Strain Name:
C57BL/6J-MtgxR6337Btlr/Mmmh
Stock Number:
044491-MU
Citation ID:
RRID:MMRRC_044491-MU
Other Names:
R6337 (G1)
Major Collection:

Strain Information

Itga8
Name: integrin alpha 8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Abca12
Name: ATP-binding cassette, sub-family A member 12
Synonyms: 4832428G11Rik, 4833417A11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74591
Homologene: 45441
Adcyap1
Name: adenylate cyclase activating polypeptide 1
Synonyms: PACAP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 11516
VEGA: 17
HGNC: HGNC:241
Homologene: 869
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, b2b1625.2Clo, Gp330, D230004K18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Vipr2
Name: vasoactive intestinal peptide receptor 2
Synonyms: VPAC2, VPAC2R, Vip2, VIP receptor subtype 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22355
Homologene: 2540
Inpp5k
Name: inositol polyphosphate 5-phosphatase K
Synonyms: Pps, PI-5-phosphatase related, C62, putative PI-5-phosphatase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19062
Homologene: 75059
Hells
Name: helicase, lymphoid specific
Synonyms: LSH, proliferation-associated SNF2-like, PASG, E130115I21Rik, YFK8, Lysh
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15201
HGNC: HGNC:4861
Homologene: 50037
Snd1
Name: staphylococcal nuclease and tudor domain containing 1
Synonyms: Tudor-SN, p100 co-activator
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56463
Homologene: 8665
Eif3e
Name: eukaryotic translation initiation factor 3, subunit E
Synonyms: Int6, 48kDa, eIF3-p46, eIF3-p48, Eif3s6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16341
VEGA: 15
HGNC: HGNC:3277
Homologene: 1205
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: 9430093H17Rik, Falz
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207165
HGNC: HGNC:3581
Homologene: 114397
Itprid2
Name: ITPR interacting domain containing 2
Synonyms: Ssfa2, SPAG13, KRAP, CS1, CS-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70599
Homologene: 4912
Zbtb17
Name: zinc finger and BTB domain containing 17
Synonyms: Miz1, mZ13, Zfp100
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22642
Homologene: 2575
Wrap53
Name: WD repeat containing, antisense to Trp53
Synonyms: Wdr79
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216853
Homologene: 9995
Tcf4
Name: transcription factor 4
Synonyms: SEF-2, ITF-2, ASP-I2, SEF2-1, ME2, bHLHb19, ITF-2b, TFE, MITF-2A, E2-2, 5730422P05Rik, E2.2, MITF-2B
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 21413
Homologene: 2407
Chd8
Name: chromodomain helicase DNA binding protein 8
Synonyms: Duplin, 5830451P18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67772
Homologene: 72405
Strada
Name: STE20-related kinase adaptor alpha
Synonyms: 2610019A05Rik, 6030402H20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72149
Homologene: 12448
Slitrk5
Name: SLIT and NTRK-like family, member 5
Synonyms: 2610019D03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 75409
VEGA: 14
Homologene: 9193
Robo2
Name: roundabout guidance receptor 2
Synonyms: D230004I22Rik, 2600013A04Rik, 9430089E08Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268902
Homologene: 43188
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: P1-Loop, Hst6.7b, Dnahc8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Gtf2e2
Name: general transcription factor II E, polypeptide 2 (beta subunit)
Synonyms: C330006J08Rik, 34kDa
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68153
HGNC: HGNC:4651
Homologene: 37573
Zfyve27
Name: zinc finger, FYVE domain containing 27
Synonyms: 2210011N02Rik, protrudin, 9530077C24Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 319740
Homologene: 16939
Tpcn2
Name: two pore segment channel 2
Synonyms: D830047E22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233979
Homologene: 16375
Nceh1
Name: neutral cholesterol ester hydrolase 1
Synonyms: mKIAA1363, Aadacl1, CPO-BP, B230106I24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320024
Homologene: 23251
Tmem108
Name: transmembrane protein 108
Synonyms: B130017P16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 81907
Homologene: 18688
Slc4a4
Name: solute carrier family 4 (anion exchanger), member 4
Synonyms: NBC, NBC1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54403
Homologene: 55776
Tbx10
Name: T-box 10
Synonyms: Tbx13, Tbx7
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 109575
VEGA: 19
Homologene: 37399
Zbtb5
Name: zinc finger and BTB domain containing 5
Synonyms: 9430083K24Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230119
Homologene: 8913
Sorcs1
Name: sortilin-related VPS10 domain containing receptor 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 58178
Homologene: 10967
Epha3
Name: Eph receptor A3
Synonyms: Mek4, Hek4, End3, Tyro4, Hek, Cek4
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13837
VEGA: 16
HGNC: HGNC:3387
Homologene: 21083
Agl
Name: amylo-1,6-glucosidase, 4-alpha-glucanotransferase
Synonyms: 9630046L06Rik, 1110061O17Rik, 9430004C13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77559
HGNC: HGNC:321
Homologene: 536
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22635
Homologene: 124417
Akna
Name: AT-hook transcription factor
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100182
Homologene: 49947
Dusp26
Name: dual specificity phosphatase 26
Synonyms: 2310043K02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66959
Homologene: 11421
Qprt
Name: quinolinate phosphoribosyltransferase
Synonyms: 2410027J01Rik, nicotinate-nucleotide pyrophosphorylase, QPRTase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67375
HGNC: HGNC:9755
Homologene: 8623
Vps37a
Name: vacuolar protein sorting 37A
Synonyms: 2210018P21Rik, 4930592A21Rik, D8Ertd531e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 52348
VEGA: 8
Homologene: 45120
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: D230016L12Rik, Top-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21974
Homologene: 134711
Flnc
Name: filamin C, gamma
Synonyms: actin binding protein 280, 1110055E19Rik, Fln2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Nell2
Name: NEL-like 2
Synonyms: A330108N19Rik, mel91
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54003
VEGA: 15
HGNC: HGNC:7751
Homologene: 4488
Zup1
Name: zinc finger containing ubiquitin peptidase 1
Synonyms: Zufsp, 2700019D07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72580
VEGA: 10
Homologene: 12472
Irf9
Name: interferon regulatory factor 9
Synonyms: Isgf3g, p48, Irf-9
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16391
HGNC: HGNC:6131
Homologene: 4436
Fpgs
Name: folylpolyglutamyl synthetase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14287
HGNC: HGNC:3824
Homologene: 6997
Hscb
Name: HscB iron-sulfur cluster co-chaperone
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100900
Homologene: 13945
Sidt1
Name: SID1 transmembrane family, member 1
Synonyms: B830021E24Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320007
Homologene: 41189
Dhcr7
Name: 7-dehydrocholesterol reductase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13360
HGNC: HGNC:2860
Homologene: 1042
Gm10549
Name: predicted gene 10549
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 433171
VEGA: 18
Or2t49
Name: olfactory receptor family 2 subfamily T member 49
Synonyms: Olfr331, GA_x6K02T2NKPP-912840-913784, MOR275-4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100502887
Homologene: 133015
Acsm5
Name: acyl-CoA synthetase medium-chain family member 5
Synonyms: C730027J19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 272428
Homologene: 69242
Acsl6
Name: acyl-CoA synthetase long-chain family member 6
Synonyms: Facl6, A330035H04Rik, Lacsl
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216739
Homologene: 100939
Krtap4-22
Name: keratin associated protein 4-22
Synonyms: Gm11595
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100040276
Homologene: 124486
Adgrg7
Name: adhesion G protein-coupled receptor G7
Synonyms: Gpr128, 9130020O16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239853
Homologene: 13115
Apol7e
Name: apolipoprotein L 7e
Synonyms: ENSMUSG00000071716
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666348
VEGA: 15
HGNC: HGNC:619
Homologene: 40940
Anks1b
Name: ankyrin repeat and sterile alpha motif domain containing 1B
Synonyms: Gm10937, C030032C09Rik, AIDA-1b, LOC380650, E530015N03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77531
Homologene: 51570
Purg
Name: purine-rich element binding protein G
Synonyms: 4930486B15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75029
Homologene: 22747
Phf11a
Name: PHD finger protein 11A
Synonyms: 4933417L10Rik, Phf11
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219131
Homologene: 87807
Serpina3a
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3A
Synonyms: alpha-1 antiproteinase,, 4933406L18Rik, antitrypsin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74069
HGNC: HGNC:16
Ccdc87
Name: coiled-coil domain containing 87
Synonyms: 4931419P11Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 399599
VEGA: 19
Homologene: 49531
Gm5591
Name: predicted gene 5591
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434171
Homologene: 80005
Speer3
Name: spermatogenesis associated glutamate (E)-rich protein 3
Synonyms: 4933405P08Rik, SPEER-3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71026
Homologene: 69402
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 71,295,013 bp
  • A to T, chromosome 2 at 12,253,469 bp
  • A to T, chromosome 2 at 32,687,941 bp
  • A to T, chromosome 2 at 69,438,467 bp
  • G to A, chromosome 2 at 79,655,119 bp
  • G to T, chromosome 3 at 27,222,807 bp
  • T to G, chromosome 3 at 90,061,733 bp
  • T to A, chromosome 3 at 116,786,777 bp
  • C to T, chromosome 3 at 146,624,577 bp
  • G to A, chromosome 4 at 44,993,459 bp
  • A to G, chromosome 4 at 63,374,003 bp
  • G to A, chromosome 4 at 141,463,383 bp
  • A to G, chromosome 5 at 13,793,355 bp
  • T to A, chromosome 5 at 89,046,372 bp
  • C to T, chromosome 5 at 93,270,921 bp
  • A to G, chromosome 5 at 110,839,494 bp
  • G to A, chromosome 5 at 137,452,488 bp
  • T to C, chromosome 6 at 28,888,289 bp
  • A to G, chromosome 6 at 29,454,319 bp
  • T to C, chromosome 7 at 38,521,895 bp
  • G to A, chromosome 7 at 119,534,235 bp
  • C to T, chromosome 7 at 127,108,929 bp
  • T to C, chromosome 7 at 143,836,731 bp
  • A to G, chromosome 7 at 145,279,343 bp
  • T to C, chromosome 8 at 31,096,297 bp
  • A to G, chromosome 8 at 33,386,423 bp
  • C to T, chromosome 8 at 33,776,015 bp
  • A to T, chromosome 8 at 40,540,708 bp
  • T to A, chromosome 9 at 99,709,942 bp
  • C to T, chromosome 9 at 103,499,761 bp
  • T to C, chromosome 10 at 33,949,256 bp
  • A to T, chromosome 10 at 90,921,296 bp
  • C to A, chromosome 11 at 54,340,542 bp
  • A to T, chromosome 11 at 58,502,012 bp
  • T to C, chromosome 11 at 69,577,685 bp
  • T to A, chromosome 11 at 75,646,814 bp
  • G to A, chromosome 11 at 99,772,555 bp
  • T to C, chromosome 11 at 106,173,317 bp
  • G to T, chromosome 11 at 107,058,779 bp
  • T to C, chromosome 12 at 104,112,878 bp
  • T to A, chromosome 12 at 116,122,743 bp
  • A to G, chromosome 14 at 16,399,026 bp
  • C to A, chromosome 14 at 52,204,109 bp
  • G to A, chromosome 14 at 55,606,342 bp
  • C to A, chromosome 14 at 59,284,368 bp
  • A to T, chromosome 14 at 111,680,252 bp
  • T to C, chromosome 15 at 43,252,296 bp
  • T to A, chromosome 15 at 77,714,382 bp
  • A to G, chromosome 15 at 95,385,144 bp
  • A to T, chromosome 16 at 44,300,935 bp
  • T to A, chromosome 16 at 56,752,425 bp
  • A to T, chromosome 16 at 63,568,443 bp
  • T to C, chromosome 16 at 73,928,151 bp
  • G to A, chromosome 17 at 30,748,568 bp
  • C to T, chromosome 17 at 67,786,019 bp
  • T to A, chromosome 17 at 93,202,281 bp
  • C to A, chromosome 18 at 33,464,305 bp
  • T to C, chromosome 18 at 69,633,580 bp
  • A to T, chromosome 19 at 3,997,312 bp
  • A to G, chromosome 19 at 4,839,801 bp
  • G to T, chromosome 19 at 38,954,810 bp
  • A to G, chromosome 19 at 42,182,657 bp
  • A to G, chromosome 19 at 50,144,124 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6337 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044491-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.