Strain Name:
C57BL/6J-MtgxR6133Btlr/Mmmh
Stock Number:
044280-MU
Citation ID:
RRID:MMRRC_044280-MU
Other Names:
R6133 (G1)
Major Collection:

Gene Information

Fn1
Name: fibronectin 1
Synonyms: Fn-1, Fn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Suco
Name: SUN domain containing ossification factor
Synonyms: osteopotentia, Opt, AI848100
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226551
HGNC: HGNC:1240
Homologene: 32212
Urb2
Name: URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382038
Homologene: 8859
Akap12
Name: A kinase (PRKA) anchor protein (gravin) 12
Synonyms: SSeCKS, Tsga12, Srcs5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 83397
VEGA: 10
HGNC: HGNC:370
Homologene: 3740
Ptpn1
Name: protein tyrosine phosphatase, non-receptor type 1
Synonyms: PTP-1B, PTP1B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19246
HGNC: HGNC:9642
Homologene: 2119
Topbp1
Name: topoisomerase (DNA) II binding protein 1
Synonyms: D430026L04Rik, 2810429C13Rik, 1110031N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235559
Homologene: 38262
Dgkd
Name: diacylglycerol kinase, delta
Synonyms: DGKdelta, dgkd-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227333
HGNC: HGNC:2851
Homologene: 100054
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: LOC381341, Dnahc7, Dnahc7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 627872
Homologene: 41287
Cmtm2a
Name: CKLF-like MARVEL transmembrane domain containing 2A
Synonyms: 1700001K04Rik, 1700041N15Rik, 1700063K20Rik, Cklf, ARR19, Cklfsf2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 73381
Homologene: 88508
Cpxm2
Name: carboxypeptidase X 2 (M14 family)
Synonyms: 4632435C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 55987
Homologene: 69259
Dsg2
Name: desmoglein 2
Synonyms: D18Ertd293e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13511
HGNC: HGNC:3049
Homologene: 1464
Zcchc2
Name: zinc finger, CCHC domain containing 2
Synonyms: 9930114B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227449
Homologene: 9808
Nsl1
Name: NSL1, MIS12 kinetochore complex component
Synonyms: LOC381318, 4833432M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381318
Homologene: 22898
Akap2
Name: A kinase (PRKA) anchor protein 2
Synonyms: B230340M18Rik, AKAP-KL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Cubn
Name: cubilin (intrinsic factor-cobalamin receptor)
Synonyms: D2Wsu88e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy-3, hy3, 1700034M11Rik, 4930545D19Rik, hyrh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244653
Homologene: 52118
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Scn2a
Name: sodium channel, voltage-gated, type II, alpha
Synonyms: Nav1.2, A230052E19Rik, Scn2a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 110876
Homologene: 75001
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Rad9b
Name: RAD9 checkpoint clamp component B
Synonyms: A630082N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231724
Homologene: 17006
Trpm5
Name: transient receptor potential cation channel, subfamily M, member 5
Synonyms: Mtr1, Ltrpc5, 9430099A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56843
Homologene: 22818
Olfr771
Name: olfactory receptor 771
Synonyms: GA_x6K02T2PULF-10846420-10845467, MOR114-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258540
Homologene: 74047
Xkr9
Name: X-linked Kx blood group related 9
Synonyms: LOC381246
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381246
Homologene: 20056
Tbx3
Name: T-box 3
Synonyms: D5Ertd189e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 21386
Homologene: 4371
Naip1
Name: NLR family, apoptosis inhibitory protein 1
Synonyms: D13Lsd1, Naip, Birc1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17940
VEGA: 13
HGNC: HGNC:7634
Homologene: 113589
Ankhd1
Name: ankyrin repeat and KH domain containing 1
Synonyms: 1110004O12Rik, 9130019P20Rik, 4933432B13Rik, A530027J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 108857
Homologene: 87006
Kcnma1
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Synonyms: Slo, mSlo1, Slo1, MaxiK, BK channel alpha subunit, 5730414M22Rik, BKCa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16531
HGNC: HGNC:6284
Homologene: 1693
Rp1l1
Name: retinitis pigmentosa 1 homolog like 1
Synonyms: Dcdc4, Rp1hl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 271209
VEGA: 14
Homologene: 105870
Frmpd1
Name: FERM and PDZ domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 666060
Homologene: 8939
Olfr638
Name: olfactory receptor 638
Synonyms: GA_x6K02T2PBJ9-6737723-6738670, MOR5-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259124
Homologene: 133592
Lrrc15
Name: leucine rich repeat containing 15
Synonyms: 5430427N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74488
Homologene: 26080
Pramel15
Name: PRAME like 15
Synonyms: EG627009, Gm13125, Pramef20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 627009
Homologene: 133194
Adcy7
Name: adenylate cyclase 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11513
HGNC: HGNC:238
Homologene: 866
Zfp52
Name: zinc finger protein 52
Synonyms: zfec29, Zfp-52, KRAB11, Zfp76
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22710
VEGA: 17
Homologene: 77326
Ssrp1
Name: structure specific recognition protein 1
Synonyms: T160, Hmgi-rs3, Hmg1-rs1, Hmgox
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20833
Homologene: 110735
Mex3d
Name: mex3 RNA binding family member D
Synonyms: Rkhd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237400
Homologene: 16890
Zfp763
Name: zinc finger protein 763
Synonyms: 1700065O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 73451
Homologene: 66274
Lrfn5
Name: leucine rich repeat and fibronectin type III domain containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238205
Homologene: 17582
Zmynd19
Name: zinc finger, MYND domain containing 19
Synonyms: 2700064H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67187
Homologene: 12093
Tmem30c
Name: transmembrane protein 30C
Synonyms: 4933409A18Rik, 4933401B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 71027
Homologene: 78138
Olfr883
Name: olfactory receptor 883
Synonyms: GA_x6K02T2PVTD-31705144-31706073, MOR162-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258414
Homologene: 86689
Mmel1
Name: membrane metallo-endopeptidase-like 1
Synonyms: Nl1, NEPLP gamma, NEPLP beta, NEPLP alpha, SEP, Mell1, Nep2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 27390
Homologene: 22778
Ebi3
Name: Epstein-Barr virus induced gene 3
Synonyms: IL-27, EBI-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 50498
VEGA: 17
HGNC: HGNC:3129
Homologene: 4207
Vmn2r43
Name: vomeronasal 2, receptor 43
Synonyms: EC2-V2R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381838
Homologene: 113703
Gm7145
Name: predicted gene 7145
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Homologene: 88945
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 13,684,135 bp
  • T to C, chromosome 1 at 53,419,655 bp
  • T to C, chromosome 1 at 71,597,727 bp
  • T to A, chromosome 1 at 87,938,240 bp
  • A to C, chromosome 1 at 106,019,879 bp
  • T to A, chromosome 1 at 117,985,888 bp
  • T to A, chromosome 1 at 161,835,183 bp
  • T to C, chromosome 1 at 191,071,206 bp
  • A to G, chromosome 2 at 13,308,618 bp
  • G to T, chromosome 2 at 24,958,119 bp
  • G to A, chromosome 2 at 65,743,104 bp
  • T to G, chromosome 2 at 85,045,339 bp
  • T to C, chromosome 2 at 167,967,796 bp
  • T to A, chromosome 4 at 45,284,915 bp
  • C to T, chromosome 4 at 57,855,516 bp
  • T to C, chromosome 4 at 144,377,777 bp
  • C to T, chromosome 4 at 154,895,018 bp
  • T to C, chromosome 5 at 119,680,953 bp
  • T to C, chromosome 5 at 122,339,768 bp
  • A to G, chromosome 7 at 8,244,971 bp
  • A to T, chromosome 7 at 104,003,325 bp
  • A to T, chromosome 7 at 120,086,246 bp
  • G to A, chromosome 7 at 132,128,453 bp
  • A to T, chromosome 7 at 143,088,951 bp
  • A to G, chromosome 8 at 88,325,439 bp
  • T to C, chromosome 8 at 104,292,730 bp
  • C to T, chromosome 8 at 110,601,276 bp
  • C to T, chromosome 8 at 124,028,561 bp
  • ATTGCTGTTT to ATTGCTGTTTGCTGTTT, chromosome 9 at 38,026,540 bp
  • T to A, chromosome 9 at 103,311,764 bp
  • G to T, chromosome 10 at 4,355,178 bp
  • A to T, chromosome 10 at 74,645,973 bp
  • A to G, chromosome 10 at 80,386,786 bp
  • G to A, chromosome 10 at 129,160,883 bp
  • C to T, chromosome 11 at 115,984,157 bp
  • A to G, chromosome 12 at 61,843,788 bp
  • A to G, chromosome 13 at 100,444,643 bp
  • C to T, chromosome 14 at 24,003,868 bp
  • C to T, chromosome 14 at 64,030,096 bp
  • C to T, chromosome 16 at 30,274,236 bp
  • T to C, chromosome 16 at 57,277,737 bp
  • T to C, chromosome 17 at 21,560,471 bp
  • C to T, chromosome 17 at 33,018,701 bp
  • T to A, chromosome 17 at 55,954,311 bp
  • A to G, chromosome 18 at 20,590,089 bp
  • T to C, chromosome 18 at 36,625,126 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6133 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044280-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.