Strain Name:
C57BL/6J-MtgxR6361Btlr/Mmmh
Stock Number:
044511-MU
Citation ID:
RRID:MMRRC_044511-MU
Other Names:
R6361 (G1)
Major Collection:

Strain Information

Cadps
Name: Ca2+-dependent secretion activator
Synonyms: CAPS1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27062
VEGA: 14
HGNC: HGNC:1426
Homologene: 2755
Zdbf2
Name: zinc finger, DBF-type containing 2
Synonyms: 4930431J08Rik, 9330107J05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73884
Homologene: 52868
Polr2a
Name: polymerase (RNA) II (DNA directed) polypeptide A
Synonyms: Rpo2-1, 220kDa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20020
HGNC: HGNC:9187
Homologene: 721
Prkd2
Name: protein kinase D2
Synonyms: PKD2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101540
Homologene: 9516
Cabin1
Name: calcineurin binding protein 1
Synonyms: A330070M20Rik, Cain, Ppp3in
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 104248
VEGA: 10
Homologene: 49307
Ercc6
Name: excision repair cross-complementing rodent repair deficiency, complementation group 6
Synonyms: C130058G22Rik, CSB, CS group B correcting gene
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 319955
VEGA: 14
HGNC: HGNC:3438
Homologene: 133552
Asap1
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain1
Synonyms: Ddef1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13196
HGNC: HGNC:2720
Homologene: 7684
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195018
Homologene: 9027
Itgb3
Name: integrin beta 3
Synonyms: platelet glycoprotein IIIa (GP3A), CD61
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16416
HGNC: HGNC:6156
Homologene: 55444
Zfp868
Name: zinc finger protein 868
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234362
Homologene: 74376
Clec18a
Name: C-type lectin domain family 18, member A
Synonyms: Mrcl
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 353287
Homologene: 18755
Crispld1
Name: cysteine-rich secretory protein LCCL domain containing 1
Synonyms: Cocoacrisp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 83691
Homologene: 12857
Pcca
Name: propionyl-Coenzyme A carboxylase, alpha polypeptide
Synonyms: C79630
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110821
HGNC: HGNC:8653
Homologene: 236
Pkd2
Name: polycystin 2, transient receptor potential cation channel
Synonyms: PC2, polycystin-2, C030034P18Rik, TRPP2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18764
HGNC: HGNC:9009
Homologene: 20104
Eif2b3
Name: eukaryotic translation initiation factor 2B, subunit 3
Synonyms: 1190002P15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 108067
HGNC: HGNC:3259
Homologene: 7005
Itsn2
Name: intersectin 2
Synonyms: Sh3p18, Ese2, Sh3d1B, Eh domain, SH3 domain regulator of endocytosis 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20403
VEGA: 12
HGNC: HGNC:6184
Homologene: 22627
Usp37
Name: ubiquitin specific peptidase 37
Synonyms: C330008N13Rik, 4932415L06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319651
Homologene: 10858
Mst1r
Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Synonyms: Fv-2, Fv2, STK, CDw136, PTK8, friend virus susceptibility 2, Ron
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19882
HGNC: HGNC:7381
Homologene: 1835
Rundc3a
Name: RUN domain containing 3A
Synonyms: Rpip8, Rap2ip
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 51799
Homologene: 4871
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Or4k51
Name: olfactory receptor family 4 subfamily K member 51
Synonyms: MOR248-5, GA_x6K02T2Q125-72805651-72806589, Olfr1301
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258889
Homologene: 74057
Dscam
Name: DS cell adhesion molecule
Synonyms: Down syndrome cell adhesion molecule, 4932410A21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13508
HGNC: HGNC:3039
Homologene: 74393
Spata31g1
Name: SPATA31 subfamily G member 1
Synonyms: 1700022I11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67317
Homologene: 52406
Hspb7
Name: heat shock protein family, member 7 (cardiovascular)
Synonyms: cvHsp, Hsp25-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 29818
HGNC: HGNC:5249
Homologene: 8480
Rhbdf1
Name: rhomboid 5 homolog 1
Synonyms: Dist, Egfr-rs, Dist1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13650
Homologene: 32085
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: Dvwa, EG235580, Vwa6, 1110001D15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68553
Homologene: 130754
Cep89
Name: centrosomal protein 89
Synonyms: Ccdc123, 2610507L03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72140
Homologene: 12444
Zfp422
Name: zinc finger protein 422
Synonyms: KOX15, 2900028O21Rik, Krox-26, Krox25, Krox-25-2, Krox26
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67255
Homologene: 5067
Tbc1d4
Name: TBC1 domain family, member 4
Synonyms: 5930406J04Rik, AS160
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 210789
Homologene: 45451
Gm4841
Name: predicted gene 4841
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225594
VEGA: 18
Fam170b
Name: family with sequence similarity 170, member B
Synonyms: 4922501K12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105511
VEGA: 14
Homologene: 19055
Or7g18
Name: olfactory receptor family 7 subfamily G member 18
Synonyms: MOR152-1, GA_x6K02T2PVTD-12618399-12619337, Olfr830
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258559
HGNC: HGNC:8466
Homologene: 79360
Or1j19
Name: olfactory receptor family 1 subfamily J member 19
Synonyms: GA_x6K02T2NLDC-33481050-33481991, MOR136-8, Olfr348
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258946
HGNC: HGNC:8209
Homologene: 105219
Flt4
Name: FMS-like tyrosine kinase 4
Synonyms: VEGFR-3, Flt-4, VEGFR3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14257
HGNC: HGNC:3767
Homologene: 7321
Cdc14b
Name: CDC14 cell division cycle 14B
Synonyms: A530086E13Rik, 2810432N10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218294
VEGA: 13
Homologene: 104197
Dhrs7
Name: dehydrogenase/reductase 7
Synonyms: 2310016E22Rik, retSDR4, 5730564L20Rik, retDSR4, dehydrogenase/reductase (SDR family) member 7
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66375
VEGA: 12
Homologene: 9350
Vwa2
Name: von Willebrand factor A domain containing 2
Synonyms: Amaco
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240675
Homologene: 18238
Or4c123
Name: olfactory receptor family 4 subfamily C member 123
Synonyms: GA_x6K02T2Q125-50741934-50741017, MOR237-1, Olfr1230
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258785
Homologene: 81570
Spef1l
Name: sperm flagellar 1 like
Synonyms: 6430531B16Rik, LOC381933
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381933
Homologene: 134514
Cln5
Name: ceroid-lipofuscinosis, neuronal 5
Synonyms: A730075N08Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211286
VEGA: 14
HGNC: HGNC:2076
Homologene: 4738
Marchf8
Name: membrane associated ring-CH-type finger 8
Synonyms: Mir, March8, 1300017E09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71779
Homologene: 12412
Or8g50
Name: olfactory receptor family 8 subfamily G member 50
Synonyms: M93, Olfr150, GA_x6K02T2PVTD-33434302-33435240, MOR171-18
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258602
VEGA: 9
Myl6b
Name: myosin, light polypeptide 6B
Synonyms: 5730437E04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216459
VEGA: 10
Homologene: 86887
Krtap10-33
Name: keratin associated protein 10-33
Synonyms: Gm19402
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100502831
VEGA: 10
Homologene: 115744
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 17,762,231 bp
  • A to C, chromosome 1 at 63,303,321 bp
  • A to G, chromosome 1 at 74,453,893 bp
  • A to G, chromosome 2 at 36,786,780 bp
  • A to T, chromosome 2 at 89,296,646 bp
  • G to T, chromosome 2 at 111,754,595 bp
  • A to T, chromosome 4 at 42,972,695 bp
  • A to G, chromosome 4 at 117,028,425 bp
  • A to G, chromosome 4 at 141,422,549 bp
  • C to T, chromosome 5 at 104,486,680 bp
  • A to T, chromosome 6 at 116,402,101 bp
  • G to A, chromosome 6 at 116,626,820 bp
  • T to C, chromosome 7 at 16,847,654 bp
  • C to T, chromosome 7 at 35,398,047 bp
  • T to A, chromosome 7 at 139,976,672 bp
  • T to C, chromosome 8 at 69,611,913 bp
  • A to G, chromosome 8 at 111,081,029 bp
  • T to C, chromosome 9 at 18,875,731 bp
  • A to C, chromosome 9 at 39,737,672 bp
  • A to T, chromosome 9 at 106,066,703 bp
  • A to G, chromosome 9 at 107,915,853 bp
  • G to A, chromosome 10 at 75,726,865 bp
  • A to T, chromosome 10 at 77,690,061 bp
  • T to A, chromosome 10 at 128,497,209 bp
  • T to C, chromosome 11 at 32,212,915 bp
  • A to G, chromosome 11 at 49,630,578 bp
  • C to A, chromosome 11 at 69,743,337 bp
  • A to G, chromosome 11 at 72,884,349 bp
  • G to A, chromosome 11 at 102,400,795 bp
  • A to G, chromosome 11 at 104,665,582 bp
  • A to G, chromosome 12 at 4,629,655 bp
  • A to C, chromosome 12 at 72,664,659 bp
  • T to C, chromosome 13 at 64,216,209 bp
  • G to A, chromosome 14 at 12,491,778 bp
  • T to C, chromosome 14 at 32,517,110 bp
  • C to A, chromosome 14 at 32,836,071 bp
  • T to C, chromosome 14 at 101,507,174 bp
  • T to A, chromosome 14 at 103,076,201 bp
  • A to G, chromosome 14 at 122,638,382 bp
  • C to T, chromosome 15 at 64,349,823 bp
  • T to C, chromosome 16 at 32,767,351 bp
  • T to C, chromosome 16 at 96,622,811 bp
  • A to G, chromosome 18 at 60,270,760 bp
  • A to T, chromosome 19 at 56,901,526 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6361 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044511-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.