Strain Name:
C57BL/6J-MtgxR6135Btlr
Stock Number:
044282-MU
Citation ID:
RRID:MMRRC_044282-MU
Other Names:
R6135 (G1)
Major Collection:

Gene Information

Vcan
Name: versican
Synonyms: hdf, Cspg2, PG-M, heart defect, 5430420N07Rik, DPEAAE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Inpp5d
Name: inositol polyphosphate-5-phosphatase D
Synonyms: SHIP, SHIP1, SHIP-1, s-SHIP, Src homology 2 domain-containing inositol-5-phosphatase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16331
HGNC: HGNC:6079
Homologene: 4046
Srek1
Name: splicing regulatory glutamine/lysine-rich protein 1
Synonyms: SRrp86, SRrp508, AL118220, Sfrs12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218543
Homologene: 10581
Akap13
Name: A kinase (PRKA) anchor protein 13
Synonyms: 5730522G15Rik, Ht31, 5830460E08Rik, PROTO-LB, PROTO-LBC, AKAP-Lbc, 1700026G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75547
HGNC: HGNC:371
Homologene: 4903
Trip12
Name: thyroid hormone receptor interactor 12
Synonyms: 6720416K24Rik, 1110036I07Rik, Gtl6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14897
Homologene: 44226
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, AnkG, Ankyrin-G, Ankyrin-3, 2900054D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Aimp1
Name: aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
Synonyms: EMAPII, AIMP1/p43, 9830137A06Rik, Emap2, Scye1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13722
Homologene: 31260
Strada
Name: STE20-related kinase adaptor alpha
Synonyms: 6030402H20Rik, 2610019A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72149
Homologene: 12448
Nat10
Name: N-acetyltransferase 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 98956
Homologene: 6785
Ahi1
Name: Abelson helper integration site 1
Synonyms: Ahi-1, D10Bwg0629e, 1700015F03Rik, Jouberin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 52906
VEGA: 10
Homologene: 9762
Ifnar1
Name: interferon (alpha and beta) receptor 1
Synonyms: Ifar, IFN-alpha/betaR, Ifrc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 15975
HGNC: HGNC:5432
Homologene: 524
Rrp9
Name: RRP9, small subunit (SSU) processome component, homolog (yeast)
Synonyms: 55kDa, U3-55k, D9Wsu10e, Rnu3ip2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 27966
Homologene: 3452
Aire
Name: autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11634
HGNC: HGNC:360
Homologene: 327
Nelfa
Name: negative elongation factor complex member A, Whsc2
Synonyms: Whsc2h, Whsc2, Nelf-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 24116
Homologene: 68478
Ccdc171
Name: coiled-coil domain containing 171
Synonyms: A330015D16Rik, 4930418J05Rik, 4930473A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320226
Homologene: 27942
Zfp653
Name: zinc finger protein 653
Synonyms: E430039K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319601
VEGA: 9
Homologene: 16346
Tnrc6c
Name: trinucleotide repeat containing 6C
Synonyms: 9930033H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217351
Homologene: 23137
Zfhx2
Name: zinc finger homeobox 2
Synonyms: zfh-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239102
Homologene: 52657
Man1a2
Name: mannosidase, alpha, class 1A, member 2
Synonyms: Man1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17156
HGNC: HGNC:6822
Homologene: 55982
Spata24
Name: spermatogenesis associated 24
Synonyms: TIPT, 2700012K08Rik, TIPT2, 5133400G04Rik, 4930583E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 71242
VEGA: 18
Homologene: 32688
Scin
Name: scinderin
Synonyms: adseverin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20259
Homologene: 36296
Ghr
Name: growth hormone receptor
Synonyms: GHBP, GHR/BP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14600
HGNC: HGNC:4263
Homologene: 134
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy-3, hy3, 4930545D19Rik, hyrh, 1700034M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244653
Homologene: 52118
Pcsk2
Name: proprotein convertase subtilisin/kexin type 2
Synonyms: prohormone convertase 2, Phpp-2, 6330411F23Rik, Nec-2, Nec2, SPC2, PC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18549
HGNC: HGNC:8744
Homologene: 37640
Abca4
Name: ATP-binding cassette, sub-family A (ABC1), member 4
Synonyms: Rim protein, Abc10, RmP, D430003I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11304
HGNC: HGNC:34
Homologene: 298
Ush2a
Name: usherin
Synonyms: Ush2a, A930037M10Rik, A930011D15Rik, Ushrn, LOC269160, MUSH2A, LOC381317
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22283
Homologene: 66151
Scn7a
Name: sodium channel, voltage-gated, type VII, alpha
Synonyms: 1110034K09Rik, Nav2.3, Nav2, NaG, Nax, Scn6a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20272
Homologene: 55706
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 672511
Homologene: 45439
Myh8
Name: myosin, heavy polypeptide 8, skeletal muscle, perinatal
Synonyms: Myhsp, 4832426G23Rik, Myhs-p, MyHC-pn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17885
HGNC: HGNC:7578
Homologene: 68256
Cul9
Name: cullin 9
Synonyms: Parc, 1810035I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 78309
Homologene: 56696
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 545030
Homologene: 83473
Ppfia2
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Synonyms: Liprin-alpha2, E130120L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 327814
VEGA: 10
HGNC: HGNC:9246
Homologene: 27953
Fhl5
Name: four and a half LIM domains 5
Synonyms: 1700027G07Rik, ACT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 57756
Homologene: 23230
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Ppargc1b
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 beta
Synonyms: 4631412G21Rik, PGC-1beta/ERRL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 170826
Homologene: 15776
Col14a1
Name: collagen, type XIV, alpha 1
Synonyms: 5730412L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12818
HGNC: HGNC:2191
Homologene: 18741
Pnpla8
Name: patatin-like phospholipase domain containing 8
Synonyms: iPLA2 gamma, 1200006O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 67452
Homologene: 12136
Kcnh2
Name: potassium voltage-gated channel, subfamily H (eag-related), member 2
Synonyms: Lqt2, M-erg, ether a go-go related, merg1b, merg1a, ERG1, LQT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16511
HGNC: HGNC:6251
Homologene: 201
Rp1l1
Name: retinitis pigmentosa 1 homolog like 1
Synonyms: Dcdc4, Rp1hl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 271209
VEGA: 14
Homologene: 105870
Pigp
Name: phosphatidylinositol glycan anchor biosynthesis, class P
Synonyms: Dcrc, Dscr5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 56176
HGNC: HGNC:3046
Homologene: 32444
Lbp
Name: lipopolysaccharide binding protein
Synonyms: Bpifd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16803
HGNC: HGNC:6517
Homologene: 3055
Krt87
Name: keratin 87
Synonyms: Krt83, Krt2-25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 406219
VEGA: 15
Homologene: 133804
Fignl1
Name: fidgetin-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 60530
Homologene: 11063
Rnf43
Name: ring finger protein 43
Synonyms: 4732452J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 207742
Homologene: 37742
2210408I21Rik
Name: RIKEN cDNA 2210408I21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 72371
Homologene: 89234
Dnm1
Name: dynamin 1
Synonyms: Ftfl, dynamin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13429
HGNC: HGNC:2972
Homologene: 123905
Spata13
Name: spermatogenesis associated 13
Synonyms: ESTM11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219140
Homologene: 19482
Ttbk2
Name: tau tubulin kinase 2
Synonyms: TTK, 2610507N02Rik, B930008N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 140810
Homologene: 62795
Olfr1447
Name: olfactory receptor 1447
Synonyms: GA_x6K02T2RE5P-3231251-3230331, MOR202-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258698
Homologene: 74233
Carf
Name: calcium response factor
Synonyms: Als2cr8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241066
Homologene: 11689
Vps16
Name: VSP16 CORVET/HOPS core subunit
Synonyms: 1810074M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 80743
Homologene: 7116
Creb3l3
Name: cAMP responsive element binding protein 3-like 3
Synonyms: CREB-H, D10Bur1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 208677
Homologene: 13080
Chpt1
Name: choline phosphotransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 212862
Homologene: 69297
Slc26a8
Name: solute carrier family 26, member 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224661
Homologene: 27095
Cldn16
Name: claudin 16
Synonyms: paracellin-1, claudin-16, PCLN1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 114141
HGNC: HGNC:2037
Homologene: 4799
Cnga3
Name: cyclic nucleotide gated channel alpha 3
Synonyms: CNG3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12790
HGNC: HGNC:2150
Homologene: 994
Gm1979
Name: predicted gene 1979
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100038949
Homologene: 69402
Pcdha6
Name: protocadherin alpha 6
Synonyms: Cnr2, Crnr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12937
HGNC: HGNC:8672
Homologene: 75098
Pcdha11
Name: protocadherin alpha 11
Synonyms: Crnr7, A830022B16Rik, Cnr7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12942
HGNC: HGNC:8665
Homologene: 75095
Zscan4-ps1
Name: zinc finger and SCAN domain containing 4, pseudogene 1
Synonyms: EG545912
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 545912
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 37,232,237 bp
  • C to T, chromosome 1 at 60,147,963 bp
  • A to T, chromosome 1 at 84,760,838 bp
  • A to G, chromosome 1 at 87,620,397 bp
  • T to A, chromosome 1 at 188,912,106 bp
  • T to A, chromosome 2 at 32,333,063 bp
  • T to A, chromosome 2 at 66,703,900 bp
  • A to G, chromosome 2 at 103,743,316 bp
  • G to A, chromosome 2 at 120,750,317 bp
  • A to G, chromosome 2 at 130,438,653 bp
  • A to G, chromosome 2 at 143,573,540 bp
  • A to G, chromosome 2 at 158,317,549 bp
  • G to A, chromosome 3 at 100,684,932 bp
  • C to T, chromosome 3 at 122,138,447 bp
  • T to C, chromosome 3 at 132,672,083 bp
  • A to T, chromosome 4 at 25,214,716 bp
  • T to A, chromosome 4 at 83,554,850 bp
  • T to A, chromosome 5 at 24,321,793 bp
  • T to G, chromosome 5 at 26,000,300 bp
  • A to G, chromosome 5 at 33,899,276 bp
  • A to T, chromosome 7 at 11,065,986 bp
  • T to A, chromosome 7 at 75,609,908 bp
  • T to C, chromosome 8 at 110,462,660 bp
  • G to A, chromosome 9 at 22,058,262 bp
  • G to A, chromosome 9 at 106,483,022 bp
  • G to A, chromosome 10 at 20,969,121 bp
  • G to A, chromosome 10 at 70,002,565 bp
  • A to G, chromosome 10 at 78,042,967 bp
  • A to G, chromosome 10 at 81,085,718 bp
  • A to T, chromosome 10 at 88,482,283 bp
  • A to G, chromosome 10 at 106,857,569 bp
  • T to C, chromosome 11 at 11,802,557 bp
  • A to G, chromosome 11 at 67,297,500 bp
  • A to G, chromosome 11 at 87,732,125 bp
  • T to C, chromosome 11 at 106,173,314 bp
  • C to T, chromosome 11 at 115,984,157 bp
  • T to C, chromosome 11 at 117,736,005 bp
  • G to A, chromosome 11 at 119,442,028 bp
  • G to T, chromosome 12 at 40,079,808 bp
  • A to C, chromosome 12 at 44,282,887 bp
  • A to G, chromosome 13 at 77,254,216 bp
  • C to T, chromosome 13 at 89,689,926 bp
  • T to C, chromosome 13 at 103,774,386 bp
  • T to A, chromosome 14 at 32,971,711 bp
  • T to C, chromosome 14 at 55,074,196 bp
  • A to G, chromosome 14 at 60,756,428 bp
  • C to T, chromosome 14 at 64,030,096 bp
  • T to C, chromosome 15 at 3,325,965 bp
  • A to G, chromosome 15 at 55,380,850 bp
  • T to A, chromosome 15 at 101,487,534 bp
  • G to A, chromosome 16 at 26,474,268 bp
  • A to G, chromosome 16 at 91,501,620 bp
  • A to G, chromosome 16 at 94,370,206 bp
  • A to T, chromosome 17 at 28,669,940 bp
  • T to C, chromosome 17 at 46,521,453 bp
  • T to A, chromosome 18 at 35,660,450 bp
  • C to A, chromosome 18 at 36,969,216 bp
  • T to A, chromosome 18 at 37,005,817 bp
  • T to C, chromosome 18 at 61,315,909 bp
  • A to C, chromosome 19 at 12,901,439 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6135 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044282-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.