Strain Name:
C57BL/6J-MtgxR6178Btlr
Stock Number:
044320-MU
Citation ID:
RRID:MMRRC_044320-MU
Other Names:
R6178 (G1)
Major Collection:

Strain Information

Atg7
Name: autophagy related 7
Synonyms: 1810013K23Rik, Apg7l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74244
Homologene: 4662
Becn1
Name: beclin 1, autophagy related
Synonyms: Atg6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56208
HGNC: HGNC:1034
Homologene: 2794
Ubap2
Name: ubiquitin-associated protein 2
Synonyms: 1190005K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68926
Homologene: 73649
Trpm7
Name: transient receptor potential cation channel, subfamily M, member 7
Synonyms: 5033407O22Rik, 4833414K03Rik, CHAK1, CHAK, TRP-PLIK, Ltpr7, 2310022G15Rik, LTRPC7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 58800
Homologene: 9774
Snx6
Name: sorting nexin 6
Synonyms: 2610032J07Rik, 2010006G21Rik, 2810425K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 72183
VEGA: 12
Homologene: 12304
Fry
Name: FRY microtubule binding protein
Synonyms: cg003, 9330186A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320365
Homologene: 113770
Nup205
Name: nucleoporin 205
Synonyms: 3830404O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 70699
Homologene: 45971
Ankfy1
Name: ankyrin repeat and FYVE domain containing 1
Synonyms: Ankhzn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11736
Homologene: 9491
Dcp1a
Name: decapping mRNA 1A
Synonyms: 1110066A22Rik, SMIF, 4930568L04Rik, D14Ertd817e, Mitc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 75901
VEGA: 14
Homologene: 10178
Naa16
Name: N(alpha)-acetyltransferase 16, NatA auxiliary subunit
Synonyms: 1300019C06Rik, Narg1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66897
Homologene: 134838
Afg3l2
Name: AFG3-like AAA ATPase 2
Synonyms: 2310036I02Rik, par, Emv66
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 69597
VEGA: 18
HGNC: HGNC:315
Homologene: 4947
Tbr1
Name: T-box brain transcription factor 1
Synonyms: T-box brain gene 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21375
Homologene: 4807
Aktip
Name: AKT interacting protein
Synonyms: Ft1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14339
Homologene: 7721
Pnpla3
Name: patatin-like phospholipase domain containing 3
Synonyms: Adpn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 116939
VEGA: 15
Homologene: 11883
Ripor2
Name: RHO family interacting cell polarization regulator 2
Synonyms: 1700108N18Rik, E430013J17Rik, 6330500D04Rik, Fam65b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 193385
Homologene: 9284
Fev
Name: FEV transcription factor, ETS family member
Synonyms: mPet-1, Pet1, Pex1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 260298
Homologene: 9706
Zfp65
Name: zinc finger protein 65
Synonyms: KRAB5, Zfp71-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 235907
Homologene: 87875
Mpdz
Name: multiple PDZ domain crumbs cell polarity complex component
Synonyms: MUPP1, B930003D11Rik, multiple PDZ domain protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17475
HGNC: HGNC:7208
Homologene: 2841
Isoc1
Name: isochorismatase domain containing 1
Synonyms: 2610034N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 66307
VEGA: 18
Homologene: 9361
Zswim1
Name: zinc finger SWIM-type containing 1
Synonyms: 2410003H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71971
Homologene: 12429
Ranbp10
Name: RAN binding protein 10
Synonyms: 4432417N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74334
Homologene: 49639
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, Hapip, 2210407G14Rik, E530005C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Robo4
Name: roundabout guidance receptor 4
Synonyms: 1200012D01Rik, Magic roundabout
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74144
Homologene: 10397
Zic5
Name: zinc finger protein of the cerebellum 5
Synonyms: odd-paired related, Opr, 1700049L20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 65100
Homologene: 11301
Mgp
Name: matrix Gla protein
Synonyms: Mglap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17313
HGNC: HGNC:7060
Homologene: 693
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: Scy, Crsh, crash, Adgrc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Kcp
Name: kielin/chordin-like protein
Synonyms: LOC333088, KCP, Crim2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 333088
Homologene: 87817
Gm4847
Name: predicted gene 4847
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226604
Homologene: 101040
Gm5422
Name: predicted pseudogene 5422
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432448
VEGA: 10
Clspn
Name: claspin
Synonyms: E130314M08Rik, C85083
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269582
Homologene: 11138
Or10aa3
Name: olfactory receptor family 10 subfamily AA member 3
Synonyms: GA_x6K02T2P20D-21124681-21123743, MOR123-2, Olfr432
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 258711
Homologene: 81532
Slc35b2
Name: solute carrier family 35, member B2
Synonyms: 1110003M08Rik, PAPST1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 73836
VEGA: 17
Homologene: 24504
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
Plcb3
Name: phospholipase C, beta 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18797
VEGA: 19
HGNC: HGNC:9056
Homologene: 47960
Or14c40
Name: olfactory receptor family 14 subfamily C member 40
Synonyms: GA_x6K02T2NHDJ-9457744-9456734, MOR221-3, Olfr293
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 257906
Homologene: 79385
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC9, MUC5, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Mrpl44
Name: mitochondrial ribosomal protein L44
Synonyms: 1810030E18Rik, 5730593H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 69163
Homologene: 11293
Abcc6
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 6
Synonyms: DCC, Mrp6, Dyscalc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 27421
HGNC: HGNC:57
Homologene: 55559
C4b
Name: complement component 4B (Chido blood group)
Synonyms: Ss, C4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12268
Homologene: 36030
Shc2
Name: SHC (Src homology 2 domain containing) transforming protein 2
Synonyms: ShcB, Sli
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216148
Homologene: 19127
Tgfb1i1
Name: transforming growth factor beta 1 induced transcript 1
Synonyms: TSC-5, hic-5, ARA55
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 21804
Homologene: 7572
Tmprss11f
Name: transmembrane protease, serine 11f
Synonyms: 4732406D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243083
Homologene: 65356
Marchf10
Name: membrane associated ring-CH-type finger 10
Synonyms: 4933417C16Rik, Rnf190, OTTMUSG00000002847, March10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 632687
Homologene: 34988
Zpld1
Name: zona pellucida like domain containing 1
Synonyms: 9430016A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239852
Homologene: 18401
Mau2
Name: MAU2 sister chromatid cohesion factor
Synonyms: A930019L04Rik, 9130404D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74549
Homologene: 12574
Or4c103
Name: olfactory receptor family 4 subfamily C member 103
Synonyms: GA_x6K02T2Q125-50163514-50162588, MOR230-4, MOR230-12_p, Olfr1195
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258748
Homologene: 103782
Mro
Name: maestro
Synonyms: 4933435E20Rik, 4930507C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 71263
Homologene: 41729
Slc39a13
Name: solute carrier family 39 (metal ion transporter), member 13
Synonyms: 1100001L14Rik, ZIP13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68427
Homologene: 62681
Ubash3b
Name: ubiquitin associated and SH3 domain containing, B
Synonyms: 2810457I06Rik, TULA-2, Sts-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72828
Homologene: 13152
Trim30d
Name: tripartite motif-containing 30D
Synonyms: TRIM30-3, Trim79
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 209387
Homologene: 114426
Mrgpre
Name: MAS-related GPR, member E
Synonyms: MrgE, C130069N09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244238
Homologene: 18469
Taar8b
Name: trace amine-associated receptor 8B
Synonyms: LOC382348
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 382348
Homologene: 77586
Or1e16
Name: olfactory receptor family 1 subfamily E member 16
Synonyms: MOR135-13, GA_x6K02T2P1NL-3556334-3555390, I54, Olfr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258923
Homologene: 115482
Gstm6
Name: glutathione S-transferase, mu 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14867
HGNC: HGNC:4632
Homologene: 117950
Tdpoz2
Name: TD and POZ domain containing 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 399673
Homologene: 133956
Gm3676
Name: predicted gene 3676
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Btnl12
Name: butyrophilin-like 12
Synonyms: Gm36028
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 102639802
Homologene: 139661
Gm30646
Name: predicted gene, 30646
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 102632619
Dmrtc1b
Name: DMRT-like family C1b
Synonyms: Dmrt8.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 632708
Homologene: 86873
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 74,884,539 bp
  • G to T, chromosome 1 at 79,778,178 bp
  • T to C, chromosome 1 at 166,642,336 bp
  • A to T, chromosome 1 at 174,050,967 bp
  • T to A, chromosome 2 at 61,804,815 bp
  • T to C, chromosome 2 at 88,683,633 bp
  • T to C, chromosome 2 at 91,068,535 bp
  • A to G, chromosome 2 at 126,837,381 bp
  • A to G, chromosome 2 at 164,826,052 bp
  • T to C, chromosome 3 at 93,652,311 bp
  • A to G, chromosome 3 at 107,941,081 bp
  • G to T, chromosome 4 at 41,206,981 bp
  • T to A, chromosome 4 at 81,308,365 bp
  • A to T, chromosome 4 at 126,577,736 bp
  • T to C, chromosome 5 at 86,556,978 bp
  • T to A, chromosome 5 at 150,454,522 bp
  • T to C, chromosome 6 at 29,482,888 bp
  • A to T, chromosome 6 at 35,243,843 bp
  • T to A, chromosome 6 at 114,724,895 bp
  • A to G, chromosome 6 at 136,872,724 bp
  • A to G, chromosome 7 at 30,432,656 bp
  • T to C, chromosome 7 at 46,029,044 bp
  • A to G, chromosome 7 at 86,664,611 bp
  • T to G, chromosome 7 at 104,487,995 bp
  • T to C, chromosome 7 at 128,253,345 bp
  • A to G, chromosome 7 at 141,856,342 bp
  • T to A, chromosome 7 at 143,780,971 bp
  • A to G, chromosome 8 at 70,042,537 bp
  • T to C, chromosome 8 at 91,126,043 bp
  • A to G, chromosome 8 at 105,771,664 bp
  • C to T, chromosome 9 at 37,405,630 bp
  • T to C, chromosome 9 at 41,014,916 bp
  • A to G, chromosome 10 at 24,091,813 bp
  • T to C, chromosome 10 at 31,249,692 bp
  • A to G, chromosome 10 at 79,630,120 bp
  • G to A, chromosome 11 at 72,754,459 bp
  • AGCGGTCGTAGGC to AGC, chromosome 11 at 73,395,654 bp
  • T to A, chromosome 11 at 101,291,510 bp
  • T to G, chromosome 11 at 105,389,614 bp
  • A to C, chromosome 12 at 54,760,464 bp
  • T to C, chromosome 13 at 24,710,130 bp
  • G to A, chromosome 13 at 67,710,318 bp
  • T to G, chromosome 14 at 30,523,304 bp
  • C to T, chromosome 14 at 41,641,495 bp
  • T to C, chromosome 14 at 79,383,340 bp
  • A to T, chromosome 14 at 122,459,336 bp
  • T to C, chromosome 15 at 48,673,458 bp
  • G to A, chromosome 15 at 84,180,931 bp
  • C to A, chromosome 15 at 85,901,021 bp
  • T to A, chromosome 16 at 34,053,639 bp
  • T to C, chromosome 16 at 37,856,060 bp
  • A to T, chromosome 16 at 55,233,630 bp
  • T to C, chromosome 17 at 34,733,406 bp
  • C to T, chromosome 17 at 45,566,376 bp
  • G to T, chromosome 18 at 58,671,592 bp
  • G to A, chromosome 18 at 67,409,528 bp
  • G to A, chromosome 18 at 73,873,224 bp
  • A to G, chromosome 19 at 6,954,703 bp
  • C to T, chromosome X at 102,713,563 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6178 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044320-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.