Strain Name:
C57BL/6J-MtgxR6385Btlr/Mmmh
Stock Number:
044534-MU
Citation ID:
RRID:MMRRC_044534-MU
Other Names:
R6385 (G1)
Major Collection:

Strain Information

Cntnap2
Name: contactin associated protein-like 2
Synonyms: Caspr2, 5430425M22Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66797
Homologene: 69159
Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Inpp5d
Name: inositol polyphosphate-5-phosphatase D
Synonyms: Src homology 2 domain-containing inositol-5-phosphatase, SHIP-1, SHIP1, s-SHIP, SHIP
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16331
HGNC: HGNC:6079
Homologene: 4046
Dst
Name: dystonin
Synonyms: nmf339, athetoid, Bpag, bullous pemphigoid antigen 1, A830042E19Rik, nmf203, Bpag1, ah, 2310001O04Rik, Macf2, BPAG1-n, bullous pemphigoid antigen 1, BPAG1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Zfp930
Name: zinc finger protein 930
Synonyms: zinc finger protein, D10627
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234358
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, D230004K18Rik, Gp330, b2b1625.2Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Poli
Name: polymerase (DNA directed), iota
Synonyms: Rad30b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 26447
HGNC: HGNC:9182
Homologene: 5209
Lgi3
Name: leucine-rich repeat LGI family, member 3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 213469
VEGA: 14
Homologene: 16406
Iars1
Name: isoleucyl-tRNA synthetase 1
Synonyms: 2510016L12Rik, E430001P04Rik, Iars
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105148
HGNC: HGNC:5330
Homologene: 5325
Zc3h11a
Name: zinc finger CCCH type containing 11A
Synonyms: 1110003F06Rik, 5730454B08Rik, G630041M05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70579
Homologene: 8888
Gtf2ird1
Name: general transcription factor II I repeat domain-containing 1
Synonyms: binding factor for early enhancer, MusTRD1, WBSCR11, BEN, ESTM9, GTF3, Cream1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57080
HGNC: HGNC:4661
Homologene: 4158
Cttnbp2nl
Name: CTTNBP2 N-terminal like
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80281
Homologene: 36371
Zfp972
Name: zinc finger protein 972
Synonyms: C330013J21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78703
Cln3
Name: CLN3 lysosomal/endosomal transmembrane protein, battenin
Synonyms: battenin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12752
HGNC: HGNC:2074
Homologene: 37259
Zfp318
Name: zinc finger protein 318
Synonyms: 2610034E08Rik, TZF, D530032D06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57908
Homologene: 22808
Gucy1a1
Name: guanylate cyclase 1, soluble, alpha 1
Synonyms: alpha 1 sGC, sGC-alpha1, 1200016O07Rik, Gucy1a3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 60596
HGNC: HGNC:4685
Homologene: 37360
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Enpp5
Name: ectonucleotide pyrophosphatase/phosphodiesterase 5
Synonyms: D17Abb1e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 83965
Homologene: 23313
St3gal1
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Synonyms: CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase, ST3GalI, Siat4, Siat4a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20442
VEGA: 15
Homologene: 7540
Slurp2
Name: secreted Ly6/Plaur domain containing 2
Synonyms: 2300005B03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69462
Homologene: 104043
Hes1
Name: hes family bHLH transcription factor 1
Synonyms: bHLHb39, Hry
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15205
HGNC: HGNC:5192
Homologene: 38067
Cep164
Name: centrosomal protein 164
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214552
Homologene: 51110
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hyrh, 1700034M11Rik, hy3, 4930545D19Rik, hy-3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Ttn
Name: titin
Synonyms: connectin, 1100001C23Rik, D330041I19Rik, D830007G01Rik, 2310074I15Rik, 2310036G12Rik, mdm, 2310057K23Rik, shru, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Arap3
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Synonyms: DRAG1, Centd3, E030006K04Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106952
VEGA: 18
Homologene: 11199
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 229003
Homologene: 14118
Btnl6
Name: butyrophilin-like 6
Synonyms: NG13, Gm6519
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 624681
Homologene: 106849
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Pear1
Name: platelet endothelial aggregation receptor 1
Synonyms: 3110045G13Rik, Jedi-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 73182
Homologene: 12492
Ube2u
Name: ubiquitin-conjugating enzyme E2U (putative)
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381534
Homologene: 17594
Abca9
Name: ATP-binding cassette, sub-family A member 9
Synonyms: D630040K07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217262
HGNC: HGNC:39
Homologene: 33332
Or4f7
Name: olfactory receptor family 4 subfamily F member 7
Synonyms: GA_x6K02T2Q125-72882187-72881249, MOR245-7, MOR245-28_p, GA_x6K02T2N82Q-3465-3764, MOR245-7, Olfr1303, Olfr276
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258397
Homologene: 88429
Myh4
Name: myosin, heavy polypeptide 4, skeletal muscle
Synonyms: MM, Minimsc, Myhsf, Minmus, MYH-2B, MyHC-IIb, MHC2B
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17884
HGNC: HGNC:7574
Homologene: 123880
Filip1
Name: filamin A interacting protein 1
Synonyms: 5730485H21Rik, FILIP
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70598
Homologene: 6700
Vmn1r46
Name: vomeronasal 1 receptor 46
Synonyms: V1rb8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113856
Homologene: 134021
Wdr90
Name: WD repeat domain 90
Synonyms: 3230401M21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106618
Homologene: 27066
Fanca
Name: Fanconi anemia, complementation group A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14087
HGNC: HGNC:3582
Homologene: 108
Notch4
Name: notch 4
Synonyms: Int-3, Int3, N4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18132
HGNC: HGNC:7884
Homologene: 3351
Daam2
Name: dishevelled associated activator of morphogenesis 2
Synonyms: 2310016D11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 76441
VEGA: 17
Homologene: 69186
Or6k6
Name: olfactory receptor family 6 subfamily K member 6
Synonyms: MOR105-4, Olfr244, GA_x6K02T02K39-452-3, GA_x6K02T2P20D-21053942-21054499, Olfr231, Olfr425, GA_x6K02T2LER7-6-623
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 404222
Homologene: 17363
3425401B19Rik
Name: RIKEN cDNA 3425401B19 gene
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100504518
VEGA: 14
Homologene: 54908
Catsper3
Name: cation channel, sperm associated 3
Synonyms: 4921522D01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76856
Homologene: 12658
Fut9
Name: fucosyltransferase 9
Synonyms: mFUT9, mFuc-TIX
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14348
HGNC: HGNC:4020
Homologene: 4800
Shank3
Name: SH3 and multiple ankyrin repeat domains 3
Synonyms: ProSAP2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 58234
Homologene: 75163
Msln
Name: mesothelin
Synonyms: MPF, megakaryocyte potentiating factor
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56047
VEGA: 17
HGNC: HGNC:7371
Homologene: 4249
Ppp3r2
Name: protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II)
Synonyms: PP2B beta 2, CnB2, CaNB2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19059
HGNC: HGNC:9318
Homologene: 133815
H2-DMb1
Name: histocompatibility 2, class II, locus Mb1
Synonyms: H2-M beta1, H2-Mb1, H-2Mb1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14999
HGNC: HGNC:4935
Homologene: 68231
Kcnh3
Name: potassium voltage-gated channel, subfamily H (eag-related), member 3
Synonyms: Melk2, Elk2, C030044P22Rik, ether a go-go like
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16512
VEGA: 15
HGNC: HGNC:6252
Homologene: 32150
Lypd10
Name: Ly6/PLAUR domain containing 10
Synonyms: BC049730
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232972
Slc2a12
Name: solute carrier family 2 (facilitated glucose transporter), member 12
Synonyms: GLUT-12, Glut12
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 353169
Homologene: 59263
Ncf2
Name: neutrophil cytosolic factor 2
Synonyms: NOXA2, NADPH oxidase subunit (67kDa), p67phox, Ncf-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17970
HGNC: HGNC:7661
Homologene: 374
Adgra2
Name: adhesion G protein-coupled receptor A2
Synonyms: 8430414O08Rik, Gpr124, 9530074E10Rik, Tem5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78560
Homologene: 13112
Slc22a28
Name: solute carrier family 22, member 28
Synonyms: Gm5631
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 434674
VEGA: 19
Homologene: 77136
Serhl
Name: serine hydrolase-like
Synonyms: 1110019M09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68607
Homologene: 65196
Apon
Name: apolipoprotein N
Synonyms: D10Ucla2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 28194
VEGA: 10
Homologene: 51183
Or52e19b
Name: olfactory receptor family 52 subfamily E member 19B
Synonyms: GA_x6K02T2PBJ9-6092550-6092362, Olfr603, GA_x6K02T2PBJ9-6096387-6095449, Olfr604, MOR32-14_i, MOR32-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259073
Homologene: 121535
Rfc5
Name: replication factor C (activator 1) 5
Synonyms: 2610020K06Rik, 36kDa, Recc5, 2610209F07Rik, 36.5kDa
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72151
HGNC: HGNC:9973
Homologene: 6730
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,307,468 bp
  • T to A, chromosome 1 at 87,699,675 bp
  • A to T, chromosome 1 at 133,637,454 bp
  • A to T, chromosome 1 at 152,830,422 bp
  • A to T, chromosome 1 at 174,117,296 bp
  • G to T, chromosome 2 at 52,185,299 bp
  • T to C, chromosome 2 at 69,495,784 bp
  • C to T, chromosome 2 at 76,917,848 bp
  • T to C, chromosome 2 at 111,814,619 bp
  • G to T, chromosome 2 at 177,921,795 bp
  • T to C, chromosome 2 at 180,196,533 bp
  • C to T, chromosome 2 at 181,233,467 bp
  • A to G, chromosome 3 at 82,109,006 bp
  • G to T, chromosome 3 at 87,754,199 bp
  • A to G, chromosome 3 at 105,005,636 bp
  • G to A, chromosome 4 at 25,620,328 bp
  • A to G, chromosome 4 at 49,681,767 bp
  • A to G, chromosome 4 at 88,820,149 bp
  • A to G, chromosome 4 at 100,532,144 bp
  • T to C, chromosome 5 at 117,385,398 bp
  • A to T, chromosome 5 at 134,404,690 bp
  • G to A, chromosome 6 at 46,856,180 bp
  • A to G, chromosome 6 at 89,976,445 bp
  • A to T, chromosome 7 at 24,714,110 bp
  • A to T, chromosome 7 at 103,383,897 bp
  • A to T, chromosome 7 at 126,575,035 bp
  • A to T, chromosome 8 at 27,118,850 bp
  • A to G, chromosome 8 at 69,228,631 bp
  • A to T, chromosome 8 at 110,312,224 bp
  • A to T, chromosome 8 at 123,305,867 bp
  • T to G, chromosome 9 at 45,779,783 bp
  • C to T, chromosome 9 at 67,278,129 bp
  • G to T, chromosome 9 at 79,820,531 bp
  • C to T, chromosome 10 at 22,694,030 bp
  • A to G, chromosome 10 at 128,254,354 bp
  • A to T, chromosome 11 at 67,255,837 bp
  • T to A, chromosome 11 at 110,134,254 bp
  • T to C, chromosome 13 at 49,701,895 bp
  • G to T, chromosome 13 at 55,786,426 bp
  • T to A, chromosome 14 at 32,661,279 bp
  • A to G, chromosome 14 at 70,531,170 bp
  • A to G, chromosome 15 at 67,111,346 bp
  • T to C, chromosome 15 at 74,746,675 bp
  • A to G, chromosome 15 at 83,101,622 bp
  • T to C, chromosome 15 at 89,521,375 bp
  • T to C, chromosome 15 at 99,227,941 bp
  • A to G, chromosome 16 at 30,065,606 bp
  • T to A, chromosome 17 at 25,751,141 bp
  • A to G, chromosome 17 at 25,848,530 bp
  • T to A, chromosome 17 at 34,155,602 bp
  • T to G, chromosome 17 at 34,508,369 bp
  • C to A, chromosome 17 at 34,573,814 bp
  • G to A, chromosome 17 at 44,085,264 bp
  • A to G, chromosome 17 at 46,411,006 bp
  • C to T, chromosome 17 at 49,463,936 bp
  • G to A, chromosome 18 at 37,997,031 bp
  • C to A, chromosome 18 at 70,530,001 bp
  • A to G, chromosome 19 at 8,101,480 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6385 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044534-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.