chromosome 3 at 92,869,058 bp
  • A to G, chromosome 3 at 95,576,302 bp
  • C to T, chromosome 3 at 101,073,089 bp
  • C to T, chromosome 3 at 109,664,365 bp
  • C to T, chromosome 3 at 127,248,151 bp
  • C to A, chromosome 4 at 118,782,195 bp
  • A to G, chromosome 4 at 156,225,239 bp
  • T to A, chromosome 5 at 33,843,266 bp
  • A to G, chromosome 5 at 35,044,384 bp
  • T to C, chromosome 5 at 113,183,756 bp
  • A to C, chromosome 6 at 57,404,617 bp
  • T to C, chromosome 6 at 116,582,485 bp
  • A to T, chromosome 6 at 129,768,135 bp
  • A to G, chromosome 7 at 55,897,943 bp
  • T to A, chromosome 7 at 64,400,275 bp
  • C to T, chromosome 7 at 74,318,506 bp
  • A to T, chromosome 7 at 108,423,518 bp
  • A to T, chromosome 7 at 140,652,594 bp
  • T to A, chromosome 7 at 140,923,247 bp
  • A to T, chromosome 8 at 26,059,272 bp
  • T to A, chromosome 8 at 36,229,200 bp
  • A to G, chromosome 8 at 84,925,307 bp
  • A to G, chromosome 10 at 31,249,400 bp
  • T to C, chromosome 10 at 80,306,351 bp
  • G to A, chromosome 10 at 80,529,681 bp
  • T to C, chromosome 10 at 83,297,252 bp
  • G to A, chromosome 10 at 129,801,820 bp
  • C to A, chromosome 10 at 129,801,821 bp
  • A to T, chromosome 11 at 59,079,044 bp
  • T to C, chromosome 13 at 33,093,813 bp
  • T to A, chromosome 13 at 38,216,463 bp
  • C to T, chromosome 13 at 68,590,218 bp
  • A to T, chromosome 14 at 51,919,480 bp
  • T to A, chromosome 17 at 18,244,059 bp
  • G to A, chromosome 17 at 34,645,329 bp
  • A to G, chromosome 18 at 78,030,045 bp
  • T to A, chromosome 19 at 32,637,128 bp
  • A to G, chromosome 19 at 56,386,026 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6124 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044271-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.