Strain Name:
C57BL/6J-MtgxR6315Btlr/Mmmh
Stock Number:
044472-MU
Citation ID:
RRID:MMRRC_044472-MU
Other Names:
R6315 (G1)
Major Collection:

Strain Information

Fgb
Name: fibrinogen beta chain
Synonyms: 2510049G14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 110135
HGNC: HGNC:3662
Homologene: 3772
B4galt5
Name: UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5
Synonyms: 9430078I07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56336
HGNC: HGNC:928
Homologene: 3507
Ppp1r1b
Name: protein phosphatase 1, regulatory inhibitor subunit 1B
Synonyms: DARPP-32, Darpp32
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19049
HGNC: HGNC:9287
Homologene: 12972
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Iqgap1
Name: IQ motif containing GTPase activating protein 1
Synonyms: D7Ertd237e, D7Ertd257e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 29875
HGNC: HGNC:6110
Homologene: 74514
Cadm1
Name: cell adhesion molecule 1
Synonyms: 2900073G06Rik, RA175A, Igsf4, SgIGSF, SynCam, Igsf4a, RA175B, Tslc1, RA175N, RA175C, 3100001I08Rik, Necl2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54725
HGNC: HGNC:5951
Homologene: 8641
Vsnl1
Name: visinin-like 1
Synonyms: VILIP
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 26950
VEGA: 12
Homologene: 2542
Zfat
Name: zinc finger and AT hook domain containing
Synonyms: Zfp406, LOC380993, Zfat1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 380993
Homologene: 16829
Zc3h13
Name: zinc finger CCCH type containing 13
Synonyms: C87618, 4930570G11Rik, 2600010B19Rik, 3110050K21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67302
VEGA: 14
Trip11
Name: thyroid hormone receptor interactor 11
Synonyms: 2610511G22Rik, 6030460N08Rik, GMAP-210, TRIP230, 3110031G15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 109181
Homologene: 20897
Nup205
Name: nucleoporin 205
Synonyms: 3830404O05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70699
Homologene: 45971
Fbxo38
Name: F-box protein 38
Synonyms: 6030410I24Rik, SP329
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 107035
VEGA: 18
Homologene: 34526
Wls
Name: wntless WNT ligand secretion mediator
Synonyms: 5031439A09Rik, Gpr177
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68151
Homologene: 11779
Ccdc18
Name: coiled-coil domain containing 18
Synonyms: 1700021E15Rik, 4932411G06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73254
Homologene: 35455
Nfe2l2
Name: nuclear factor, erythroid derived 2, like 2
Synonyms: Nrf2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18024
HGNC: HGNC:7782
Homologene: 2412
Impdh2
Name: inosine monophosphate dehydrogenase 2
Synonyms: IMP dehydrogenase type II
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23918
HGNC: HGNC:6053
Homologene: 48919
Zc3h18
Name: zinc finger CCCH-type containing 18
Synonyms: 1190001B23Rik, 5830416A07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76014
Homologene: 44894
Sv2a
Name: synaptic vesicle glycoprotein 2a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 64051
Homologene: 32237
Cadm3
Name: cell adhesion molecule 3
Synonyms: Tsll1, Necl-1, SynCAM3, Igsf4b, BIgR, Necl1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 94332
Homologene: 10919
Gpn3
Name: GPN-loop GTPase 3
Synonyms: Atpbd1c, A930018B01Rik, D5Ertd708e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68080
Homologene: 6487
Eif5b
Name: eukaryotic translation initiation factor 5B
Synonyms: IF2, A030003E17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226982
Homologene: 134613
Atp8b1
Name: ATPase, class I, type 8B, member 1
Synonyms: Ic, FIC1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 54670
VEGA: 18
HGNC: HGNC:3706
Homologene: 21151
Dsg3
Name: desmoglein 3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13512
VEGA: 18
HGNC: HGNC:3050
Homologene: 55513
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Zfyve9
Name: zinc finger, FYVE domain containing 9
Synonyms: Madhip
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230597
HGNC: HGNC:6775
Homologene: 3527
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 229003
Homologene: 14118
Cfap58
Name: cilia and flagella associated protein 58
Synonyms: LOC381229, Ccdc147
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381229
VEGA: 19
Homologene: 77312
Fbn2
Name: fibrillin 2
Synonyms: Sne, sy, Fib-2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Impg1
Name: interphotoreceptor matrix proteoglycan 1
Synonyms: IMP150, A930015H12Rik, SPACR
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 63859
HGNC: HGNC:6055
Homologene: 1201
Plcb1
Name: phospholipase C, beta 1
Synonyms: 3110043I21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18795
Homologene: 22876
Abca15
Name: ATP-binding cassette, sub-family A member 15
Synonyms: 4930500I12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320631
Homologene: 87255
Col19a1
Name: collagen, type XIX, alpha 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12823
HGNC: HGNC:2196
Homologene: 55608
Ros1
Name: Ros1 proto-oncogene
Synonyms: c-ros, Ros-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19886
Homologene: 2207
Ahnak
Name: AHNAK nucleoprotein
Synonyms: 2310047C17Rik, DY6, 1110004P15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Ak9
Name: adenylate kinase 9
Synonyms: LOC215946, Gm7127, Akd1, Akd2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 633979
Homologene: 67934
Myt1l
Name: myelin transcription factor 1-like
Synonyms: 2900046C06Rik, C630034G21Rik, Png-1, 2900093J19Rik, Nztf1, Pmng1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 17933
VEGA: 12
HGNC: HGNC:7623
Homologene: 7435
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Col6a5, Gm7455
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 665033
Homologene: 122792
Mgat4b
Name: mannoside acetylglucosaminyltransferase 4, isoenzyme B
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103534
HGNC: HGNC:7048
Homologene: 8611
Sirpb1c
Name: signal-regulatory protein beta 1C
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100038947
Homologene: 82993
Arhgef4
Name: Rho guanine nucleotide exchange factor 4
Synonyms: C230030N03Rik, Asef, 9330140K16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226970
HGNC: HGNC:684
Homologene: 49414
Usp20
Name: ubiquitin specific peptidase 20
Synonyms: Vdu2, 1700055M05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74270
Homologene: 4861
Atp1a2
Name: ATPase, Na+/K+ transporting, alpha 2 polypeptide
Synonyms: Atpa-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98660
HGNC: HGNC:800
Homologene: 47947
Tectb
Name: tectorin beta
Synonyms: [b]-tectorin, Tctnb
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21684
Homologene: 7568
Nin
Name: ninein
Synonyms: 3110068G20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18080
Homologene: 40632
Myrfl
Name: myelin regulatory factor-like
Synonyms: Gm239, LOC237558
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237558
VEGA: 10
Homologene: 88588
Bpifa1
Name: BPI fold containing family A, member 1
Synonyms: Plunc, SPLUNC1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18843
Homologene: 7895
Sec14l5
Name: SEC14-like lipid binding 5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 665119
VEGA: 16
Homologene: 96163
Neil2
Name: nei like 2 (E. coli)
Synonyms: NEH2, LOC382913
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 382913
VEGA: 14
Homologene: 17032
Vmn1r181
Name: vomeronasal 1 receptor 181
Synonyms: V1rd20
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404289
Homologene: 104166
Fut9
Name: fucosyltransferase 9
Synonyms: mFuc-TIX, mFUT9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14348
HGNC: HGNC:4020
Homologene: 4800
Vmn2r8
Name: vomeronasal 2, receptor 8
Synonyms: EG627479
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 627479
Homologene: 129606
Plch1
Name: phospholipase C, eta 1
Synonyms: Plcl3, PLCeta1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269437
Homologene: 88833
Ano3
Name: anoctamin 3
Synonyms: Tmem16c, B230324K02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228432
Homologene: 57147
Icam4
Name: intercellular adhesion molecule 4, Landsteiner-Wiener blood group
Synonyms: Cd242, 1810015M19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78369
VEGA: 9
HGNC: HGNC:5347
Homologene: 74401
Gabrg2
Name: gamma-aminobutyric acid type A receptor, subunit gamma 2
Synonyms: gamma2, Gabrg-2, GABAA-R
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14406
HGNC: HGNC:4087
Homologene: 22443
Amdhd2
Name: amidohydrolase domain containing 2
Synonyms: 5730457F11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 245847
Homologene: 9311
Mrgprb8
Name: MAS-related GPR, member B8
Synonyms: MrgB8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404240
Homologene: 83620
Or5k16
Name: olfactory receptor family 5 subfamily K member 16
Synonyms: MOR184-11P, Olfr180, MOR184-11P, GA_x54KRFPKG5P-55134972-55134019, MOR184-9, Olfr1563-ps1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258178
Homologene: 79337
Cers4
Name: ceramide synthase 4
Synonyms: CerS4, 2900019C14Rik, Trh1, Lass4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67260
Homologene: 11582
Wdr55
Name: WD repeat domain 55
Synonyms: 2410080P20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67936
VEGA: 18
Homologene: 9789
Nup42
Name: nucleoporin 42
Synonyms: CG1, Nupl2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231042
Homologene: 40573
Spata19
Name: spermatogenesis associated 19
Synonyms: 1700001L23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75469
VEGA: 9
Homologene: 12602
Tslp
Name: thymic stromal lymphopoietin
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 53603
VEGA: 18
Homologene: 81957
Or5b114-ps1
Name: olfactory receptor family 5 subfamily B member 114, pseudogene 1
Synonyms: GA_x6K02T2RE5P-3706029-3706953, MOR202-21, Olfr1468-ps1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258192
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 24,526,452 bp
  • G to A, chromosome 1 at 34,723,477 bp
  • A to G, chromosome 1 at 38,018,033 bp
  • C to G, chromosome 1 at 172,289,336 bp
  • T to C, chromosome 1 at 173,344,352 bp
  • C to T, chromosome 2 at 31,017,758 bp
  • G to T, chromosome 2 at 75,676,819 bp
  • A to G, chromosome 2 at 110,697,039 bp
  • A to T, chromosome 2 at 135,346,341 bp
  • A to G, chromosome 2 at 154,146,076 bp
  • A to T, chromosome 2 at 167,305,809 bp
  • A to G, chromosome 2 at 181,233,202 bp
  • A to G, chromosome 3 at 15,832,306 bp
  • C to T, chromosome 3 at 63,781,390 bp
  • T to A, chromosome 3 at 83,045,055 bp
  • G to A, chromosome 3 at 96,188,186 bp
  • T to A, chromosome 3 at 159,934,371 bp
  • A to T, chromosome 4 at 25,619,774 bp
  • G to A, chromosome 4 at 59,691,132 bp
  • T to A, chromosome 4 at 108,674,488 bp
  • T to C, chromosome 5 at 24,167,504 bp
  • A to G, chromosome 5 at 108,161,582 bp
  • A to T, chromosome 5 at 108,801,891 bp
  • C to T, chromosome 5 at 122,372,575 bp
  • T to A, chromosome 6 at 35,236,869 bp
  • T to C, chromosome 6 at 73,191,605 bp
  • G to A, chromosome 7 at 23,984,758 bp
  • C to T, chromosome 7 at 48,389,235 bp
  • C to T, chromosome 7 at 80,799,890 bp
  • T to C, chromosome 7 at 120,346,092 bp
  • G to A, chromosome 8 at 4,516,980 bp
  • A to G, chromosome 8 at 122,383,865 bp
  • T to C, chromosome 9 at 21,029,952 bp
  • T to C, chromosome 9 at 27,400,837 bp
  • C to T, chromosome 9 at 47,810,119 bp
  • C to A, chromosome 9 at 80,394,074 bp
  • G to T, chromosome 9 at 105,881,970 bp
  • T to C, chromosome 9 at 108,563,439 bp
  • A to T, chromosome 10 at 41,406,841 bp
  • A to T, chromosome 10 at 52,118,210 bp
  • T to G, chromosome 10 at 116,822,819 bp
  • T to C, chromosome 11 at 41,971,861 bp
  • T to A, chromosome 11 at 50,231,764 bp
  • A to G, chromosome 11 at 98,355,390 bp
  • T to A, chromosome 12 at 11,332,155 bp
  • T to C, chromosome 12 at 29,827,798 bp
  • A to T, chromosome 12 at 70,045,615 bp
  • T to G, chromosome 12 at 101,885,578 bp
  • A to G, chromosome 13 at 13,643,504 bp
  • C to T, chromosome 13 at 55,011,157 bp
  • A to G, chromosome 14 at 63,183,471 bp
  • A to G, chromosome 14 at 75,308,915 bp
  • A to G, chromosome 15 at 68,084,462 bp
  • A to C, chromosome 16 at 5,180,277 bp
  • A to C, chromosome 16 at 58,916,246 bp
  • A to C, chromosome 17 at 24,158,356 bp
  • A to T, chromosome 17 at 43,626,338 bp
  • A to G, chromosome 18 at 20,524,586 bp
  • A to G, chromosome 18 at 32,817,090 bp
  • A to T, chromosome 18 at 36,762,069 bp
  • T to C, chromosome 18 at 58,054,953 bp
  • A to T, chromosome 18 at 62,536,147 bp
  • C to A, chromosome 18 at 64,531,479 bp
  • T to C, chromosome 19 at 9,006,626 bp
  • T to C, chromosome 19 at 13,375,405 bp
  • G to A, chromosome 19 at 47,941,277 bp
  • A to G, chromosome 19 at 55,191,472 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6315 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044472-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.