Strain Name:
C57BL/6J-MtgxR6253Btlr
Stock Number:
044370-MU
Citation ID:
RRID:MMRRC_044370-MU
Other Names:
R6253 (G1)
Major Collection:

Gene Information

Dnm2
Name: dynamin 2
Synonyms: Dyn2, b2b2159Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13430
HGNC: HGNC:2974
Homologene: 90883
Cdh3
Name: cadherin 3
Synonyms: P-cadherin, Pcad, Cadp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12560
HGNC: HGNC:1762
Homologene: 20425
Mtss1
Name: MTSS I-BAR domain containing 1
Synonyms: MIM, D130001D01Rik, 2310003N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 211401
VEGA: 15
Homologene: 8841
Ppp1r13b
Name: protein phosphatase 1, regulatory subunit 13B
Synonyms: ASPP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 21981
VEGA: 12
Homologene: 9090
Aasdh
Name: aminoadipate-semialdehyde dehydrogenase
Synonyms: A230062G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231326
Homologene: 71711
Arpp19
Name: cAMP-regulated phosphoprotein 19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 59046
Homologene: 21318
Uhmk1
Name: U2AF homology motif (UHM) kinase 1
Synonyms: KIS, Kist, OTTMUSG00000021542, C820018A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16589
Homologene: 7801
Kansl1
Name: KAT8 regulatory NSL complex subunit 1
Synonyms: 1700081L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76719
Homologene: 9140
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: TPRD, D16Ium21, 2610202A04Rik, D16Ium21e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 22129
Homologene: 2487
Ddx4
Name: DEAD box helicase 4
Synonyms: mvh / m'vasa, VASA, Mvh, DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13206
VEGA: 13
Homologene: 49227
Zfhx3
Name: zinc finger homeobox 3
Synonyms: WBP9, A230102L03Rik, Atbf1, Sci
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11906
HGNC: HGNC:777
Homologene: 21366
Cog3
Name: component of oligomeric golgi complex 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 338337
VEGA: 14
Homologene: 5854
Cep170
Name: centrosomal protein 170
Synonyms: 4933426L22Rik, A330004A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 545389
Homologene: 22844
Mdn1
Name: midasin AAA ATPase 1
Synonyms: LOC213784, 4833432B22Rik, D4Abb1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100019
Homologene: 39689
Lpin2
Name: lipin 2
Synonyms: 2610511G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 64898
Homologene: 8769
Lrpprc
Name: leucine-rich PPR-motif containing
Synonyms: Lrp130, 3110001K13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72416
Homologene: 32695
Aqr
Name: aquarius
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11834
Homologene: 7629
Pum2
Name: pumilio RNA-binding family member 2
Synonyms: Pumm2, 5730503J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 80913
Homologene: 69183
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 665775
Homologene: 45109
Ern1
Name: endoplasmic reticulum (ER) to nucleus signalling 1
Synonyms: 9030414B18Rik, Ire1p, Ire1alpha, Ire1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 78943
HGNC: HGNC:3449
Homologene: 55580
Rbp4
Name: retinol binding protein 4, plasma
Synonyms: retinol binding protein 4, cellular, Rbp-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 19662
VEGA: 19
HGNC: HGNC:9922
Homologene: 4908
Pwwp3a
Name: PWWP domain containing 3A, DNA repair factor
Synonyms: 9430059D04Rik, Mum1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 68114
Homologene: 11349
Hnrnpa3
Name: heterogeneous nuclear ribonucleoprotein A3
Synonyms: 2410013L13Rik, 2610209F03Rik, 2610510D13Rik, Hnrpa3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 229279
Homologene: 138303
Ice1
Name: interactor of little elongation complex ELL subunit 1
Synonyms: BC018507
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218333
VEGA: 13
Homologene: 18902
Frmd6
Name: FERM domain containing 6
Synonyms: 2610019M19Rik, 4930488L10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319710
VEGA: 12
Homologene: 12449
Znrf3
Name: zinc and ring finger 3
Synonyms: LOC382477
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 407821
Homologene: 46592
Soga1
Name: suppressor of glucose, autophagy associated 1
Synonyms: D430036N24Rik, 9830001H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320706
Homologene: 52382
Prol1
Name: proline rich, lacrimal 1
Synonyms: Muc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17830
Hspa1a
Name: heat shock protein 1A
Synonyms: Hsp70.3, Hsp70-3, Hsp68, Hsp70a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 193740
Homologene: 74294
Abca3
Name: ATP-binding cassette, sub-family A (ABC1), member 3
Synonyms: ABC-C, Abc3, 1810036E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 27410
HGNC: HGNC:33
Homologene: 37437
Cfap46
Name: cilia and flagella associated protein 46
Synonyms: 9330101J02Rik, Ttc40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 212124
Fat2
Name: FAT atypical cadherin 2
Synonyms: LOC245827, mKIAA0811, Fath2, EMI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Myh8
Name: myosin, heavy polypeptide 8, skeletal muscle, perinatal
Synonyms: MyHC-pn, Myhs-p, Myhsp, 4832426G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17885
HGNC: HGNC:7578
Homologene: 68256
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329628
Homologene: 14377
Zfand4
Name: zinc finger, AN1-type domain 4
Synonyms: 2810002D23Rik, Anubl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67492
VEGA: 6
Homologene: 18373
Phactr1
Name: phosphatase and actin regulator 1
Synonyms: Rpel1, 9630030F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218194
Homologene: 33597
Ece2
Name: endothelin converting enzyme 2
Synonyms: 6330509A19Rik, 9630025D12Rik, 1810009K13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 107522
Homologene: 56679
Golgb1
Name: golgi autoantigen, golgin subfamily b, macrogolgin 1
Synonyms: Giantin, C130074L01Rik, F730017E11Rik, 6330407A06Rik, Gm6840
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224139
HGNC: HGNC:4429
Homologene: 68401
Plch2
Name: phospholipase C, eta 2
Synonyms: PLCeta2, A930027K05Rik, Plcl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269615
Homologene: 85172
Myo5c
Name: myosin VC
Synonyms: 9130003O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208943
VEGA: 9
HGNC: HGNC:7604
Homologene: 135711
Myom3
Name: myomesin family, member 3
Synonyms: 8430427K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242702
Homologene: 19432
Serpinb6b
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6b
Synonyms: ovalbumin, Spi12, NK13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20708
HGNC: HGNC:8950
Homologene: 22633
Selenbp1
Name: selenium binding protein 1
Synonyms: Lp56, Lpsb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20341
Homologene: 2930
Acvr2b
Name: activin receptor IIB
Synonyms: ActRIIB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 11481
VEGA: 9
HGNC: HGNC:174
Homologene: 863
Tigd3
Name: tigger transposable element derived 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 332359
VEGA: 19
Homologene: 129795
Decr1
Name: 2,4-dienoyl CoA reductase 1, mitochondrial
Synonyms: Decr, Nadph, 1200012F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67460
HGNC: HGNC:2753
Homologene: 68178
Bpifa5
Name: BPI fold containing family A, member 5
Synonyms: 2310074B19Rik, 2310021H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67135
Homologene: 12087
Olfr17
Name: olfactory receptor 17
Synonyms: P2, MOR263-5, GA_x6K02T2PBJ9-9470146-9471093
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18314
Homologene: 23241
4921504E06Rik
Name: RIKEN cDNA 4921504E06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70909
Homologene: 87049
Zfp697
Name: zinc finger protein 697
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242109
Homologene: 18241
Col23a1
Name: collagen, type XXIII, alpha 1
Synonyms: 2810458L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237759
Homologene: 72101
Gm5431
Name: predicted gene 5431
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 432555
Olfr1336
Name: olfactory receptor 1336
Synonyms: GA_x6K02T2QGBW-3190370-3191314, MOR103-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258917
Homologene: 37007
Zfp935
Name: zinc finger protein 935
Synonyms: 8430426H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 71508
VEGA: 13
Cyp2a22
Name: cytochrome P450, family 2, subfamily a, polypeptide 22
Synonyms: EG233005
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233005
Homologene: 69128
Olfr715b
Name: olfactory receptor 715B
Synonyms: EG384732, Gm10081
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384732
HGNC: HGNC:8244
Homologene: 81541
Rbp2
Name: retinol binding protein 2, cellular
Synonyms: Crbp-2, Rbp-2, CrbpII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19660
HGNC: HGNC:9920
Homologene: 3070
Tigd5
Name: tigger transposable element derived 5
Synonyms: FLJ14926
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105734
Homologene: 129878
Igkv19-93
Name: immunoglobulin kappa chain variable 19-93
Synonyms: Vx38C, Igk-V38
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 692161
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 170,199,880 bp
  • A to T, chromosome 1 at 176,780,394 bp
  • A to G, chromosome 2 at 19,524,118 bp
  • C to G, chromosome 2 at 75,662,570 bp
  • T to C, chromosome 2 at 114,156,277 bp
  • A to G, chromosome 2 at 154,163,500 bp
  • T to C, chromosome 2 at 157,021,419 bp
  • T to A, chromosome 3 at 38,951,356 bp
  • T to C, chromosome 3 at 94,943,846 bp
  • T to G, chromosome 3 at 98,427,539 bp
  • A to T, chromosome 4 at 15,931,179 bp
  • A to G, chromosome 4 at 32,749,593 bp
  • A to T, chromosome 4 at 135,785,892 bp
  • A to G, chromosome 4 at 135,801,003 bp
  • T to A, chromosome 4 at 155,007,101 bp
  • A to G, chromosome 5 at 41,826,538 bp
  • A to G, chromosome 5 at 76,886,258 bp
  • A to G, chromosome 5 at 88,327,877 bp
  • T to A, chromosome 6 at 68,736,339 bp
  • T to C, chromosome 6 at 116,273,614 bp
  • T to C, chromosome 7 at 6,460,548 bp
  • T to A, chromosome 7 at 26,934,232 bp
  • G to A, chromosome 7 at 107,098,257 bp
  • A to T, chromosome 7 at 107,105,938 bp
  • CCTTCTTCT to CCTTCT, chromosome 7 at 139,638,900 bp
  • T to A, chromosome 8 at 106,537,063 bp
  • C to T, chromosome 8 at 108,955,388 bp
  • T to C, chromosome 9 at 21,500,275 bp
  • G to T, chromosome 9 at 75,056,734 bp
  • A to T, chromosome 9 at 75,245,037 bp
  • G to T, chromosome 9 at 98,490,647 bp
  • C to T, chromosome 9 at 119,428,561 bp
  • T to A, chromosome 10 at 80,233,014 bp
  • G to T, chromosome 11 at 5,280,865 bp
  • A to G, chromosome 11 at 48,894,999 bp
  • C to T, chromosome 11 at 51,574,168 bp
  • G to A, chromosome 11 at 55,296,271 bp
  • A to G, chromosome 11 at 67,301,967 bp
  • G to A, chromosome 11 at 104,357,526 bp
  • A to T, chromosome 11 at 106,426,908 bp
  • A to G, chromosome 12 at 8,748,205 bp
  • A to G, chromosome 12 at 70,877,213 bp
  • A to G, chromosome 12 at 111,835,726 bp
  • T to C, chromosome 13 at 32,972,272 bp
  • T to A, chromosome 13 at 43,094,771 bp
  • T to C, chromosome 13 at 62,454,871 bp
  • A to G, chromosome 13 at 70,603,164 bp
  • C to A, chromosome 13 at 112,636,022 bp
  • T to G, chromosome 13 at 112,636,023 bp
  • A to G, chromosome 14 at 75,719,712 bp
  • A to G, chromosome 15 at 58,943,719 bp
  • T to A, chromosome 15 at 75,911,022 bp
  • A to C, chromosome 16 at 20,639,182 bp
  • T to C, chromosome 16 at 36,915,622 bp
  • T to C, chromosome 16 at 94,457,413 bp
  • G to A, chromosome 17 at 24,397,552 bp
  • A to G, chromosome 17 at 34,970,550 bp
  • T to A, chromosome 17 at 71,231,269 bp
  • T to A, chromosome 17 at 84,740,637 bp
  • A to T, chromosome 19 at 5,892,842 bp
  • G to A, chromosome 19 at 38,124,980 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6253 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044370-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.