Strain Name:
C57BL/6J-MtgxR6358Btlr/Mmmh
Stock Number:
044508-MU
Citation ID:
RRID:MMRRC_044508-MU
Other Names:
R6358 (G1)
Major Collection:

Strain Information

H2-DMa
Name: histocompatibility 2, class II, locus DMa
Synonyms: H2-Ma, H2-M alpha, H-2Ma
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14998
HGNC: HGNC:4934
Homologene: 4464
Crhr2
Name: corticotropin releasing hormone receptor 2
Synonyms: CRFR2beta, CRF 2 receptor, Crfr2, CRH-R2, CRFR2alpha, CRF-R2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12922
HGNC: HGNC:2358
Homologene: 55612
Ptch1
Name: patched 1
Synonyms: wig, Ptc, A230106A15Rik, Ptc1, Patched 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: TRIP8, D630035I23Rik, 5430433L24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108829
Homologene: 3129
Setx
Name: senataxin
Synonyms: Als4, A930037J23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Erbin
Name: Erbb2 interacting protein
Synonyms: 1700028E05Rik, Erbb2ip, Erbin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 59079
Homologene: 41282
Iars1
Name: isoleucyl-tRNA synthetase 1
Synonyms: E430001P04Rik, Iars, 2510016L12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105148
HGNC: HGNC:5330
Homologene: 5325
Mon2
Name: MON2 homolog, regulator of endosome to Golgi trafficking
Synonyms: SF21, 2610528O22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67074
VEGA: 10
Homologene: 44309
Prpf8
Name: pre-mRNA processing factor 8
Synonyms: DBF3/PRP8, Prp8, D11Bwg0410e, Sfprp8l
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192159
Homologene: 4706
Ndufs6
Name: NADH:ubiquinone oxidoreductase core subunit S6
Synonyms: IP13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 407785
HGNC: HGNC:7713
Homologene: 37935
Ankrd28
Name: ankyrin repeat domain 28
Synonyms: E430019N21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105522
VEGA: 14
Homologene: 35374
Npnt
Name: nephronectin
Synonyms: 1110009H02Rik, POEM
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 114249
Homologene: 14138
Slf2
Name: SMC5-SMC6 complex localization factor 2
Synonyms: Fam178a, 6030443O07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226151
VEGA: 19
Homologene: 23077
D5Ertd579e
Name: DNA segment, Chr 5, ERATO Doi 579, expressed
Synonyms: 9030221A05Rik, A930018H20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320661
Homologene: 19716
Car14
Name: carbonic anhydrase 14
Synonyms: CA XIV
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23831
HGNC: HGNC:1372
Homologene: 69105
Ppib
Name: peptidylprolyl isomerase B
Synonyms: CyP-20b, Cphn-2, Cphn2, cyclophilin B
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19035
VEGA: 9
HGNC: HGNC:9255
Homologene: 726
Tbc1d10b
Name: TBC1 domain family, member 10b
Synonyms: 1110003P22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68449
Homologene: 9177
Magi3
Name: membrane associated guanylate kinase, WW and PDZ domain containing 3
Synonyms: 4732496O19Rik, 6530407C02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99470
Homologene: 26431
Gorasp2
Name: golgi reassembly stacking protein 2
Synonyms: 9430094F20Rik, 5730520M13Rik, p59, ENSMUSG00000075299, GOLPH2, GRS2, GRASP55
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70231
Homologene: 9180
Tctn1
Name: tectonic family member 1
Synonyms: G730031O11Rik, Tect1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 654470
Homologene: 49770
Tmeff2
Name: transmembrane protein with EGF-like and two follistatin-like domains 2
Synonyms: 7630402F16Rik, 4832418D20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56363
Homologene: 9417
Tspan18
Name: tetraspanin 18
Synonyms: 2610042G18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241556
Homologene: 24122
Hspa12b
Name: heat shock protein 12B
Synonyms: 2700081N06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72630
Homologene: 41749
Tmprss7
Name: transmembrane serine protease 7
Synonyms: matriptase-3, B230219I23Rik, LOC385645
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208171
Homologene: 18178
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Mass1, Gpr98, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Cdhr2
Name: cadherin-related family member 2
Synonyms: Pcdh24, LOC268663
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 268663
Homologene: 134510
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 81877
Homologene: 49589
Ntsr2
Name: neurotensin receptor 2
Synonyms: NT2R, NTRL
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18217
VEGA: 12
HGNC: HGNC:8040
Homologene: 7452
Or11j4
Name: olfactory receptor family 11 subfamily J member 4
Synonyms: MOR106-5, GA_x6K02T2PMLR-6089963-6090901, Olfr736
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258660
Homologene: 64902
Shank2
Name: SH3 and multiple ankyrin repeat domains 2
Synonyms: ProSAP1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210274
Homologene: 105965
Adam39
Name: a disintegrin and metallopeptidase domain 39
Synonyms: 1700056P18Rik, testase 9
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 546055
HGNC: HGNC:199
Homologene: 128364
Rfx4
Name: regulatory factor X, 4 (influences HLA class II expression)
Synonyms: 4933412G19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71137
HGNC: HGNC:9985
Homologene: 31119
Myo5c
Name: myosin VC
Synonyms: 9130003O20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208943
VEGA: 9
HGNC: HGNC:7604
Homologene: 135711
Tnrc18
Name: trinucleotide repeat containing 18
Synonyms: Zfp469, EG381742
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231861
Homologene: 45603
Glp1r
Name: glucagon-like peptide 1 receptor
Synonyms: GLP1Rc, GLP-1R
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14652
VEGA: 17
HGNC: HGNC:4324
Homologene: 1558
Emilin1
Name: elastin microfibril interfacer 1
Synonyms: 5830419M17Rik, EMILIN-1, gp115
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100952
Homologene: 5117
Tnfsf18
Name: tumor necrosis factor (ligand) superfamily, member 18
Synonyms: GITR ligand, Gitrl
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240873
Homologene: 3732
Rpl27
Name: ribosomal protein L27
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19942
Homologene: 105144
Polr1e
Name: polymerase (RNA) I polypeptide E
Synonyms: Praf1, 53kDa, D030019D19Rik, Paf53
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 64424
Homologene: 41486
Tbxas1
Name: thromboxane A synthase 1, platelet
Synonyms: TXAS, TXS, CYP5A1, CYP5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21391
Homologene: 130979
Aldh18a1
Name: aldehyde dehydrogenase 18 family, member A1
Synonyms: 2810433K04Rik, Pycs
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56454
HGNC: HGNC:9722
Homologene: 2142
Tgm4
Name: transglutaminase 4 (prostate)
Synonyms: 9530008N10Rik, experimental autoimmune prostatitis antigen 1, Eapa1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 331046
Homologene: 20689
Rgl2
Name: ral guanine nucleotide dissociation stimulator-like 2
Synonyms: Rlf, KE1.5, Rgt2, Rab2l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19732
HGNC: HGNC:9769
Homologene: 3494
Musk
Name: muscle, skeletal, receptor tyrosine kinase
Synonyms: Nsk2, Nsk3, MDK4, Nsk1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18198
HGNC: HGNC:7525
Homologene: 4084
Ralb
Name: v-ral simian leukemia viral oncogene B
Synonyms: 5730472O18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 64143
HGNC: HGNC:9840
Homologene: 20632
Zfpm1
Name: zinc finger protein, multitype 1
Synonyms: Fog1, Friend of GATA-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22761
Homologene: 7606
Hsd3b7
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101502
Homologene: 41617
Zbtb22
Name: zinc finger and BTB domain containing 22
Synonyms: Zfp297, Bing1, 1110008J20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 81630
Homologene: 3982
Zfp2
Name: zinc finger protein 2
Synonyms: 9930007F06Rik, mkr-2, Zfp-2, Fnp-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22678
Homologene: 121779
Slc22a28
Name: solute carrier family 22, member 28
Synonyms: Gm5631
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 434674
VEGA: 19
Homologene: 77136
Ppl
Name: periplakin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19041
VEGA: 16
HGNC: HGNC:9273
Homologene: 2026
Tmem167b
Name: transmembrane protein 167B
Synonyms: 2010200O16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67495
Homologene: 10594
Mia
Name: MIA SH3 domain containing
Synonyms: Cdrap, Mia1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12587
HGNC: HGNC:7076
Homologene: 4763
Tomm40l
Name: translocase of outer mitochondrial membrane 40-like
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 641376
Homologene: 134180
Sdc1
Name: syndecan 1
Synonyms: Synd, CD138, syn-1, Synd1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20969
Homologene: 2252
Tspan8
Name: tetraspanin 8
Synonyms: Tm4sf3, E330007O21Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216350
VEGA: 10
Homologene: 20968
Gm527
Name: predicted gene 527
Synonyms: LOC217648
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217648
VEGA: 12
Homologene: 19024
Or5aq7
Name: olfactory receptor family 5 subfamily AQ member 7
Synonyms: Olfr259, GA_x6K02T2N869-1820-882, MOR172-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258766
Homologene: 106833
Gm10220
Name: predicted gene 10220
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 434689
Homologene: 69402
Pkmyt1
Name: protein kinase, membrane associated tyrosine/threonine 1
Synonyms: Myt1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268930
VEGA: 17
Homologene: 31227
Eif1ad3
Name: eukaryotic translation initiation factor 1A domain containing 3
Synonyms: Gm2016
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100039042
Homologene: 103865
Trbv2
Name: T cell receptor beta, variable 2
Synonyms: Gm16752, Tcrb-V4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100124659
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 51,133,114 bp
  • C to A, chromosome 1 at 119,476,005 bp
  • T to A, chromosome 1 at 161,503,579 bp
  • C to T, chromosome 1 at 171,219,637 bp
  • T to A, chromosome 2 at 29,171,348 bp
  • T to A, chromosome 2 at 70,672,760 bp
  • T to C, chromosome 2 at 87,108,434 bp
  • T to C, chromosome 2 at 93,209,874 bp
  • T to C, chromosome 2 at 131,137,066 bp
  • T to A, chromosome 3 at 95,898,175 bp
  • T to C, chromosome 3 at 104,050,952 bp
  • C to T, chromosome 3 at 108,558,895 bp
  • C to T, chromosome 3 at 132,904,718 bp
  • T to C, chromosome 4 at 45,026,813 bp
  • T to A, chromosome 4 at 58,373,171 bp
  • C to G, chromosome 5 at 26,120,305 bp
  • A to G, chromosome 5 at 30,918,218 bp
  • T to A, chromosome 5 at 36,616,236 bp
  • A to G, chromosome 5 at 122,261,512 bp
  • A to T, chromosome 5 at 142,727,981 bp
  • G to A, chromosome 6 at 38,952,112 bp
  • A to G, chromosome 6 at 41,047,902 bp
  • A to G, chromosome 6 at 55,093,043 bp
  • T to C, chromosome 7 at 27,180,978 bp
  • T to C, chromosome 7 at 127,203,412 bp
  • T to A, chromosome 7 at 127,801,537 bp
  • A to G, chromosome 7 at 144,031,297 bp
  • T to C, chromosome 8 at 40,826,681 bp
  • A to G, chromosome 8 at 122,337,111 bp
  • T to G, chromosome 9 at 66,061,474 bp
  • A to T, chromosome 9 at 75,296,012 bp
  • A to G, chromosome 9 at 123,056,518 bp
  • T to C, chromosome 10 at 67,225,939 bp
  • T to A, chromosome 10 at 84,844,235 bp
  • G to T, chromosome 10 at 115,833,227 bp
  • A to T, chromosome 10 at 123,013,504 bp
  • A to T, chromosome 11 at 50,900,601 bp
  • T to C, chromosome 11 at 75,491,495 bp
  • A to G, chromosome 11 at 101,443,956 bp
  • A to C, chromosome 12 at 8,791,297 bp
  • A to G, chromosome 12 at 16,656,768 bp
  • A to T, chromosome 12 at 64,923,548 bp
  • A to G, chromosome 12 at 87,877,000 bp
  • C to A, chromosome 13 at 49,727,143 bp
  • T to C, chromosome 13 at 54,736,546 bp
  • T to G, chromosome 13 at 63,513,689 bp
  • C to T, chromosome 13 at 73,320,319 bp
  • T to A, chromosome 13 at 81,414,583 bp
  • T to A, chromosome 13 at 103,845,565 bp
  • A to C, chromosome 14 at 31,710,864 bp
  • A to T, chromosome 14 at 50,393,388 bp
  • C to A, chromosome 16 at 5,087,929 bp
  • T to G, chromosome 16 at 45,669,573 bp
  • T to A, chromosome 17 at 23,733,656 bp
  • T to C, chromosome 17 at 30,932,644 bp
  • T to C, chromosome 17 at 33,918,737 bp
  • T to A, chromosome 17 at 33,937,131 bp
  • T to A, chromosome 17 at 34,137,984 bp
  • A to G, chromosome 17 at 34,678,994 bp
  • T to A, chromosome 19 at 8,071,888 bp
  • A to T, chromosome 19 at 40,577,678 bp
  • A to T, chromosome 19 at 44,935,425 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6358 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044508-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.