Strain Name:
C57BL/6J-MtgxR6403Btlr/Mmmh
Stock Number:
044382-MU
Citation ID:
RRID:MMRRC_044382-MU
Other Names:
R6403 (G1)
Major Collection:

Strain Information

Rprd2
Name: regulation of nuclear pre-mRNA domain containing 2
Synonyms: 6720469I21Rik, 2810036A19Rik, 4930535B03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 75137
Homologene: 19997
Enpp2
Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
Synonyms: Autotaxin, Npps2, PD-Ialpha, Pdnp2, ATX
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18606
HGNC: HGNC:3357
Homologene: 4526
Carmil1
Name: capping protein regulator and myosin 1 linker 1
Synonyms: 1110037D04Rik, Lrrc16, Carmil, Lrrc16a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68732
Homologene: 9757
Copb1
Name: coatomer protein complex, subunit beta 1
Synonyms: Copb1, 2610019B04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70349
HGNC: HGNC:2231
Homologene: 5664
Trappc8
Name: trafficking protein particle complex 8
Synonyms: 5033403J15Rik, D030074E01Rik, Trs85
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75964
VEGA: 18
Homologene: 40993
Iars1
Name: isoleucyl-tRNA synthetase 1
Synonyms: E430001P04Rik, 2510016L12Rik, Iars
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105148
HGNC: HGNC:5330
Homologene: 5325
Trit1
Name: tRNA isopentenyltransferase 1
Synonyms: MOD5, 2310075G14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66966
Homologene: 7010
Camsap2
Name: calmodulin regulated spectrin-associated protein family, member 2
Synonyms: 1600013L13Rik, 4930541M15Rik, Camsap1l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67886
Homologene: 18927
Tmem87a
Name: transmembrane protein 87A
Synonyms: A930025J12Rik, Elkin1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 211499
Homologene: 9165
Hexa
Name: hexosaminidase A
Synonyms: Hex-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15211
VEGA: 9
HGNC: HGNC:4878
Homologene: 20146
Ncbp3
Name: nuclear cap binding subunit 3
Synonyms: 1200014J11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66874
Homologene: 10231
Zfp617
Name: zinc finger protein 617
Synonyms: Zfps11-6, Zinc finger protein s11-6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170938
Homologene: 135689
Aars1
Name: alanyl-tRNA synthetase 1
Synonyms: Aars
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234734
HGNC: HGNC:20
Homologene: 1213
Nxn
Name: nucleoredoxin
Synonyms: l11Jus13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18230
Homologene: 69028
Dnajb11
Name: DnaJ heat shock protein family (Hsp40) member B11
Synonyms: Dj9, 1810031F23Rik, ABBP-2, ERdj3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67838
Homologene: 9464
Mb21d2
Name: Mab-21 domain containing 2
Synonyms: 1600021P15Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239796
VEGA: 16
Homologene: 18614
Aox1
Name: aldehyde oxidase 1
Synonyms: retinal oxidase, Aox-1, Aox-2, Aox2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11761
HGNC: HGNC:553
Homologene: 68165
Iqcm
Name: IQ motif containing M
Synonyms: 1700007B14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71831
Homologene: 53050
Ces2b
Name: carboxyesterase 2B
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234669
HGNC: HGNC:1864
Homologene: 135851
Vmn2r114
Name: vomeronasal 2, receptor 114
Synonyms: EG666002
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 666002
Homologene: 86604
Pramel22
Name: PRAME like 22
Synonyms: Gm13088
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 277668
Homologene: 129883
Il3ra
Name: interleukin 3 receptor, alpha chain
Synonyms: IL-3 receptor alpha chain, CD123, SUT-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16188
VEGA: 14
HGNC: HGNC:6012
Homologene: 48088
Or8d2b
Name: olfactory receptor family 8 subfamily D member 2D
Synonyms: GA_x6K02T2PVTD-32573036-32573962, MOR171-8, Olfr926
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258811
VEGA: 9
HGNC: HGNC:8482
Homologene: 128215
Dok5
Name: docking protein 5
Synonyms: 2700055C10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76829
Homologene: 10195
Lca5l
Name: Leber congenital amaurosis 5-like
Synonyms: 4921526F01Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 385668
HGNC: HGNC:1255
Homologene: 47978
Nckipsd
Name: NCK interacting protein with SH3 domain
Synonyms: WISH, SPIN90, AF3P21, ORF1, DIP1, Wasbp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80987
Homologene: 9514
Krt9
Name: keratin 9
Synonyms: K9, Krt1-9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 107656
HGNC: HGNC:6447
Homologene: 138337
Tspan13
Name: tetraspanin 13
Synonyms: 1100001I23Rik, Tm4sf13
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66109
Homologene: 8671
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 58,068,435 bp
  • G to A, chromosome 1 at 136,280,800 bp
  • A to T, chromosome 2 at 120,380,771 bp
  • G to T, chromosome 2 at 170,829,900 bp
  • C to A, chromosome 3 at 95,766,087 bp
  • C to A, chromosome 4 at 123,039,579 bp
  • G to A, chromosome 4 at 143,655,773 bp
  • T to A, chromosome 7 at 114,238,451 bp
  • C to T, chromosome 8 at 71,929,171 bp
  • T to C, chromosome 8 at 75,577,996 bp
  • T to A, chromosome 8 at 104,836,269 bp
  • A to G, chromosome 8 at 111,042,249 bp
  • T to C, chromosome 9 at 38,877,242 bp
  • G to A, chromosome 9 at 59,557,361 bp
  • G to T, chromosome 9 at 108,811,683 bp
  • A to G, chromosome 11 at 73,078,976 bp
  • A to G, chromosome 11 at 76,399,020 bp
  • G to T, chromosome 11 at 100,189,659 bp
  • A to G, chromosome 12 at 36,015,705 bp
  • G to A, chromosome 13 at 24,081,967 bp
  • T to C, chromosome 13 at 49,687,495 bp
  • G to T, chromosome 14 at 14,347,137 bp
  • T to C, chromosome 15 at 54,863,764 bp
  • T to A, chromosome 16 at 22,870,941 bp
  • A to G, chromosome 16 at 28,828,517 bp
  • T to C, chromosome 16 at 96,173,845 bp
  • C to T, chromosome 17 at 23,309,965 bp
  • A to G, chromosome 18 at 20,866,071 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6403 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044382-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.