Strain Name:
C57BL/6J-MtgxR6363Btlr/Mmmh
Stock Number:
044513-MU
Citation ID:
RRID:MMRRC_044513-MU
Other Names:
R6363 (G1)
Major Collection:

Strain Information

Utp20
Name: UTP20 small subunit processome component
Synonyms: DRIM, 3830408P06Rik, mDRIM
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Nr4a1
Name: nuclear receptor subfamily 4, group A, member 1
Synonyms: TR3, Gfrp, GFRP1, NP10, TIS1, Nur77, N10, Hmr, Hbr-1, NGFI-B, Hbr1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 15370
VEGA: 15
HGNC: HGNC:7980
Homologene: 1612
Camsap3
Name: calmodulin regulated spectrin-associated protein family, member 3
Synonyms: 2310057J16Rik, Nezha
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69697
Homologene: 18966
Srgap2
Name: SLIT-ROBO Rho GTPase activating protein 2
Synonyms: 9930124L22Rik, FBP2, Fnbp2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14270
Homologene: 52683
Patj
Name: PATJ, crumbs cell polarity complex component
Synonyms: Cipp, Inadl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12695
Homologene: 72199
Rev1
Name: REV1, DNA directed polymerase
Synonyms: 1110027I23Rik, Rev1l, REV1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56210
Homologene: 32309
Klhl24
Name: kelch-like 24
Synonyms: 4930429H24Rik, 1110046J11Rik, 6530402O20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 75785
VEGA: 16
Homologene: 32352
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21745
VEGA: 14
Homologene: 5157
Slc8a2
Name: solute carrier family 8 (sodium/calcium exchanger), member 2
Synonyms: Ncx2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 110891
Homologene: 27358
Wwc2
Name: WW, C2 and coiled-coil domain containing 2
Synonyms: D8Ertd594e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 52357
Homologene: 32618
Zfp719
Name: zinc finger protein 719
Synonyms: 9430094P17Rik, mszf6, C630016O21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210105
Ptgfrn
Name: prostaglandin F2 receptor negative regulator
Synonyms: CD9P-1, 4833445A08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19221
HGNC: HGNC:9601
Homologene: 7908
Fcrl1
Name: Fc receptor-like 1
Synonyms: BXMAS1-like, A230020G22Rik, moFcRH1S, Fcrh1, mIFGP1, moFcRH1, moFcRH1L, IFGP1, mBXMH1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229499
Homologene: 50472
Rb1
Name: RB transcriptional corepressor 1
Synonyms: Rb, retinoblastoma 1, pRb, Rb-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19645
HGNC: HGNC:9884
Homologene: 272
Msh3
Name: mutS homolog 3
Synonyms: Rep-3, D13Em1, Rep3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17686
HGNC: HGNC:7326
Homologene: 1829
Ercc8
Name: excision repaiross-complementing rodent repair deficiency, complementation group 8
Synonyms: 2410022P04Rik, 2810431L23Rik, 4631412O06Rik, Csa, B130065P18Rik, Ckn1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 71991
HGNC: HGNC:3439
Homologene: 62
Prkaa1
Name: protein kinase, AMP-activated, alpha 1 catalytic subunit
Synonyms: AMPKalpha1, C130083N04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105787
VEGA: 15
HGNC: HGNC:9376
Homologene: 49590
Pdgfra
Name: platelet derived growth factor receptor, alpha polypeptide
Synonyms: Pdgfr-2, CD140a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18595
HGNC: HGNC:8803
Homologene: 31361
Nbas
Name: neuroblastoma amplified sequence
Synonyms: 4933425L03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71169
VEGA: 12
Homologene: 41073
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233651
Homologene: 2771
Eral1
Name: Era like 12S mitochondrial rRNA chaperone 1
Synonyms: 2610524P08Rik, MERA-W, MERA-S, 9130407C09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57837
HGNC: HGNC:3424
Homologene: 4167
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: Dnahcl1, Dnahc17, LOC382552, 2810003K23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Ogfrl1
Name: opioid growth factor receptor-like 1
Synonyms: 2210417C17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70155
Homologene: 11595
Uba7
Name: ubiquitin-like modifier activating enzyme 7
Synonyms: Ube1l, 1300004C08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74153
Homologene: 2502
Gm7298
Name: predicted gene 7298
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 640530
HGNC: HGNC:9750
Sos2
Name: SOS Ras/Rho guanine nucleotide exchange factor 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20663
Homologene: 38253
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329942
Homologene: 89034
Hid1
Name: HID1 domain containing
Synonyms: C630004H02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217310
Homologene: 12737
Col5a1
Name: collagen, type V, alpha 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12831
HGNC: HGNC:2209
Homologene: 55434
Ccndbp1
Name: cyclin D-type binding-protein 1
Synonyms: GCIP, stage specific embryonic cDNA-8, SSEC-8, DIP1, Maid
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17151
HGNC: HGNC:1587
Homologene: 7826
Or9k7
Name: olfactory receptor family 9 subfamily K member 7
Synonyms: GA_x6K02T2PULF-11878777-11877809, Olfr827, MOR210-5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258297
Homologene: 27117
Ctsk
Name: cathepsin K
Synonyms: catK, Cat K
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13038
HGNC: HGNC:2536
Homologene: 68053
Ccdc33
Name: coiled-coil domain containing 33
Synonyms: 4930535E21Rik, LOC382077
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382077
Homologene: 19641
Agbl4
Name: ATP/GTP binding protein-like 4
Synonyms: 4931433A01Rik, 4930578N11Rik, Ccp6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 78933
Homologene: 84880
Cyp3a41b
Name: cytochrome P450, family 3, subfamily a, polypeptide 41B
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041375
HGNC: HGNC:2638
Homologene: 133568
Eif2b4
Name: eukaryotic translation initiation factor 2B, subunit 4 delta
Synonyms: Eif2b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13667
HGNC: HGNC:3260
Homologene: 5976
Or5a1
Name: olfactory receptor family 5 subfamily A member 1
Synonyms: MOR215-3, GA_x6K02T2RE5P-2479601-2478648, Olfr76, V5
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258677
HGNC: HGNC:8319
Homologene: 17342
Orm2
Name: orosomucoid 2
Synonyms: Orm-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18406
Homologene: 130632
Krtcap2
Name: keratinocyte associated protein 2
Synonyms: 0610010I12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66059
Homologene: 15494
Antxrl
Name: anthrax toxin receptor-like
Synonyms: 1700112N15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239029
VEGA: 14
Homologene: 52111
Or5p55
Name: olfactory receptor family 5 subfamily P member 55
Synonyms: MOR204-3, GA_x6K02T2PBJ9-10296787-10297719, Olfr476
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258926
Or13a25
Name: olfactory receptor family 13 subfamily A member 25
Synonyms: Olfr539, GA_x6K02T2PBJ9-42813436-42814368, MOR253-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258963
Homologene: 79393
Serpinb13
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13
Synonyms: HURPIN, PI13, headpin, HUR7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241196
HGNC: HGNC:8944
Homologene: 22718
Hspa8
Name: heat shock protein 8
Synonyms: Hsc71, Hsp73, Hsc73, Hsc70, 2410008N15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15481
HGNC: HGNC:5241
Homologene: 68524
Ttyh3
Name: tweety family member 3
Synonyms: 2900029G13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 78339
Homologene: 18431
Etfa
Name: electron transferring flavoprotein, alpha polypeptide
Synonyms: 2010200I21Rik, D9Ertd394e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110842
HGNC: HGNC:3481
Homologene: 100
Gpr171
Name: G protein-coupled receptor 171
Synonyms: H963, F730001G15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229323
Homologene: 36330
Ttc36
Name: tetratricopeptide repeat domain 36
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 192653
VEGA: 9
Homologene: 14626
Tas2r119
Name: taste receptor, type 2, member 119
Synonyms: T2R19, Tas2r19, mt2r19, mGR19
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 57254
Homologene: 10480
Zdhhc21
Name: zinc finger, DHHC domain containing 21
Synonyms: 9130404H11Rik, D130004H04Rik, dep
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68268
Homologene: 32668
Gpr17
Name: G protein-coupled receptor 17
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 574402
HGNC: HGNC:4471
Homologene: 83191
Naaladl2
Name: N-acetylated alpha-linked acidic dipeptidase-like 2
Synonyms: EG635702, LOC381500, 2810043G22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 635702
Homologene: 45786
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 23,370,113 bp
  • T to A, chromosome 1 at 38,071,489 bp
  • A to T, chromosome 1 at 107,000,774 bp
  • G to A, chromosome 1 at 131,298,468 bp
  • C to T, chromosome 2 at 27,928,195 bp
  • C to T, chromosome 2 at 121,012,973 bp
  • C to T, chromosome 3 at 24,335,317 bp
  • A to G, chromosome 3 at 59,097,892 bp
  • A to T, chromosome 3 at 87,385,168 bp
  • T to C, chromosome 3 at 89,249,106 bp
  • A to T, chromosome 3 at 95,501,551 bp
  • A to G, chromosome 3 at 101,045,578 bp
  • G to A, chromosome 4 at 63,362,604 bp
  • A to T, chromosome 4 at 82,847,674 bp
  • T to A, chromosome 4 at 98,431,860 bp
  • A to G, chromosome 4 at 111,566,785 bp
  • A to T, chromosome 4 at 128,400,379 bp
  • A to G, chromosome 5 at 31,191,239 bp
  • G to T, chromosome 5 at 75,170,836 bp
  • A to T, chromosome 5 at 140,635,224 bp
  • A to T, chromosome 5 at 145,570,387 bp
  • A to G, chromosome 6 at 121,788,606 bp
  • C to A, chromosome 7 at 16,134,045 bp
  • A to G, chromosome 7 at 43,589,866 bp
  • A to G, chromosome 7 at 105,758,472 bp
  • A to G, chromosome 7 at 107,967,750 bp
  • T to A, chromosome 7 at 140,668,082 bp
  • T to C, chromosome 8 at 3,601,971 bp
  • A to T, chromosome 8 at 47,887,162 bp
  • T to C, chromosome 9 at 40,803,065 bp
  • T to A, chromosome 9 at 44,799,639 bp
  • A to G, chromosome 9 at 55,500,133 bp
  • T to C, chromosome 9 at 58,114,335 bp
  • G to A, chromosome 9 at 107,980,183 bp
  • A to C, chromosome 10 at 88,757,080 bp
  • A to C, chromosome 10 at 130,211,037 bp
  • A to G, chromosome 11 at 78,074,317 bp
  • T to A, chromosome 11 at 115,352,596 bp
  • A to G, chromosome 11 at 118,110,505 bp
  • A to G, chromosome 12 at 13,482,576 bp
  • A to T, chromosome 12 at 69,632,111 bp
  • C to A, chromosome 13 at 92,212,524 bp
  • T to C, chromosome 13 at 108,183,870 bp
  • G to T, chromosome 14 at 34,069,287 bp
  • T to G, chromosome 14 at 50,824,548 bp
  • A to T, chromosome 14 at 73,287,641 bp
  • T to C, chromosome 15 at 5,176,956 bp
  • G to T, chromosome 15 at 32,177,888 bp
  • C to T, chromosome 15 at 101,274,115 bp
  • C to T, chromosome 16 at 20,120,183 bp
  • A to G, chromosome 18 at 31,947,572 bp
  • T to A, chromosome 19 at 12,120,166 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6363 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044513-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.