Beutler Mutagenetix

Strain Name:
C57BL/6J-MtgxR6224Btlr
Stock Number:
044355-MU
Citation ID:
RRID:MMRRC_044355-MU
Other Names:
R6224 (G1)
Major Collection:

Gene Information

Sesn2
Name: sestrin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230784
Homologene: 12873
Nsd1
Name: nuclear receptor-binding SET-domain protein 1
Synonyms: KMT3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 18193
VEGA: 13
Homologene: 32543
Zc3h13
Name: zinc finger CCCH type containing 13
Synonyms: 2600010B19Rik, 3110050K21Rik, 4930570G11Rik, C87618
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 67302
VEGA: 14
Homologene: null
Dcun1d3
Name: DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
Synonyms: 1700020A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233805
Homologene: 16155
Gspt1
Name: G1 to S phase transition 1
Synonyms: Gst-1, Gst-1, G1st
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 14852
HGNC: HGNC:4621
Homologene: 68226
Brd1
Name: bromodomain containing 1
Synonyms: 1110059H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223770
HGNC: HGNC:1102
Homologene: 40956
Ttc37
Name: tetratricopeptide repeat domain 37
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218343
VEGA: 13
Homologene: 40966
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 195018
Homologene: 9027
Dab1
Name: disabled 1
Synonyms: C630028C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 13131
HGNC: HGNC:2661
Homologene: 32084
Slitrk5
Name: SLIT and NTRK-like family, member 5
Synonyms: 2610019D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 75409
VEGA: 14
Homologene: 9193
Dcps
Name: decapping enzyme, scavenger
Synonyms: 1700001E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 69305
Homologene: 32202
Mphosph8
Name: M-phase phosphoprotein 8
Synonyms: 1500035L22Rik, 4930548G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 75339
Homologene: 11380
Pdgfrb
Name: platelet derived growth factor receptor, beta polypeptide
Synonyms: Pdgfr, CD140b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 18596
HGNC: HGNC:8804
Homologene: 1960
Cpxm2
Name: carboxypeptidase X 2 (M14 family)
Synonyms: 4632435C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 55987
Homologene: 69259
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Cenpe
Name: centromere protein E
Synonyms: CENP-E, 312kDa, Kif10, N-7 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229841
HGNC: HGNC:1856
Homologene: 20429
Foxo1
Name: forkhead box O1
Synonyms: FKHR, Afxh, Fkhr1, Foxo1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 56458
HGNC: HGNC:3819
Homologene: 1527
Atad1
Name: ATPase family, AAA domain containing 1
Synonyms: Thorase, 4921525H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 67979
VEGA: 19
Homologene: 5960
Pbrm1
Name: polybromo 1
Synonyms: BAF180, Pb1, 2310032M22Rik, 2610016F04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 66923
Homologene: 10044
Slitrk1
Name: SLIT and NTRK-like family, member 1
Synonyms: 3200001I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 76965
VEGA: 14
Homologene: 14174
Eml1
Name: echinoderm microtubule associated protein like 1
Synonyms: ELP79, A930030P13Rik, heco, 1110008N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 68519
HGNC: HGNC:3330
Homologene: 20931
Klc4
Name: kinesin light chain 4
Synonyms: 1200014P03Rik, Knsl8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 74764
VEGA: 17
Homologene: 12584
Ogdhl
Name: oxoglutarate dehydrogenase-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 239017
VEGA: 14
Homologene: 56801
Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
Synonyms: LOC380658, 4930503E15Rik, Gm1557
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 74978
Homologene: 46007
Cadm2
Name: cell adhesion molecule 2
Synonyms: SynCAM2, Igsf4d, A830029E02Rik, Necl3, 2900078E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 239857
Homologene: 17705
Pnpla8
Name: patatin-like phospholipase domain containing 8
Synonyms: 1200006O19Rik, iPLA2 gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 67452
Homologene: 12136
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: CMF608, Adlican2, 6530405F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 242050
Homologene: 18712
Zfp607a
Name: zinc finger protein 607A
Synonyms: 4732475C15Rik, Zfp607
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 545938
Homologene: 134321
Pitrm1
Name: pitrilysin metallepetidase 1
Synonyms: PreP, Ntup1, 2310012C15Rik, MP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 69617
VEGA: 13
Homologene: 5742
Adamtsl4
Name: ADAMTS-like 4
Synonyms: Tsrc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229595
Homologene: 23141
Zcwpw1
Name: zinc finger, CW type with PWWP domain 1
Synonyms: LOC381678
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 381678
Homologene: 9944
Tmprss15
Name: transmembrane protease, serine 15
Synonyms: enteropeptidase, A130097D21Rik, Prss7, enterokinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 19146
HGNC: HGNC:9490
Homologene: 2075
Gli3
Name: GLI-Kruppel family member GLI3
Synonyms: Bph, brachyphalangy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 14634
HGNC: HGNC:4319
Homologene: 139
Gp6
Name: glycoprotein 6 (platelet)
Synonyms: Gpvi, 9830166G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243816
Homologene: 9488
Fanca
Name: Fanconi anemia, complementation group A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 14087
HGNC: HGNC:3582
Homologene: 108
Psd4
Name: pleckstrin and Sec7 domain containing 4
Synonyms: EFA6B, SEC7 homolog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 215632
Homologene: 8261
Bpifa6
Name: BPI fold containing family A, member 6
Synonyms: Gm5840
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 545477
HGNC: null
Homologene: 129594
Cyp46a1
Name: cytochrome P450, family 46, subfamily a, polypeptide 1
Synonyms: cholestrol 24-hydroxylase, Cyp46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 13116
VEGA: 12
HGNC: HGNC:2641
Homologene: 134501
Olfr813
Name: olfactory receptor 813
Synonyms: MOR108-3, GA_x6K02T2PULF-11535078-11536010
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258252
Homologene: 138308
Lilrb4a
Name: leukocyte immunoglobulin-like receptor, subfamily B, member 4A
Synonyms: HM18, Gp49b, ILT3, CD85K, Lilrb4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 14728
VEGA: 10
HGNC: HGNC:6608
Homologene: 86756
Lrfn2
Name: leucine rich repeat and fibronectin type III domain containing 2
Synonyms: SALM1, 5730420O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 70530
Homologene: 19182
4930505A04Rik
Name: RIKEN cDNA 4930505A04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 75087
Homologene: 18988
Krt1
Name: keratin 1
Synonyms: Krt-2.1, Krt2-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 16678
VEGA: 15
HGNC: HGNC:6412
Homologene: 38146
Olfr480
Name: olfactory receptor 480
Synonyms: GA_x6K02T2PBJ9-10395807-10394869, MOR204-32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 56861
Homologene: 72039
Irgm1
Name: immunity-related GTPase family M member 1
Synonyms: LRG-47, Ifi1, Irgm, Iigp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 15944
HGNC: null
Homologene: 134089
Asgr2
Name: asialoglycoprotein receptor 2
Synonyms: Asgr-2, Asgr, ASGPR2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11890
HGNC: HGNC:743
Homologene: 912
Ccdc183
Name: coiled-coil domain containing 183
Synonyms: 4921530D09Rik, Cccd183
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 77058
Homologene: 50023
Tgoln1
Name: trans-golgi network protein
Synonyms: TGN38, D6Ertd384e, Ttgn1, TGN38A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 22134
HGNC: null
Homologene: 137224
Psmc3
Name: proteasome (prosome, macropain) 26S subunit, ATPase 3
Synonyms: Tat binding protein 1, TBP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 19182
HGNC: HGNC:9549
Homologene: 2097
Rptn
Name: repetin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 20129
Homologene: 84780
2300003K06Rik
Name: RIKEN cDNA 2300003K06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 100502865
HGNC: null
Homologene: null
Gpha2
Name: glycoprotein hormone alpha 2
Synonyms: zsig51, GPA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 170458
Homologene: 15605
Gm5741
Name: predicted gene 5741
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 100503710
Homologene: 133234
Spata31d1a
Name: spermatogenesis associated 31 subfamily D, member 1A
Synonyms: 1700013B16Rik, Fam75d1a, Fam75d3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 72219
VEGA: 13
Homologene: 122131
Slc6a16
Name: solute carrier family 6, member 16
Synonyms: LOC381884
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 381884
Homologene: 49366
Crls1
Name: cardiolipin synthase 1
Synonyms: 5730490M08Rik, 0610009I22Rik, 4930557M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 66586
Homologene: 32438
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 2 at 24,401,557 bp
  • C to T, chromosome 2 at 25,610,582 bp
  • G to T, chromosome 2 at 91,054,630 bp
  • T to A, chromosome 2 at 132,849,850 bp
  • G to A, chromosome 2 at 153,987,153 bp
  • T to A, chromosome 3 at 52,345,672 bp
  • C to A, chromosome 3 at 59,325,510 bp
  • C to G, chromosome 3 at 93,398,130 bp
  • T to C, chromosome 3 at 95,681,729 bp
  • T to C, chromosome 3 at 135,243,775 bp
  • C to T, chromosome 4 at 104,731,751 bp
  • A to G, chromosome 4 at 132,502,570 bp
  • T to C, chromosome 5 at 137,812,036 bp
  • A to T, chromosome 6 at 72,616,001 bp
  • A to T, chromosome 7 at 4,394,212 bp
  • A to G, chromosome 7 at 27,878,582 bp
  • G to A, chromosome 7 at 45,261,148 bp
  • T to C, chromosome 7 at 108,066,742 bp
  • A to T, chromosome 7 at 119,859,491 bp
  • T to C, chromosome 7 at 132,143,731 bp
  • A to T, chromosome 8 at 85,067,591 bp
  • T to A, chromosome 8 at 123,305,281 bp
  • T to A, chromosome 9 at 35,136,481 bp
  • T to A, chromosome 10 at 51,491,649 bp
  • A to G, chromosome 10 at 103,215,757 bp
  • A to G, chromosome 10 at 129,857,192 bp
  • A to C, chromosome 11 at 30,454,815 bp
  • T to C, chromosome 11 at 48,866,886 bp
  • T to C, chromosome 11 at 70,098,246 bp
  • T to A, chromosome 11 at 72,855,383 bp
  • A to C, chromosome 11 at 99,838,014 bp
  • T to C, chromosome 12 at 44,283,028 bp
  • T to C, chromosome 12 at 108,361,560 bp
  • T to C, chromosome 12 at 108,514,508 bp
  • T to C, chromosome 13 at 6,565,054 bp
  • T to C, chromosome 13 at 15,725,145 bp
  • T to C, chromosome 13 at 55,313,132 bp
  • T to A, chromosome 13 at 59,706,320 bp
  • C to T, chromosome 13 at 76,118,291 bp
  • T to A, chromosome 14 at 31,050,111 bp
  • G to A, chromosome 14 at 32,342,061 bp
  • T to C, chromosome 14 at 56,668,353 bp
  • T to A, chromosome 14 at 75,337,409 bp
  • A to G, chromosome 14 at 108,912,022 bp
  • GACTAC to GACTACTAC, chromosome 14 at 111,679,816 bp
  • A to T, chromosome 15 at 88,688,355 bp
  • A to T, chromosome 15 at 101,850,267 bp
  • C to A, chromosome 16 at 11,224,542 bp
  • A to T, chromosome 16 at 66,664,395 bp
  • T to A, chromosome 16 at 79,024,378 bp
  • A to G, chromosome 17 at 46,640,062 bp
  • A to G, chromosome 17 at 49,096,351 bp
  • T to C, chromosome 17 at 67,802,987 bp
  • C to A, chromosome 18 at 61,081,939 bp
  • T to A, chromosome 19 at 6,227,112 bp
  • T to C, chromosome 19 at 32,698,628 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6224 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044355-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.