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Strain Name:
C57BL/6J-MtgxR6283Btlr/Mmmh
Stock Number:
044453-MU
Citation ID:
RRID:MMRRC_044453-MU
Other Names:
R6283 (G1)
Major Collection:

Strain Information

Adamts20
Name: ADAM metallopeptidase with thrombospondin type 1 motif 20
Synonyms: ADAMTS-20, bt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223838
Homologene: 11808
Cks2
Name: CDC28 protein kinase regulatory subunit 2
Synonyms: CKSHS2, 1110038L14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66197
HGNC: HGNC:2000
Homologene: 86883
Rabep1
Name: rabaptin, RAB GTPase binding effector protein 1
Synonyms: RAB5 effector protein, neurocrescin, rabaptin-5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54189
Homologene: 3451
Hcrtr1
Name: hypocretin (orexin) receptor 1
Synonyms: OX1R
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230777
HGNC: HGNC:4848
Homologene: 37492
Swt1
Name: SWT1 RNA endoribonuclease homolog (S. cerevisiae)
Synonyms: 1200016B10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66875
Homologene: 32355
Knl1
Name: kinetochore scaffold 1
Synonyms: 2310043D08Rik, 5730505K17Rik, Casc5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76464
Homologene: 44890
Copa
Name: coatomer protein complex subunit alpha
Synonyms: xenin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12847
HGNC: HGNC:2230
Homologene: 3218
Lpar6
Name: lysophosphatidic acid receptor 6
Synonyms: 2610302I02Rik, P2y5, P2ry5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67168
Homologene: 55925
Zfp90
Name: zinc finger protein 90
Synonyms: Nk10 expressed protein, NK10, 6430515L01Rik, Zfp64, KRAB17, Zfp83
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22751
Homologene: 86800
Cic
Name: capicua transcriptional repressor
Synonyms: 1200010B10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71722
Homologene: 87637
Prr14l
Name: proline rich 14-like
Synonyms: 6030436E02Rik, C330019G07Rik, Prl14l
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 215476
Homologene: 65866
Ino80d
Name: INO80 complex subunit D
Synonyms: A430093A21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227195
Homologene: 9819
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: l(7)-3Rn, Ten-m4, Doc4, l7Rn3, ELM2, Odz4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23966
Homologene: 8034
Ctdsp2
Name: CTD small phosphatase 2
Synonyms: SCP2, OS4, D10Ertd73e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52468
VEGA: 10
Homologene: 128791
Chd1l
Name: chromodomain helicase DNA binding protein 1-like
Synonyms: Snf2p, 4432404A22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68058
HGNC: HGNC:1916
Homologene: 11590
Slc25a27
Name: solute carrier family 25, member 27
Synonyms: D530043E16Rik, Ucp4, 3632410G24Rik, 9430092A03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74011
VEGA: 17
Homologene: 12523
Grina
Name: glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
Synonyms: 1110025J15Rik, Tmbim3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66168
VEGA: 15
HGNC: HGNC:4589
Homologene: 41517
Bhlhe40
Name: basic helix-loop-helix family, member e40
Synonyms: eip1 (E47 interaction protein 1), Stra13, CR8, cytokine response gene 8, Clast5, C130042M06Rik, Stra14, DEC1, Sharp2, Bhlhb2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20893
HGNC: HGNC:1046
Homologene: 2722
Dock2
Name: dedicator of cyto-kinesis 2
Synonyms: MBC, CED-5, Hch
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94176
HGNC: HGNC:2988
Homologene: 37984
Itga2
Name: integrin alpha 2
Synonyms: VLA-2 receptor, alpha 2 subunit, CD49B, DX5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16398
VEGA: 13
HGNC: HGNC:6137
Homologene: 1662
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Dhx57
Name: DExH-box helicase 57
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106794
VEGA: 17
Homologene: 56267
Pcdh10
Name: protocadherin 10
Synonyms: 6430703F07Rik, 6430521D13Rik, OL-pc, Olpc
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18526
Homologene: 74967
Zfp804b
Name: zinc finger protein 804B
Synonyms: LOC207618
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 207618
Homologene: 52304
Vmn2r111
Name: vomeronasal 2, receptor 111
Synonyms: EG210876
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210876
Homologene: 86604
Ccdc180
Name: coiled-coil domain containing 180
Synonyms: LOC381522, E230008N13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381522
Homologene: 117988
Ces2c
Name: carboxylesterase 2C
Synonyms: Ces2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234671
HGNC: HGNC:1864
Homologene: 138298
Vmn2r93
Name: vomeronasal 2, receptor 93
Synonyms: EG627132
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627132
Homologene: 129750
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: 6530405F15Rik, CMF608, Adlican2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242050
Homologene: 18712
Vmn2r73
Name: vomeronasal 2, receptor 73
Synonyms: EG620928
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 620928
Homologene: 115466
Trpm8
Name: transient receptor potential cation channel, subfamily M, member 8
Synonyms: CMR1, TRPP8, Trp-p8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 171382
Homologene: 23433
Inpp4b
Name: inositol polyphosphate-4-phosphatase, type II
Synonyms: E130107I17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234515
HGNC: HGNC:6075
Homologene: 20832
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 628870
Homologene: 46008
Cd300e
Name: CD300E molecule
Synonyms: Clm2, Trem5, Cd300le
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217306
Homologene: 18145
Pcnx2
Name: pecanex homolog 2
Synonyms: E330039K12Rik, Pcnxl2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Cd209e
Name: CD209e antigen
Synonyms: SIGNR4, mSIGNR4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170780
HGNC: HGNC:1641
Homologene: 128353
Ccdc83
Name: coiled-coil domain containing 83
Synonyms: 4930549K11Rik, 4930554C01Rik, 4932423M01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75338
Homologene: 32709
Or7a36
Name: olfactory receptor family 7 subfamily A member 36
Synonyms: GA_x6K02T2QGN0-2828447-2827518, MOR139-1, Olfr1352
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 259074
Homologene: 131141
Or5m3
Name: olfactory receptor family 5 subfamily M member 3
Synonyms: GA_x6K02T2Q125-47485813-47486745, MOR199-1, Olfr1032
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258572
Homologene: 17299
Inhca
Name: inhibitor of carbonic anhydrase
Synonyms: mICA, 1300017J02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71775
Homologene: 826
Uevld
Name: UEV and lactate/malate dehyrogenase domains
Synonyms: 8430408E05Rik, Attp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54122
Homologene: 69251
Acsf3
Name: acyl-CoA synthetase family member 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 257633
Homologene: 14958
Ggps1
Name: geranylgeranyl diphosphate synthase 1
Synonyms: GGPP synthase, 9530089B04Rik, 1810026C22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14593
VEGA: 13
HGNC: HGNC:4249
Homologene: 31267
Gm10549
Name: predicted gene 10549
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 433171
VEGA: 18
Tfap2d
Name: transcription factor AP-2, delta
Synonyms: Tcfap2d
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226896
Homologene: 17700
Cfap61
Name: cilia and flagella associated protein 61
Synonyms: 4930529M08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78774
Or4f58
Name: olfactory receptor family 4 subfamily F member 58
Synonyms: GA_x6K02T2Q125-73069292-73068354, MOR245-21, Olfr1311
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258271
Homologene: 133656
Rnf150
Name: ring finger protein 150
Synonyms: Greul5, A630007N06Rik, C030044C12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330812
Homologene: 33783
Cyp2j13
Name: cytochrome P450, family 2, subfamily j, polypeptide 13
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230459
HGNC: HGNC:2634
Homologene: 138297
Ldc1
Name: leucine decarboxylase 1
Synonyms: LOC332942, Gm853
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 332942
Homologene: 128653
Pdzd9
Name: PDZ domain containing 9
Synonyms: 4930408O21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67983
Homologene: 27865
Mzf1
Name: myeloid zinc finger 1
Synonyms: Znf42, Mzf2, Zfp121, Zfp98
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 109889
Homologene: 9633
Pinx1
Name: PIN2/TERF1 interacting, telomerase inhibitor 1
Synonyms: LPTS, 2210403I16Rik, 2610028A01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72400
VEGA: 14
Homologene: 134540
Krtap4-16
Name: keratin associated protein 4-16
Synonyms: OTTMUSG00000002196
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 435285
Homologene: 128438
Gm11444
Name: predicted gene 11444
Type: Gene
Species: Mouse
Chromosome: 11
Or5d46
Name: olfactory receptor family 5 subfamily D member 46
Synonyms: GA_x6K02T2Q125-49824309-49825256, MOR174-5, Olfr1176
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258767
Qpctl
Name: glutaminyl-peptide cyclotransferase-like
Synonyms: 1810019P04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67369
Homologene: 9765
Ttc6
Name: tetratricopeptide repeat domain 6
Synonyms: LOC217602, EG639426, Gm9813, 4921506M07Rik, AU024163
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70846
Homologene: 78002
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to C, chromosome 1 at 19,104,478 bp
  • C to T, chromosome 1 at 63,062,126 bp
  • C to T, chromosome 1 at 88,348,332 bp
  • A to G, chromosome 1 at 151,384,333 bp
  • A to T, chromosome 1 at 172,118,848 bp
  • G to T, chromosome 2 at 86,008,099 bp
  • T to A, chromosome 2 at 88,339,658 bp
  • A to C, chromosome 2 at 112,021,260 bp
  • A to G, chromosome 2 at 119,070,286 bp
  • T to A, chromosome 2 at 146,129,102 bp
  • T to A, chromosome 3 at 45,381,554 bp
  • T to A, chromosome 3 at 59,319,449 bp
  • G to A, chromosome 3 at 97,587,167 bp
  • A to G, chromosome 4 at 45,902,486 bp
  • A to G, chromosome 4 at 96,056,837 bp
  • G to A, chromosome 4 at 130,135,340 bp
  • A to G, chromosome 4 at 130,221,741 bp
  • T to A, chromosome 5 at 6,769,908 bp
  • T to C, chromosome 5 at 32,830,264 bp
  • T to C, chromosome 6 at 108,665,031 bp
  • T to C, chromosome 7 at 13,053,369 bp
  • T to A, chromosome 7 at 19,148,420 bp
  • C to T, chromosome 7 at 25,286,034 bp
  • G to T, chromosome 7 at 46,937,981 bp
  • C to T, chromosome 7 at 85,871,841 bp
  • T to A, chromosome 7 at 90,236,407 bp
  • A to G, chromosome 7 at 96,874,494 bp
  • T to A, chromosome 7 at 120,660,226 bp
  • T to G, chromosome 7 at 127,564,872 bp
  • C to A, chromosome 7 at 141,816,864 bp
  • G to A, chromosome 8 at 3,849,212 bp
  • C to T, chromosome 8 at 81,770,833 bp
  • A to G, chromosome 8 at 82,990,554 bp
  • A to T, chromosome 8 at 104,849,699 bp
  • T to C, chromosome 8 at 106,425,394 bp
  • C to A, chromosome 8 at 122,785,955 bp
  • G to T, chromosome 8 at 125,877,586 bp
  • G to A, chromosome 9 at 103,282,635 bp
  • T to C, chromosome 10 at 78,984,279 bp
  • T to G, chromosome 10 at 107,790,500 bp
  • T to C, chromosome 10 at 126,995,880 bp
  • T to C, chromosome 11 at 34,707,325 bp
  • C to T, chromosome 11 at 70,917,679 bp
  • T to C, chromosome 11 at 85,846,791 bp
  • A to G, chromosome 11 at 99,851,035 bp
  • G to A, chromosome 11 at 115,054,554 bp
  • T to G, chromosome 12 at 57,702,262 bp
  • A to G, chromosome 13 at 14,057,794 bp
  • A to G, chromosome 13 at 51,645,459 bp
  • A to G, chromosome 13 at 114,869,250 bp
  • A to C, chromosome 14 at 63,878,172 bp
  • A to T, chromosome 14 at 73,238,857 bp
  • A to G, chromosome 15 at 76,248,551 bp
  • A to G, chromosome 15 at 94,351,721 bp
  • T to A, chromosome 17 at 18,304,104 bp
  • T to C, chromosome 17 at 22,559,051 bp
  • A to C, chromosome 17 at 43,657,730 bp
  • A to G, chromosome 17 at 80,274,805 bp
  • C to A, chromosome 18 at 33,464,305 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6283 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044453-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.