Strain Name:
C57BL/6J-MtgxR6406Btlr/Mmmh
Stock Number:
044551-MU
Citation ID:
RRID:MMRRC_044551-MU
Other Names:
R6406 (G1)
Major Collection:

Strain Information

Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Gm4392, Ankyrin-B, Ank-2, Ankyrin-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Cbx1
Name: chromobox 1
Synonyms: Hp1beta, HP1B, MOD1, M31, Cbx-rs2, E430007M08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12412
HGNC: HGNC:1551
Homologene: 89116
Dock1
Name: dedicator of cytokinesis 1
Synonyms: Dock180, b2b3190Clo, 9130006G06Rik, D630004B07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: slip, DNAPDcs, DNA-PKcs, DNA-PK, DOXNPH, XRCC7, dxnph
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Spats1
Name: spermatogenesis associated, serine-rich 1
Synonyms: Srsp1, 1700011H05Rik, 4933400B06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71020
VEGA: 17
Homologene: 12376
Trp53bp1
Name: transformation related protein 53 binding protein 1
Synonyms: p53BP1, 53BP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27223
Homologene: 4137
Gria4
Name: glutamate receptor, ionotropic, AMPA4 (alpha 4)
Synonyms: Glur4, spkw1, Gluralpha4, Glur-4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14802
HGNC: HGNC:4574
Homologene: 20227
Synj2
Name: synaptojanin 2
Synonyms: SJ2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20975
Homologene: 117703
Mier3
Name: MIER family member 3
Synonyms: D130064H19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218613
Homologene: 18196
Ilf3
Name: interleukin enhancer binding factor 3
Synonyms: NF90
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16201
VEGA: 9
HGNC: HGNC:6038
Homologene: 7785
Pafah1b1
Name: platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
Synonyms: Pafaha, Lis1, PAF-AH 45, lissencephaly-1 protein, Mdsh, LIS-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18472
HGNC: HGNC:8574
Homologene: 371
Thoc1
Name: THO complex 1
Synonyms: 3110002N20Rik, NMP-84
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225160
VEGA: 18
Homologene: 38012
Rsf1
Name: remodeling and spacing factor 1
Synonyms: Hbxap, p325, XAP8, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Ncapd2
Name: non-SMC condensin I complex, subunit D2
Synonyms: CAP-D2, 2810406C15Rik, CNAP1, 2810465G24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68298
Homologene: 6497
Pdcd6ip
Name: programmed cell death 6 interacting protein
Synonyms: Alix, AIP1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18571
HGNC: HGNC:8766
Homologene: 22614
Ahi1
Name: Abelson helper integration site 1
Synonyms: D10Bwg0629e, Jouberin, 1700015F03Rik, Ahi-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52906
VEGA: 10
Homologene: 9762
Islr2
Name: immunoglobulin superfamily containing leucine-rich repeat 2
Synonyms: Linx, mbu-3, B930052A04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320563
VEGA: 9
Homologene: 10833
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Lrrc8a
Name: leucine rich repeat containing 8A VRAC subunit A
Synonyms: Lrrc8, ebo, SWELL1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241296
Homologene: 18617
Ncbp2
Name: nuclear cap binding protein subunit 2
Synonyms: 20kDa
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 68092
Homologene: 56377
Stard3
Name: StAR related lipid transfer domain containing 3
Synonyms: es64, Mln64
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 59045
Homologene: 38227
Galnt12
Name: polypeptide N-acetylgalactosaminyltransferase 12
Synonyms: A630062B03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230145
Homologene: 11637
Jag1
Name: jagged 1
Synonyms: Serrate-1, Headturner, Ozz, Htu, Gsfabe2, ABE2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16449
HGNC: HGNC:6188
Homologene: 180
Bhlhe40
Name: basic helix-loop-helix family, member e40
Synonyms: eip1 (E47 interaction protein 1), DEC1, cytokine response gene 8, Stra13, CR8, Bhlhb2, Clast5, C130042M06Rik, Sharp2, Stra14
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20893
HGNC: HGNC:1046
Homologene: 2722
Klhl8
Name: kelch-like 8
Synonyms: 2310001P09Rik, D5Ertd431e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 246293
Homologene: 10819
Nkx6-1
Name: NK6 homeobox 1
Synonyms: Nkx6.1, NKX6A
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18096
HGNC: HGNC:7839
Homologene: 4495
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237954
Homologene: 138824
Ndst4
Name: N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
Synonyms: 4930439H17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 64580
Homologene: 11208
Acsm1
Name: acyl-CoA synthetase medium-chain family member 1
Synonyms: Macs, Bucs1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 117147
Homologene: 24930
Dclk1
Name: doublecortin-like kinase 1
Synonyms: Click-I, 1700113D08Rik, Dcl, DCLK, CPG16, Dcamkl1, 2810480F11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13175
HGNC: HGNC:2700
Homologene: 130530
Nek9
Name: NIMA (never in mitosis gene a)-related expressed kinase 9
Synonyms: C130021H08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217718
Homologene: 13222
Fzd1
Name: frizzled class receptor 1
Synonyms: FZ-1, Fz1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14362
HGNC: HGNC:4038
Homologene: 20750
Ptprt
Name: protein tyrosine phosphatase receptor type T
Synonyms: RPTPrho
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19281
HGNC: HGNC:9682
Homologene: 56924
Nt5dc1
Name: 5'-nucleotidase domain containing 1
Synonyms: 6030401B09Rik, Nt5c2l1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 319638
Homologene: 16281
Map1a
Name: microtubule-associated protein 1 A
Synonyms: Mtap1a, Mtap-1, Mtap1, 6330416M19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17754
HGNC: HGNC:6835
Homologene: 1778
Or5b94
Name: olfactory receptor family 5 subfamily B member 94
Synonyms: MOR202-9, GA_x6K02T2RE5P-3000589-3001527, Olfr1442
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258692
Homologene: 138315
Parp2
Name: poly (ADP-ribose) polymerase family, member 2
Synonyms: Adprt2, Adprtl2, PARP-2, C78626, Aspartl2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11546
VEGA: 14
HGNC: HGNC:272
Homologene: 4004
Pkd1l2
Name: polycystic kidney disease 1 like 2
Synonyms: 1700126L06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76645
Homologene: 124481
Thumpd3
Name: THUMP domain containing 3
Synonyms: Gtrosa26as
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14911
Homologene: 7351
Bpifb6
Name: BPI fold containing family B, member 6
Synonyms: Bpil3, LOC228796
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228796
Homologene: 18375
Trim61
Name: tripartite motif-containing 61
Synonyms: 2czf61, Rnf35, E330039K03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 260296
Tsnaxip1
Name: translin-associated factor X (Tsnax) interacting protein 1
Synonyms: TXI1, 1700016K08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72236
Homologene: 10194
Aars2
Name: alanyl-tRNA synthetase 2, mitochondrial
Synonyms: Aarsl
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224805
VEGA: 17
Homologene: 56897
Cr2
Name: complement receptor 2
Synonyms: CD35, Cr-2, Cr1, C3DR, CD21, Cr-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12902
HGNC: HGNC:2336
Homologene: 55611
Or9g3
Name: olfactory receptor family 9 subfamily G member 3
Synonyms: MOR213-6, Olfr1012, GA_x6K02T2Q125-47239120-47238185
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258561
Homologene: 64889
Sele
Name: selectin, endothelial cell
Synonyms: E-selectin, CD62E, Elam
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20339
Homologene: 389
Msantd1
Name: Myb/SANT-like DNA-binding domain containing 1
Synonyms: LOC231132, A930005I04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 403174
Homologene: 45807
C2cd6
Name: C2 calcium dependent domain containing 6
Synonyms: 1700052H20Rik, C2cd6b, Gm33589, Als2cr11, 4930408G06Rik, Als2cr11b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73463
Homologene: 134310
Gm12888
Name: predicted gene 12888
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 545677
Homologene: 111034
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 59,058,676 bp
  • G to T, chromosome 1 at 164,050,743 bp
  • A to G, chromosome 1 at 195,169,771 bp
  • A to G, chromosome 2 at 30,257,091 bp
  • T to A, chromosome 2 at 85,760,307 bp
  • T to C, chromosome 2 at 121,270,612 bp
  • A to T, chromosome 2 at 121,300,743 bp
  • T to A, chromosome 2 at 137,087,643 bp
  • C to A, chromosome 2 at 153,904,537 bp
  • T to C, chromosome 2 at 161,553,783 bp
  • A to T, chromosome 2 at 180,197,464 bp
  • A to G, chromosome 3 at 55,480,406 bp
  • T to C, chromosome 3 at 125,438,501 bp
  • T to A, chromosome 3 at 127,032,225 bp
  • A to G, chromosome 4 at 47,122,534 bp
  • A to G, chromosome 4 at 121,319,457 bp
  • T to G, chromosome 5 at 4,756,089 bp
  • C to A, chromosome 5 at 34,923,321 bp
  • C to T, chromosome 5 at 101,663,811 bp
  • T to A, chromosome 5 at 103,863,115 bp
  • TG to TGG, chromosome 6 at 108,664,857 bp
  • G to A, chromosome 6 at 113,055,963 bp
  • C to A, chromosome 6 at 125,173,878 bp
  • CGGCGGCGG to CGGCGGCGGGGGCGGCGG, chromosome 7 at 97,579,926 bp
  • A to G, chromosome 7 at 119,662,261 bp
  • C to A, chromosome 7 at 135,145,486 bp
  • T to C, chromosome 8 at 65,013,725 bp
  • C to T, chromosome 8 at 105,843,983 bp
  • A to G, chromosome 8 at 117,035,847 bp
  • A to T, chromosome 9 at 4,427,077 bp
  • C to T, chromosome 9 at 21,396,244 bp
  • A to G, chromosome 9 at 58,199,980 bp
  • T to C, chromosome 9 at 113,674,344 bp
  • T to G, chromosome 10 at 20,977,049 bp
  • T to C, chromosome 10 at 34,324,408 bp
  • A to G, chromosome 11 at 74,682,272 bp
  • A to T, chromosome 11 at 96,801,538 bp
  • T to C, chromosome 11 at 98,378,769 bp
  • T to A, chromosome 11 at 103,497,535 bp
  • T to C, chromosome 12 at 85,339,172 bp
  • T to C, chromosome 13 at 111,709,809 bp
  • A to G, chromosome 14 at 50,819,477 bp
  • T to A, chromosome 16 at 15,717,801 bp
  • CTCGTCTGG to C, chromosome 16 at 31,956,341 bp
  • CGTCTGGATG to CG, chromosome 16 at 31,956,343 bp
  • T to A, chromosome 17 at 6,019,571 bp
  • T to A, chromosome 17 at 45,457,265 bp
  • C to T, chromosome 17 at 45,506,939 bp
  • T to A, chromosome 18 at 9,977,963 bp
  • T to C, chromosome 19 at 12,674,820 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6406 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044551-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.