Strain Name:
C57BL/6J-MtgxR6141Btlrd/Mmmh
Stock Number:
044288-MU
Citation ID:
RRID:MMRRC_044288-MU
Other Names:
R6141 (G1)
Major Collection:

Gene Information

Pcp2
Name: Purkinje cell protein 2 (L7)
Synonyms: L7, Pcp-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18545
Homologene: 7464
Satb1
Name: special AT-rich sequence binding protein 1
Synonyms: 2610306G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20230
Homologene: 2232
Nsd1
Name: nuclear receptor-binding SET-domain protein 1
Synonyms: KMT3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18193
VEGA: 13
Homologene: 32543
Gpatch4
Name: G patch domain containing 4
Synonyms: 2610029K21Rik, Gpatc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66614
Homologene: 9203
Mllt10
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10
Synonyms: Af10, B130021D15Rik, D630001B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17354
Homologene: 20973
Ambra1
Name: autophagy/beclin 1 regulator 1
Synonyms: 2310079H06Rik, D030051N19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228361
Homologene: 18204
Nckap1
Name: NCK-associated protein 1
Synonyms: mh19, Hem-2, H19, Nap1, Hem2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 50884
HGNC: HGNC:7666
Homologene: 8384
Tubgcp5
Name: tubulin, gamma complex associated protein 5
Synonyms: GCP5, B130010C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233276
Homologene: 14172
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: A630086P08Rik, opm, b2b327Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Iqgap2
Name: IQ motif containing GTPase activating protein 2
Synonyms: 4933417J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 544963
VEGA: 13
HGNC: HGNC:6111
Homologene: 101543
Ccdc14
Name: coiled-coil domain containing 14
Synonyms: G630039H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239839
VEGA: 16
Homologene: 32549
Msr1
Name: macrophage scavenger receptor 1
Synonyms: SR-AII, SR-AI, MSR-A, Scara1, Scvr, MRS-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20288
HGNC: HGNC:7376
Homologene: 12822
Snupn
Name: snurportin 1
Synonyms: 0610031A09Rik, Rnut1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66069
Homologene: 4166
Dbf4
Name: DBF4 zinc finger
Synonyms: Ask
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 27214
Homologene: 40892
Ric1
Name: RAB6A GEF complex partner 1
Synonyms: C130057E09Rik, C030046E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226089
Homologene: 13806
Ift122
Name: intraflagellar transport 122
Synonyms: C86139, Wdr10, sopb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 81896
Homologene: 12819
Abhd5
Name: abhydrolase domain containing 5
Synonyms: NCIE2, IECN5, 1300003D03Rik, 2010002J10Rik, CGI-58
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67469
Homologene: 41088
Brca2
Name: breast cancer 2, early onset
Synonyms: RAB163, Fancd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12190
HGNC: HGNC:1101
Homologene: 41
Pdgfra
Name: platelet derived growth factor receptor, alpha polypeptide
Synonyms: CD140a, Pdgfr-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18595
HGNC: HGNC:8803
Homologene: 31361
Tnr
Name: tenascin R
Synonyms: janusin, restrictin, TN-R, J1-tenascin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21960
Homologene: 124416
Ush2a
Name: usherin
Synonyms: MUSH2A, A930011D15Rik, LOC381317, LOC269160, A930037M10Rik, Ushrn, Ush2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22283
Homologene: 66151
Vmn2r100
Name: vomeronasal 2, receptor 100
Synonyms: EG627537
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627537
Homologene: 129750
Slc66a1
Name: solute carrier family 66 member 1
Synonyms: Pqlc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 212555
Homologene: 56784
Naip6
Name: NLR family, apoptosis inhibitory protein 6
Synonyms: Naip-rs4A, Naip-rs4, Birc1f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17952
HGNC: HGNC:7634
Homologene: 113589
Kcnq4
Name: potassium voltage-gated channel, subfamily Q, member 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 60613
HGNC: HGNC:6298
Homologene: 78107
Ccdc110
Name: coiled-coil domain containing 110
Synonyms: LOC212392
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 212392
Homologene: 17668
Myom2
Name: myomesin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17930
HGNC: HGNC:7614
Homologene: 2953
Slc4a10
Name: solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
Synonyms: NCBE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94229
Homologene: 23340
Grik1
Name: glutamate receptor, ionotropic, kainate 1
Synonyms: Glur-5, Glur5, D16Ium24, A830007B11Rik, D16Ium24e, Glurbeta1, GluK5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 14805
HGNC: HGNC:4579
Homologene: 68992
Naaladl1
Name: N-acetylated alpha-linked acidic dipeptidase-like 1
Synonyms: LOC381204
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 381204
Homologene: 21124
Cntn5
Name: contactin 5
Synonyms: LOC244683, NB-2, A830025P08Rik, 6720426O10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244682
HGNC: HGNC:2175
Homologene: 28447
Tlr1
Name: toll-like receptor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 21897
Homologene: 20694
Zfyve16
Name: zinc finger, FYVE domain containing 16
Synonyms: B130024H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218441
Homologene: 8826
Tnfsf11
Name: tumor necrosis factor (ligand) superfamily, member 11
Synonyms: RANKL, OPGL, ODF, Ly109l, Trance, osteoclast differentiation factor, OPGL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21943
VEGA: 14
Homologene: 2744
Or7e176
Name: olfactory receptor family 7 subfamily E member 176
Synonyms: GA_x6K02T2PVTD-13999915-14000844, MOR145-3, Olfr872
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258553
HGNC: HGNC:8396
Homologene: 138312
Map3k3
Name: mitogen-activated protein kinase kinase kinase 3
Synonyms: MAPKKK3, Mekk3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 26406
HGNC: HGNC:6855
Homologene: 69110
Stard13
Name: StAR-related lipid transfer (START) domain containing 13
Synonyms: GT650, DLC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243362
Homologene: 64844
Or5ac17
Name: olfactory receptor family 5 subfamily AC member 17
Synonyms: GA_x54KRFPKG5P-55430495-55429569, MOR182-14, Olfr199
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 404310
Homologene: 37011
Or52ae9
Name: olfactory receptor family 52 subfamily AE member 9
Synonyms: GA_x6K02T2PBJ9-6466772-6465828, MOR26-2, Olfr629
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258818
Homologene: 105159
Ndufs2
Name: NADH:ubiquinone oxidoreductase core subunit S2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226646
HGNC: HGNC:7708
Homologene: 56659
Etfa
Name: electron transferring flavoprotein, alpha polypeptide
Synonyms: 2010200I21Rik, D9Ertd394e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 110842
HGNC: HGNC:3481
Homologene: 100
Eepd1
Name: endonuclease/exonuclease/phosphatase family domain containing 1
Synonyms: 2310005P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67484
Homologene: 12144
Slc1a7
Name: solute carrier family 1 (glutamate transporter), member 7
Synonyms: EAAT5, A930031E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242607
Homologene: 21327
Or4k42
Name: olfactory receptor family 4 subfamily K member 42
Synonyms: GA_x6K02T2Q125-72541649-72540711, MOR248-9, Olfr1290
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 257662
Homologene: 74248
4933421I07Rik
Name: RIKEN cDNA 4933421I07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71162
Homologene: 86127
Reep5
Name: receptor accessory protein 5
Synonyms: DP1/TB2, TB2/DP1, Dp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13476
VEGA: 18
Homologene: 68479
Cavin2
Name: caveolae associated 2
Synonyms: cavin 2, Sdpr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20324
Homologene: 3422
Defb22
Name: defensin beta 22
Synonyms: 9230002F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 442835
Homologene: 83152
Wdr49
Name: WD repeat domain 49
Synonyms: EG213248
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213248
Homologene: 18714
Or5b114-ps1
Name: olfactory receptor family 5 subfamily B member 114, pseudogene 1
Synonyms: GA_x6K02T2RE5P-3706029-3706953, MOR202-21, Olfr1468-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258192
Gm44419
Name: predicted gene, 44419
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 115490378
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 51,300,938 bp
  • T to A, chromosome 1 at 159,887,122 bp
  • T to C, chromosome 1 at 171,236,616 bp
  • A to T, chromosome 1 at 188,357,963 bp
  • T to C, chromosome 2 at 18,210,793 bp
  • A to G, chromosome 2 at 62,211,445 bp
  • C to A, chromosome 2 at 80,530,207 bp
  • A to T, chromosome 2 at 91,875,754 bp
  • A to G, chromosome 2 at 111,490,119 bp
  • A to T, chromosome 2 at 152,485,802 bp
  • A to T, chromosome 3 at 75,323,682 bp
  • C to T, chromosome 3 at 88,054,740 bp
  • T to A, chromosome 4 at 108,002,182 bp
  • A to T, chromosome 4 at 120,715,869 bp
  • A to G, chromosome 4 at 139,300,245 bp
  • T to C, chromosome 5 at 8,408,545 bp
  • T to C, chromosome 5 at 64,925,213 bp
  • A to G, chromosome 5 at 75,173,396 bp
  • A to G, chromosome 5 at 150,540,637 bp
  • A to T, chromosome 5 at 151,042,242 bp
  • T to A, chromosome 6 at 65,150,956 bp
  • T to C, chromosome 6 at 115,916,011 bp
  • A to T, chromosome 7 at 42,448,059 bp
  • A to G, chromosome 7 at 55,806,778 bp
  • C to A, chromosome 7 at 103,740,787 bp
  • G to A, chromosome 8 at 3,623,543 bp
  • A to T, chromosome 8 at 15,063,903 bp
  • A to T, chromosome 8 at 39,631,319 bp
  • A to G, chromosome 8 at 45,941,770 bp
  • A to T, chromosome 9 at 10,144,157 bp
  • T to A, chromosome 9 at 20,260,458 bp
  • T to A, chromosome 9 at 25,482,984 bp
  • T to C, chromosome 9 at 55,464,819 bp
  • C to A, chromosome 9 at 56,982,824 bp
  • A to T, chromosome 9 at 122,377,933 bp
  • G to T, chromosome 11 at 106,097,048 bp
  • A to C, chromosome 12 at 51,746,092 bp
  • T to C, chromosome 13 at 55,291,284 bp
  • A to G, chromosome 13 at 92,511,597 bp
  • A to T, chromosome 13 at 95,721,686 bp
  • T to C, chromosome 13 at 100,308,233 bp
  • A to G, chromosome 14 at 78,307,859 bp
  • T to A, chromosome 16 at 34,706,562 bp
  • T to A, chromosome 16 at 59,216,553 bp
  • T to G, chromosome 16 at 87,896,872 bp
  • T to C, chromosome 17 at 19,522,314 bp
  • T to C, chromosome 17 at 51,775,376 bp
  • A to T, chromosome 18 at 34,372,458 bp
  • T to A, chromosome 19 at 6,109,755 bp
  • A to T, chromosome 19 at 13,375,283 bp
  • T to C, chromosome 19 at 29,595,442 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6141 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044288-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.