Strain Name:
C57BL/6J-MtgxR6279Btlr/Mmmh
Stock Number:
044449-MU
Citation ID:
RRID:MMRRC_044449-MU
Other Names:
R6279 (G1)
Major Collection:

Strain Information

Tnpo1
Name: transportin 1
Synonyms: Kpnb2, D13Ertd688e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238799
HGNC: HGNC:6401
Homologene: 5358
Sez6
Name: seizure related gene 6
Synonyms: sez-6, D11Bhm177e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20370
Homologene: 10948
Pds5b
Name: PDS5 cohesin associated factor B
Synonyms: Aprin, AS3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100710
Homologene: 41001
Ggta1
Name: glycoprotein galactosyltransferase alpha 1, 3
Synonyms: Ggta-1, Gal, Ggta, glycoprotein alpha galactosyl transferase 1, GALT, alpha3GalT, alpha Gal
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14594
HGNC: HGNC:4253
Homologene: 7730
Slk
Name: STE20-like kinase
Synonyms: mSLK, Etk4, SLK, Stk2, 9A2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20874
Homologene: 22515
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: D3Ertd775e, Lba
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Cul3
Name: cullin 3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26554
HGNC: HGNC:2553
Homologene: 2661
Safb2
Name: scaffold attachment factor B2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224902
Homologene: 35210
Arid1b
Name: AT-rich interaction domain 1B
Synonyms: 9330189K18Rik, B230217J03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 239985
Homologene: 32344
Slc19a2
Name: solute carrier family 19 (thiamine transporter), member 2
Synonyms: DDA1, TRMA, THTR1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 116914
Homologene: 38258
Sh3d19
Name: SH3 domain protein D19
Synonyms: Kryn
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 27059
Homologene: 19064
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Sfrp4
Name: secreted frizzled-related protein 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20379
VEGA: 13
Homologene: 2267
Msh6
Name: mutS homolog 6
Synonyms: Gtmbp, GTBP, Msh6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17688
VEGA: 17
HGNC: HGNC:7329
Homologene: 149
Hspe1
Name: heat shock protein 1 (chaperonin 10)
Synonyms: Hsp10, mitochondrial chaperonin 10
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15528
HGNC: HGNC:5269
Homologene: 20500
Top3a
Name: topoisomerase (DNA) III alpha
Synonyms: Top IIIa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21975
Homologene: 3394
Kat6a
Name: K(lysine) acetyltransferase 6A
Synonyms: 9930021N24Rik, MOZ, Myst3, Zfp220
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244349
Homologene: 4924
Skor1
Name: SKI family transcriptional corepressor 1
Synonyms: C230094B15Rik, Corl1, Lbxcor1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 207667
Homologene: 18175
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: skrr, Ryr, calcium release channel isoform 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Rdh9
Name: retinol dehydrogenase 9
Synonyms: Crad3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103142
Homologene: 129514
Mef2b
Name: myocyte enhancer factor 2B
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17259
Homologene: 48381
Reln
Name: reelin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Mmrn2
Name: multimerin 2
Synonyms: Emilin3, EndoGlyx-1, ENDOGLYX1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105450
VEGA: 14
Homologene: 11697
Exph5
Name: exophilin 5
Synonyms: B130009M24Rik, Slac2b, slac2-b, AC079869.22gm5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320051
Homologene: 9007
Pde10a
Name: phosphodiesterase 10A
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 23984
HGNC: HGNC:8772
Homologene: 4852
Vwa3a
Name: von Willebrand factor A domain containing 3A
Synonyms: E030013G06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233813
Homologene: 18607
Faap24
Name: Fanconi anemia core complex associated protein 24
Synonyms: C230052I12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101831
Homologene: 17535
Slc8a3
Name: solute carrier family 8 (sodium/calcium exchanger), member 3
Synonyms: Ncx3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 110893
Homologene: 62645
Tshz1
Name: teashirt zinc finger family member 1
Synonyms: 5730407I04Rik, D18Bwg1409e, Mtsh1, Tsh1, Sdccag33, NY-CO-33, teashirt1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 110796
Homologene: 4227
Bmal2
Name: basic helix-loop-helix ARNT like 2
Synonyms: bHLHe6, MOP9, 4632430A05Rik, Arntl2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 272322
Homologene: 10609
Ttc21a
Name: tetratricopeptide repeat domain 21A
Synonyms: Thm2, 4921538N17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74052
Homologene: 14728
Pde4dip
Name: phosphodiesterase 4D interacting protein (myomegalin)
Synonyms: D130016K21Rik, 9430063L05Rik, Usmg4, 4732458A06Rik, D3Bwg1078e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 83679
Homologene: 66961
Slc13a2
Name: solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
Synonyms: sodium/dicarboxylate co-transporter, mNaDC-1, Nadc1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20500
Homologene: 2965
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 435626
Homologene: 52359
Or4c105
Name: olfactory receptor family 4 subfamily C member 105
Synonyms: MOR232-7, Olfr1202, GA_x6K02T2Q125-50290367-50291296
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258454
Homologene: 133021
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Cacna1e
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms: alpha1E, Cav2.3, Cchra1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12290
HGNC: HGNC:1392
Homologene: 20185
Cyp2d22
Name: cytochrome P450, family 2, subfamily d, polypeptide 22
Synonyms: 2D22
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56448
VEGA: 15
Homologene: 75003
Bag6
Name: BCL2-associated athanogene 6
Synonyms: D17H6S52E, 2410045D21Rik, G3, Scythe, Bat3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224727
Homologene: 3409
Zfp672
Name: zinc finger protein 672
Synonyms: 4930488P06Rik, 4930511N19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319475
Homologene: 23493
Tcte1
Name: t-complex-associated testis expressed 1
Synonyms: D17Sil1, Tcte-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21645
VEGA: 17
Homologene: 8434
Gabrg2
Name: gamma-aminobutyric acid type A receptor, subunit gamma 2
Synonyms: gamma2, GABAA-R, Gabrg-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14406
HGNC: HGNC:4087
Homologene: 22443
Il12a
Name: interleukin 12a
Synonyms: IL-12p35, p35
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16159
HGNC: HGNC:5969
Homologene: 681
Klhl18
Name: kelch-like 18
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270201
Homologene: 14805
Cd163
Name: CD163 antigen
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 93671
HGNC: HGNC:1631
Homologene: 128811
Nek5
Name: NIMA (never in mitosis gene a)-related expressed kinase 5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330721
HGNC: HGNC:7748
Homologene: 87952
Il2rb
Name: interleukin 2 receptor, beta chain
Synonyms: IL-15 receptor beta chain, IL-2/15Rbeta, IL15Rbeta, IL-15Rbeta, Il-2Rbeta, CD122
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16185
VEGA: 15
HGNC: HGNC:6009
Homologene: 47955
Or52e19
Name: olfactory receptor family 52 subfamily E member 19
Synonyms: Olfr596-ps1, GA_x6K02T2PBJ9-6019769-6019943, Olfr596, Gm15117, ENSMUSG00000073953
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100041187
Homologene: 121535
Prr5l
Name: proline rich 5 like
Synonyms: 2600010E01Rik, 4833411O04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72446
Homologene: 11753
Endod1
Name: endonuclease domain containing 1
Synonyms: 2310067E08Rik, 2210414F18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71946
VEGA: 9
Homologene: 12425
Pphln1-ps1
Name: periphilin 1, pseudogene 1
Synonyms: 3110001I22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66598
Or2y15
Name: olfactory receptor family 2 subfamily Y member 15
Synonyms: Olfr1387, MOR256-22, GA_x6K02T2QP88-5975166-5974231
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258465
Homologene: 74034
Or52e7
Name: olfactory receptor family 52 subfamily E member 7
Synonyms: GA_x6K02T2PBJ9-7664016-7664969, MOR32-1, Olfr676
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259099
Homologene: 64955
Ap1s3
Name: adaptor-related protein complex AP-1, sigma 3
Synonyms: Jr2, [s]3A
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 252903
Homologene: 65622
Pkmyt1
Name: protein kinase, membrane associated tyrosine/threonine 1
Synonyms: Myt1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268930
VEGA: 17
Homologene: 31227
Pcdhgb5
Name: protocadherin gamma subfamily B, 5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93702
HGNC: HGNC:8712
Homologene: 55773
Or10w3
Name: olfactory receptor family 10 subfamily W member 3
Synonyms: GA_x6K02T2RE5P-4059239-4060188, Olfr1493, MOR266-3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258735
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 46,325,886 bp
  • T to A, chromosome 1 at 55,090,701 bp
  • T to A, chromosome 1 at 74,133,224 bp
  • T to C, chromosome 1 at 79,625,123 bp
  • A to G, chromosome 1 at 80,286,952 bp
  • T to A, chromosome 1 at 154,425,932 bp
  • C to T, chromosome 1 at 164,256,775 bp
  • A to G, chromosome 2 at 35,407,994 bp
  • A to T, chromosome 2 at 88,817,375 bp
  • A to T, chromosome 2 at 101,717,420 bp
  • A to T, chromosome 3 at 68,697,979 bp
  • A to T, chromosome 3 at 86,104,102 bp
  • A to G, chromosome 3 at 86,348,864 bp
  • A to C, chromosome 3 at 97,699,180 bp
  • A to G, chromosome 5 at 21,896,841 bp
  • T to A, chromosome 5 at 150,723,248 bp
  • A to T, chromosome 6 at 73,065,815 bp
  • T to A, chromosome 6 at 124,317,991 bp
  • A to G, chromosome 6 at 146,821,946 bp
  • A to T, chromosome 7 at 29,087,428 bp
  • A to C, chromosome 7 at 35,396,284 bp
  • A to T, chromosome 7 at 103,310,429 bp
  • A to G, chromosome 7 at 104,840,691 bp
  • G to A, chromosome 7 at 105,035,671 bp
  • A to G, chromosome 7 at 120,782,400 bp
  • T to A, chromosome 8 at 22,107,721 bp
  • A to G, chromosome 8 at 22,939,612 bp
  • C to T, chromosome 8 at 70,167,119 bp
  • T to C, chromosome 9 at 14,356,870 bp
  • A to G, chromosome 9 at 53,373,946 bp
  • A to T, chromosome 9 at 63,145,314 bp
  • T to A, chromosome 9 at 110,436,062 bp
  • T to C, chromosome 9 at 119,961,839 bp
  • A to G, chromosome 10 at 127,776,758 bp
  • T to C, chromosome 11 at 42,000,523 bp
  • T to A, chromosome 11 at 49,460,212 bp
  • A to T, chromosome 11 at 58,317,268 bp
  • T to C, chromosome 11 at 60,749,408 bp
  • T to C, chromosome 11 at 77,976,541 bp
  • CGTTATCTGT to CGT, chromosome 11 at 78,403,480 bp
  • C to T, chromosome 12 at 8,007,769 bp
  • T to A, chromosome 12 at 81,314,978 bp
  • T to A, chromosome 13 at 11,680,999 bp
  • G to A, chromosome 13 at 19,623,853 bp
  • G to A, chromosome 13 at 98,890,708 bp
  • T to C, chromosome 14 at 34,397,657 bp
  • T to C, chromosome 15 at 78,481,538 bp
  • C to A, chromosome 15 at 82,373,968 bp
  • T to C, chromosome 16 at 13,677,270 bp
  • C to A, chromosome 17 at 5,341,999 bp
  • T to C, chromosome 17 at 8,978,957 bp
  • C to T, chromosome 17 at 23,732,502 bp
  • T to C, chromosome 17 at 35,138,601 bp
  • T to C, chromosome 17 at 45,533,289 bp
  • T to C, chromosome 17 at 56,563,226 bp
  • T to C, chromosome 17 at 87,980,249 bp
  • T to A, chromosome 18 at 37,732,699 bp
  • A to T, chromosome 18 at 84,015,311 bp
  • A to G, chromosome 19 at 13,726,665 bp
  • A to G, chromosome 19 at 47,642,004 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6279 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044449-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.