Strain Name:
C57BL/6J-MtgxR6237Btlr
Stock Number:
044362-MU
Citation ID:
RRID:MMRRC_044362-MU
Other Names:
R6237 (G1)
Major Collection:

Gene Information

Mbtps1
Name: membrane-bound transcription factor peptidase, site 1
Synonyms: subtilisin/kexin isozyme-1, SKI-1, S1P, 0610038M03Rik, site-1 protease
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56453
Homologene: 2808
E2f2
Name: E2F transcription factor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242705
HGNC: HGNC:3114
Homologene: 48264
Wnk1
Name: WNK lysine deficient protein kinase 1
Synonyms: 6430573H23Rik, Prkwnk1, EG406236, Hsn2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232341
Homologene: 14253
Srbd1
Name: S1 RNA binding domain 1
Synonyms: D530025C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 78586
VEGA: 17
Homologene: 9994
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: P400, IP3R1, Pcp-1, Itpr-1, Ip3r, opt, InsP3R type I, Pcp1, wblo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Wdr62
Name: WD repeat domain 62
Synonyms: 2310038K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233064
Homologene: 15927
Pnrc2
Name: proline-rich nuclear receptor coactivator 2
Synonyms: 0610011E17Rik, D4Bwg0593e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 52830
Homologene: 9821
Mgat4a
Name: mannoside acetylglucosaminyltransferase 4, isoenzyme A
Synonyms: GnT-IVa, 9530018I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269181
HGNC: HGNC:7047
Homologene: 8153
Galnt5
Name: polypeptide N-acetylgalactosaminyltransferase 5
Synonyms: ppGaNTase-T5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241391
HGNC: HGNC:4127
Homologene: 8733
Osbpl9
Name: oxysterol binding protein-like 9
Synonyms: 2600011I06Rik, ORP-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100273
Homologene: 69380
Sbf1
Name: SET binding factor 1
Synonyms: 2610510A08Rik, Mtmr5, B230113C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 77980
Homologene: 84710
Klk8
Name: kallikrein related-peptidase 8
Synonyms: BSP1, Prss19, Nrpn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259277
HGNC: HGNC:6369
Homologene: 21410
Glipr1l1
Name: GLI pathogenesis-related 1 like 1
Synonyms: 1700011E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 69286
VEGA: 10
Homologene: 83452
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Col4a4
Name: collagen, type IV, alpha 4
Synonyms: [a]4(IV), E130010M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12829
HGNC: HGNC:2206
Homologene: 20071
Kcnab3
Name: potassium voltage-gated channel, shaker-related subfamily, beta member 3
Synonyms: mKv(beta)4, Kcnab4, C330022D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16499
HGNC: HGNC:6230
Homologene: 55844
Slfn4
Name: schlafen 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20558
Homologene: 133236
Kcnu1
Name: potassium channel, subfamily U, member 1
Synonyms: Slo3, Kcnma3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16532
Homologene: 7392
Fer1l6
Name: fer-1-like 6 (C. elegans)
Synonyms: EG631797
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 631797
Homologene: 53396
Cyp2b9
Name: cytochrome P450, family 2, subfamily b, polypeptide 9
Synonyms: Cyp2b, phenobarbitol inducible, type a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13094
Homologene: 74933
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Ppfia2
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Synonyms: E130120L08Rik, Liprin-alpha2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 327814
VEGA: 10
HGNC: HGNC:9246
Homologene: 27953
Plcb1
Name: phospholipase C, beta 1
Synonyms: 3110043I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18795
Homologene: 22876
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: Cchl1a3, fmd, mdg, sj, muscle dysgenesis, Cav1.1, DHPR alpha1s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Ikzf3
Name: IKAROS family zinc finger 3
Synonyms: Aiolos, 5830411O07Rik, Zfpn1a3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22780
Homologene: 8269
Urah
Name: urate (5-hydroxyiso-) hydrolase
Synonyms: 2810420C16Rik, HIU hydrolase, 1190003J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76974
Homologene: 45975
Myo5b
Name: myosin VB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17919
HGNC: HGNC:7603
Homologene: 49481
Zbtb4
Name: zinc finger and BTB domain containing 4
Synonyms: 2310026P19Rik, 9230111I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75580
Homologene: 10846
Mindy2
Name: MINDY lysine 48 deubiquitinase 2
Synonyms: B230380D07Rik, Fam63b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235461
VEGA: 9
Homologene: 101023
Olfr862
Name: olfactory receptor 862
Synonyms: GA_x6K02T2PVTD-13624132-13623212, MOR146-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258555
Homologene: 115540
Faxc
Name: failed axon connections homolog
Synonyms: 6230409E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76132
Homologene: 32781
Gzmc
Name: granzyme C
Synonyms: CCP2, Ctla5, Ctla-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14940
VEGA: 14
Homologene: 105844
Eef1akmt3
Name: EEF1A lysine methyltransferase 3
Synonyms: EG546486, Gm16109, Fam119b, Mettl21b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 100504608
Homologene: 79538
Slc35c2
Name: solute carrier family 35, member C2
Synonyms: D2Wsu58e, CGI-15, Ovcov1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228875
Homologene: 6581
Grk5
Name: G protein-coupled receptor kinase 5
Synonyms: Gprk5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14773
VEGA: 19
HGNC: HGNC:4544
Homologene: 3879
Phf2
Name: PHD finger protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18676
VEGA: 13
HGNC: HGNC:8920
Homologene: 3934
Gbp2
Name: guanylate binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14469
HGNC: HGNC:4183
Homologene: 10289
Hhla1
Name: HERV-H LTR-associating 1
Synonyms: F930104E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 654498
HGNC: HGNC:4904
Homologene: 129987
Hspa1l
Name: heat shock protein 1-like
Synonyms: Msh5, Hsc70t, 70kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15482
HGNC: HGNC:5234
Homologene: 135835
Cr2
Name: complement receptor 2
Synonyms: CD21, CD35, Cr-1, Cr-2, Cr1, C3DR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12902
HGNC: HGNC:2336
Homologene: 55611
Gm4353
Name: predicted gene 4353
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100043313
VEGA: 7
Olfr324
Name: olfactory receptor 324
Synonyms: GA_x6K02T2NKPP-822947-822000, MOR102-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 257892
Homologene: 79395
Hace1
Name: HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
Synonyms: A730034A22Rik, 1700042J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 209462
Homologene: 10807
Adad2
Name: adenosine deaminase domain containing 2
Synonyms: 4930403J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 75773
Homologene: 16392
Mllt11
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11
Synonyms: Af1q
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56772
Homologene: 4964
Cbx8
Name: chromobox 8
Synonyms: polycomb 3, Pc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 30951
Homologene: 32199
Akr1c12
Name: aldo-keto reductase family 1, member C12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 622402
Homologene: 121208
Sephs2
Name: selenophosphate synthetase 2
Synonyms: Ysg3, Sps2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20768
Homologene: 7550
Ccdc87
Name: coiled-coil domain containing 87
Synonyms: 4931419P11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 399599
VEGA: 19
Homologene: 49531
Rpl12
Name: ribosomal protein L12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269261
Homologene: 128047
Igkv4-78
Name: immunoglobulin kappa variable 4-78
Synonyms: Igkv4-78 immunoglobulin light chain variable region
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 545849
Nmrk2
Name: nicotinamide riboside kinase 2
Synonyms: 2310015C21Rik, Itgb1bp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 69564
VEGA: 10
Homologene: 113783
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 37,456,592 bp
  • C to T, chromosome 1 at 82,507,031 bp
  • A to T, chromosome 1 at 136,105,844 bp
  • T to A, chromosome 1 at 195,157,502 bp
  • G to A, chromosome 2 at 32,962,988 bp
  • G to T, chromosome 2 at 58,035,249 bp
  • A to G, chromosome 2 at 135,370,566 bp
  • A to T, chromosome 2 at 165,280,697 bp
  • G to T, chromosome 3 at 95,220,291 bp
  • G to A, chromosome 3 at 142,632,032 bp
  • A to T, chromosome 4 at 21,993,376 bp
  • T to C, chromosome 4 at 109,156,702 bp
  • A to T, chromosome 4 at 135,872,086 bp
  • A to G, chromosome 4 at 136,178,485 bp
  • A to T, chromosome 6 at 69,059,699 bp
  • C to T, chromosome 6 at 108,378,203 bp
  • C to A, chromosome 6 at 119,952,767 bp
  • T to A, chromosome 7 at 26,173,574 bp
  • A to G, chromosome 7 at 30,242,435 bp
  • T to A, chromosome 7 at 43,798,670 bp
  • A to C, chromosome 7 at 116,083,899 bp
  • A to C, chromosome 7 at 120,009,384 bp
  • G to A, chromosome 7 at 127,273,946 bp
  • T to A, chromosome 7 at 140,835,705 bp
  • C to T, chromosome 8 at 25,932,334 bp
  • A to G, chromosome 8 at 119,528,961 bp
  • G to A, chromosome 8 at 119,615,763 bp
  • G to T, chromosome 9 at 19,884,069 bp
  • T to C, chromosome 9 at 70,605,198 bp
  • T to C, chromosome 10 at 45,648,890 bp
  • T to C, chromosome 10 at 81,200,962 bp
  • A to T, chromosome 10 at 106,913,594 bp
  • A to T, chromosome 10 at 112,060,427 bp
  • T to A, chromosome 10 at 127,033,008 bp
  • T to A, chromosome 11 at 58,598,005 bp
  • T to C, chromosome 11 at 69,328,575 bp
  • C to A, chromosome 11 at 69,778,243 bp
  • T to A, chromosome 11 at 83,189,112 bp
  • C to A, chromosome 11 at 98,467,053 bp
  • C to A, chromosome 11 at 119,040,387 bp
  • C to A, chromosome 13 at 4,275,768 bp
  • T to A, chromosome 13 at 48,803,655 bp
  • T to A, chromosome 14 at 56,234,029 bp
  • A to T, chromosome 15 at 58,625,177 bp
  • A to G, chromosome 15 at 58,638,006 bp
  • G to T, chromosome 15 at 65,941,797 bp
  • C to T, chromosome 15 at 89,293,476 bp
  • T to A, chromosome 17 at 30,747,854 bp
  • C to T, chromosome 17 at 34,977,452 bp
  • T to C, chromosome 17 at 85,985,295 bp
  • G to A, chromosome 18 at 74,742,178 bp
  • A to G, chromosome 19 at 4,841,379 bp
  • A to G, chromosome 19 at 61,089,942 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6237 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044362-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.