Strain Name:
C57BL/6J-MtgxR6126Btlr
Stock Number:
044273-MU
Citation ID:
RRID:MMRRC_044273-MU
Other Names:
R6126 (G1)
Major Collection:

Gene Information

Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: GENA 60, GENA 47, Gena 52, Cyn, A730019I05Rik, WBE1, Cycn, Whi, Todo, Obt, Mt, Lda, Flo, Edy, Dz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320790
Homologene: 19067
Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Sez6
Name: seizure related gene 6
Synonyms: sez-6, D11Bhm177e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20370
Homologene: 10948
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Srsf11
Name: serine and arginine-rich splicing factor 11
Synonyms: 0610009J05Rik, 2610019N13Rik, Sfrs11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 69207
Homologene: 36164
Mnx1
Name: motor neuron and pancreas homeobox 1
Synonyms: HB9, MNR2, Hlxb9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15285
HGNC: HGNC:4979
Homologene: 21137
Phf20l1
Name: PHD finger protein 20-like 1
Synonyms: CGI-72, E130113K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239510
VEGA: 15
Homologene: 9341
Hsf2
Name: heat shock factor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15500
VEGA: 10
HGNC: HGNC:5225
Homologene: 37931
Fblim1
Name: filamin binding LIM protein 1
Synonyms: 2410043F08Rik, migfilin(s), migfilin, Fblp1, Cal
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74202
Homologene: 56774
Wdr20
Name: WD repeat domain 20
Synonyms: 2310040A13Rik, Wdr20a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 69641
Homologene: 32684
Zfp462
Name: zinc finger protein 462
Synonyms: Gt4-2, 9430078C22Rik, Zfpip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242466
Homologene: 41430
Smchd1
Name: SMC hinge domain containing 1
Synonyms: 4931400A14Rik, MommeD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74355
Homologene: 23665
Slc12a2
Name: solute carrier family 12, member 2
Synonyms: sodium/potassium/chloride cotransporters, mBSC2, Nkcc1, sy-ns
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 20496
VEGA: 18
Homologene: 20283
Rsf1
Name: remodeling and spacing factor 1
Synonyms: p325, XAP8, Hbxap, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233532
Homologene: 41142
Zfp292
Name: zinc finger protein 292
Synonyms: Zn-16, Zn-15, Krox-10, Zfp-15, 9430062L07Rik, 5730450D02Rik, Zfp15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 30046
Homologene: 8493
Panx1
Name: pannexin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 55991
HGNC: HGNC:8599
Homologene: 49416
Robo2
Name: roundabout guidance receptor 2
Synonyms: 9430089E08Rik, D230004I22Rik, 2600013A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 268902
Homologene: 43188
Ppp6r1
Name: protein phosphatase 6, regulatory subunit 1
Synonyms: 2010309P17Rik, B430201G11Rik, Pp6r1, Saps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243819
Homologene: 86982
Fan1
Name: FANCD2/FANCI-associated nuclease 1
Synonyms: 6030441H18Rik, Mtmr15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330554
Homologene: 45598
Il31ra
Name: interleukin 31 receptor A
Synonyms: GLM-R, GPL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218624
VEGA: 13
Homologene: 51395
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72205
Homologene: 8125
Rab35
Name: RAB35, member RAS oncogene family
Synonyms: RAB1C, H-ray, 9530019H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 77407
HGNC: HGNC:9774
Homologene: 21361
Pask
Name: PAS domain containing serine/threonine kinase
Synonyms: Paskin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269224
Homologene: 9038
Pdgfra
Name: platelet derived growth factor receptor, alpha polypeptide
Synonyms: CD140a, Pdgfr-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18595
HGNC: HGNC:8803
Homologene: 31361
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: calcium release channel isoform 1, Ryr, skrr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20190
Homologene: 68069
Mef2b
Name: myocyte enhancer factor 2B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17259
HGNC: HGNC:6995
Homologene: 48381
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Tex15
Name: testis expressed gene 15
Synonyms: 2210014E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 104271
Homologene: 12837
Fig4
Name: FIG4 phosphoinositide 5-phosphatase
Synonyms: A530089I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103199
VEGA: 10
Homologene: 6713
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Ifi208
Name: interferon activated gene 208
Synonyms: E430029J22Rik, Pydc3, Pyr-rv1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100033459
HGNC: HGNC:5395
Homologene: 115929
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20192
Homologene: 68151
Kif1a
Name: kinesin family member 1A
Synonyms: Kns1, ATSV, N-3 kinesin, LOC381283, C630002N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16560
HGNC: HGNC:888
Homologene: 99729
Slc4a5
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 5
Synonyms: C330016K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232156
Homologene: 31125
Clec11a
Name: C-type lectin domain family 11, member a
Synonyms: Clecsf3, Scgf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20256
Homologene: 2236
Wnk4
Name: WNK lysine deficient protein kinase 4
Synonyms: 2010002J11Rik, Prkwnk4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69847
Homologene: 13020
Rdh1
Name: retinol dehydrogenase 1 (all trans)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 107605
Homologene: 129514
Tpk1
Name: thiamine pyrophosphokinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 29807
Homologene: 6960
Apoh
Name: apolipoprotein H
Synonyms: beta-2-glycoprotein 1, beta-2-GPI, B2GPI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11818
HGNC: HGNC:616
Homologene: 26
Alk
Name: anaplastic lymphoma kinase
Synonyms: Tcrz, CD246
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 11682
VEGA: 17
HGNC: HGNC:427
Homologene: 68387
Cactin
Name: cactin, spliceosome C complex subunit
Synonyms: 2510012J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70312
VEGA: 10
Homologene: 69553
Rimbp3
Name: RIMS binding protein 3
Synonyms: LOC239731, LOC385766, RIM-BP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239731
Homologene: 77940
Atp8a2
Name: ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
Synonyms: Ib, wl, agil
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50769
Homologene: 4443
Ecd
Name: ecdysoneless cell cycle regulator
Synonyms: 5730461K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 70601
VEGA: 14
Homologene: 5256
Zfp647
Name: zinc finger protein 647
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239546
VEGA: 15
Homologene: 27805
Gm906
Name: predicted gene 906
Synonyms: LOC380882
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 380882
VEGA: 13
Homologene: 134512
Ntpcr
Name: nucleoside-triphosphatase, cancer-related
Synonyms: 2310079N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66566
Homologene: 11989
Ggcx
Name: gamma-glutamyl carboxylase
Synonyms: vitamin K-dependent carboxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56316
HGNC: HGNC:4247
Homologene: 639
Olfr530
Name: olfactory receptor 530
Synonyms: GA_x6K02T2PBJ9-42523824-42522901, MOR252-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258512
Homologene: 128384
Foxd2
Name: forkhead box D2
Synonyms: Mf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17301
HGNC: HGNC:3803
Homologene: 3292
Mfsd8
Name: major facilitator superfamily domain containing 8
Synonyms: 2810423E13Rik, Cln7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72175
Homologene: 115814
4933434E20Rik
Name: RIKEN cDNA 4933434E20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99650
Homologene: 41041
Gm21976
Name: predicted gene 21976
Synonyms: ENSMUSG00000071224, Gm8780
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 102637808
Dnase1l1
Name: deoxyribonuclease 1-like 1
Synonyms: G4.8, Dnl1ll, 2310005K03Rik, Dnase1ll
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 69537
HGNC: HGNC:2957
Homologene: 4896
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 34,228,183 bp
  • A to T, chromosome 1 at 93,019,899 bp
  • T to C, chromosome 1 at 93,314,359 bp
  • A to G, chromosome 1 at 173,677,708 bp
  • A to G, chromosome 2 at 112,757,670 bp
  • A to G, chromosome 3 at 40,832,011 bp
  • G to A, chromosome 3 at 90,056,574 bp
  • C to T, chromosome 3 at 158,023,344 bp
  • T to C, chromosome 4 at 8,826,482 bp
  • T to C, chromosome 4 at 34,808,497 bp
  • G to A, chromosome 4 at 55,023,573 bp
  • C to A, chromosome 4 at 114,908,505 bp
  • G to A, chromosome 4 at 141,584,722 bp
  • G to T, chromosome 5 at 29,478,112 bp
  • A to G, chromosome 5 at 75,170,529 bp
  • A to G, chromosome 5 at 115,645,708 bp
  • A to T, chromosome 6 at 43,423,660 bp
  • A to T, chromosome 6 at 72,417,983 bp
  • A to T, chromosome 6 at 83,226,265 bp
  • T to C, chromosome 7 at 4,643,377 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • A to C, chromosome 7 at 29,076,239 bp
  • C to T, chromosome 7 at 44,304,921 bp
  • T to A, chromosome 7 at 64,364,570 bp
  • ATGGCG to ATGGCGACGGTGGCG, chromosome 7 at 97,579,904 bp
  • T to G, chromosome 7 at 140,373,253 bp
  • G to T, chromosome 7 at 141,638,772 bp
  • A to T, chromosome 7 at 141,801,232 bp
  • A to G, chromosome 8 at 33,573,563 bp
  • C to A, chromosome 8 at 70,166,876 bp
  • G to A, chromosome 8 at 125,735,887 bp
  • T to A, chromosome 9 at 15,007,790 bp
  • A to G, chromosome 10 at 41,265,447 bp
  • T to C, chromosome 10 at 57,495,917 bp
  • G to A, chromosome 10 at 81,324,309 bp
  • A to T, chromosome 10 at 127,763,214 bp
  • T to C, chromosome 11 at 21,996,457 bp
  • A to T, chromosome 11 at 77,973,804 bp
  • A to G, chromosome 11 at 101,276,348 bp
  • A to T, chromosome 11 at 108,397,373 bp
  • A to T, chromosome 12 at 110,794,102 bp
  • G to T, chromosome 13 at 50,246,290 bp
  • G to A, chromosome 13 at 98,287,313 bp
  • A to C, chromosome 13 at 112,530,374 bp
  • T to C, chromosome 14 at 20,338,425 bp
  • C to T, chromosome 14 at 60,044,326 bp
  • A to G, chromosome 15 at 66,636,824 bp
  • G to A, chromosome 15 at 76,912,085 bp
  • A to T, chromosome 16 at 17,212,276 bp
  • C to T, chromosome 16 at 73,920,682 bp
  • A to T, chromosome 17 at 71,370,285 bp
  • G to A, chromosome 17 at 71,875,042 bp
  • A to G, chromosome 18 at 57,944,044 bp
  • C to T, chromosome X at 74,277,038 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
(Deceased) Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6126 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044273-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.