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Strain Name:
C57BL/6J-MtgxR6170Btlr/Mmmh
Stock Number:
044431-MU
Citation ID:
RRID:MMRRC_044431-MU
Other Names:
R6170 (G1)
Major Collection:

Strain Information

Cdh11
Name: cadherin 11
Synonyms: osteoblast-cadherin, OB-cadherin, Cad11
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12552
HGNC: HGNC:1750
Homologene: 1361
Bpifb3
Name: BPI fold containing family B, member 3
Synonyms: Rya3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 378700
Homologene: 18807
Nrg1
Name: neuregulin 1
Synonyms: HGL, HRG, Hgl, SMDF, GGF, ARIA, heregulin, D230005F13Rik, HRGalpha, 6030402G23Rik, GGFII, NDF
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 211323
HGNC: HGNC:7997
Homologene: 138451
Sipa1l1
Name: signal-induced proliferation-associated 1 like 1
Synonyms: 4931426N11Rik, Spar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217692
VEGA: 12
Homologene: 9189
Dmtn
Name: dematin actin binding protein
Synonyms: dematin, Epb4.9
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13829
VEGA: 14
HGNC: HGNC:3382
Homologene: 1496
Ireb2
Name: iron responsive element binding protein 2
Synonyms: Irp2, D9Ertd85e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 64602
VEGA: 9
HGNC: HGNC:6115
Homologene: 11280
Zfp532
Name: zinc finger protein 532
Synonyms: C530030I18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 328977
Homologene: 138627
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 59,483,845 bp
  • T to A, chromosome 1 at 85,818,455 bp
  • T to C, chromosome 1 at 156,656,573 bp
  • C to A, chromosome 1 at 160,075,173 bp
  • G to A, chromosome 2 at 25,288,764 bp
  • A to G, chromosome 2 at 25,503,603 bp
  • A to G, chromosome 2 at 111,227,948 bp
  • T to C, chromosome 2 at 138,278,942 bp
  • T to A, chromosome 2 at 153,919,637 bp
  • G to A, chromosome 2 at 176,811,144 bp
  • T to G, chromosome 3 at 85,871,941 bp
  • T to C, chromosome 3 at 88,058,230 bp
  • A to G, chromosome 3 at 90,259,600 bp
  • A to G, chromosome 3 at 115,990,743 bp
  • A to G, chromosome 3 at 145,891,506 bp
  • A to G, chromosome 3 at 148,823,009 bp
  • A to G, chromosome 4 at 42,849,345 bp
  • A to G, chromosome 4 at 62,463,424 bp
  • A to C, chromosome 4 at 115,327,446 bp
  • A to G, chromosome 4 at 139,366,378 bp
  • T to A, chromosome 4 at 141,890,952 bp
  • T to C, chromosome 5 at 38,529,671 bp
  • C to A, chromosome 5 at 51,473,911 bp
  • A to T, chromosome 5 at 107,433,894 bp
  • T to A, chromosome 6 at 72,348,572 bp
  • G to A, chromosome 6 at 72,356,745 bp
  • A to G, chromosome 7 at 19,370,437 bp
  • T to G, chromosome 7 at 26,759,094 bp
  • A to G, chromosome 7 at 42,135,621 bp
  • T to G, chromosome 7 at 83,947,230 bp
  • T to C, chromosome 7 at 85,957,140 bp
  • T to A, chromosome 7 at 108,924,464 bp
  • T to C, chromosome 7 at 126,771,164 bp
  • A to T, chromosome 7 at 131,174,487 bp
  • A to G, chromosome 8 at 31,818,480 bp
  • T to A, chromosome 8 at 47,192,020 bp
  • C to T, chromosome 8 at 71,621,870 bp
  • A to G, chromosome 8 at 102,634,810 bp
  • A to T, chromosome 8 at 109,623,179 bp
  • T to C, chromosome 9 at 22,368,497 bp
  • T to A, chromosome 9 at 31,053,382 bp
  • C to T, chromosome 9 at 48,392,804 bp
  • T to C, chromosome 9 at 53,399,742 bp
  • G to A, chromosome 9 at 54,887,372 bp
  • A to G, chromosome 9 at 96,519,441 bp
  • A to G, chromosome 9 at 107,527,334 bp
  • C to A, chromosome 9 at 108,966,443 bp
  • T to C, chromosome 10 at 13,127,231 bp
  • C to T, chromosome 10 at 82,377,231 bp
  • T to A, chromosome 11 at 44,883,885 bp
  • T to A, chromosome 11 at 71,156,079 bp
  • T to C, chromosome 12 at 59,204,649 bp
  • A to G, chromosome 12 at 82,341,672 bp
  • T to C, chromosome 12 at 104,038,241 bp
  • T to C, chromosome 13 at 4,602,724 bp
  • T to A, chromosome 13 at 13,002,172 bp
  • T to G, chromosome 13 at 54,106,507 bp
  • T to C, chromosome 13 at 76,056,557 bp
  • T to C, chromosome 14 at 70,617,355 bp
  • T to C, chromosome 15 at 10,328,849 bp
  • A to C, chromosome 16 at 25,884,853 bp
  • A to G, chromosome 16 at 37,045,812 bp
  • T to C, chromosome 16 at 78,545,267 bp
  • G to T, chromosome 17 at 33,302,110 bp
  • T to A, chromosome 17 at 34,515,506 bp
  • C to A, chromosome 17 at 35,021,210 bp
  • A to T, chromosome 18 at 20,335,986 bp
  • T to A, chromosome 18 at 65,624,438 bp
  • T to C, chromosome 18 at 73,785,781 bp
  • T to A, chromosome 18 at 80,877,347 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6170 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044431-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.