Strain Name:
C57BL/6J-MtgxR6139Btlr
Stock Number:
044286-MU
Citation ID:
RRID:MMRRC_044286-MU
Other Names:
R6139 (G1)
Major Collection:

Gene Information

Wrn
Name: Werner syndrome RecQ like helicase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 22427
Homologene: 6659
Grm1
Name: glutamate receptor, metabotropic 1
Synonyms: mGluR1, Grm1, Gprc1a, nmf373, rcw, 4930455H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14816
HGNC: HGNC:4593
Homologene: 649
Slc12a5
Name: solute carrier family 12, member 5
Synonyms: KCC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 57138
Homologene: 10665
Ptpn14
Name: protein tyrosine phosphatase, non-receptor type 14
Synonyms: PTP36, C130080N23Rik, OTTMUSG00000022087
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19250
HGNC: HGNC:9647
Homologene: 3941
Pds5b
Name: PDS5 cohesin associated factor B
Synonyms: AS3, Aprin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100710
Homologene: 41001
Wdr70
Name: WD repeat domain 70
Synonyms: 4833422F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 545085
VEGA: 15
Homologene: 9972
Ddx42
Name: DEAD box helicase 42
Synonyms: B430002H05Rik, 1810047H21Rik, SF3b125, DEAD (Asp-Glu-Ala-Asp) box polypeptide 42
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72047
Homologene: 49137
Arhgap35
Name: Rho GTPase activating protein 35
Synonyms: P190 RhoGAP, 6430596G11Rik, p190RhoGAP, p190A, Grlf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232906
HGNC: HGNC:4591
Homologene: 35136
Asap1
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain1
Synonyms: Ddef1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13196
HGNC: HGNC:2720
Homologene: 7684
Kif1b
Name: kinesin family member 1B
Synonyms: D4Mil1e, Kif1b alpha, Kif1b beta, KIF1Bp130, KIF1Bp204, N-3 kinesin, A530096N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16561
Homologene: 99835
Pop1
Name: processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)
Synonyms: 4932434G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67724
Homologene: 41000
Cep350
Name: centrosomal protein 350
Synonyms: 6430546F08Rik, 4933409L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74081
Homologene: 8879
Snupn
Name: snurportin 1
Synonyms: 0610031A09Rik, Rnut1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66069
Homologene: 4166
Rnf39
Name: ring finger protein 39
Synonyms: LIRF, LOC240094, LOC386465, LOC386454
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 386454
Homologene: 11891
St7
Name: suppression of tumorigenicity 7
Synonyms: RAY1, HELG, SEN4, TSG7, Fam4a2, 9430001H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 64213
Homologene: 10185
Fam81a
Name: family with sequence similarity 81, member A
Synonyms: 6430514L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 76886
Homologene: 17584
Dsp
Name: desmoplakin
Synonyms: DP, 2300002E22Rik, 5730453H04Rik, rul
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
C2cd5
Name: C2 calcium-dependent domain containing 5
Synonyms: C030008B15Rik, CDP138, 5730419I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74741
Homologene: 8873
Xpot
Name: exportin, tRNA (nuclear export receptor for tRNAs)
Synonyms: EXPORTIN-T, C79645, 1110004L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 73192
VEGA: 10
Homologene: 38291
Casz1
Name: castor zinc finger 1
Synonyms: 2410019P08Rik, D4Ertd432e, castor, Cst
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69743
Homologene: 9824
6030468B19Rik
Name: RIKEN cDNA 6030468B19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77727
Homologene: 90660
Mtmr9
Name: myotubularin related protein 9
Synonyms: mMTMH3, LIP-STYX, MTMR8, 9430075G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 210376
VEGA: 14
Homologene: 9148
Nr4a2
Name: nuclear receptor subfamily 4, group A, member 2
Synonyms: HZF-3, RNR-1, Nurr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18227
HGNC: HGNC:7981
Homologene: 4509
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: MDHC7, E030034C22Rik, B230373P09Rik, Dnahc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Mgst3
Name: microsomal glutathione S-transferase 3
Synonyms: GST-III, 2010306B17Rik, 2010012L10Rik, 2700004G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66447
HGNC: HGNC:7064
Homologene: 3327
Rdh9
Name: retinol dehydrogenase 9
Synonyms: Crad3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103142
Homologene: 129514
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Acacb
Name: acetyl-Coenzyme A carboxylase beta
Synonyms: Accb, Acc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100705
HGNC: HGNC:85
Homologene: 74382
Myh11
Name: myosin, heavy polypeptide 11, smooth muscle
Synonyms: smMHC, SM2, SM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17880
VEGA: 16
HGNC: HGNC:7569
Homologene: 128512
Gsap
Name: gamma-secretase activating protein
Synonyms: A530088I07Rik, Pion
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 212167
Homologene: 45504
Antxr2
Name: anthrax toxin receptor 2
Synonyms: cI-35, CMG-2, CMG2, 2310046B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71914
Homologene: 43236
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241516
Homologene: 110349
Slc16a12
Name: solute carrier family 16 (monocarboxylic acid transporters), member 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240638
Homologene: 130007
Cma1
Name: chymase 1, mast cell
Synonyms: MMCP-5, Mcp-5, Mcpt5, Mcp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 17228
VEGA: 14
HGNC: HGNC:2097
Homologene: 55606
Me3
Name: malic enzyme 3, NADP(+)-dependent, mitochondrial
Synonyms: B230207H15Rik, 1700020C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 109264
HGNC: HGNC:6985
Homologene: 100773
Sfmbt1
Name: Scm-like with four mbt domains 1
Synonyms: Smr, 4930442N21Rik, 9330180L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 54650
Homologene: 9472
Pfkfb4
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270198
HGNC: HGNC:8875
Homologene: 48288
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330267
Homologene: 46582
Disp2
Name: dispatched RND tramsporter family member 2
Synonyms: DispB, B230210L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 214240
Homologene: 24916
Lgals12
Name: lectin, galactose binding, soluble 12
Synonyms: galectin-related inhibitor of proliferation, GRIP1, galectin-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56072
Homologene: 10462
Vmn2r7
Name: vomeronasal 2, receptor 7
Synonyms: 4933425M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 319217
Homologene: 129754
Olfr689
Name: olfactory receptor 689
Synonyms: GA_x6K02T2PBJ9-7942985-7943947, MOR40-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258745
Homologene: 128074
Gcnt4
Name: glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase)
Synonyms: LOC218476, LOC238786, C2GNT3, Gm73
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218476
VEGA: 13
Homologene: 41144
Ugt2b36
Name: UDP glucuronosyltransferase 2 family, polypeptide B36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231396
Homologene: 128251
Acsl6
Name: acyl-CoA synthetase long-chain family member 6
Synonyms: Lacsl, A330035H04Rik, Facl6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216739
Homologene: 100939
Aebp1
Name: AE binding protein 1
Synonyms: ACLP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11568
HGNC: HGNC:303
Homologene: 878
Olfr993
Name: olfactory receptor 993
Synonyms: GA_x6K02T2Q125-46891524-46890580, MOR203-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258427
Homologene: 79352
Catsper4
Name: cation channel, sperm associated 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329954
Homologene: 18638
Gk2
Name: glycerol kinase 2
Synonyms: Gk-rs2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14626
HGNC: HGNC:4291
Homologene: 133273
Rnf223
Name: ring finger 223
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100045778
Homologene: 27073
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 155,953,279 bp
  • T to G, chromosome 1 at 167,378,305 bp
  • T to G, chromosome 1 at 189,851,165 bp
  • T to A, chromosome 2 at 57,108,689 bp
  • G to A, chromosome 2 at 76,852,069 bp
  • A to G, chromosome 2 at 82,991,044 bp
  • A to T, chromosome 2 at 85,414,346 bp
  • T to A, chromosome 2 at 118,790,662 bp
  • T to A, chromosome 2 at 164,992,311 bp
  • G to A, chromosome 3 at 64,715,918 bp
  • A to G, chromosome 4 at 134,217,866 bp
  • C to T, chromosome 4 at 148,951,697 bp
  • G to A, chromosome 4 at 149,237,532 bp
  • T to C, chromosome 4 at 156,132,803 bp
  • T to A, chromosome 5 at 21,281,540 bp
  • A to T, chromosome 5 at 87,092,171 bp
  • A to G, chromosome 5 at 97,456,280 bp
  • A to C, chromosome 5 at 97,977,706 bp
  • T to C, chromosome 5 at 114,212,652 bp
  • T to A, chromosome 5 at 150,800,777 bp
  • T to C, chromosome 6 at 12,379,573 bp
  • T to C, chromosome 6 at 17,694,354 bp
  • A to C, chromosome 6 at 143,035,058 bp
  • T to C, chromosome 7 at 16,563,467 bp
  • G to T, chromosome 7 at 89,632,900 bp
  • A to T, chromosome 7 at 105,314,246 bp
  • A to T, chromosome 8 at 33,353,332 bp
  • C to A, chromosome 9 at 56,982,824 bp
  • A to T, chromosome 9 at 70,102,818 bp
  • A to G, chromosome 9 at 109,027,757 bp
  • T to C, chromosome 10 at 10,746,331 bp
  • T to A, chromosome 10 at 121,611,708 bp
  • A to T, chromosome 10 at 127,776,737 bp
  • A to G, chromosome 11 at 5,871,842 bp
  • C to A, chromosome 11 at 54,340,542 bp
  • C to T, chromosome 11 at 106,240,017 bp
  • A to G, chromosome 11 at 117,806,324 bp
  • T to C, chromosome 13 at 38,192,406 bp
  • G to A, chromosome 13 at 96,946,852 bp
  • T to A, chromosome 14 at 30,811,418 bp
  • T to C, chromosome 14 at 31,286,027 bp
  • T to A, chromosome 14 at 47,726,215 bp
  • T to A, chromosome 14 at 55,942,700 bp
  • T to C, chromosome 14 at 63,529,778 bp
  • T to C, chromosome 15 at 8,079,251 bp
  • T to A, chromosome 15 at 34,529,058 bp
  • T to A, chromosome 15 at 64,166,539 bp
  • T to C, chromosome 16 at 14,215,874 bp
  • A to G, chromosome 17 at 36,943,338 bp
  • T to A, chromosome 19 at 7,604,377 bp
  • T to A, chromosome 19 at 34,670,895 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6139 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044286-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.