Strain Name:
C57BL/6J-MtgxR6411Btlr
Stock Number:
044384-MU
Citation ID:
RRID:MMRRC_044384-MU
Other Names:
R6411 (G1)
Major Collection:

Gene Information

Mitf
Name: melanogenesis associated transcription factor
Synonyms: mi, wh, BCC2, bHLHe32, Gsfbcc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17342
HGNC: HGNC:7105
Homologene: 4892
Nbea
Name: neurobeachin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Lmtk2
Name: lemur tyrosine kinase 2
Synonyms: 2900041G10Rik, KPI-2, cprk, KPI2, A330101P12Rik, BREK, AATYK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231876
Homologene: 8948
Myo9b
Name: myosin IXb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17925
HGNC: HGNC:7609
Homologene: 3058
Safb2
Name: scaffold attachment factor B2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224902
Homologene: 35210
Rsrc1
Name: arginine/serine-rich coiled-coil 1
Synonyms: SRrp53, 1200013F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66880
Homologene: 41147
Hgsnat
Name: heparan-alpha-glucosaminide N-acetyltransferase
Synonyms: 9430010M12Rik, Tmem76, D8Ertd354e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 52120
Homologene: 15586
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Naip-rs3, Birc1e, Lgn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Izumo2
Name: IZUMO family member 2
Synonyms: 1700023D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75510
Dennd4a
Name: DENN/MADD domain containing 4A
Synonyms: F730015K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102442
VEGA: 9
Homologene: 55933
Capn7
Name: calpain 7
Synonyms: PalBH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12339
HGNC: HGNC:1484
Homologene: 7651
Guf1
Name: GUF1 homolog, GTPase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231279
Homologene: 6505
Slc8b1
Name: solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
Synonyms: NCKX6, NCLX, Slc24a6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 170756
Homologene: 41602
Rfc4
Name: replication factor C (activator 1) 4
Synonyms: RFC37, A1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 106344
HGNC: HGNC:9972
Homologene: 6288
Olfr1130
Name: olfactory receptor 1130
Synonyms: GA_x6K02T2Q125-49112575-49113519, MOR264-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258835
Homologene: 133705
Sele
Name: selectin, endothelial cell
Synonyms: E-selectin, CD62E, Elam
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20339
Homologene: 389
Oxnad1
Name: oxidoreductase NAD-binding domain containing 1
Synonyms: 2410002F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218885
Homologene: 16303
Olfr328
Name: olfactory receptor 328
Synonyms: GA_x6K02T2NKPP-873285-874217, MOR275-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258495
Homologene: 133015
Olfr1441
Name: olfactory receptor 1441
Synonyms: GA_x6K02T2RE5P-2753221-2754177, MOR215-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258678
Homologene: 17343
Carmil2
Name: capping protein regulator and myosin 1 linker 2
Synonyms: D130029J02Rik, Rltpr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234695
Homologene: 128439
Zfp758
Name: zinc finger protein 758
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224598
Homologene: 138293
Vmn1r88
Name: vomeronasal 1 receptor, 88
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100312474
Homologene: 74345
Rab8b
Name: RAB8B, member RAS oncogene family
Synonyms: Rab8b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235442
VEGA: 9
Homologene: 69220
Olfr449
Name: olfactory receptor 449
Synonyms: GA_x6K02T2P3E9-4722003-4721068, MOR103-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 259067
HGNC: HGNC:8354
Homologene: 17485
Carns1
Name: carnosine synthase 1
Synonyms: Atpgd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107239
VEGA: 19
Homologene: 26439
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 164,049,415 bp
  • G to T, chromosome 2 at 87,607,973 bp
  • A to C, chromosome 3 at 55,805,357 bp
  • C to T, chromosome 3 at 66,994,649 bp
  • T to C, chromosome 5 at 69,560,511 bp
  • T to A, chromosome 5 at 120,521,126 bp
  • A to T, chromosome 5 at 144,174,586 bp
  • A to G, chromosome 6 at 42,838,720 bp
  • T to C, chromosome 6 at 98,010,472 bp
  • A to T, chromosome 7 at 13,178,043 bp
  • A to T, chromosome 7 at 44,719,760 bp
  • C to T, chromosome 8 at 25,946,275 bp
  • T to A, chromosome 8 at 71,322,955 bp
  • G to T, chromosome 8 at 105,697,026 bp
  • A to G, chromosome 9 at 64,871,899 bp
  • A to T, chromosome 9 at 66,854,666 bp
  • T to A, chromosome 11 at 58,551,657 bp
  • A to G, chromosome 13 at 100,223,405 bp
  • A to G, chromosome 14 at 31,340,096 bp
  • C to G, chromosome 14 at 32,091,652 bp
  • T to C, chromosome 16 at 23,114,073 bp
  • A to T, chromosome 17 at 22,375,094 bp
  • A to G, chromosome 17 at 56,571,289 bp
  • G to T, chromosome 19 at 4,166,464 bp
  • G to A, chromosome 19 at 12,422,986 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6411 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044384-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.