Strain Name:
C57BL/6J-MtgxR6369Btlr/Mmmh
Stock Number:
044519-MU
Citation ID:
RRID:MMRRC_044519-MU
Other Names:
R6369 (G1)
Major Collection:

Strain Information

Eno1
Name: enolase 1, alpha non-neuron
Synonyms: 2-phospho-D-glycerate hydrolase, alpha-enolase, Eno-1, MBP-1, c-Myc promoter binding protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13806
HGNC: HGNC:3350
Homologene: 134343
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Bri3bp
Name: Bri3 binding protein
Synonyms: 2410150I18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76809
Homologene: 50955
Syngr1
Name: synaptogyrin 1
Synonyms: Syngr1b, p29
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20972
Homologene: 3456
Rad54l
Name: RAD54 like (S. cerevisiae)
Synonyms: RAD54
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19366
HGNC: HGNC:9826
Homologene: 48227
Washc4
Name: WASH complex subunit 4
Synonyms: A230046K03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 319277
VEGA: 10
Homologene: 123926
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: ASC1p200, B630009I04Rik, Helic1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Rrm1
Name: ribonucleotide reductase M1
Synonyms: RnrM1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20133
Homologene: 806
Ccdc191
Name: coiled-coil domain containing 191
Synonyms: 2610015P09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 212153
Homologene: 19484
Afdn
Name: afadin, adherens junction formation factor
Synonyms: AF6, Afadin, S-afadin, I-afadin, 5033403D15Rik, Mllt4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17356
HGNC: HGNC:7137
Homologene: 21202
Hk2
Name: hexokinase 2
Synonyms: HKII
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15277
HGNC: HGNC:4923
Homologene: 37273
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: eyem02Jus, heb, QBRICK, crf11, eyes2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329872
Homologene: 27049
Hs3st3a1
Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
Synonyms: 3Ost3a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15478
HGNC: HGNC:5196
Homologene: 88735
Rad52
Name: RAD52 homolog, DNA repair protein
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19365
HGNC: HGNC:9824
Homologene: 31118
Ero1a
Name: endoplasmic reticulum oxidoreductase 1 alpha
Synonyms: Ero1l
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50527
VEGA: 14
Homologene: 49392
Ppp1r21
Name: protein phosphatase 1, regulatory subunit 21
Synonyms: 1110018J12Rik, Ccdc128, Klraq1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 73825
Homologene: 44811
Atl2
Name: atlastin GTPase 2
Synonyms: Aip-2, 2010110I21Rik, Arl6ip2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56298
VEGA: 17
Homologene: 56949
Tbc1d2
Name: TBC1 domain family, member 2
Synonyms: PARIS-1, LOC381605, A630005A06Rik, PARIS1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381605
Homologene: 10190
Ppp1r12b
Name: protein phosphatase 1, regulatory subunit 12B
Synonyms: 1810037O03Rik, 9530009M10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329251
HGNC: HGNC:7619
Homologene: 135710
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Pink1
Name: PTEN induced putative kinase 1
Synonyms: 1190006F07Rik, brpk
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68943
Homologene: 32672
Mef2b
Name: myocyte enhancer factor 2B
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17259
Homologene: 48381
Reln
Name: reelin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Crb1
Name: crumbs family member 1, photoreceptor morphogenesis associated
Synonyms: A930008G09Rik, 7530426H14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 170788
HGNC: HGNC:2343
Homologene: 8092
Sec14l2
Name: SEC14-like lipid binding 2
Synonyms: tap, 1300013M05Rik, Spf
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67815
Homologene: 8245
Kcp
Name: kielin/chordin-like protein
Synonyms: LOC333088, KCP, Crim2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 333088
Homologene: 87817
Trappc11
Name: trafficking protein particle complex 11
Synonyms: D030016E14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320714
Homologene: 11076
Megf10
Name: multiple EGF-like-domains 10
Synonyms: LOC240312, 3000002B06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70417
Homologene: 23771
Rnf224
Name: ring finger protein 224
Synonyms: LOC329360, Gm757
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329360
Homologene: 121711
Vmn2r111
Name: vomeronasal 2, receptor 111
Synonyms: EG210876
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210876
Homologene: 86604
Slc22a5
Name: solute carrier family 22 (organic cation transporter), member 5
Synonyms: Octn2, Lstpl
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20520
Homologene: 68295
Itga1
Name: integrin alpha 1
Synonyms: CD49A, Vla1, E130012M19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109700
VEGA: 13
HGNC: HGNC:6134
Homologene: 57137
Myom1
Name: myomesin 1
Synonyms: skelemin, D430047A17Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17929
VEGA: 17
HGNC: HGNC:7613
Homologene: 31196
Rbm42
Name: RNA binding motif protein 42
Synonyms: 1700003D06Rik, 3100004P22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68035
Homologene: 32579
Zfp212
Name: Zinc finger protein 212
Synonyms: Znf212
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232784
Homologene: 8170
Smarcd3
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
Synonyms: BAF60C, 2210409C08Rik, 1500001J14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66993
Homologene: 2314
Axdnd1
Name: axonemal dynein light chain domain containing 1
Synonyms: LOC381304, 9430070O13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77352
Homologene: 52328
Fam186a
Name: family with sequence similarity 186, member A
Synonyms: LOC380973, 1700030F18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72277
Sncaip
Name: synuclein, alpha interacting protein (synphilin)
Synonyms: synphilin-1, SYPH1, 4933427B05Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67847
Homologene: 3987
Skint7
Name: selection and upkeep of intraepithelial T cells 7
Synonyms: C130057D23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 328505
Homologene: 106613
Cd300c
Name: CD300C molecule
Synonyms: Clm6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 387565
Homologene: 74580
Or2g1
Name: olfactory receptor family 2 subfamily G member 1
Synonyms: GA_x6K02T2PSCP-2255106-2256035, MOR256-9, Olfr123
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258623
Homologene: 105169
Pnpla1
Name: patatin-like phospholipase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 433091
Homologene: 25324
Ctnna2
Name: catenin alpha 2
Synonyms: alpha(N)-catenin, alpha N-catenin, Catna, chp, Catna2, catenin (cadherin associated protein), alpha 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12386
HGNC: HGNC:2510
Homologene: 68394
Nab1
Name: Ngfi-A binding protein 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17936
HGNC: HGNC:7626
Homologene: 4352
Serpinb3d
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 394252
Homologene: 130559
Krtap4-22
Name: keratin associated protein 4-22
Synonyms: Gm11595
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100040276
Homologene: 124486
Asb18
Name: ankyrin repeat and SOCS box-containing 18
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208372
Homologene: 16382
Cchcr1
Name: coiled-coil alpha-helical rod protein 1
Synonyms: Hcr
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240084
Homologene: 10396
Rasgrf2
Name: RAS protein-specific guanine nucleotide-releasing factor 2
Synonyms: Grf2, 6330417G04Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19418
HGNC: HGNC:9876
Homologene: 2169
Tmem198
Name: transmembrane protein 198
Synonyms: Tmem198-1, Tmem198a, A230078I05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319998
Homologene: 44245
Cd209c
Name: CD209c antigen
Synonyms: SIGNR2, mSIGNR2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170776
HGNC: HGNC:1641
Homologene: 87186
Uox
Name: urate oxidase
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22262
Homologene: 7584
Zfp92
Name: zinc finger protein 92
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 22754
Homologene: 69050
Pate1
Name: prostate and testis expressed 1
Synonyms: Gm17252
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 100312987
Homologene: 89136
Gjb5
Name: gap junction protein, beta 5
Synonyms: Cnx31.1, connexin 31.1, Gjb-5, Cx31.1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14622
HGNC: HGNC:4287
Homologene: 3858
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 52,490,222 bp
  • T to C, chromosome 1 at 75,479,743 bp
  • A to T, chromosome 1 at 90,014,471 bp
  • G to T, chromosome 1 at 107,080,753 bp
  • T to C, chromosome 1 at 134,886,542 bp
  • C to T, chromosome 1 at 139,237,462 bp
  • A to G, chromosome 1 at 156,392,745 bp
  • A to G, chromosome 2 at 25,235,942 bp
  • C to T, chromosome 3 at 146,624,577 bp
  • A to G, chromosome 4 at 46,614,420 bp
  • A to T, chromosome 4 at 82,913,792 bp
  • A to T, chromosome 4 at 111,980,293 bp
  • A to G, chromosome 4 at 116,111,189 bp
  • T to C, chromosome 4 at 123,410,562 bp
  • G to T, chromosome 4 at 127,355,930 bp
  • T to C, chromosome 4 at 138,320,734 bp
  • T to C, chromosome 4 at 150,239,568 bp
  • A to G, chromosome 5 at 22,051,361 bp
  • A to T, chromosome 5 at 24,594,984 bp
  • A to G, chromosome 5 at 125,454,701 bp
  • A to G, chromosome 6 at 29,484,694 bp
  • T to C, chromosome 6 at 47,930,897 bp
  • A to G, chromosome 6 at 76,980,695 bp
  • G to T, chromosome 6 at 82,736,753 bp
  • A to G, chromosome 6 at 119,914,207 bp
  • A to G, chromosome 7 at 30,641,313 bp
  • C to A, chromosome 7 at 102,446,702 bp
  • T to C, chromosome 8 at 3,944,984 bp
  • C to T, chromosome 8 at 17,535,004 bp
  • T to C, chromosome 8 at 47,512,285 bp
  • T to A, chromosome 8 at 70,165,559 bp
  • A to G, chromosome 9 at 35,687,028 bp
  • G to A, chromosome 10 at 50,699,985 bp
  • A to G, chromosome 10 at 83,574,444 bp
  • T to C, chromosome 11 at 4,103,962 bp
  • T to G, chromosome 11 at 53,891,370 bp
  • A to T, chromosome 11 at 64,520,601 bp
  • G to A, chromosome 11 at 99,772,555 bp
  • C to A, chromosome 11 at 114,957,555 bp
  • T to C, chromosome 13 at 92,131,446 bp
  • T to C, chromosome 13 at 114,965,660 bp
  • T to C, chromosome 14 at 45,299,958 bp
  • A to C, chromosome 15 at 80,115,590 bp
  • A to G, chromosome 15 at 99,947,331 bp
  • A to G, chromosome 16 at 43,915,485 bp
  • C to T, chromosome 17 at 13,835,343 bp
  • C to T, chromosome 17 at 22,548,602 bp
  • T to A, chromosome 17 at 28,878,481 bp
  • T to C, chromosome 17 at 35,528,176 bp
  • T to G, chromosome 17 at 37,795,496 bp
  • T to C, chromosome 17 at 71,101,076 bp
  • T to C, chromosome 17 at 79,854,555 bp
  • C to A, chromosome 17 at 88,582,412 bp
  • A to G, chromosome 18 at 52,868,604 bp
  • A to T, chromosome 18 at 57,261,187 bp
  • G to A, chromosome X at 73,421,968 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6369 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044519-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.