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Strain Name:
C57BL/6J-MtgxR6170Btlr/Mmmh
Stock Number:
044431-MU
Citation ID:
RRID:MMRRC_044431-MU
Other Names:
R6170 (G1)
Major Collection:

Strain Information

Cdh11
Name: cadherin 11
Synonyms: osteoblast-cadherin, OB-cadherin, Cad11
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12552
HGNC: HGNC:1750
Homologene: 1361
Bpifb3
Name: BPI fold containing family B, member 3
Synonyms: Rya3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 378700
Homologene: 18807
Nrg1
Name: neuregulin 1
Synonyms: HGL, HRG, Hgl, SMDF, GGF, ARIA, heregulin, D230005F13Rik, HRGalpha, 6030402G23Rik, GGFII, NDF
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 211323
HGNC: HGNC:7997
Homologene: 138451
Sipa1l1
Name: signal-induced proliferation-associated 1 like 1
Synonyms: 4931426N11Rik, Spar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217692
VEGA: 12
Homologene: 9189
Dmtn
Name: dematin actin binding protein
Synonyms: dematin, Epb4.9
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13829
VEGA: 14
HGNC: HGNC:3382
Homologene: 1496
Ireb2
Name: iron responsive element binding protein 2
Synonyms: Irp2, D9Ertd85e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 64602
VEGA: 9
HGNC: HGNC:6115
Homologene: 11280
Zfp532
Name: zinc finger protein 532
Synonyms: C530030I18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 328977
Homologene: 138627
Adgrl2
Name: adhesion G protein-coupled receptor L2
Synonyms: Lphh1, Lec1, Lphn2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99633
Homologene: 22712
Anln
Name: anillin, actin binding protein
Synonyms: 1110037A17Rik, Scraps, 2900037I21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68743
VEGA: 9
Homologene: 41281
Wdr1
Name: WD repeat domain 1
Synonyms: D5Wsu185e, Aip1, rede
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22388
Homologene: 6628
Slc30a7
Name: solute carrier family 30 (zinc transporter), member 7
Synonyms: ZnT7, 1810059J10Rik, ZnT-7, 4833428C12Rik, 2610034N15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66500
Homologene: 11332
Atp9b
Name: ATPase, class II, type 9B
Synonyms: IIb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 50771
VEGA: 18
Homologene: 21915
Sfxn1
Name: sideroflexin 1
Synonyms: 2810002O05Rik, A930015P12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14057
VEGA: 13
Homologene: 41494
Fzd7
Name: frizzled class receptor 7
Synonyms: Fz7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14369
HGNC: HGNC:4045
Homologene: 20751
Gm4924
Name: predicted gene 4924
Synonyms: mIF1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237412
Cemip
Name: cell migration inducing protein, hyaluronan binding
Synonyms: 12H19.01.T7, 6330404C01Rik, 9930013L23Rik, Hybid
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80982
Homologene: 10268
D16Ertd472e
Name: DNA segment, Chr 16, ERATO Doi 472, expressed
Synonyms: 2310009O17Rik, E330003K22Rik, 1700010I10Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67102
Homologene: 9696
Ddah1
Name: dimethylarginine dimethylaminohydrolase 1
Synonyms: 2410006N07Rik, 2510015N06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69219
HGNC: HGNC:2715
Homologene: 8120
Crtc2
Name: CREB regulated transcription coactivator 2
Synonyms: 4632407F12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74343
Homologene: 18765
Emc1
Name: ER membrane protein complex subunit 1
Synonyms: C230096C10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230866
Homologene: 9002
Ppp1r13l
Name: protein phosphatase 1, regulatory subunit 13 like
Synonyms: NFkB interacting protein 1, wa3, IASPP
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 333654
Homologene: 84635
Zbtb44
Name: zinc finger and BTB domain containing 44
Synonyms: 6030404E16Rik, Btbd15
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235132
VEGA: 9
Homologene: 18221
Me2
Name: malic enzyme 2, NAD(+)-dependent, mitochondrial
Synonyms: D030040L20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 107029
VEGA: 18
HGNC: HGNC:6984
Homologene: 37615
Ebf1
Name: early B cell factor 1
Synonyms: Olf-1, O/E-1, Olf1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13591
HGNC: HGNC:3126
Homologene: 7297
Plagl1
Name: pleiomorphic adenoma gene-like 1
Synonyms: Zac1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22634
HGNC: HGNC:9046
Homologene: 31401
Fbxo33
Name: F-box protein 33
Synonyms: 5730501N20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70611
Homologene: 16501
Prlr
Name: prolactin receptor
Synonyms: Pr-1, Prlr-rs1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19116
HGNC: HGNC:9446
Homologene: 733
Gdpd3
Name: glycerophosphodiester phosphodiesterase domain containing 3
Synonyms: 1110015E22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68616
Homologene: 23441
Cacna2d2
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 2
Synonyms: a2d2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56808
HGNC: HGNC:1400
Homologene: 4400
Naxe
Name: NAD(P)HX epimerase
Synonyms: ESTM37, APOA1BP, AI-BP, Apoa1bp
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 246703
Homologene: 70948
Colgalt1
Name: collagen beta(1-O)galactosyltransferase 1
Synonyms: 2810024B22Rik, Glt25d1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234407
Homologene: 23465
Nlrp1b
Name: NLR family, pyrin domain containing 1B
Synonyms: Nalp1b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 637515
Homologene: 19080
Col7a1
Name: collagen, type VII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12836
HGNC: HGNC:2214
Homologene: 73
Vwa7
Name: von Willebrand factor A domain containing 7
Synonyms: G7c, D17H6S56E-3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27762
Homologene: 11895
Cdcp3
Name: CUB domain containing protein 3
Synonyms: 5430419D17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71395
Homologene: 138430
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Btnl6
Name: butyrophilin-like 6
Synonyms: NG13, Gm6519
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 624681
Homologene: 106849
Fhad1
Name: forkhead-associated phosphopeptide binding domain 1
Synonyms: 2900090M10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329977
Homologene: 77947
Serpina12
Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
Synonyms: vaspin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68054
Homologene: 23588
Wdr31
Name: WD repeat domain 31
Synonyms: 5430402I10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71354
Homologene: 11360
Cyp2b19
Name: cytochrome P450, family 2, subfamily b, polypeptide 19
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13090
HGNC: HGNC:2615
Homologene: 104114
Tmem150a
Name: transmembrane protein 150A
Synonyms: Tmem150
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232086
Homologene: 16378
Stox2
Name: storkhead box 2
Synonyms: 4933409N07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71069
Homologene: 18414
Trp63
Name: transformation related protein 63
Synonyms: KET protein, p63, p73L, Trp53rp1, TAp63, p51/p63, deltaNp63
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22061
Homologene: 31189
Cyp4a12a
Name: cytochrome P450, family 4, subfamily a, polypeptide 12a
Synonyms: Cyp4a12
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 277753
Homologene: 134044
Nlrp10
Name: NLR family, pyrin domain containing 10
Synonyms: 6430548I20Rik, Pynod, Nalp10
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244202
Homologene: 18468
Vmn2r74
Name: vomeronasal 2, receptor 74
Synonyms: EG546980
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546980
Homologene: 115466
Dsg1a
Name: desmoglein 1 alpha
Synonyms: Dsg1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13510
HGNC: HGNC:3048
Homologene: 1463
Tmem210
Name: transmembrane protein 210
Synonyms: 4930571C24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78217
Homologene: 90047
Spata31f1a
Name: spermatogenesis associated 31 subfamily F member 1A
Synonyms: Gm12429, Fam205a1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433698
Homologene: 79022
Vmn2r60
Name: vomeronasal 2, receptor 60
Synonyms: Casr-rs3, EG637898, Gprc2a-rs3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637898
Homologene: 129683
Cab39
Name: calcium binding protein 39
Synonyms: 39kDa, MO25alpha
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12283
Homologene: 69212
Zfp955b
Name: zinc finger protein 955B
Synonyms: C430039G02Rik, A430003O12Rik, Gm4455
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100043468
VEGA: 17
Homologene: 104925
Fbxw5
Name: F-box and WD-40 domain protein 5
Synonyms: Fbw5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 30839
Homologene: 8496
Glt28d2
Name: glycosyltransferase 28 domain containing 2
Synonyms: 4732486J07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320302
Homologene: 44843
Nxpe4
Name: neurexophilin and PC-esterase domain family, member 4
Synonyms: D930028F11Rik, Fam55d
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244853
VEGA: 9
Homologene: 83471
Akr1e1
Name: aldo-keto reductase family 1, member E1
Synonyms: 1810061I10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56043
Homologene: 74313
Lpcat2b
Name: lysophosphatidylcholine acyltransferase 2B
Synonyms: 4921521K07Rik, Aytl1b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70902
Homologene: 86793
Prl2c2
Name: prolactin family 2, subfamily c, member 2
Synonyms: MRP-1, PLF-1, Plf, Plf1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18811
VEGA: 13
Homologene: 40763
Gpr150
Name: G protein-coupled receptor 150
Synonyms: PGR11, C030001A19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238725
Homologene: 18457
Poglut3
Name: protein O-glucosyltransferase 3
Synonyms: 4833410J10Rik, 2010004J24Rik, Kdelc2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68304
VEGA: 9
Homologene: 17805
Ppargc1a
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Synonyms: Pgc1, PPAR Gamma Coactivator-1, Pgco1, Pgc-1alpha, Pgc-1alphaa, A830037N07Rik, Gm11133
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19017
HGNC: HGNC:9237
Homologene: 7485
4930523C07Rik
Name: RIKEN cDNA 4930523C07 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67647
Homologene: 124386
Tor3a
Name: torsin family 3, member A
Synonyms: Adir
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 30935
Homologene: 23359
0610030E20Rik
Name: RIKEN cDNA 0610030E20 gene
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68364
Homologene: 19243
Lrrc78
Name: leucine rich repeat containing 78
Synonyms: Gm28729
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102635744
Homologene: 139355
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 59,483,845 bp
  • T to A, chromosome 1 at 85,818,455 bp
  • T to C, chromosome 1 at 156,656,573 bp
  • C to A, chromosome 1 at 160,075,173 bp
  • G to A, chromosome 2 at 25,288,764 bp
  • A to G, chromosome 2 at 25,503,603 bp
  • A to G, chromosome 2 at 111,227,948 bp
  • T to C, chromosome 2 at 138,278,942 bp
  • T to A, chromosome 2 at 153,919,637 bp
  • G to A, chromosome 2 at 176,811,144 bp
  • T to G, chromosome 3 at 85,871,941 bp
  • T to C, chromosome 3 at 88,058,230 bp
  • A to G, chromosome 3 at 90,259,600 bp
  • A to G, chromosome 3 at 115,990,743 bp
  • A to G, chromosome 3 at 145,891,506 bp
  • A to G, chromosome 3 at 148,823,009 bp
  • A to G, chromosome 4 at 42,849,345 bp
  • A to G, chromosome 4 at 62,463,424 bp
  • A to C, chromosome 4 at 115,327,446 bp
  • A to G, chromosome 4 at 139,366,378 bp
  • T to A, chromosome 4 at 141,890,952 bp
  • T to C, chromosome 5 at 38,529,671 bp
  • C to A, chromosome 5 at 51,473,911 bp
  • A to T, chromosome 5 at 107,433,894 bp
  • T to A, chromosome 6 at 72,348,572 bp
  • G to A, chromosome 6 at 72,356,745 bp
  • A to G, chromosome 7 at 19,370,437 bp
  • T to G, chromosome 7 at 26,759,094 bp
  • A to G, chromosome 7 at 42,135,621 bp
  • T to G, chromosome 7 at 83,947,230 bp
  • T to C, chromosome 7 at 85,957,140 bp
  • T to A, chromosome 7 at 108,924,464 bp
  • T to C, chromosome 7 at 126,771,164 bp
  • A to T, chromosome 7 at 131,174,487 bp
  • A to G, chromosome 8 at 31,818,480 bp
  • T to A, chromosome 8 at 47,192,020 bp
  • C to T, chromosome 8 at 71,621,870 bp
  • A to G, chromosome 8 at 102,634,810 bp
  • A to T, chromosome 8 at 109,623,179 bp
  • T to C, chromosome 9 at 22,368,497 bp
  • T to A, chromosome 9 at 31,053,382 bp
  • C to T, chromosome 9 at 48,392,804 bp
  • T to C, chromosome 9 at 53,399,742 bp
  • G to A, chromosome 9 at 54,887,372 bp
  • A to G, chromosome 9 at 96,519,441 bp
  • A to G, chromosome 9 at 107,527,334 bp
  • C to A, chromosome 9 at 108,966,443 bp
  • T to C, chromosome 10 at 13,127,231 bp
  • C to T, chromosome 10 at 82,377,231 bp
  • T to A, chromosome 11 at 44,883,885 bp
  • T to A, chromosome 11 at 71,156,079 bp
  • T to C, chromosome 12 at 59,204,649 bp
  • A to G, chromosome 12 at 82,341,672 bp
  • T to C, chromosome 12 at 104,038,241 bp
  • T to C, chromosome 13 at 4,602,724 bp
  • T to A, chromosome 13 at 13,002,172 bp
  • T to G, chromosome 13 at 54,106,507 bp
  • T to C, chromosome 13 at 76,056,557 bp
  • T to C, chromosome 14 at 70,617,355 bp
  • T to C, chromosome 15 at 10,328,849 bp
  • A to C, chromosome 16 at 25,884,853 bp
  • A to G, chromosome 16 at 37,045,812 bp
  • T to C, chromosome 16 at 78,545,267 bp
  • G to T, chromosome 17 at 33,302,110 bp
  • T to A, chromosome 17 at 34,515,506 bp
  • C to A, chromosome 17 at 35,021,210 bp
  • A to T, chromosome 18 at 20,335,986 bp
  • T to A, chromosome 18 at 65,624,438 bp
  • T to C, chromosome 18 at 73,785,781 bp
  • T to A, chromosome 18 at 80,877,347 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6170 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044431-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.