Strain Name:
C57BL/6J-MtgxR6138Btlr
Stock Number:
044285-MU
Citation ID:
RRID:MMRRC_044285-MU
Other Names:
R6138 (G1)
Major Collection:

Gene Information

Kitl
Name: kit ligand
Synonyms: Gb, SCF, Steel, Mgf, Sl, Kitlg, SF, grizzle-belly, blz, stem cell factor, Steel factor, SLF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 17311
HGNC: HGNC:6343
Homologene: 692
Gcg
Name: glucagon
Synonyms: GLP-1, glucagon-like peptide I, PPG, Glu
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14526
HGNC: HGNC:4191
Homologene: 1553
Gk5
Name: glycerol kinase 5 (putative)
Synonyms: G630067D24Rik, C330018K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235533
Homologene: 15141
Ppp4r1
Name: protein phosphatase 4, regulatory subunit 1
Synonyms: 3110001J10Rik, Pp4r1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 70351
HGNC: HGNC:9320
Homologene: 81737
Shroom3
Name: shroom family member 3
Synonyms: Shrm3, Shrm, D5Ertd287e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 27428
Homologene: 9263
Akap9
Name: A kinase (PRKA) anchor protein (yotiao) 9
Synonyms: mei2-5, G1-448-15, 5730481H23Rik, AKAP450, repro12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Lgr6
Name: leucine-rich repeat-containing G protein-coupled receptor 6
Synonyms: A530037C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 329252
Homologene: 49680
Pgk1
Name: phosphoglycerate kinase 1
Synonyms: Pgk-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 18655
HGNC: HGNC:8896
Homologene: 21542
Synrg
Name: synergin, gamma
Synonyms: L71-5, Ap1gbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217030
HGNC: HGNC:557
Homologene: 105680
Dlat
Name: dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
Synonyms: 6332404G05Rik, PDC-E2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235339
HGNC: HGNC:2896
Homologene: 6814
Plagl1
Name: pleiomorphic adenoma gene-like 1
Synonyms: Zac1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 22634
HGNC: HGNC:9046
Homologene: 31401
Myo7a
Name: myosin VIIA
Synonyms: USH1B, Hdb, Myo7, polka, nmf371
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 17921
HGNC: HGNC:7606
Homologene: 219
Itgae
Name: integrin alpha E, epithelial-associated
Synonyms: alpha-E1, CD103
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 16407
HGNC: HGNC:6147
Homologene: 113560
Tns2
Name: tensin 2
Synonyms: nep, Tenc1, nph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 209039
VEGA: 15
Homologene: 37077
Ccr6
Name: chemokine (C-C motif) receptor 6
Synonyms: Cmkbr6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 12458
VEGA: 17
HGNC: HGNC:1607
Homologene: 3214
Abhd14a
Name: abhydrolase domain containing 14A
Synonyms: 1110013B16Rik, Dorz1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 68644
Homologene: 22889
Adamts2
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2
Synonyms: procollagen N-proteinase, hPCPNI, ADAM-TS2, a disintegrin and metalloproteinase with thrombospondin repeats
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216725
HGNC: HGNC:218
Homologene: 8597
Myo3b
Name: myosin IIIB
Synonyms: A430065P19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 329421
Homologene: 51393
Theg
Name: testicular haploid expressed gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 21830
Homologene: 7976
Olfr510
Name: olfactory receptor 510
Synonyms: GA_x6K02T2PBJ9-10997715-10998659, MOR204-34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258308
Vmn2r79
Name: vomeronasal 2, receptor 79
Synonyms: EG621430
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 621430
Homologene: 115466
Olfr356
Name: olfactory receptor 356
Synonyms: GA_x6K02T2NLDC-33631647-33632594, MOR134-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258617
Homologene: 85948
Gm13103
Name: predicted gene 13103
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 194225
Homologene: 129883
Pik3c2b
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
Synonyms: PI3K-C2beta, C330011J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 240752
HGNC: HGNC:8972
Homologene: 20582
6820408C15Rik
Name: RIKEN cDNA 6820408C15 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228778
Homologene: 51916
Tbx5
Name: T-box 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 21388
Homologene: 160
1700012B07Rik
Name: RIKEN cDNA 1700012B07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69324
Homologene: 78000
Insm2
Name: insulinoma-associated 2
Synonyms: mlt 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 56856
VEGA: 12
Homologene: 10651
Adgra2
Name: adhesion G protein-coupled receptor A2
Synonyms: 9530074E10Rik, 8430414O08Rik, Tem5, Gpr124
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 78560
Homologene: 13112
Satl1
Name: spermidine/spermine N1-acetyl transferase-like 1
Synonyms: 4930404K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 73809
Homologene: 28332
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 133,074,627 bp
  • C to T, chromosome 1 at 134,994,010 bp
  • G to A, chromosome 2 at 36,937,229 bp
  • A to G, chromosome 2 at 62,475,804 bp
  • T to C, chromosome 2 at 70,238,899 bp
  • T to C, chromosome 2 at 152,440,870 bp
  • T to G, chromosome 4 at 143,851,585 bp
  • T to C, chromosome 5 at 4,067,924 bp
  • G to T, chromosome 5 at 92,943,086 bp
  • T to C, chromosome 5 at 119,883,146 bp
  • T to A, chromosome 7 at 87,004,111 bp
  • C to T, chromosome 7 at 98,065,790 bp
  • T to A, chromosome 7 at 108,668,205 bp
  • G to A, chromosome 8 at 27,114,429 bp
  • A to T, chromosome 9 at 50,645,117 bp
  • C to T, chromosome 9 at 96,176,237 bp
  • A to T, chromosome 9 at 106,443,866 bp
  • G to A, chromosome 10 at 13,127,746 bp
  • A to G, chromosome 10 at 79,584,755 bp
  • G to A, chromosome 10 at 100,076,906 bp
  • T to A, chromosome 11 at 50,756,706 bp
  • A to G, chromosome 11 at 73,115,574 bp
  • A to G, chromosome 11 at 84,024,300 bp
  • G to T, chromosome 11 at 109,794,154 bp
  • T to C, chromosome 12 at 55,600,014 bp
  • C to T, chromosome 15 at 102,108,934 bp
  • G to A, chromosome 17 at 8,256,382 bp
  • G to A, chromosome 17 at 65,814,348 bp
  • C to A, chromosome X at 106,194,492 bp
  • T to C, chromosome X at 112,405,916 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6138 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044285-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.