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Strain Name:
C57BL/6J-MtgxR6381Btlr/Mmmh
Stock Number:
044530-MU
Citation ID:
RRID:MMRRC_044530-MU
Other Names:
R6381 (G1)
Major Collection:

Strain Information

Dicer1
Name: dicer 1, ribonuclease type III
Synonyms: 1110006F08Rik, D12Ertd7e, Dicer1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 192119
VEGA: 12
Homologene: 13251
Cd74
Name: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
Synonyms: CLIP, Ii
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16149
VEGA: 18
HGNC: HGNC:1697
Homologene: 3209
Inpp5a
Name: inositol polyphosphate-5-phosphatase A
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 212111
HGNC: HGNC:6076
Homologene: 4045
Cep97
Name: centrosomal protein 97
Synonyms: 4932439K18Rik, E130116N02Rik, 2810403B08Rik, Lrriq2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74201
Homologene: 11579
Aplf
Name: aprataxin and PNKP like factor
Synonyms: 2010301N04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72103
Homologene: 49753
Gtse1
Name: G two S phase expressed protein 1
Synonyms: B99, Gtse-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 29870
VEGA: 15
Homologene: 8489
Tars2
Name: threonyl-tRNA synthetase 2, mitochondrial (putative)
Synonyms: 2610024N01Rik, Tarsl1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71807
Homologene: 23520
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 82,287,684 bp
  • G to T, chromosome 1 at 91,984,525 bp
  • C to T, chromosome 1 at 117,985,939 bp
  • T to A, chromosome 1 at 132,456,765 bp
  • A to G, chromosome 1 at 134,746,850 bp
  • A to T, chromosome 1 at 156,435,803 bp
  • A to G, chromosome 2 at 26,385,081 bp
  • T to C, chromosome 2 at 107,294,972 bp
  • G to C, chromosome 2 at 127,431,918 bp
  • G to A, chromosome 3 at 35,976,727 bp
  • A to G, chromosome 3 at 73,701,799 bp
  • A to T, chromosome 3 at 95,754,487 bp
  • T to C, chromosome 3 at 108,481,814 bp
  • G to A, chromosome 4 at 63,472,684 bp
  • G to T, chromosome 4 at 130,308,228 bp
  • T to C, chromosome 5 at 33,433,976 bp
  • G to T, chromosome 5 at 43,715,776 bp
  • G to T, chromosome 5 at 73,675,216 bp
  • A to T, chromosome 6 at 87,658,977 bp
  • A to G, chromosome 6 at 122,578,931 bp
  • C to T, chromosome 7 at 13,344,008 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • T to G, chromosome 7 at 29,075,257 bp
  • T to C, chromosome 7 at 41,428,818 bp
  • T to A, chromosome 7 at 45,719,592 bp
  • T to C, chromosome 7 at 48,552,390 bp
  • A to G, chromosome 7 at 121,767,499 bp
  • A to T, chromosome 7 at 139,400,673 bp
  • T to C, chromosome 8 at 85,642,509 bp
  • T to A, chromosome 8 at 93,217,578 bp
  • T to C, chromosome 10 at 127,664,351 bp
  • T to A, chromosome 10 at 127,903,673 bp
  • C to T, chromosome 11 at 60,744,023 bp
  • G to T, chromosome 11 at 106,320,311 bp
  • A to T, chromosome 11 at 117,791,600 bp
  • A to G, chromosome 11 at 118,129,185 bp
  • T to C, chromosome 12 at 104,696,462 bp
  • T to A, chromosome 13 at 4,574,184 bp
  • T to A, chromosome 13 at 67,138,905 bp
  • A to G, chromosome 14 at 44,504,256 bp
  • T to C, chromosome 14 at 50,845,431 bp
  • A to C, chromosome 14 at 51,057,094 bp
  • A to G, chromosome 14 at 52,179,546 bp
  • G to T, chromosome 15 at 11,256,994 bp
  • G to T, chromosome 15 at 31,467,692 bp
  • G to A, chromosome 15 at 85,862,148 bp
  • A to G, chromosome 16 at 20,655,273 bp
  • T to A, chromosome 16 at 49,101,481 bp
  • C to T, chromosome 16 at 55,922,171 bp
  • C to T, chromosome 17 at 25,372,569 bp
  • C to T, chromosome 17 at 37,086,085 bp
  • A to G, chromosome 17 at 45,518,545 bp
  • T to C, chromosome 17 at 47,505,224 bp
  • G to T, chromosome 18 at 60,811,363 bp
  • T to A, chromosome 18 at 70,467,717 bp
  • T to A, chromosome 19 at 34,524,746 bp
  • T to C, chromosome 19 at 34,612,471 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6381 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044530-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.