Strain Name:
C57BL/6J-MtgxR6415Btlr/Mmmh
Stock Number:
044557-MU
Citation ID:
RRID:MMRRC_044557-MU
Other Names:
R6415 (G1)
Major Collection:

Strain Information

Col1a1
Name: collagen, type I, alpha 1
Synonyms: Cola1, Mov-13, Cola-1, Col1a-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12842
HGNC: HGNC:2197
Homologene: 73874
Adamts20
Name: ADAM metallopeptidase with thrombospondin type 1 motif 20
Synonyms: ADAMTS-20, bt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223838
Homologene: 11808
Dysf
Name: dysferlin
Synonyms: 2310004N10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 26903
HGNC: HGNC:3097
Homologene: 20748
Pcdh9
Name: protocadherin 9
Synonyms: 1500001L12Rik, C630029H24Rik, A730003J17Rik, C530050I23Rik, LOC382930
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211712
HGNC: HGNC:8661
Homologene: 10698
Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: a1G, Cav3.1d
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Fxyd2
Name: FXYD domain-containing ion transport regulator 2
Synonyms: Atp1g1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11936
VEGA: 9
HGNC: HGNC:4026
Tanc1
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Synonyms: 1200003E16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66860
Homologene: 18946
Khdc4
Name: KH domain containing 4, pre-mRNA splicing factor
Synonyms: 2810403A07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74200
Homologene: 41761
Rprd2
Name: regulation of nuclear pre-mRNA domain containing 2
Synonyms: 6720469I21Rik, 2810036A19Rik, 4930535B03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 75137
Homologene: 19997
Mapt
Name: microtubule-associated protein tau
Synonyms: Mtapt, Tau
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17762
HGNC: HGNC:6893
Homologene: 74962
Ppil2
Name: peptidylprolyl isomerase (cyclophilin)-like 2
Synonyms: C130078A06Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66053
HGNC: HGNC:9261
Homologene: 8643
Dscaml1
Name: DS cell adhesion molecule like 1
Synonyms: 4930435C18Rik, 4921507G06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 114873
VEGA: 9
Homologene: 79549
Sptlc1
Name: serine palmitoyltransferase, long chain base subunit 1
Synonyms: Spt1, Lcb1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 268656
VEGA: 13
Homologene: 4681
Cdk13
Name: cyclin dependent kinase 13
Synonyms: Cdc2l5, 2310015O17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69562
VEGA: 13
HGNC: HGNC:1733
Homologene: 135707
Vps35l
Name: VPS35 endosomal protein sorting factor like
Synonyms: 9030624J02Rik, Vsp35l
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71517
Homologene: 10659
Fam91a1
Name: family with sequence similarity 91, member A1
Synonyms: D15Ertd621e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 210998
VEGA: 15
Homologene: 13388
Tut7
Name: terminal uridylyl transferase 7
Synonyms: 6030448M23Rik, Zcchc6, Tent3b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 214290
VEGA: 13
Homologene: 51941
Sub1
Name: SUB1 homolog, transcriptional regulator
Synonyms: Rpo2tc1, Pc4, P15
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20024
Homologene: 38218
Ccdc18
Name: coiled-coil domain containing 18
Synonyms: 4932411G06Rik, 1700021E15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73254
Homologene: 35455
Gab1
Name: growth factor receptor bound protein 2-associated protein 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14388
HGNC: HGNC:4066
Homologene: 1542
Scp2
Name: sterol carrier protein 2, liver
Synonyms: SCPx, nonspecific lipid transfer protein, NSL-TP, ns-LTP, SCP-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20280
Homologene: 37717
Gps1
Name: G protein pathway suppressor 1
Synonyms: Csn1, COPS1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 209318
HGNC: HGNC:4549
Homologene: 3046
Dhx8
Name: DEAH-box helicase 8
Synonyms: Ddx8, mDEAH6, RNA helicase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217207
HGNC: HGNC:2749
Homologene: 3628
Cul5
Name: cullin 5
Synonyms: C030032G03Rik, VACM-1, 8430423K24Rik, 4921514I20Rik, C330021I08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75717
HGNC: HGNC:2556
Homologene: 2597
Dock7
Name: dedicator of cytokinesis 7
Synonyms: m, LOC242555, 3110056M06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67299
Homologene: 23566
Ercc1
Name: excision repair cross-complementing rodent repair deficiency, complementation group 1
Synonyms: Ercc-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13870
HGNC: HGNC:3433
Homologene: 1501
Trap1
Name: TNF receptor-associated protein 1
Synonyms: HSP75, 2410002K23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 68015
Homologene: 9457
Csnk1g2
Name: casein kinase 1, gamma 2
Synonyms: 2810429I12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103236
VEGA: 10
HGNC: HGNC:2455
Homologene: 100845
Tmem231
Name: transmembrane protein 231
Synonyms: 4932417I16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234740
Homologene: 78035
B3gnt5
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 108105
Homologene: 24989
Zbtb44
Name: zinc finger and BTB domain containing 44
Synonyms: Btbd15, 6030404E16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235132
VEGA: 9
Homologene: 18221
Lrp3
Name: low density lipoprotein receptor-related protein 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 435965
HGNC: HGNC:6695
Homologene: 1745
Pgk2
Name: phosphoglycerate kinase 2
Synonyms: Tcp-2, Pgk-2, Tcp-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18663
VEGA: 17
HGNC: HGNC:8898
Homologene: 57138
Rab38
Name: RAB38, member RAS oncogene family
Synonyms: 2310011F14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72433
HGNC: HGNC:9776
Homologene: 21353
Grk1
Name: G protein-coupled receptor kinase 1
Synonyms: Rhok, RK
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 24013
Homologene: 2197
Or10al2
Name: olfactory receptor family 10 subfamily AL member 2
Synonyms: GA_x6K02T2PSCP-2131124-2132089, MOR263-13, Olfr118
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 404308
Homologene: 110622
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Slco1a4
Name: solute carrier organic anion transporter family, member 1a4
Synonyms: Slc21a5, Oatp1a4, Oatp2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28250
Homologene: 130782
Or1j12
Name: olfactory receptor family 1 subfamily J member 12
Synonyms: GA_x6K02T2NLDC-33147742-33148680, Olfr340, MOR136-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258953
Homologene: 74159
Ddx60
Name: DExD/H box helicase 60
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234311
Homologene: 23031
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50720
Adam9
Name: ADAM metallopeptidase domain 9
Synonyms: Mltng, MDC9, Mltng, MDC9
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11502
HGNC: HGNC:216
Homologene: 20824
Hic1
Name: hypermethylated in cancer 1
Synonyms: HIC-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15248
HGNC: HGNC:4909
Homologene: 4740
Cckar
Name: cholecystokinin A receptor
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12425
HGNC: HGNC:1570
Homologene: 37337
Ttc14
Name: tetratricopeptide repeat domain 14
Synonyms: 4930434D01Rik, 4933402I15Rik, 2700016E08Rik, 4931403I22Rik, cI-44
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67120
Homologene: 12085
Plin4
Name: perilipin 4
Synonyms: S3-12
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57435
Homologene: 69311
Zswim5
Name: zinc finger SWIM-type containing 5
Synonyms: 4933426E21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74464
Homologene: 18958
Gpr182
Name: G protein-coupled receptor 182
Synonyms: NOW, G10-D, Gpcr22, Gpcr17, AM-R, Admr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11536
Homologene: 5255
Lactb
Name: lactamase, beta
Synonyms: Mrpl56
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80907
VEGA: 9
Homologene: 12755
Or7g19
Name: olfactory receptor family 7 subfamily G member 19
Synonyms: Olfr832, MOR153-1, GA_x6K02T2PVTD-12687800-12688738
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258075
HGNC: HGNC:8467
Homologene: 128143
Cyp2c69
Name: cytochrome P450, family 2, subfamily c, polypeptide 69
Synonyms: AI098658
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 100043108
VEGA: 19
Homologene: 74936
Or4c10b
Name: olfactory receptor family 4 subfamily C member 10B
Synonyms: GA_x6K02T2Q125-51319458-51320387, Olfr1257, MOR232-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258984
Homologene: 115501
Or6c207
Name: olfactory receptor family 6 subfamily C member 207
Synonyms: MOR114-9, Olfr777, GA_x6K02T2PULF-10955551-10954616
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258537
Homologene: 27203
Or7e165
Name: olfactory receptor family 7 subfamily E member 165
Synonyms: Olfr58, MOR146-7P, GA_x6K02T2PVTD-13523015-13523944, IG6, MOR146-3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18358
Homologene: 134093
Oxsm
Name: 3-oxoacyl-ACP synthase, mitochondrial
Synonyms: 4933425A18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71147
Homologene: 5820
Prelp
Name: proline arginine-rich end leucine-rich repeat
Synonyms: 7330409J17Rik, SLRR2A
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 116847
HGNC: HGNC:9357
Homologene: 2041
H2bc15
Name: H2B clustered histone 15
Synonyms: Hist1h2bn
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319187
Homologene: 136772
Ppargc1a
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Synonyms: Pgc-1alpha, Pgco1, PPAR Gamma Coactivator-1, Gm11133, Pgc1, Pgc-1alphaa, A830037N07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19017
HGNC: HGNC:9237
Homologene: 7485
Tmem140
Name: transmembrane protein 140
Synonyms: 1110007F12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68487
Homologene: 10116
Prss27
Name: serine protease 27
Synonyms: Mpn, CAPH2, Pancreasin, marapsin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 213171
Homologene: 23743
Sftpb
Name: surfactant associated protein B
Synonyms: Sftp-3, SP-B, SF-B, Sftp3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20388
Homologene: 456
4930563M21Rik
Name: RIKEN cDNA 4930563M21 gene
Synonyms: Rfpl3s
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75258
VEGA: 9
Homologene: 138467
Tpt1
Name: tumor protein, translationally-controlled 1
Synonyms: Trt, fortilin, TCTP
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 22070
Homologene: 55730
Pcdha8
Name: protocadherin alpha 8
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 353235
HGNC: HGNC:8675
Homologene: 129614
Or4b1c
Name: olfactory receptor family 4 subfamily B member 1C
Synonyms: Olfr1273-ps, GA_x6K02T2Q125-51650793-51649870, MOR227-4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258977
Homologene: 133649
Igkv4-61
Name: immunoglobulin kappa chain variable 4-61
Synonyms: Gm16895
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 546244
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 133,912,778 bp
  • A to T, chromosome 1 at 133,914,657 bp
  • A to G, chromosome 2 at 36,452,605 bp
  • T to C, chromosome 2 at 59,837,114 bp
  • T to C, chromosome 2 at 89,880,862 bp
  • T to A, chromosome 2 at 90,296,037 bp
  • A to G, chromosome 3 at 33,803,575 bp
  • T to C, chromosome 3 at 88,699,972 bp
  • G to A, chromosome 3 at 95,774,219 bp
  • C to T, chromosome 4 at 98,992,448 bp
  • T to G, chromosome 4 at 108,105,140 bp
  • T to C, chromosome 4 at 116,980,866 bp
  • T to C, chromosome 5 at 51,462,834 bp
  • A to T, chromosome 5 at 53,703,056 bp
  • A to G, chromosome 5 at 108,161,746 bp
  • A to T, chromosome 6 at 34,872,723 bp
  • C to A, chromosome 6 at 69,417,154 bp
  • T to G, chromosome 6 at 72,304,649 bp
  • G to A, chromosome 6 at 84,140,042 bp
  • A to T, chromosome 6 at 141,834,689 bp
  • G to A, chromosome 7 at 19,355,177 bp
  • A to T, chromosome 7 at 35,204,168 bp
  • G to A, chromosome 7 at 88,430,540 bp
  • T to C, chromosome 7 at 118,792,646 bp
  • A to G, chromosome 8 at 13,413,127 bp
  • A to G, chromosome 8 at 24,978,482 bp
  • A to G, chromosome 8 at 61,983,905 bp
  • C to A, chromosome 8 at 80,788,597 bp
  • G to A, chromosome 8 at 111,926,892 bp
  • T to C, chromosome 9 at 18,945,119 bp
  • T to A, chromosome 9 at 19,783,748 bp
  • T to A, chromosome 9 at 31,064,214 bp
  • T to A, chromosome 9 at 45,403,294 bp
  • C to T, chromosome 9 at 45,683,677 bp
  • T to C, chromosome 9 at 53,646,683 bp
  • G to A, chromosome 9 at 55,974,012 bp
  • T to C, chromosome 9 at 66,970,645 bp
  • T to C, chromosome 10 at 80,638,296 bp
  • T to A, chromosome 10 at 127,750,506 bp
  • T to C, chromosome 10 at 129,269,021 bp
  • A to T, chromosome 11 at 59,035,130 bp
  • G to A, chromosome 11 at 75,166,317 bp
  • A to G, chromosome 11 at 94,463,417 bp
  • A to G, chromosome 11 at 94,940,160 bp
  • G to T, chromosome 11 at 101,737,687 bp
  • G to A, chromosome 11 at 104,298,998 bp
  • T to C, chromosome 11 at 120,787,722 bp
  • C to T, chromosome 13 at 17,739,154 bp
  • T to C, chromosome 13 at 21,754,486 bp
  • T to C, chromosome 13 at 53,351,692 bp
  • T to A, chromosome 13 at 59,816,296 bp
  • A to T, chromosome 14 at 16,241,904 bp
  • A to T, chromosome 14 at 61,205,359 bp
  • T to C, chromosome 14 at 75,846,371 bp
  • C to T, chromosome 14 at 93,015,842 bp
  • T to A, chromosome 15 at 11,986,474 bp
  • T to C, chromosome 15 at 58,442,917 bp
  • C to T, chromosome 15 at 94,324,659 bp
  • C to T, chromosome 16 at 4,043,992 bp
  • A to G, chromosome 16 at 17,103,574 bp
  • A to G, chromosome 16 at 19,770,009 bp
  • T to A, chromosome 17 at 24,042,908 bp
  • G to T, chromosome 17 at 37,672,557 bp
  • A to T, chromosome 17 at 40,207,568 bp
  • A to G, chromosome 17 at 56,103,264 bp
  • T to C, chromosome 18 at 36,994,561 bp
  • A to G, chromosome 19 at 39,842,921 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6415 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044557-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.