Strain Name:
C57BL/6J-MtgxR6452Btlr/Mmmh
Stock Number:
044588-MU
Citation ID:
RRID:MMRRC_044588-MU
Other Names:
R6452 (G1)
Major Collection:

Strain Information

Dhx35
Name: DEAH-box helicase 35
Synonyms: 1200009D07Rik, Ddx35
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71715
Homologene: 6406
Larp4b
Name: La ribonucleoprotein 4B
Synonyms: A130023E24Rik, D13Wsu64e, Larp5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 217980
Homologene: 18195
Fasn
Name: fatty acid synthase
Synonyms: FAS, A630082H08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14104
HGNC: HGNC:3594
Homologene: 55800
Cetn3
Name: centrin 3
Synonyms: MmCEN3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12626
VEGA: 13
HGNC: HGNC:1868
Homologene: 74521
Itgb3
Name: integrin beta 3
Synonyms: CD61, platelet glycoprotein IIIa (GP3A)
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16416
HGNC: HGNC:6156
Homologene: 55444
Fnbp1l
Name: formin binding protein 1-like
Synonyms: 2610318I01Rik, TOCA1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 214459
Homologene: 134636
Dnajc14
Name: DnaJ heat shock protein family (Hsp40) member C14
Synonyms: DRIP78, 5730551F12Rik, LIP6, HDJ3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74330
VEGA: 10
Homologene: 12553
Magel2
Name: MAGE family member L2
Synonyms: NDNL1, ns7, nM15, Mage-l2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27385
HGNC: HGNC:6814
Homologene: 8460
Enpp5
Name: ectonucleotide pyrophosphatase/phosphodiesterase 5
Synonyms: D17Abb1e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 83965
Homologene: 23313
Vezf1
Name: vascular endothelial zinc finger 1
Synonyms: db1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22344
Homologene: 5175
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 5430439G14Rik, 6330406J24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71389
Homologene: 32772
Ccdc171
Name: coiled-coil domain containing 171
Synonyms: 4930418J05Rik, A330015D16Rik, 4930473A06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320226
Homologene: 27942
Fzd2
Name: frizzled class receptor 2
Synonyms: Mfz10a, Mfz10, Fz10
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57265
HGNC: HGNC:4040
Homologene: 20377
Slc4a4
Name: solute carrier family 4 (anion exchanger), member 4
Synonyms: NBC, NBC1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54403
Homologene: 55776
Myo7a
Name: myosin VIIA
Synonyms: polka, nmf371, Myo7, USH1B, Hdb
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17921
HGNC: HGNC:7606
Homologene: 219
Alox12e
Name: arachidonate lipoxygenase, epidermal
Synonyms: Aloxe, e-LOX1, Alox12-ps2, 8-LOX, Alox12-ps1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11685
Homologene: 105868
Tex15
Name: testis expressed gene 15 meiosis and synapsis associated
Synonyms: 2210014E14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 104271
Homologene: 12837
Mocos
Name: molybdenum cofactor sulfurase
Synonyms: 1110018O12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 68591
VEGA: 18
Homologene: 9931
Fermt3
Name: fermitin family member 3
Synonyms: Kindlin-3, C79673
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 108101
VEGA: 19
Homologene: 12877
Myh8
Name: myosin, heavy polypeptide 8, skeletal muscle, perinatal
Synonyms: 4832426G23Rik, Myhs-p, MyHC-pn, Myhsp
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17885
HGNC: HGNC:7578
Homologene: 68256
Slc4a9
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 9
Synonyms: AE4, D630024F24Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240215
VEGA: 18
Homologene: 23732
Gjd4
Name: gap junction protein, delta 4
Synonyms: Cx39, 9430022F06Rik, connexin 39
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225152
VEGA: 18
Homologene: 17692
Rabgap1l
Name: RAB GTPase activating protein 1-like
Synonyms: 5830411O09Rik, Hh1, 8430421H08Rik, 9630005B12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 29809
Homologene: 8143
Mprip
Name: myosin phosphatase Rho interacting protein
Synonyms: RIP3, p116 Rho interacting protein, Gm34094, Rhoip3, p116Rip
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26936
Homologene: 9034
Sema4f
Name: sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain
Synonyms: Sema W
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20355
Homologene: 3147
Bmal2
Name: basic helix-loop-helix ARNT like 2
Synonyms: MOP9, Arntl2, bHLHe6, 4632430A05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 272322
Homologene: 10609
Zfp53
Name: zinc finger protein 53
Synonyms: Zfp118, KRAZ1, Zfp-53, zfas8, D030067O06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 24132
VEGA: 17
Homologene: 135946
Or10h5
Name: olfactory receptor family 10 subfamily H member 5
Synonyms: Gm4461, Olfr1564
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100043474
Homologene: 133726
Sppl2c
Name: signal peptide peptidase 2C
Synonyms: 4933407P14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237958
Homologene: 18491
Dglucy
Name: D-glutamate cyclase
Synonyms: 9030617O03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217830
Homologene: 11798
Zfp217
Name: zinc finger protein 217
Synonyms: 4933431C08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228913
Homologene: 4757
Qrich2
Name: glutamine rich 2
Synonyms: LOC217341
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217341
Homologene: 12951
Kctd21
Name: potassium channel tetramerisation domain containing 21
Synonyms: EG622320
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 622320
Homologene: 54754
Tnrc18
Name: trinucleotide repeat containing 18
Synonyms: Zfp469, EG381742
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231861
Homologene: 45603
Rnf43
Name: ring finger protein 43
Synonyms: 4732452J19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207742
Homologene: 37742
Vmn1r210
Name: vomeronasal 1 receptor 210
Synonyms: V1rh10
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171269
Homologene: 110880
Vmn2r96
Name: vomeronasal 2, receptor 96
Synonyms: EG433070
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 433070
Slco6d1
Name: solute carrier organic anion transporter family, member 6d1
Synonyms: 4921511I05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70866
Homologene: 86643
Lrriq4
Name: leucine-rich repeats and IQ motif containing 4
Synonyms: 4930558O21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68307
Homologene: 12260
Cimip1
Name: ciliary microtubule inner protein 1
Synonyms: 1700021F07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72221
Homologene: 82371
Or5p66
Name: olfactory receptor family 5 subfamily P member 66
Synonyms: Olfr490, GA_x6K02T2PBJ9-10617173-10616229, MOR204-17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258491
Homologene: 73955
Prl8a2
Name: prolactin family 8, subfamily a, member 2
Synonyms: D/tPRP, Dtprp, DPRP, mdPRP
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13529
Homologene: 49230
Samm50
Name: SAMM50 sorting and assembly machinery component
Synonyms: 1110030L07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68653
VEGA: 15
Homologene: 41034
Mmp24
Name: matrix metallopeptidase 24
Synonyms: MT5-MMP, Membrane type 5-MMP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17391
HGNC: HGNC:7172
Homologene: 21331
Zscan4d
Name: zinc finger and SCAN domain containing 4D
Synonyms: EG545913
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545913
Homologene: 85986
Rundc3b
Name: RUN domain containing 3B
Synonyms: LOC242819
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242819
Homologene: 16286
Cyp2d34
Name: cytochrome P450, family 2, subfamily d, polypeptide 34
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223706
VEGA: 15
Homologene: 86099
Spg7
Name: SPG7, paraplegin matrix AAA peptidase subunit
Synonyms: spastic paraplegia 7 homolog (human), paraplegin, Cmar
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234847
Homologene: 31133
Filip1l
Name: filamin A interacting protein 1-like
Synonyms: 4631422O05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78749
Homologene: 37121
Klra4
Name: killer cell lectin-like receptor, subfamily A, member 4
Synonyms: Ly49d, Chok, ly49r129
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16635
Homologene: 110821
Tlcd3a
Name: TLC domain containing 3A
Synonyms: 5430402E13Rik, Fam57a, 4932415L08Rik, 2310047D13Rik, Wdt3, 5430420K21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 116972
Homologene: 11720
Tigd5
Name: tigger transposable element derived 5
Synonyms: FLJ14926
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105734
Homologene: 129878
3110070M22Rik
Name: RIKEN cDNA 3110070M22 gene
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67304
VEGA: 13
Smim1
Name: small integral membrane protein 1
Synonyms: 1190007F08Rik, 0610011H04Rik, 2700009I11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68859
Homologene: 130039
Gm32742
Name: predicted gene, 32742
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102635385
Homologene: 132734
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 98,421,212 bp
  • A to G, chromosome 1 at 160,453,761 bp
  • A to T, chromosome 2 at 52,179,483 bp
  • G to A, chromosome 2 at 150,408,108 bp
  • A to T, chromosome 2 at 155,815,753 bp
  • A to G, chromosome 2 at 158,831,687 bp
  • G to T, chromosome 2 at 160,965,498 bp
  • C to G, chromosome 2 at 170,119,294 bp
  • C to A, chromosome 2 at 173,527,907 bp
  • T to C, chromosome 3 at 30,655,733 bp
  • A to G, chromosome 3 at 122,544,549 bp
  • A to G, chromosome 4 at 83,864,290 bp
  • T to C, chromosome 4 at 101,941,443 bp
  • T to C, chromosome 4 at 154,023,614 bp
  • A to T, chromosome 5 at 8,579,175 bp
  • A to G, chromosome 5 at 89,228,980 bp
  • A to C, chromosome 5 at 142,727,012 bp
  • G to A, chromosome 6 at 82,917,662 bp
  • G to T, chromosome 6 at 130,065,366 bp
  • G to A, chromosome 6 at 146,823,207 bp
  • C to T, chromosome 7 at 11,162,072 bp
  • A to G, chromosome 7 at 62,380,384 bp
  • T to A, chromosome 7 at 97,347,662 bp
  • C to T, chromosome 7 at 98,073,167 bp
  • A to G, chromosome 7 at 108,286,893 bp
  • A to G, chromosome 8 at 33,572,816 bp
  • A to G, chromosome 8 at 123,079,423 bp
  • T to C, chromosome 9 at 51,146,190 bp
  • G to T, chromosome 10 at 58,478,157 bp
  • A to G, chromosome 10 at 128,807,490 bp
  • A to T, chromosome 11 at 59,752,783 bp
  • A to T, chromosome 11 at 67,292,449 bp
  • A to T, chromosome 11 at 67,305,739 bp
  • A to T, chromosome 11 at 70,320,005 bp
  • G to T, chromosome 11 at 76,207,146 bp
  • T to A, chromosome 11 at 87,732,253 bp
  • A to G, chromosome 11 at 88,081,670 bp
  • T to G, chromosome 11 at 102,604,985 bp
  • A to T, chromosome 11 at 104,188,191 bp
  • T to A, chromosome 11 at 104,633,464 bp
  • G to A, chromosome 11 at 116,455,888 bp
  • G to T, chromosome 11 at 120,815,411 bp
  • T to C, chromosome 12 at 100,835,209 bp
  • T to C, chromosome 13 at 9,147,467 bp
  • T to A, chromosome 13 at 22,827,670 bp
  • T to C, chromosome 13 at 27,352,797 bp
  • C to T, chromosome 13 at 81,784,678 bp
  • A to G, chromosome 13 at 119,488,115 bp
  • A to T, chromosome 15 at 75,911,438 bp
  • A to T, chromosome 15 at 82,616,089 bp
  • T to G, chromosome 15 at 84,204,097 bp
  • C to A, chromosome 16 at 57,506,800 bp
  • A to C, chromosome 17 at 18,583,855 bp
  • A to C, chromosome 17 at 21,509,613 bp
  • T to C, chromosome 17 at 33,215,945 bp
  • G to A, chromosome 17 at 44,085,264 bp
  • G to A, chromosome 18 at 9,280,457 bp
  • A to G, chromosome 18 at 24,695,941 bp
  • A to G, chromosome 18 at 36,531,459 bp
  • A to T, chromosome 19 at 7,014,737 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6452 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044588-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.