Strain Name:
C57BL/6J-MtgxR6445Btlr
Stock Number:
044388-MU
Citation ID:
RRID:MMRRC_044388-MU
Other Names:
R6445 (G1)
Major Collection:

Gene Information

Wdr3
Name: WD repeat domain 3
Synonyms: D030020G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 269470
Homologene: 4937
Zfp451
Name: zinc finger protein 451
Synonyms: Kiaa0576-hp, 4933435G09Rik, 4930515K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98403
Homologene: 9188
Nktr
Name: natural killer tumor recognition sequence
Synonyms: D9Wsu172e, 5330401F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18087
HGNC: HGNC:7833
Homologene: 122148
Pms1
Name: PMS1 homolog 1, mismatch repair system component
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227099
HGNC: HGNC:9121
Homologene: 449
Cntrl
Name: centriolin
Synonyms: IB3/5, 6720467O09Rik, Ma2a8, Cep1, b2b1468Clo, Cep110
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 26920
HGNC: HGNC:1858
Homologene: 38260
Smcr8
Name: Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)
Synonyms: D030073L15Rik, 2310076G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237782
Homologene: 16989
Reln
Name: reelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Efcab6
Name: EF-hand calcium binding domain 6
Synonyms: 4932408N08Rik, 4931407K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 77627
Homologene: 11259
Cyp2b9
Name: cytochrome P450, family 2, subfamily b, polypeptide 9
Synonyms: Cyp2b, phenobarbitol inducible, type a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13094
Homologene: 74933
Pik3r2
Name: phosphoinositide-3-kinase regulatory subunit 2
Synonyms: p85beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18709
HGNC: HGNC:8980
Homologene: 3687
Synm
Name: synemin, intermediate filament protein
Synonyms: 4930412K21Rik, Synemin, Dmn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233335
Homologene: 9081
Krt71
Name: keratin 71
Synonyms: mK6irs, Cu, mK6irs1, Ca, Krt2-6g, Cal4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 56735
Homologene: 88864
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: oxygen-regulated protein 1, Orp1, mG145, Dcdc3, Rp1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19888
Homologene: 4564
Peli2
Name: pellino 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 93834
VEGA: 14
HGNC: HGNC:8828
Homologene: 41431
Gna11
Name: guanine nucleotide binding protein, alpha 11
Synonyms: Dsk7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14672
HGNC: HGNC:4379
Homologene: 20474
Ikzf4
Name: IKAROS family zinc finger 4
Synonyms: Eos, A630026H08Rik, Zfpn1a4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22781
Homologene: 69103
Efcab14
Name: EF-hand calcium binding domain 14
Synonyms: 4732418C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230648
Homologene: 8858
Syt10
Name: synaptotagmin X
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 54526
Homologene: 10303
Sned1
Name: sushi, nidogen and EGF-like domains 1
Synonyms: 6720455I24Rik, Snep, D430044C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208777
Homologene: 14708
Olfr199
Name: olfactory receptor 199
Synonyms: GA_x54KRFPKG5P-55430495-55429569, MOR182-14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 404310
Homologene: 37011
Cdh22
Name: cadherin 22
Synonyms: PB-cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 104010
Homologene: 23148
Mfsd8
Name: major facilitator superfamily domain containing 8
Synonyms: 2810423E13Rik, Cln7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72175
Homologene: 115814
BC061237
Name: cDNA sequence BC061237
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 385138
Homologene: 128452
Il9r
Name: interleukin 9 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16199
HGNC: HGNC:6030
Homologene: 37591
Gm36864
Name: predicted gene, 36864
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 102640913
Homologene: 141046
Olfr562-ps1
Name: olfactory receptor 562, pseudogene 1
Synonyms: GA_x6K02T2PBJ9-5498153-5499103, MOR14-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259090
Gm3055
Name: predicted gene 3055
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 100040944
VEGA: 10
Homologene: 137344
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 4,226,617 bp
  • A to C, chromosome 1 at 33,773,011 bp
  • A to T, chromosome 1 at 53,192,194 bp
  • A to T, chromosome 1 at 93,283,596 bp
  • A to G, chromosome 2 at 35,162,848 bp
  • T to C, chromosome 2 at 76,914,536 bp
  • T to C, chromosome 2 at 165,170,692 bp
  • T to C, chromosome 3 at 40,837,118 bp
  • T to C, chromosome 3 at 100,156,403 bp
  • C to A, chromosome 4 at 115,756,471 bp
  • T to C, chromosome 5 at 21,919,214 bp
  • A to G, chromosome 7 at 26,186,987 bp
  • A to T, chromosome 7 at 44,237,418 bp
  • A to G, chromosome 7 at 67,733,645 bp
  • T to C, chromosome 7 at 102,782,258 bp
  • C to T, chromosome 8 at 70,772,026 bp
  • G to T, chromosome 9 at 121,748,414 bp
  • A to T, chromosome 10 at 81,533,333 bp
  • T to A, chromosome 10 at 82,109,672 bp
  • C to A, chromosome 10 at 128,636,555 bp
  • C to T, chromosome 11 at 32,191,000 bp
  • T to C, chromosome 11 at 60,779,015 bp
  • C to A, chromosome 14 at 44,501,274 bp
  • T to C, chromosome 14 at 48,256,448 bp
  • T to C, chromosome 15 at 83,868,357 bp
  • G to A, chromosome 15 at 89,814,268 bp
  • C to T, chromosome 15 at 101,740,340 bp
  • A to T, chromosome 16 at 59,216,109 bp
  • T to C, chromosome 18 at 3,309,671 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
(Deceased) Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6445 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044388-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.