Strain Name:
C57BL/6J-MtgxR6272Btlr/Mmmh
Stock Number:
044442-MU
Citation ID:
RRID:MMRRC_044442-MU
Other Names:
R6272 (G1)
Major Collection:

Strain Information

Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Nup210l
Name: nucleoporin 210-like
Synonyms: 4930548O11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77595
Homologene: 28122
Apbb2
Name: amyloid beta precursor protein binding family B member 2
Synonyms: TR2L, Rirl1, 2310007D03Rik, Zfra, FE65L1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11787
HGNC: HGNC:582
Homologene: 32079
Ttc17
Name: tetratricopeptide repeat domain 17
Synonyms: D2Bwg1005e, 9130020K17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74569
Homologene: 10100
Wwox
Name: WW domain-containing oxidoreductase
Synonyms: WOX1, 9030416C10Rik, 5330426P09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 80707
Homologene: 56334
Ube4b
Name: ubiquitination factor E4B
Synonyms: UFD2, 4933406G05Rik, 4930551I19Rik, UFD2a, Ufd2p, D4Bwg0973e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 63958
Homologene: 107623
Tasor2
Name: transcription activation suppressor family member 2
Synonyms: BC016423, Fam208b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105203
VEGA: 13
Homologene: 26435
Gprin3
Name: GPRIN family member 3
Synonyms: C030038J10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243385
Homologene: 52334
Cryab
Name: crystallin, alpha B
Synonyms: alpha B-crystallin, Crya-2, Crya2, HspB5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12955
VEGA: 9
HGNC: HGNC:2389
Homologene: 68209
Platr25
Name: pluripotency associated transcript 25
Synonyms: Gm5665, 6720490N10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 435366
Zfp451
Name: zinc finger protein 451
Synonyms: Kiaa0576-hp, 4930515K21Rik, 4933435G09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98403
Homologene: 9188
Adgra3
Name: adhesion G protein-coupled receptor A3
Synonyms: 3830613O22Rik, Tem5-like, Gpr125
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70693
Homologene: 19235
Edrf1
Name: erythroid differentiation regulatory factor 1
Synonyms: 2700050L05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 214764
Homologene: 27985
Prdm4
Name: PR domain containing 4
Synonyms: 2810470D21Rik, SC-1, 1700031E19Rik, SC1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72843
VEGA: 10
HGNC: HGNC:9348
Homologene: 8235
Mettl8
Name: methyltransferase 8, methylcytidine
Synonyms: TIP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228019
Homologene: 11706
H3c6
Name: H3 clustered histone 6
Synonyms: H3-f, H3.1, Hist1h3e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319151
Homologene: 134496
Szt2
Name: SZT2 subunit of KICSTOR complex
Synonyms: seaizure threshold 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230676
Homologene: 49413
Foxd3
Name: forkhead box D3
Synonyms: Genesis, Hfh2, CWH3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15221
HGNC: HGNC:3804
Homologene: 49239
Ern2
Name: endoplasmic reticulum to nucleus signalling 2
Synonyms: Ire1b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26918
Homologene: 22687
Hmgcll1
Name: 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208982
Homologene: 27863
Ttc8
Name: tetratricopeptide repeat domain 8
Synonyms: 0610012F22Rik, BBS8
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76260
Homologene: 14988
Slc4a3
Name: solute carrier family 4 (anion exchanger), member 3
Synonyms: Ae3, A930038D23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20536
Homologene: 129474
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Rtcb
Name: RNA 2',3'-cyclic phosphate and 5'-OH ligase
Synonyms: HSPC117, D10Wsu52e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 28088
Homologene: 36344
Vmn2r61
Name: vomeronasal 2, receptor 61
Synonyms: Casr-rs2, EG637873, Gprc2a-rs2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637873
Homologene: 129683
Dbn1
Name: drebrin 1
Synonyms: drebrin E2, drebrin A
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56320
HGNC: HGNC:2695
Homologene: 3236
Or5ac25
Name: olfactory receptor family 5 subfamily AC member 25
Synonyms: GA_x54KRFPKG5P-55590495-55589578, MOR182-6, MOR182-6, GA_x54KRFPKG5P-55580232-55579315, Olfr208, Olfr209, MOR182-9, GA_x54KRFPKG5P-55570276-55569359, Olfr207
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 404311
Homologene: 133040
Vmn2r70
Name: vomeronasal 2, receptor 70
Synonyms: EG620835
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 670940
Homologene: 115466
Prg4
Name: proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
Synonyms: MSF, DOL54, lubricin, SZP
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 96875
HGNC: HGNC:9364
Homologene: 137352
Nhsl1
Name: NHS like 1
Synonyms: A630035H13Rik, D10Bwg0940e, 5730409E15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215819
Homologene: 27834
Or2y13
Name: olfactory receptor family 2 subfamily Y member 14
Synonyms: GA_x6K02T2QP88-5912627-5911692, MOR256-56, Olfr1383
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 404337
Homologene: 105344
Arfgef3
Name: ARFGEF family member 3
Synonyms: B930094H20Rik, D10Bwg1379e, BIG3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215821
VEGA: 10
Homologene: 41366
Kynu
Name: kynureninase
Synonyms: 4432411A05Rik, L-kynurenine hydrolase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70789
HGNC: HGNC:6469
Homologene: 2925
Or8g4
Name: olfactory receptor family 8 subfamily G member 4
Synonyms: GA_x6K02T2PVTD-33447884-33448816, MOR171-30P, Olfr967
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258086
VEGA: 9
HGNC: HGNC:8484
Homologene: 115535
Adgrg3
Name: adhesion G protein-coupled receptor G3
Synonyms: Pb99, A030001G24Rik, Gpr97
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54672
Homologene: 18129
Neto1
Name: neuropilin (NRP) and tolloid (TLL)-like 1
Synonyms: C130005O10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 246317
VEGA: 18
Homologene: 16367
Or5w20
Name: olfactory receptor family 5 subfamily W member 20
Synonyms: GA_x6K02T2Q125-49395950-49396882, MOR177-7, Olfr1153
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258633
Homologene: 27230
Matn2
Name: matrilin 2
Synonyms: Crtm2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17181
VEGA: 15
HGNC: HGNC:6908
Homologene: 20538
Atxn1
Name: ataxin 1
Synonyms: Atx1, Sca1, 2900016G23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20238
VEGA: 13
Homologene: 281
AW551984
Name: expressed sequence AW551984
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244810
HGNC: HGNC:6658
Kbtbd11
Name: kelch repeat and BTB (POZ) domain containing 11
Synonyms: 4930465M17Rik, 2900016B01Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74901
Homologene: 28701
Ampd1
Name: adenosine monophosphate deaminase 1
Synonyms: Ampd-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229665
HGNC: HGNC:468
Homologene: 20
F830016B08Rik
Name: RIKEN cDNA F830016B08 gene
Synonyms: Ifgga4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240328
VEGA: 18
Homologene: 129714
Map1lc3b
Name: microtubule-associated protein 1 light chain 3 beta
Synonyms: 1010001C15Rik, Map1lc3, LC3b, Atg8
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67443
Homologene: 69359
Fah
Name: fumarylacetoacetate hydrolase
Synonyms: swst
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14085
HGNC: HGNC:3579
Homologene: 110
Pnpla1
Name: patatin-like phospholipase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 433091
Homologene: 25324
Plekhg3
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 3
Synonyms: MGC40768
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 263406
VEGA: 12
Homologene: 77478
Dip2a
Name: disco interacting protein 2 homolog A
Synonyms: Kiaa0184-hp, 4931420H10Rik, Dip2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64451
Homologene: 41012
Prpf18
Name: pre-mRNA processing factor 18
Synonyms: 2810441A10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67229
Homologene: 2726
H2-Ob
Name: histocompatibility 2, O region beta locus
Synonyms: Ob, H-2I, H2-IAb2, H2-Ab, H-2Ob, H2-Ab2, A-beta2, A-beta-2, vic1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15002
HGNC: HGNC:4937
Homologene: 1602
Vmn2r97
Name: vomeronasal 2, receptor 97
Synonyms: EG627367
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627367
Homologene: 115024
Phc2
Name: polyhomeotic 2
Synonyms: Mph2, D4Ertd810e, Edr2, D130050K19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 54383
HGNC: HGNC:3183
Homologene: 75090
Or6k2
Name: olfactory receptor family 6 subfamily K member 2
Synonyms: GA_x6K02T2P20D-20995211-20994246, MOR105-10, Olfr420
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258302
Homologene: 17185
Ubqln3
Name: ubiquilin 3
Synonyms: 4933400K24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244178
Homologene: 9700
Or13l2
Name: olfactory receptor family 13 subfamily L member 2
Synonyms: GA_x6K02T2R76Y-3201307-3200360, MOR217-1, Olfr1402
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 258272
VEGA: 3
Homologene: 17165
Tfap2e
Name: transcription factor AP-2, epsilon
Synonyms: AP-2e, Tcfap2e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 332937
Homologene: 2422
Trav19
Name: T cell receptor alpha variable 19
Synonyms: Gm13893
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 547428
Zfp582
Name: zinc finger protein 582
Synonyms: Gm3854
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100416477
Or14c42-ps1
Name: olfactory receptor family 14 subfamily C member 42, pseudogene 1
Synonyms: GA_x6K02T2NHDJ-9553029-9552092, MOR220-5_p, Olfr296-ps1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404375
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 33,803,244 bp
  • G to A, chromosome 1 at 75,554,697 bp
  • T to C, chromosome 1 at 150,454,766 bp
  • C to T, chromosome 1 at 174,159,175 bp
  • G to A, chromosome 2 at 4,633,447 bp
  • A to T, chromosome 2 at 43,634,989 bp
  • T to C, chromosome 2 at 70,976,075 bp
  • G to A, chromosome 2 at 87,896,657 bp
  • A to C, chromosome 2 at 94,358,755 bp
  • A to G, chromosome 3 at 90,170,024 bp
  • A to G, chromosome 3 at 97,410,891 bp
  • A to G, chromosome 3 at 103,085,383 bp
  • A to G, chromosome 4 at 99,656,740 bp
  • A to C, chromosome 4 at 118,374,290 bp
  • A to T, chromosome 4 at 126,721,864 bp
  • A to G, chromosome 4 at 128,709,647 bp
  • A to G, chromosome 4 at 149,387,133 bp
  • A to T, chromosome 5 at 50,009,449 bp
  • T to C, chromosome 5 at 66,311,072 bp
  • G to A, chromosome 6 at 59,353,331 bp
  • C to T, chromosome 7 at 6,353,845 bp
  • A to T, chromosome 7 at 42,299,818 bp
  • C to A, chromosome 7 at 84,595,545 bp
  • A to T, chromosome 7 at 85,558,986 bp
  • A to G, chromosome 7 at 86,561,873 bp
  • C to T, chromosome 7 at 104,142,178 bp
  • A to T, chromosome 7 at 122,176,646 bp
  • C to T, chromosome 7 at 133,637,808 bp
  • T to A, chromosome 8 at 15,029,118 bp
  • A to G, chromosome 8 at 95,036,261 bp
  • G to A, chromosome 8 at 114,488,952 bp
  • G to A, chromosome 8 at 121,596,690 bp
  • A to T, chromosome 9 at 39,598,037 bp
  • A to T, chromosome 9 at 39,750,520 bp
  • A to G, chromosome 9 at 50,754,525 bp
  • G to A, chromosome 9 at 76,130,345 bp
  • A to G, chromosome 10 at 18,524,505 bp
  • A to T, chromosome 10 at 18,646,963 bp
  • A to T, chromosome 10 at 76,286,407 bp
  • G to A, chromosome 10 at 85,907,830 bp
  • A to T, chromosome 10 at 85,955,774 bp
  • C to A, chromosome 11 at 21,997,037 bp
  • C to A, chromosome 11 at 49,524,126 bp
  • T to A, chromosome 11 at 119,414,548 bp
  • A to T, chromosome 12 at 76,576,845 bp
  • A to G, chromosome 12 at 98,982,494 bp
  • C to T, chromosome 13 at 3,581,891 bp
  • A to T, chromosome 13 at 23,562,226 bp
  • T to A, chromosome 13 at 45,567,762 bp
  • G to A, chromosome 13 at 55,475,104 bp
  • T to C, chromosome 13 at 62,672,997 bp
  • A to G, chromosome 14 at 53,845,798 bp
  • T to A, chromosome 15 at 34,355,607 bp
  • T to C, chromosome 15 at 76,174,853 bp
  • A to C, chromosome 16 at 59,361,585 bp
  • T to C, chromosome 17 at 18,947,599 bp
  • G to A, chromosome 17 at 28,881,368 bp
  • T to C, chromosome 17 at 34,242,644 bp
  • T to C, chromosome 18 at 60,300,078 bp
  • A to T, chromosome 18 at 86,494,815 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6272 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044442-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.