Strain Name:
C57BL/6J-MtgxR6132Btlr/Mmmh
Stock Number:
044279-MU
Citation ID:
RRID:MMRRC_044279-MU
Other Names:
R6132 (G1)
Major Collection:

Strain Information

Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Nrcam
Name: neuronal cell adhesion molecule
Synonyms: Bravo, C030017F07Rik, C130076O07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319504
VEGA: 12
HGNC: HGNC:7994
Homologene: 21041
Omd
Name: osteomodulin
Synonyms: osteoadherin, SLRR2C, OSAD
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 27047
VEGA: 13
HGNC: HGNC:8134
Homologene: 3677
Dlg1
Name: discs large MAGUK scaffold protein 1
Synonyms: B130052P05Rik, SAP97, Dlgh1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13383
HGNC: HGNC:2900
Homologene: 20869
Tet1
Name: tet methylcytosine dioxygenase 1
Synonyms: 2510010B09Rik, D10Ertd17e, Cxxc6, BB001228
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52463
Homologene: 12735
Depdc5
Name: DEP domain containing 5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 277854
Homologene: 34718
Kdm5a
Name: lysine demethylase 5A
Synonyms: RBP2, Rbbp2, Jarid1a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214899
HGNC: HGNC:9886
Homologene: 3419
Exoc4
Name: exocyst complex component 4
Synonyms: Sec8, Sec8l1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20336
Homologene: 40654
Golph3l
Name: golgi phosphoprotein 3-like
Synonyms: GPP34R, 2010204I15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229593
Homologene: 23082
Lman2
Name: lectin, mannose-binding 2
Synonyms: VIP36, GP36B, 1300009F09Rik, 1110003H06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66890
VEGA: 13
Homologene: 4962
Esf1
Name: ESF1 nucleolar pre-rRNA processing protein homolog
Synonyms: 2610101J03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66580
Homologene: 5717
Rttn
Name: rotatin
Synonyms: 4921538A15Rik, C530033I08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 246102
VEGA: 18
Homologene: 65275
Ddx52
Name: DExD box helicase 52
Synonyms: ROK1, 2700029C06Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78394
Homologene: 5093
Alkbh5
Name: alkB homolog 5, RNA demethylase
Synonyms: Ofoxd, Abh5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268420
Homologene: 9818
Afg3l2
Name: AFG3-like AAA ATPase 2
Synonyms: 2310036I02Rik, par, Emv66
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 69597
VEGA: 18
HGNC: HGNC:315
Homologene: 4947
Erap1
Name: endoplasmic reticulum aminopeptidase 1
Synonyms: PILSAP, ERAAP, Arts1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 80898
VEGA: 13
Homologene: 56754
Scn10a
Name: sodium channel, voltage-gated, type X, alpha
Synonyms: Nav1.8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20264
VEGA: 9
Homologene: 21300
Crebrf
Name: CREB3 regulatory factor
Synonyms: A930001N09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 77128
Homologene: 12672
Slf2
Name: SMC5-SMC6 complex localization factor 2
Synonyms: 6030443O07Rik, Fam178a
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226151
VEGA: 19
Homologene: 23077
Zfp457
Name: zinc finger protein 457
Synonyms: Rslcan-6
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 431706
Homologene: 75311
Otor
Name: otoraplin
Synonyms: Fdp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 57329
HGNC: HGNC:8517
Homologene: 10600
Mkln1
Name: muskelin 1, intracellular mediator containing kelch motifs
Synonyms: A130067F06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 27418
HGNC: HGNC:7109
Homologene: 8305
Pwwp2a
Name: PWWP domain containing 2A
Synonyms: D930040F23Rik, 4631424J17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70802
Homologene: 19687
Tarbp1
Name: TAR RNA binding protein 1
Synonyms: Gm17296
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212728
Homologene: 38082
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, syne-2, D12Ertd777e, 6820443O06Rik, Nesp2g, Cpfl8, diminished cone electroretinogram, dice
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Efcab6
Name: EF-hand calcium binding domain 6
Synonyms: 4932408N08Rik, 4931407K02Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 77627
Homologene: 11259
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: Hdhc3, HL-19, DLP12, HL19, DHC3, LOC380889, 4921531P07Rik, Dnahc7l, Dnahc12
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Or5ak24
Name: olfactory receptor family 5 subfamily AK member 24
Synonyms: GA_x6K02T2Q125-46907515-46906571, MOR203-4, Olfr994
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258425
Homologene: 17245
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: VLGR1, Mass1, Mgr1, Gpr98
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Tnn
Name: tenascin N
Synonyms: Tnw, tenascin-W
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329278
Homologene: 18634
Abca15
Name: ATP-binding cassette, sub-family A member 15
Synonyms: 4930500I12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320631
Homologene: 87255
Fbxo44
Name: F-box protein 44
Synonyms: Fbx6a, FBX30, FBG3, Fbxo6a
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230903
Homologene: 13232
Gprc6a
Name: G protein-coupled receptor, family C, group 6, member A
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 210198
VEGA: 10
Homologene: 17529
Or5ac19
Name: olfactory receptor family 5 subfamily AC member 19
Synonyms: GA_x54KRFPKG5P-55483936-55483010, MOR182-2, Olfr201
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258996
Homologene: 37011
Sema3a
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
Synonyms: SemD, semaphorin III, sema III, collapsin-1, Semad
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20346
Homologene: 31358
Sel1l3
Name: sel-1 suppressor of lin-12-like 3 (C. elegans)
Synonyms: 2310045A20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231238
Homologene: 9054
Dhx30
Name: DExH-box helicase 30
Synonyms: Ddx30, 2810477H02Rik, C130058C04Rik, helG, DEAH (Asp-Glu-Ala-His) box polypeptide 30
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72831
Homologene: 15779
Map3k19
Name: mitogen-activated protein kinase kinase kinase 19
Synonyms: Ysk4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22625
Homologene: 19318
Tsr3
Name: TSR3 20S rRNA accumulation
Synonyms: 1110014B11Rik, 0610007P22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68327
VEGA: 17
Homologene: 6922
Spmip6
Name: sperm microtubule inner protein 6
Synonyms: Smrp1, Cbe1, 1110017D15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73721
Homologene: 13074
Vmn2r106
Name: vomeronasal 2, receptor 106
Synonyms: EG224576
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224576
Homologene: 135824
S1pr4
Name: sphingosine-1-phosphate receptor 4
Synonyms: lpC1, S1P4, Edg6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13611
VEGA: 10
HGNC: HGNC:3170
Homologene: 2799
Grin3b
Name: glutamate receptor, ionotropic, NMDA3B
Synonyms: NR3B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 170483
Homologene: 15606
Cyp2c68
Name: cytochrome P450, family 2, subfamily c, polypeptide 68
Synonyms: 9030012A22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 433247
Homologene: 74936
Oacyl
Name: O-acyltransferase like
Synonyms: 5330437I02Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319888
Homologene: 129774
Gal3st2b
Name: galactose-3-O-sulfotransferase 2B
Synonyms: Gm9994
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100041596
Homologene: 41471
Or8b36
Name: olfactory receptor family 8 subfamily B member 36
Synonyms: GA_x6K02T2PVTD-31705144-31706073, MOR162-6, Olfr883
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258414
Homologene: 86689
Mmel1
Name: membrane metallo-endopeptidase-like 1
Synonyms: Nl1, NEPLP gamma, NEPLP beta, NEPLP alpha, SEP, Mell1, Nep2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 27390
Homologene: 22778
Tollip
Name: toll interacting protein
Synonyms: Toll interacting protein, 4930403G24Rik, 4931428G15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54473
Homologene: 10375
Nova2
Name: NOVA alternative splicing regulator 2
Synonyms: LOC384569
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384569
HGNC: HGNC:7887
Homologene: 134398
Ctsr
Name: cathepsin R
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56835
VEGA: 13
Homologene: 75127
Atp5mc1
Name: ATP synthase membrane subunit c locus 1
Synonyms: Atp5g1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11951
HGNC: HGNC:841
Homologene: 38017
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 93,939,966 bp
  • T to C, chromosome 1 at 127,850,476 bp
  • A to G, chromosome 1 at 160,146,071 bp
  • A to T, chromosome 2 at 85,430,146 bp
  • A to G, chromosome 2 at 140,159,779 bp
  • A to T, chromosome 2 at 143,078,600 bp
  • C to G, chromosome 3 at 95,591,834 bp
  • C to T, chromosome 4 at 41,517,160 bp
  • G to A, chromosome 4 at 148,156,108 bp
  • C to T, chromosome 4 at 154,895,018 bp
  • T to G, chromosome 5 at 13,523,175 bp
  • T to A, chromosome 5 at 32,910,467 bp
  • T to C, chromosome 5 at 53,200,189 bp
  • G to A, chromosome 6 at 31,431,220 bp
  • A to G, chromosome 6 at 33,758,098 bp
  • C to T, chromosome 6 at 120,374,931 bp
  • G to A, chromosome 7 at 18,957,869 bp
  • T to C, chromosome 7 at 120,361,420 bp
  • A to G, chromosome 7 at 141,889,597 bp
  • T to A, chromosome 8 at 126,434,809 bp
  • ATTGCTGTTT to ATTGCTGTTTGCTGTTT, chromosome 9 at 38,026,540 bp
  • A to T, chromosome 9 at 110,085,779 bp
  • C to T, chromosome 9 at 119,613,695 bp
  • T to A, chromosome 10 at 51,615,260 bp
  • A to C, chromosome 10 at 62,813,300 bp
  • T to C, chromosome 10 at 79,976,440 bp
  • G to A, chromosome 10 at 81,499,196 bp
  • A to T, chromosome 11 at 21,999,406 bp
  • A to G, chromosome 11 at 43,705,628 bp
  • G to T, chromosome 11 at 60,537,995 bp
  • A to G, chromosome 11 at 83,959,457 bp
  • A to G, chromosome 11 at 96,075,024 bp
  • T to A, chromosome 12 at 44,570,224 bp
  • T to C, chromosome 12 at 75,945,147 bp
  • A to C, chromosome 13 at 49,590,367 bp
  • A to G, chromosome 13 at 55,362,225 bp
  • A to C, chromosome 13 at 61,161,768 bp
  • G to T, chromosome 13 at 67,293,296 bp
  • A to G, chromosome 13 at 74,660,282 bp
  • G to T, chromosome 13 at 81,506,076 bp
  • T to A, chromosome 14 at 26,717,911 bp
  • A to G, chromosome 15 at 84,032,972 bp
  • A to T, chromosome 16 at 31,836,241 bp
  • A to G, chromosome 16 at 59,269,004 bp
  • T to C, chromosome 17 at 20,268,404 bp
  • G to T, chromosome 17 at 25,241,861 bp
  • C to T, chromosome 17 at 26,763,403 bp
  • G to T, chromosome 18 at 65,726,355 bp
  • G to T, chromosome 18 at 67,421,259 bp
  • T to A, chromosome 18 at 89,115,646 bp
  • A to G, chromosome 19 at 39,703,414 bp
  • T to A, chromosome 19 at 44,960,861 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6132 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044279-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.