Strain Name:
C57BL/6J-MtgxR6086Btlr/Mmmh
Stock Number:
044427-MU
Citation ID:
RRID:MMRRC_044427-MU
Other Names:
R6086 (G1)
Major Collection:

Strain Information

Sema3b
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
Synonyms: LUCA-1, SemA, sema5, SemA, semaV, Semaa
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20347
Homologene: 20972
Gabrg1
Name: gamma-aminobutyric acid type A receptor subunit gamma 1
Synonyms: GabaA
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14405
HGNC: HGNC:4086
Homologene: 22570
Htr3b
Name: 5-hydroxytryptamine (serotonin) receptor 3B
Synonyms: 5-HT3 receptor subunit B, 5-HT3B
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57014
VEGA: 9
HGNC: HGNC:5298
Homologene: 38131
Crlf3
Name: cytokine receptor-like factor 3
Synonyms: Creme9, cytor4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54394
Homologene: 9327
Cdyl2
Name: chromodomain protein, Y chromosome-like 2
Synonyms: 1700029M19Rik, 4930453I21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75796
Homologene: 41779
Enpp2
Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
Synonyms: Pdnp2, PD-Ialpha, ATX, Npps2, Autotaxin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18606
HGNC: HGNC:3357
Homologene: 4526
Zranb2
Name: zinc finger, RAN-binding domain containing 2
Synonyms: Znf265, Zis, Zfp265
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53861
Washc2
Name: WASH complex subunit 2
Synonyms: C530005J20Rik, D6Wsu116e, Fam21
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28006
Homologene: 41686
Recql4
Name: RecQ protein-like 4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 79456
VEGA: 15
HGNC: HGNC:9949
Homologene: 3144
Knl1
Name: kinetochore scaffold 1
Synonyms: 2310043D08Rik, Casc5, 5730505K17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76464
Homologene: 44890
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: D3Bwg1534e, Ten-m2, 9330187F13Rik, Odz2, 2610040L17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23964
Homologene: 22672
Bora
Name: bora, aurora kinase A activator
Synonyms: 6720463M24Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 77744
VEGA: 14
Homologene: 11728
Tsen2
Name: tRNA splicing endonuclease subunit 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381802
Homologene: 41622
Klf10
Name: Kruppel-like transcription factor 10
Synonyms: Gdnfif, Egral, Tieg1, mGIF
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21847
VEGA: 15
Homologene: 4135
Myo9a
Name: myosin IXa
Synonyms: 4732465J09Rik, C130068I12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270163
HGNC: HGNC:7608
Homologene: 21371
Sema4d
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Synonyms: CD100, M-sema G, Semcl2, Semaj, Semacl2, coll-4, semaphorin H
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20354
Homologene: 21282
Psmg1
Name: proteasome (prosome, macropain) assembly chaperone 1
Synonyms: Dscr2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 56088
HGNC: HGNC:3043
Homologene: 2759
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Furin
Name: furin, paired basic amino acid cleaving enzyme
Synonyms: PACE, Fur, SPC1, 9130404I01Rik, Pcsk3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18550
HGNC: HGNC:8568
Homologene: 1930
Hnrnpdl
Name: heterogeneous nuclear ribonucleoprotein D-like
Synonyms: D5Ertd650e, JKTBP, D5Wsu145e, hnRNP-DL, Hnrpdl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50926
HGNC: HGNC:5037
Homologene: 75314
Tmod3
Name: tropomodulin 3
Synonyms: U-Tmod, UTMOD, ubiquitous tropomodulin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 50875
VEGA: 9
Homologene: 8727
Bcl9
Name: B cell CLL/lymphoma 9
Synonyms: 2610202E01Rik, 8030475K17Rik, A330041G23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77578
HGNC: HGNC:1008
Homologene: 3191
Ncapg
Name: non-SMC condensin I complex, subunit G
Synonyms: Hcapg, MFT.M05.13, 5730507H05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54392
Homologene: 44071
Piezo1
Name: piezo-type mechanosensitive ion channel component 1
Synonyms: Fam38a, Piezo1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234839
Homologene: 124356
Asic4
Name: acid-sensing ion channel family member 4
Synonyms: Accn4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241118
Homologene: 11166
Fgd3
Name: FYVE, RhoGEF and PH domain containing 3
Synonyms: ZFYVE5, 5830461L01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 30938
Homologene: 22925
Dnajc6
Name: DnaJ heat shock protein family (Hsp40) member C6
Synonyms: auxilin, 2810027M23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72685
Homologene: 8865
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: 2900022L05Rik, Dnhd3, Dnahc2, D330014H01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Oc90
Name: otoconin 90
Synonyms: Pla2ll, Ocn-95, PLA2L
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18256
HGNC: HGNC:8100
Homologene: 19021
Rab11fip4
Name: RAB11 family interacting protein 4 (class II)
Synonyms: A730072L08Rik, RAB11-FIP4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268451
Homologene: 8803
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: Dnahc9, D11Ertd686e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Tnn
Name: tenascin N
Synonyms: Tnw, tenascin-W
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329278
Homologene: 18634
Gm10801
Name: predicted gene 10801
Type: Gene
Species: Mouse
Chromosome: 2
Vmn2r26
Name: vomeronasal 2, receptor 26
Synonyms: V2r1b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56552
Homologene: 135915
Or5b105
Name: olfactory receptor family 5 subfamily B member 105
Synonyms: GA_x6K02T2RE5P-3430689-3429787, Olfr1458, EG667271, MOR202-24
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 667271
HGNC: HGNC:8324
Urah
Name: urate (5-hydroxyiso-) hydrolase
Synonyms: HIU hydrolase, 2810420C16Rik, 1190003J15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76974
Homologene: 45975
Slco3a1
Name: solute carrier organic anion transporter family, member 3a1
Synonyms: Slc21a11, 5830414C08Rik, MJAM, Anr1, OATP-D
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108116
Homologene: 40862
Myt1l
Name: myelin transcription factor 1-like
Synonyms: 2900093J19Rik, C630034G21Rik, Nztf1, Pmng1, 2900046C06Rik, Png-1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 17933
VEGA: 12
HGNC: HGNC:7623
Homologene: 7435
Cap2
Name: cyclase associated actin cytoskeleton regulatory protein 2
Synonyms: 2810452G09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67252
Homologene: 101397
Dnm3
Name: dynamin 3
Synonyms: 9630020E24Rik, B230343F03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 103967
Homologene: 22906
Pbk
Name: PDZ binding kinase
Synonyms: 2810434B10Rik, D14Ertd732e, TOPK
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 52033
Homologene: 32415
Rnpepl1
Name: arginyl aminopeptidase (aminopeptidase B)-like 1
Synonyms: 1110014H17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108657
Homologene: 36367
Vmn2r27
Name: vomeronasal 2, receptor27
Synonyms: EG232367
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232367
Spmap2l
Name: sperm microtubule associated protein 2 like
Synonyms: 1700023E05Rik, Thegl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71868
Homologene: 128474
Fah
Name: fumarylacetoacetate hydrolase
Synonyms: swst
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14085
HGNC: HGNC:3579
Homologene: 110
Cimap2
Name: ciliary microtubule associated protein 2
Synonyms: BC055111, Lexm
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242602
Homologene: 17630
Hspa1l
Name: heat shock protein 1-like
Synonyms: 70kDa, Msh5, Hsc70t
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15482
HGNC: HGNC:5234
Homologene: 135835
Zfp955b
Name: zinc finger protein 955B
Synonyms: C430039G02Rik, Gm4455, A430003O12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100043468
VEGA: 17
Homologene: 104925
Tmem40
Name: transmembrane protein 40
Synonyms: 9030407H20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 94346
Homologene: 10124
Gpcpd1
Name: glycerophosphocholine phosphodiesterase 1
Synonyms: 2310004G06Rik, 2310032D16Rik, Prei4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74182
Homologene: 10478
Nfxl1
Name: nuclear transcription factor, X-box binding-like 1
Synonyms: D430033A06Rik, LOC381696, TCF9, 1700012H24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100978
Homologene: 26752
Gm9742
Name: predicted gene 9742
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 791083
VEGA: 13
Trgc3
Name: T cell receptor gamma, constant 3
Synonyms: Gm17356, Tcrg-C3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 107575
Or4c123
Name: olfactory receptor family 4 subfamily C member 123
Synonyms: MOR237-1, GA_x6K02T2Q125-50741934-50741017, Olfr1230
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258785
Homologene: 81570
Scnm1
Name: sodium channel modifier 1
Synonyms: 3110001I17Rik, Scnm1-ps
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69269
Homologene: 11431
Ces1a
Name: carboxylesterase 1A
Synonyms: Gm4976
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244595
HGNC: HGNC:1863
Homologene: 134142
Atf4
Name: activating transcription factor 4
Synonyms: C/ATF, CREB2, Atf-4, TAXREB67
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11911
VEGA: 15
HGNC: HGNC:786
Homologene: 1266
Tpmt
Name: thiopurine methyltransferase
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 22017
Homologene: 313
Cybb
Name: cytochrome b-245, beta polypeptide
Synonyms: Nox2, gp91phox, gp91phox, Cgd
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 13058
HGNC: HGNC:2578
Homologene: 68054
Klk1b3
Name: kallikrein 1-related peptidase b3
Synonyms: Ngfg, mGk-3, Ngfg
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18050
Homologene: 68141
Ntaq1
Name: N-terminal glutamine amidase 1
Synonyms: 2410187C16Rik, Wdyhv1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76773
VEGA: 15
Homologene: 9968
Reep5
Name: receptor accessory protein 5
Synonyms: Dp1, TB2/DP1, DP1/TB2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13476
VEGA: 18
Homologene: 68479
Cyren
Name: cell cycle regulator of NHEJ
Synonyms: 3110062M04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 78412
Homologene: 49745
Fam220a
Name: family with sequence similarity 220, member A
Synonyms: 1500026F15Rik, 2810453I06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67238
Homologene: 57041
Trib1
Name: tribbles pseudokinase 1
Synonyms: Trb1, A530090O15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 211770
Homologene: 75216
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 75,473,243 bp
  • T to C, chromosome 1 at 92,917,681 bp
  • C to T, chromosome 1 at 160,086,120 bp
  • C to A, chromosome 1 at 162,321,033 bp
  • A to G, chromosome 2 at 89,296,854 bp
  • AAGT to AAGTAGT, chromosome 2 at 98,663,803 bp
  • A to G, chromosome 2 at 119,094,068 bp
  • A to G, chromosome 2 at 132,538,114 bp
  • T to C, chromosome 3 at 95,130,285 bp
  • A to G, chromosome 3 at 97,205,524 bp
  • T to C, chromosome 3 at 157,543,246 bp
  • C to T, chromosome 4 at 101,597,807 bp
  • T to C, chromosome 4 at 106,613,206 bp
  • T to C, chromosome 5 at 45,693,236 bp
  • A to T, chromosome 5 at 70,754,053 bp
  • A to C, chromosome 5 at 72,541,019 bp
  • T to A, chromosome 5 at 77,061,305 bp
  • C to T, chromosome 5 at 100,036,481 bp
  • T to A, chromosome 5 at 143,563,041 bp
  • A to G, chromosome 6 at 34,874,620 bp
  • A to G, chromosome 6 at 115,560,075 bp
  • G to T, chromosome 6 at 115,733,667 bp
  • A to G, chromosome 6 at 116,256,216 bp
  • T to A, chromosome 6 at 124,039,560 bp
  • G to C, chromosome 6 at 124,191,999 bp
  • T to A, chromosome 7 at 44,201,734 bp
  • G to A, chromosome 7 at 74,318,590 bp
  • G to T, chromosome 7 at 80,395,431 bp
  • A to T, chromosome 7 at 84,588,912 bp
  • A to G, chromosome 7 at 140,836,798 bp
  • T to G, chromosome 8 at 93,027,353 bp
  • A to G, chromosome 8 at 116,589,296 bp
  • A to G, chromosome 8 at 122,501,657 bp
  • T to C, chromosome 9 at 48,947,298 bp
  • C to T, chromosome 9 at 59,790,057 bp
  • T to C, chromosome 9 at 75,500,123 bp
  • T to C, chromosome 9 at 107,600,848 bp
  • T to A, chromosome 11 at 36,008,646 bp
  • C to T, chromosome 11 at 65,989,915 bp
  • A to C, chromosome 11 at 66,085,174 bp
  • T to C, chromosome 11 at 69,516,008 bp
  • G to A, chromosome 11 at 79,683,480 bp
  • C to T, chromosome 11 at 80,048,610 bp
  • G to T, chromosome 12 at 8,015,164 bp
  • G to A, chromosome 12 at 29,832,332 bp
  • T to C, chromosome 13 at 8,030,033 bp
  • T to C, chromosome 13 at 19,263,284 bp
  • C to A, chromosome 13 at 46,635,712 bp
  • T to A, chromosome 13 at 47,035,030 bp
  • T to A, chromosome 13 at 49,287,296 bp
  • C to T, chromosome 13 at 51,713,745 bp
  • A to T, chromosome 14 at 65,815,253 bp
  • A to T, chromosome 14 at 99,062,294 bp
  • G to T, chromosome 15 at 38,296,937 bp
  • T to C, chromosome 15 at 54,845,834 bp
  • C to A, chromosome 15 at 58,150,628 bp
  • G to A, chromosome 15 at 59,654,475 bp
  • A to G, chromosome 15 at 65,889,711 bp
  • T to C, chromosome 15 at 76,704,587 bp
  • T to A, chromosome 15 at 80,257,453 bp
  • T to A, chromosome 16 at 95,980,044 bp
  • T to A, chromosome 17 at 33,302,504 bp
  • T to C, chromosome 17 at 34,978,155 bp
  • A to C, chromosome 18 at 34,357,131 bp
  • A to G, chromosome 19 at 13,102,381 bp
  • C to G, chromosome X at 9,450,750 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6086 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044427-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.