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Strain Name:
C57BL/6J-MtgxR6415Btlr/Mmmh
Stock Number:
044557-MU
Citation ID:
RRID:MMRRC_044557-MU
Other Names:
R6415 (G1)
Major Collection:

Strain Information

Col1a1
Name: collagen, type I, alpha 1
Synonyms: Col1a-1, Mov-13, Cola1, Cola-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12842
HGNC: HGNC:2197
Homologene: 73874
Adamts20
Name: ADAM metallopeptidase with thrombospondin type 1 motif 20
Synonyms: ADAMTS-20, bt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223838
Homologene: 11808
Pcdh9
Name: protocadherin 9
Synonyms: C630029H24Rik, 1500001L12Rik, LOC382930, A730003J17Rik, C530050I23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211712
HGNC: HGNC:8661
Homologene: 10698
Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: a1G, Cav3.1d
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Fxyd2
Name: FXYD domain-containing ion transport regulator 2
Synonyms: Atp1g1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11936
VEGA: 9
HGNC: HGNC:4026
Tanc1
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Synonyms: 1200003E16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66860
Homologene: 18946
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 133,912,778 bp
  • A to T, chromosome 1 at 133,914,657 bp
  • A to G, chromosome 2 at 36,452,605 bp
  • T to C, chromosome 2 at 59,837,114 bp
  • T to C, chromosome 2 at 89,880,862 bp
  • T to A, chromosome 2 at 90,296,037 bp
  • A to G, chromosome 3 at 33,803,575 bp
  • T to C, chromosome 3 at 88,699,972 bp
  • G to A, chromosome 3 at 95,774,219 bp
  • C to T, chromosome 4 at 98,992,448 bp
  • T to G, chromosome 4 at 108,105,140 bp
  • T to C, chromosome 4 at 116,980,866 bp
  • T to C, chromosome 5 at 51,462,834 bp
  • A to T, chromosome 5 at 53,703,056 bp
  • A to G, chromosome 5 at 108,161,746 bp
  • A to T, chromosome 6 at 34,872,723 bp
  • C to A, chromosome 6 at 69,417,154 bp
  • T to G, chromosome 6 at 72,304,649 bp
  • G to A, chromosome 6 at 84,140,042 bp
  • A to T, chromosome 6 at 141,834,689 bp
  • G to A, chromosome 7 at 19,355,177 bp
  • A to T, chromosome 7 at 35,204,168 bp
  • G to A, chromosome 7 at 88,430,540 bp
  • T to C, chromosome 7 at 118,792,646 bp
  • A to G, chromosome 8 at 13,413,127 bp
  • A to G, chromosome 8 at 24,978,482 bp
  • A to G, chromosome 8 at 61,983,905 bp
  • C to A, chromosome 8 at 80,788,597 bp
  • G to A, chromosome 8 at 111,926,892 bp
  • T to C, chromosome 9 at 18,945,119 bp
  • T to A, chromosome 9 at 19,783,748 bp
  • T to A, chromosome 9 at 31,064,214 bp
  • T to A, chromosome 9 at 45,403,294 bp
  • C to T, chromosome 9 at 45,683,677 bp
  • T to C, chromosome 9 at 53,646,683 bp
  • G to A, chromosome 9 at 55,974,012 bp
  • T to C, chromosome 9 at 66,970,645 bp
  • T to C, chromosome 10 at 80,638,296 bp
  • T to A, chromosome 10 at 127,750,506 bp
  • T to C, chromosome 10 at 129,269,021 bp
  • A to T, chromosome 11 at 59,035,130 bp
  • G to A, chromosome 11 at 75,166,317 bp
  • A to G, chromosome 11 at 94,463,417 bp
  • A to G, chromosome 11 at 94,940,160 bp
  • G to T, chromosome 11 at 101,737,687 bp
  • G to A, chromosome 11 at 104,298,998 bp
  • T to C, chromosome 11 at 120,787,722 bp
  • C to T, chromosome 13 at 17,739,154 bp
  • T to C, chromosome 13 at 21,754,486 bp
  • T to C, chromosome 13 at 53,351,692 bp
  • T to A, chromosome 13 at 59,816,296 bp
  • A to T, chromosome 14 at 16,241,904 bp
  • A to T, chromosome 14 at 61,205,359 bp
  • T to C, chromosome 14 at 75,846,371 bp
  • C to T, chromosome 14 at 93,015,842 bp
  • T to A, chromosome 15 at 11,986,474 bp
  • T to C, chromosome 15 at 58,442,917 bp
  • C to T, chromosome 15 at 94,324,659 bp
  • C to T, chromosome 16 at 4,043,992 bp
  • A to G, chromosome 16 at 17,103,574 bp
  • A to G, chromosome 16 at 19,770,009 bp
  • T to A, chromosome 17 at 24,042,908 bp
  • G to T, chromosome 17 at 37,672,557 bp
  • A to T, chromosome 17 at 40,207,568 bp
  • A to G, chromosome 17 at 56,103,264 bp
  • T to C, chromosome 18 at 36,994,561 bp
  • A to G, chromosome 19 at 39,842,921 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6415 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044557-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.