Strain Name:
C57BL/6J-MtgxR6346Btlr/Mmmh
Stock Number:
044500-MU
Citation ID:
RRID:MMRRC_044500-MU
Other Names:
R6346 (G1)
Major Collection:

Strain Information

Snx1
Name: sorting nexin 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56440
Homologene: 99716
Secisbp2
Name: SECIS binding protein 2
Synonyms: 2210413N07Rik, 2810012K13Rik, SBP2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75420
Homologene: 11415
Plekha1
Name: pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
Synonyms: TAPP1, C920009D07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101476
Homologene: 11001
Hcn4
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330953
VEGA: 9
Homologene: 3997
Ube2o
Name: ubiquitin-conjugating enzyme E2O
Synonyms: B230113M03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217342
Homologene: 11113
Lmnb1
Name: lamin B1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16906
HGNC: HGNC:6637
Homologene: 55912
Akap13
Name: A kinase anchor protein 13
Synonyms: 5730522G15Rik, 1700026G02Rik, PROTO-LB, Ht31, PROTO-LBC, 5830460E08Rik, AKAP-Lbc
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75547
HGNC: HGNC:371
Homologene: 4903
Myo1b
Name: myosin IB
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17912
HGNC: HGNC:7596
Homologene: 7856
Rsf1
Name: remodeling and spacing factor 1
Synonyms: Hbxap, p325, XAP8, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Mllt3
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
Synonyms: 2610012I03Rik, 2210011H10Rik, 3830408D16Rik, D4Ertd321e, Af9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70122
HGNC: HGNC:7136
Homologene: 37933
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930543C13Rik, D330038K10Rik, 4930516E05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Nrde2
Name: nrde-2 necessary for RNA interference, domain containing
Synonyms: BC002230, 6720454P05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217827
VEGA: 12
Homologene: 41213
Atp4a
Name: ATPase, H+/K+ exchanging, gastric, alpha polypeptide
Synonyms: H+K+-transporting alpha 1, H+/K+-ATPase alpha
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11944
HGNC: HGNC:819
Homologene: 68081
Cmya5
Name: cardiomyopathy associated 5
Synonyms: 2310076E21Rik, Myospryn, 2310076E16Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244646
Homologene: 14627
Pcdhgb8
Name: protocadherin gamma subfamily B, 8
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93705
Homologene: 81868
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 229003
Homologene: 14118
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: mXin beta, myomaxin, 2310003D02Rik, Cmya3, 2310008C07Rik, A530024P18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241431
Homologene: 19388
Dock10
Name: dedicator of cytokinesis 10
Synonyms: A630054M16Rik, Zizimin3, Jr5, Jr4, ZIZ3, 9330153B10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210293
Homologene: 45952
Slc27a2
Name: solute carrier family 27 (fatty acid transporter), member 2
Synonyms: Vlacs, FATP2, VLCS, Vlac, ACSVL1, FATP2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26458
Homologene: 37830
Cd244a
Name: CD244 molecule A
Synonyms: Nmrk, F730046O15Rik, Cd244, C9.1, 2B4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18106
Homologene: 9493
Zfp804b
Name: zinc finger protein 804B
Synonyms: LOC207618
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 207618
Homologene: 52304
Kdm7a
Name: lysine (K)-specific demethylase 7A
Synonyms: ENSMUSG00000073143, A630082K20Rik, Jhdm1d, Kdm7a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 338523
Homologene: 25281
Ceacam12
Name: CEA cell adhesion molecule 12
Synonyms: 1600031J20Rik, Ceacam12-C1, Ceacam12-C3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67315
Homologene: 137375
Ksr1
Name: kinase suppressor of ras 1
Synonyms: B-KSR1, D11Bhm183e, D11Bhm184e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16706
HGNC: HGNC:6465
Homologene: 8410
Cyp2b23
Name: cytochrome P450, family 2, subfamily b, polypeptide 23
Synonyms: EG243881
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243881
HGNC: HGNC:2615
Homologene: 117483
Ntn4
Name: netrin 4
Synonyms: beta-netrin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 57764
Homologene: 10934
Fam20c
Name: FAM20C, golgi associated secretory pathway kinase
Synonyms: DMP4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 80752
Homologene: 56879
Dixdc1
Name: DIX domain containing 1
Synonyms: Ccd1, 4930563F16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330938
Homologene: 82369
Myom3
Name: myomesin family, member 3
Synonyms: 8430427K15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242702
Homologene: 19432
Apbb1ip
Name: amyloid beta precursor protein binding family B member 1 interacting protein
Synonyms: proline-rich protein 48, Prp48, 9930118P07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54519
Homologene: 32434
Carf
Name: calcium response factor
Synonyms: Als2cr8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241066
Homologene: 11689
Nup43
Name: nucleoporin 43
Synonyms: 43kDa, 2610016K01Rik, p42, 2610529I12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69912
Homologene: 11639
Shc3
Name: src homology 2 domain-containing transforming protein C3
Synonyms: ShcC, N-Shc, Rai
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20418
VEGA: 13
Homologene: 7536
Arl14epl
Name: ADP-ribosylation factor-like 14 effector protein-like
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381142
VEGA: 18
Homologene: 85362
Senp5
Name: SUMO/sentrin specific peptidase 5
Synonyms: 6230429P13Rik, A730063F07Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320213
Homologene: 17647
Arhgap18
Name: Rho GTPase activating protein 18
Synonyms: 4833419J07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73910
Homologene: 14135
Ubd
Name: ubiquitin D
Synonyms: Diubiquitin, FAT10
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 24108
Homologene: 4665
Bfar
Name: bifunctional apoptosis regulator
Synonyms: RNF47
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67118
Homologene: 9563
Prss29
Name: serine protease 29
Synonyms: mISP-2, Isp2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 114662
VEGA: 17
Homologene: 70877
Slc27a5
Name: solute carrier family 27 (fatty acid transporter), member 5
Synonyms: FACVL3, VLCSH2, FATP5, VLCS-H2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26459
Homologene: 7596
Pcdha6
Name: protocadherin alpha 6
Synonyms: Cnr2, Crnr2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12937
Homologene: 75098
Psmb5
Name: proteasome (prosome, macropain) subunit, beta type 5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19173
VEGA: 14
HGNC: HGNC:9542
Homologene: 55690
Trir
Name: telomerase RNA component interacting RNase
Synonyms: 2310036O22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68544
Homologene: 11428
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 51,784,507 bp
  • C to T, chromosome 1 at 60,141,540 bp
  • T to A, chromosome 1 at 80,575,856 bp
  • T to C, chromosome 1 at 171,577,321 bp
  • T to G, chromosome 2 at 22,866,993 bp
  • C to A, chromosome 2 at 67,516,081 bp
  • G to A, chromosome 2 at 126,587,880 bp
  • C to T, chromosome 2 at 181,233,467 bp
  • T to C, chromosome 4 at 87,841,208 bp
  • A to T, chromosome 4 at 135,806,051 bp
  • T to C, chromosome 5 at 6,770,534 bp
  • T to C, chromosome 5 at 138,766,695 bp
  • A to T, chromosome 6 at 39,151,211 bp
  • T to A, chromosome 7 at 12,990,972 bp
  • T to A, chromosome 7 at 18,069,401 bp
  • T to G, chromosome 7 at 26,681,725 bp
  • T to A, chromosome 7 at 30,715,356 bp
  • C to T, chromosome 7 at 75,685,254 bp
  • A to AGGGCGACGG, chromosome 7 at 97,579,904 bp
  • T to A, chromosome 7 at 130,877,782 bp
  • A to G, chromosome 8 at 85,027,014 bp
  • A to G, chromosome 8 at 109,631,384 bp
  • T to C, chromosome 9 at 50,683,953 bp
  • C to T, chromosome 9 at 58,859,044 bp
  • T to C, chromosome 9 at 66,094,648 bp
  • T to A, chromosome 10 at 7,675,062 bp
  • A to T, chromosome 10 at 26,846,065 bp
  • A to T, chromosome 10 at 93,644,861 bp
  • A to C, chromosome 11 at 79,019,664 bp
  • T to C, chromosome 11 at 116,541,368 bp
  • A to G, chromosome 12 at 100,132,306 bp
  • T to A, chromosome 13 at 51,451,615 bp
  • C to T, chromosome 13 at 51,679,887 bp
  • T to C, chromosome 13 at 93,092,190 bp
  • C to A, chromosome 14 at 54,616,673 bp
  • T to C, chromosome 16 at 13,702,133 bp
  • A to G, chromosome 16 at 31,983,847 bp
  • A to G, chromosome 17 at 25,321,110 bp
  • C to T, chromosome 17 at 37,195,351 bp
  • G to A, chromosome 18 at 36,968,060 bp
  • T to C, chromosome 18 at 37,762,078 bp
  • A to T, chromosome 18 at 46,926,342 bp
  • A to G, chromosome 18 at 56,743,238 bp
  • T to C, chromosome 19 at 16,682,214 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6346 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044500-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.