Strain Name:
C57BL/6J-MtgxR6331Btlr/Mmmh
Stock Number:
044485-MU
Citation ID:
RRID:MMRRC_044485-MU
Other Names:
R6331 (G1)
Major Collection:

Strain Information

Tnrc6b
Name: trinucleotide repeat containing 6b
Synonyms: D230019K20Rik, A730065C02Rik, 2700090M07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 213988
VEGA: 15
Homologene: 66194
Mtarc2
Name: mitochondrial amidoxime reducing component 2
Synonyms: Mosc2, 2810484M10Rik, Marc2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67247
Homologene: 9904
Lcmt1
Name: leucine carboxyl methyltransferase 1
Synonyms: Lcmt, LCMT-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 30949
Homologene: 41123
Nbea
Name: neurobeachin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Usp32
Name: ubiquitin specific peptidase 32
Synonyms: 2900074J03Rik, 6430526O11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237898
Homologene: 13066
Diaph3
Name: diaphanous related formin 3
Synonyms: Diap3, mDia2, Drf3, 4930417P13Rik, p134MDia2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56419
VEGA: 14
Homologene: 84829
Hars1
Name: histidyl-tRNA synthetase 1
Synonyms: Hars, MMHRS
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15115
VEGA: 18
HGNC: HGNC:4816
Homologene: 1592
Ptpn11
Name: protein tyrosine phosphatase, non-receptor type 11
Synonyms: PTP1D, 2700084A17Rik, SH2 domain-containing protein tyrosine phosphatase-2, PTP2C, Syp, SH-PTP2, SHP-2, Shp2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19247
HGNC: HGNC:9644
Homologene: 2122
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: 5430435M13Rik, C130002K18Rik, 2610207I05Rik, SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233789
Homologene: 56697
Sdad1
Name: SDA1 domain containing 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231452
Homologene: 6036
Bltp3a
Name: bridge-like lipid transfer protein family member 3A
Synonyms: F830021D11Rik, Uhrf1bp1, 1110020K19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224648
Homologene: 9816
Slc39a1
Name: solute carrier family 39 (zinc transporter), member 1
Synonyms: zip1, Zirtl
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 30791
Homologene: 40906
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: chromatin remodeling factor, E430018P19Rik, KMT2H, 8030453L17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 192195
Homologene: 10225
Otof
Name: otoferlin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83762
HGNC: HGNC:8515
Homologene: 12892
Krt25
Name: keratin 25
Synonyms: mIRSa1, 4631426H08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70810
Homologene: 77127
Clint1
Name: clathrin interactor 1
Synonyms: Epn4, C530049I24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216705
Homologene: 133740
Pms2
Name: PMS1 homolog2, mismatch repair system component
Synonyms: mismatch repair, DNA mismatch repair
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18861
Homologene: 133560
Ptgfrn
Name: prostaglandin F2 receptor negative regulator
Synonyms: 4833445A08Rik, CD9P-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19221
HGNC: HGNC:9601
Homologene: 7908
Dmp1
Name: dentin matrix protein 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13406
HGNC: HGNC:2932
Homologene: 68396
Bach2
Name: BTB and CNC homology, basic leucine zipper transcription factor 2
Synonyms: E030004N02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12014
Homologene: 7240
Adamts12
Name: ADAM metallopeptidase with thrombospondin type 1 motif 12
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239337
VEGA: 15
Homologene: 12808
Htt
Name: huntingtin
Synonyms: C430023I11Rik, Hdh, htt, huntingtin, HD, IT15
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15194
HGNC: HGNC:4851
Homologene: 1593
Dapk1
Name: death associated protein kinase 1
Synonyms: DAP-Kinase, 2310039H24Rik, 2810425C21Rik, D13Ucla1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69635
VEGA: 13
HGNC: HGNC:2674
Homologene: 3626
Tube1
Name: tubulin, epsilon 1
Synonyms: 2310061K05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71924
VEGA: 10
Homologene: 17762
Trim33
Name: tripartite motif-containing 33
Synonyms: 8030451N04Rik, Tif1g, Ecto, ectodermin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 94093
Homologene: 9296
Usp33
Name: ubiquitin specific peptidase 33
Synonyms: Vdu1, 9830169D19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170822
Homologene: 8996
Siglecg
Name: sialic acid binding Ig-like lectin G
Synonyms: mSiglec-G, A630096C01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243958
Homologene: 13228
Atp2b2
Name: ATPase, Ca++ transporting, plasma membrane 2
Synonyms: PMCA2, wms, jog, D6Abb2e, Tmy, Gena300
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11941
HGNC: HGNC:815
Homologene: 56150
Tgfb3
Name: transforming growth factor, beta 3
Synonyms: Tgfb-3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 21809
VEGA: 12
Homologene: 2433
Ttn
Name: titin
Synonyms: connectin, 1100001C23Rik, D330041I19Rik, D830007G01Rik, 2310074I15Rik, 2310036G12Rik, mdm, 2310057K23Rik, shru, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Zfp646
Name: zinc finger protein 646
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233905
Homologene: 8802
Wdr24
Name: WD repeat domain 24
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268933
Homologene: 6870
Gucy1b1
Name: guanylate cyclase 1, soluble, beta 1
Synonyms: beta 1 sGC, Gucy1b3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 54195
HGNC: HGNC:4687
Homologene: 664
Uspl1
Name: ubiquitin specific peptidase like 1
Synonyms: E430026A01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231915
Homologene: 4235
Brd10
Name: bromodomain containing 10
Synonyms: Gm9832, 9930021J03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240613
Homologene: 19046
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Vmn2r3
Name: vomeronasal 2, receptor 3
Synonyms: EG637004
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 637004
Slc5a4a
Name: solute carrier family 5, member 4a
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64452
VEGA: 10
Ahnak
Name: AHNAK nucleoprotein
Synonyms: 2310047C17Rik, 1110004P15Rik, DY6
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
A2ml1
Name: alpha-2-macroglobulin like 1
Synonyms: Ovos2, BC048546
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232400
Homologene: 45969
Ak9
Name: adenylate kinase 9
Synonyms: Akd1, LOC215946, Gm7127, Akd2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 633979
Homologene: 67934
Chd5
Name: chromodomain helicase DNA binding protein 5
Synonyms: 4930532L22Rik, B230399N07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269610
Homologene: 56712
Vmn1r20
Name: vomeronasal 1 receptor 20
Synonyms: Gm5569
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 434017
Homologene: 79462
Or13p3
Name: olfactory receptor family 13 subfamily P member 3
Synonyms: MOR258-1, GA_x6K02T2QD9B-18838170-18837232, Olfr1341
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258852
Homologene: 27281
Myo5b
Name: myosin VB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17919
HGNC: HGNC:7603
Homologene: 49481
Pklr
Name: pyruvate kinase liver and red blood cell
Synonyms: Pk-1, R-PK, Pk1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18770
HGNC: HGNC:9020
Homologene: 37286
Nod1
Name: nucleotide-binding oligomerization domain containing 1
Synonyms: Nlrc1, Card4, F830007N14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 107607
Homologene: 4440
Tbc1d9b
Name: TBC1 domain family, member 9B
Synonyms: 2700008N14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76795
Homologene: 28106
Kif14
Name: kinesin family member 14
Synonyms: D1Ertd367e, N-3 kinesin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381293
Homologene: 8916
Samd9l
Name: sterile alpha motif domain containing 9-like
Synonyms: ESTM25
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 209086
HGNC: HGNC:1349
Homologene: 7707
Mctp1
Name: multiple C2 domains, transmembrane 1
Synonyms: 2810465F10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78771
Homologene: 75211
Tufm
Name: Tu translation elongation factor, mitochondrial
Synonyms: EF-TuMT, 2300002G02Rik, C76308
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233870
Homologene: 2490
Hapln4
Name: hyaluronan and proteoglycan link protein 4
Synonyms: Bral2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330790
Homologene: 11304
Rims3
Name: regulating synaptic membrane exocytosis 3
Synonyms: Nim3, A730060M23Rik, Rim3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242662
Homologene: 8837
Rmc1
Name: regulator of MON1-CCZ1
Synonyms: 3110002H16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 76482
Homologene: 8341
Gcc2
Name: GRIP and coiled-coil domain containing 2
Synonyms: 2600014C01Rik, 2210420P05Rik, 0610043A03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70297
Homologene: 45639
Or13c25
Name: olfactory receptor family 13 subfamily C member 25
Synonyms: Olfr272, MOR262-7, GA_x6K02T2N78B-7084885-7085844
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258836
Homologene: 17409
Or5m12
Name: olfactory receptor family 5 subfamily M member 12
Synonyms: GA_x6K02T2Q125-47384320-47383337, Olfr1024, MOR197-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257900
Homologene: 128271
Or4a2
Name: olfactory receptor family 4 subfamily A member 2
Synonyms: Olfr1239, GA_x6K02T2Q125-50861284-50860367, MOR231-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258972
Homologene: 74244
Myom3
Name: myomesin family, member 3
Synonyms: 8430427K15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242702
Homologene: 19432
Vmn1r201
Name: vomeronasal 1 receptor 201
Synonyms: V1ri4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171255
Homologene: 110880
Abcc1
Name: ATP-binding cassette, sub-family C member 1
Synonyms: Abcc1b, Mdrap, Mrp1, Abcc1a, MRP
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17250
HGNC: HGNC:51
Homologene: 133779
Pnpla2
Name: patatin-like phospholipase domain containing 2
Synonyms: Atgl, 1110001C14Rik, 0610039C21Rik, desnutrin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66853
Homologene: 10687
Ccdc102a
Name: coiled-coil domain containing 102A
Synonyms: LOC234582
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234582
Homologene: 13240
Obox1
Name: oocyte specific homeobox 1
Synonyms: 7420700M11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71468
Homologene: 44937
Tle6
Name: transducin-like enhancer of split 6
Synonyms: Grg6, 1810057E06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 114606
Homologene: 11701
Gldn
Name: gliomedin
Synonyms: Crlg2, CRG-L2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235379
Homologene: 14529
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 136,515,986 bp
  • A to G, chromosome 1 at 184,819,328 bp
  • A to T, chromosome 2 at 40,803,209 bp
  • A to T, chromosome 2 at 76,802,354 bp
  • T to C, chromosome 2 at 85,904,216 bp
  • C to T, chromosome 2 at 89,418,351 bp
  • A to T, chromosome 3 at 56,000,616 bp
  • A to G, chromosome 3 at 64,278,761 bp
  • A to G, chromosome 3 at 82,034,411 bp
  • A to G, chromosome 3 at 89,007,865 bp
  • A to G, chromosome 3 at 89,137,355 bp
  • A to G, chromosome 3 at 90,252,281 bp
  • A to C, chromosome 3 at 101,045,620 bp
  • T to C, chromosome 3 at 103,341,609 bp
  • A to T, chromosome 3 at 152,376,250 bp
  • G to T, chromosome 4 at 32,238,816 bp
  • A to G, chromosome 4 at 52,911,399 bp
  • A to G, chromosome 4 at 118,709,947 bp
  • T to A, chromosome 4 at 120,883,153 bp
  • A to G, chromosome 4 at 135,776,377 bp
  • G to T, chromosome 4 at 152,382,408 bp
  • T to C, chromosome 5 at 30,371,935 bp
  • T to A, chromosome 5 at 34,895,887 bp
  • T to C, chromosome 5 at 92,303,930 bp
  • T to C, chromosome 5 at 104,207,125 bp
  • T to A, chromosome 5 at 121,144,653 bp
  • T to A, chromosome 5 at 143,914,633 bp
  • C to A, chromosome 5 at 149,214,287 bp
  • A to G, chromosome 6 at 3,376,361 bp
  • T to C, chromosome 6 at 54,924,983 bp
  • A to G, chromosome 6 at 57,431,670 bp
  • C to T, chromosome 6 at 113,797,131 bp
  • T to C, chromosome 6 at 128,552,236 bp
  • A to G, chromosome 7 at 15,555,369 bp
  • T to C, chromosome 7 at 43,408,754 bp
  • T to C, chromosome 7 at 118,154,277 bp
  • T to C, chromosome 7 at 123,378,182 bp
  • T to C, chromosome 7 at 126,489,238 bp
  • C to T, chromosome 7 at 127,883,681 bp
  • T to C, chromosome 7 at 141,459,285 bp
  • T to A, chromosome 8 at 70,084,423 bp
  • T to C, chromosome 8 at 94,911,516 bp
  • A to G, chromosome 9 at 54,286,878 bp
  • G to A, chromosome 10 at 39,134,101 bp
  • T to C, chromosome 10 at 41,382,829 bp
  • T to C, chromosome 10 at 58,271,465 bp
  • A to G, chromosome 10 at 76,178,200 bp
  • A to G, chromosome 10 at 81,595,239 bp
  • T to C, chromosome 11 at 45,895,081 bp
  • C to T, chromosome 11 at 50,131,497 bp
  • T to C, chromosome 11 at 84,986,576 bp
  • T to A, chromosome 11 at 99,317,427 bp
  • G to T, chromosome 12 at 86,063,864 bp
  • T to C, chromosome 13 at 22,475,351 bp
  • T to A, chromosome 13 at 60,729,442 bp
  • T to A, chromosome 13 at 77,020,863 bp
  • T to G, chromosome 14 at 86,866,540 bp
  • A to G, chromosome 15 at 11,241,433 bp
  • A to G, chromosome 15 at 80,879,614 bp
  • C to A, chromosome 16 at 14,465,056 bp
  • T to G, chromosome 17 at 25,825,676 bp
  • T to C, chromosome 17 at 27,893,201 bp
  • G to A, chromosome 18 at 12,180,514 bp
  • A to G, chromosome 18 at 36,771,332 bp
  • G to A, chromosome 18 at 74,616,993 bp
  • A to T, chromosome 19 at 9,006,625 bp
  • C to T, chromosome 19 at 29,717,747 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6331 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044485-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.