Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR6130Btlr/Mmmh
Stock Number:
044277-MU
Citation ID:
RRID:MMRRC_044277-MU
Other Names:
R6130 (G1)
Major Collection:

Strain Information

Igf2bp1
Name: insulin-like growth factor 2 mRNA binding protein 1
Synonyms: CRD-BP, Crdbp, IMP-1, Zbp1, D030026A21Rik, D11Moh45, D11Moh40e, IMP1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 140486
Homologene: 4772
Tmem59l
Name: transmembrane protein 59-like
Synonyms: 5330410G16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67937
Homologene: 8104
Auts2
Name: autism susceptibility candidate 2
Synonyms: D830032G16Rik, A730011F23Rik, 2700063G02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319974
Homologene: 22907
Rsf1
Name: remodeling and spacing factor 1
Synonyms: p325, XAP8, Hbxap, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Aen
Name: apoptosis enhancing nuclease
Synonyms: 2700083B06Rik, Isg20l1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68048
Homologene: 23382
Ctla4
Name: cytotoxic T-lymphocyte-associated protein 4
Synonyms: Ctla-4, Ly-56, Cd152
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12477
HGNC: HGNC:2505
Homologene: 3820
Robo2
Name: roundabout guidance receptor 2
Synonyms: 9430089E08Rik, D230004I22Rik, 2600013A04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268902
Homologene: 43188
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 60,912,491 bp
  • T to A, chromosome 1 at 93,036,901 bp
  • T to C, chromosome 1 at 153,136,777 bp
  • A to T, chromosome 2 at 36,794,043 bp
  • T to C, chromosome 3 at 33,841,192 bp
  • T to C, chromosome 3 at 90,276,259 bp
  • A to G, chromosome 3 at 93,292,716 bp
  • A to C, chromosome 3 at 146,042,804 bp
  • T to C, chromosome 4 at 88,868,359 bp
  • A to T, chromosome 4 at 101,765,372 bp
  • T to A, chromosome 4 at 115,029,861 bp
  • A to G, chromosome 4 at 135,762,571 bp
  • A to T, chromosome 4 at 148,149,522 bp
  • T to C, chromosome 5 at 98,004,272 bp
  • T to C, chromosome 5 at 121,815,563 bp
  • T to C, chromosome 5 at 131,440,223 bp
  • T to A, chromosome 5 at 134,558,268 bp
  • A to G, chromosome 6 at 4,641,948 bp
  • T to A, chromosome 6 at 73,188,494 bp
  • T to C, chromosome 6 at 142,086,429 bp
  • G to A, chromosome 7 at 19,515,294 bp
  • A to G, chromosome 7 at 23,404,173 bp
  • A to T, chromosome 7 at 78,902,639 bp
  • G to A, chromosome 7 at 97,579,910 bp
  • A to T, chromosome 7 at 102,563,291 bp
  • A to G, chromosome 8 at 70,484,605 bp
  • G to A, chromosome 8 at 121,753,087 bp
  • A to G, chromosome 9 at 18,590,698 bp
  • C to T, chromosome 9 at 50,772,602 bp
  • T to A, chromosome 9 at 56,488,607 bp
  • T to A, chromosome 9 at 78,242,565 bp
  • A to G, chromosome 9 at 110,380,379 bp
  • A to G, chromosome 11 at 58,720,307 bp
  • A to C, chromosome 11 at 59,077,945 bp
  • A to G, chromosome 11 at 73,296,483 bp
  • A to G, chromosome 11 at 75,525,739 bp
  • T to A, chromosome 11 at 95,837,095 bp
  • A to C, chromosome 11 at 95,974,020 bp
  • T to C, chromosome 12 at 40,069,436 bp
  • T to A, chromosome 13 at 74,372,341 bp
  • A to C, chromosome 13 at 81,427,745 bp
  • A to G, chromosome 13 at 112,318,446 bp
  • A to G, chromosome 15 at 102,111,241 bp
  • C to T, chromosome 16 at 73,920,682 bp
  • T to A, chromosome 17 at 17,877,635 bp
  • C to A, chromosome 18 at 33,464,305 bp
  • T to A, chromosome 18 at 37,727,527 bp
  • G to A, chromosome 19 at 10,477,764 bp
  • A to T, chromosome 19 at 17,511,556 bp
  • C to T, chromosome X at 74,277,038 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6130 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044277-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.