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Strain Name:
C57BL/6J-MtgxR6406Btlr/Mmmh
Stock Number:
044551-MU
Citation ID:
RRID:MMRRC_044551-MU
Other Names:
R6406 (G1)
Major Collection:

Strain Information

Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Cbx1
Name: chromobox 1
Synonyms: MOD1, M31, Cbx-rs2, HP1B, E430007M08Rik, Hp1beta
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12412
HGNC: HGNC:1551
Homologene: 89116
Dock1
Name: dedicator of cytokinesis 1
Synonyms: D630004B07Rik, 9130006G06Rik, Dock180, b2b3190Clo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, slip, DNAPDcs, XRCC7, DNA-PK, DOXNPH, dxnph
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Spats1
Name: spermatogenesis associated, serine-rich 1
Synonyms: 1700011H05Rik, Srsp1, 4933400B06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71020
VEGA: 17
Homologene: 12376
Trp53bp1
Name: transformation related protein 53 binding protein 1
Synonyms: 53BP1, p53BP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27223
Homologene: 4137
Gria4
Name: glutamate receptor, ionotropic, AMPA4 (alpha 4)
Synonyms: Glur-4, Glur4, spkw1, Gluralpha4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14802
HGNC: HGNC:4574
Homologene: 20227
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 59,058,676 bp
  • G to T, chromosome 1 at 164,050,743 bp
  • A to G, chromosome 1 at 195,169,771 bp
  • A to G, chromosome 2 at 30,257,091 bp
  • T to A, chromosome 2 at 85,760,307 bp
  • T to C, chromosome 2 at 121,270,612 bp
  • A to T, chromosome 2 at 121,300,743 bp
  • T to A, chromosome 2 at 137,087,643 bp
  • C to A, chromosome 2 at 153,904,537 bp
  • T to C, chromosome 2 at 161,553,783 bp
  • A to T, chromosome 2 at 180,197,464 bp
  • A to G, chromosome 3 at 55,480,406 bp
  • T to C, chromosome 3 at 125,438,501 bp
  • T to A, chromosome 3 at 127,032,225 bp
  • A to G, chromosome 4 at 47,122,534 bp
  • A to G, chromosome 4 at 121,319,457 bp
  • T to G, chromosome 5 at 4,756,089 bp
  • C to A, chromosome 5 at 34,923,321 bp
  • C to T, chromosome 5 at 101,663,811 bp
  • T to A, chromosome 5 at 103,863,115 bp
  • TG to TGG, chromosome 6 at 108,664,857 bp
  • G to A, chromosome 6 at 113,055,963 bp
  • C to A, chromosome 6 at 125,173,878 bp
  • CGGCGGCGG to CGGCGGCGGGGGCGGCGG, chromosome 7 at 97,579,926 bp
  • A to G, chromosome 7 at 119,662,261 bp
  • C to A, chromosome 7 at 135,145,486 bp
  • T to C, chromosome 8 at 65,013,725 bp
  • C to T, chromosome 8 at 105,843,983 bp
  • A to G, chromosome 8 at 117,035,847 bp
  • A to T, chromosome 9 at 4,427,077 bp
  • C to T, chromosome 9 at 21,396,244 bp
  • A to G, chromosome 9 at 58,199,980 bp
  • T to C, chromosome 9 at 113,674,344 bp
  • T to G, chromosome 10 at 20,977,049 bp
  • T to C, chromosome 10 at 34,324,408 bp
  • A to G, chromosome 11 at 74,682,272 bp
  • A to T, chromosome 11 at 96,801,538 bp
  • T to C, chromosome 11 at 98,378,769 bp
  • T to A, chromosome 11 at 103,497,535 bp
  • T to C, chromosome 12 at 85,339,172 bp
  • T to C, chromosome 13 at 111,709,809 bp
  • A to G, chromosome 14 at 50,819,477 bp
  • T to A, chromosome 16 at 15,717,801 bp
  • CTCGTCTGG to C, chromosome 16 at 31,956,341 bp
  • CGTCTGGATG to CG, chromosome 16 at 31,956,343 bp
  • T to A, chromosome 17 at 6,019,571 bp
  • T to A, chromosome 17 at 45,457,265 bp
  • C to T, chromosome 17 at 45,506,939 bp
  • T to A, chromosome 18 at 9,977,963 bp
  • T to C, chromosome 19 at 12,674,820 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6406 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044551-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.